RGD Reference Report - SNHG20 knockdown suppresses proliferation, migration and invasion, and promotes apoptosis in non-small cell lung cancer through acting as a miR-154 sponge. - Rat Genome Database

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SNHG20 knockdown suppresses proliferation, migration and invasion, and promotes apoptosis in non-small cell lung cancer through acting as a miR-154 sponge.

Authors: Lingling, Jin  Xiangao, Jiang  Guiqing, He  Jichan, Shi  Feifei, Su  Haiyan, Zhu 
Citation: Lingling J, etal., Biomed Pharmacother. 2019 Apr;112:108648. doi: 10.1016/j.biopha.2019.108648. Epub 2019 Feb 16.
RGD ID: 152995466
Pubmed: PMID:30780105   (View Abstract at PubMed)
DOI: DOI:10.1016/j.biopha.2019.108648   (Journal Full-text)

Long noncoding RNAs (LncRNAs) play critical roles in the development and progression of cancers. However, little is known about the function and mechanism of lncRNAs in non-small cell lung cancer (NSCLC). In this study, we investigated the expression and functional role of lncRNA small nucleolar RNA host gene 20 (SNHG20) as well as its underlying mechanism in NSCLC. Our results showed that SNHG20 was significantly up-regulated in NSCLC tissues and cells. High SNHG20 expression was implicated with poor prognosis in NSCLC patients. Moreover, SNHG20 knockdown suppressed proliferation, migration and invasion, and induced apoptosis in NSCLC cells. Furthermore, SNHG20 could function as a competing endogenous RNA (ceRNA) to elevate ZEB2 and RUNX2 expression by sponging miR-154. Rescue assays revealed that miR-154 inhibition could reverse the inhibitory effect of SNHG20 silence on proliferation, migration and invasion in NSCLC cells. More importantly, SNHG20 knockdown suppressed tumor growth in NSCLC in vivo through suppressing miR-154 and elevating ZEB2 and RUNX2 expression. In summary, knockdown of lncRNA SNHG20 suppressed proliferation, migration and invasion, and promotes apoptosis through up-regulating ZEB2 and RUNX2 expression by sponging miR-154 in NSCLC, providing a promising therapeutic target for NSCLC patients.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
MIR154Humanlung non-small cell carcinoma treatmentIDA human cells in mouse modelRGD 
Mir154Mouselung non-small cell carcinoma treatmentISOMIR154 (Homo sapiens)human cells in mouse modelRGD 
Mir154Ratlung non-small cell carcinoma treatmentISOMIR154 (Homo sapiens)human cells in mouse modelRGD 
RUNX2Humanlung non-small cell carcinoma  IDA human cells in mouse modelRGD 
Runx2Ratlung non-small cell carcinoma  ISORUNX2 (Homo sapiens)human cells in mouse modelRGD 
Runx2Mouselung non-small cell carcinoma  ISORUNX2 (Homo sapiens)human cells in mouse modelRGD 
SNHG20Humanlung non-small cell carcinoma treatmentIMP  RGD 
Snhg20Mouselung non-small cell carcinoma treatmentISOSNHG20 (Homo sapiens) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Mir154  (microRNA 154)
Runx2  (RUNX family transcription factor 2)

Genes (Mus musculus)
Mir154  (microRNA 154)
Runx2  (runt related transcription factor 2)
Snhg20  (small nucleolar RNA host gene 20)

Genes (Homo sapiens)
MIR154  (microRNA 154)
RUNX2  (RUNX family transcription factor 2)
SNHG20  (small nucleolar RNA host gene 20)


Additional Information