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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619979
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hdac4
Name: histone deacetylase 4
Acc ID: CHEBI:140475
Term: MC1568
Definition: A hydroxamic acid that is N-methylpyrrole which is substituted at positions 2 and 5 by 3-(hydroxyamino)-3-oxoprop-1-en-1-yl and 3-(m-fluorophenyl)-3-oxoprop-1-en-1-yl groups, respectively. It is a potent and selective inhibitor of class II (IIa) histone deacetylase (HDAC II).
Chemical ID: MESH:C577554
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hdac4multiple interactionsEXP 6480464CTDMC1568 inhibits the reaction [Thimerosal results in increased expression of HDAC4 protein]

PMID:27660204
Hdac4multiple interactionsISORGD:13168326480464CTDMC1568 inhibits the reaction [Thimerosal results in increased expression of HDAC4 protein]

PMID:27660204
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.