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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2282
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Runx2
Name: RUNX family transcription factor 2
Acc ID: CHEBI:2942
Term: azadirachtin A
Definition: A member of the family of azadirachtins that is isolated from the neem tree (Azadirachta indica).
Chemical ID: MESH:C010329
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Runx2increases expressionISORunx2 (Mus musculus)6480464CTDazadirachtin results in increased expression of RUNX2 mRNA; azadirachtin results in increased expression of RUNX2 proteinPMID:31225646
Runx2multiple interactionsISORunx2 (Mus musculus)6480464CTDESR1 protein promotes the reaction [azadirachtin results in increased expression of RUNX2 mRNA]; ESR1 protein promotes the reaction [azadirachtin results in increased expression of RUNX2 protein]PMID:31225646
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