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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619979
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hdac4
Name: histone deacetylase 4
Acc ID: CHEBI:17688
Term: (S)-nicotine
Definition: A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hdac4increases expressionEXP 6480464CTDNicotine results in increased expression of HDAC4 mRNA; Nicotine results in increased expression of HDAC4 proteinPMID:31846720
Hdac4increases expressionISOHdac4 (Mus musculus)6480464CTDNicotine results in increased expression of HDAC4 mRNA; Nicotine results in increased expression of HDAC4 proteinPMID:31846720
Hdac4multiple interactionsISOHdac4 (Mus musculus)6480464CTDVecuronium Bromide inhibits the reaction [Nicotine results in increased expression of HDAC4 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of HDAC4 protein]PMID:31846720
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