Runx2 (RUNX family transcription factor 2) - Rat Genome Database

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Gene: Runx2 (RUNX family transcription factor 2) Chinchilla lanigera
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Symbol: Runx2
Name: RUNX family transcription factor 2
RGD ID: 8751440
Description: ENCODES a protein that exhibits bHLH transcription factor binding (ortholog); chromatin binding (ortholog); chromatin DNA binding (ortholog); INVOLVED IN BMP signaling pathway (ortholog); bone mineralization (ortholog); cell maturation (ortholog); PARTICIPATES IN fibroblast growth factor signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; ASSOCIATED WITH Bone Fractures (ortholog); Breast Neoplasms (ortholog); cleidocranial dysplasia (ortholog); FOUND IN chromatin (ortholog); cytoplasm (ortholog); nucleoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: runt related transcription factor 2; runt-related transcription factor 2
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543710,598,145 - 10,800,560 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543710,598,145 - 10,885,858 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
BMP signaling pathway  (ISO)
bone mineralization  (ISO)
cell maturation  (ISO)
cell population proliferation  (ISO)
cellular response to fibroblast growth factor stimulus  (ISO)
cellular response to zinc ion starvation  (ISO)
chondrocyte development  (ISO)
chondrocyte differentiation  (ISO)
embryonic cranial skeleton morphogenesis  (ISO)
embryonic forelimb morphogenesis  (ISO)
endochondral ossification  (ISO)
epithelial cell proliferation  (ISO)
gene expression  (ISO)
ligamentous ossification  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of smoothened signaling pathway  (ISO)
odontogenesis of dentin-containing tooth  (ISO)
osteoblast development  (ISO)
osteoblast differentiation  (ISO)
osteoblast fate commitment  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of chondrocyte differentiation  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of ossification  (ISO)
positive regulation of osteoblast differentiation  (ISO)
positive regulation of stem cell proliferation  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
regulation of fibroblast growth factor receptor signaling pathway  (ISO)
regulation of gene expression  (ISO)
regulation of odontogenesis of dentin-containing tooth  (ISO)
regulation of ossification  (ISO)
regulation of osteoblast differentiation  (ISO)
response to insulin  (ISO)
response to sodium phosphate  (ISO)
skeletal system development  (ISO)
skeletal system morphogenesis  (ISO)
SMAD protein signal transduction  (ISO)
smoothened signaling pathway  (ISO)
stem cell differentiation  (ISO)
stem cell proliferation  (ISO)
T cell differentiation  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Runx2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543710,598,145 - 10,800,560 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543710,598,145 - 10,885,858 (+)NCBIChiLan1.0ChiLan1.0
RUNX2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38645,328,330 - 45,551,082 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl645,328,157 - 45,664,349 (+)EnsemblGRCh38hg38GRCh38
GRCh37645,296,067 - 45,518,819 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36645,404,032 - 45,626,797 (+)NCBINCBI36Build 36hg18NCBI36
Build 34645,498,291 - 45,623,020NCBI
Celera646,849,063 - 47,071,816 (+)NCBICelera
Cytogenetic Map6p21.1NCBI
HuRef645,018,738 - 45,241,794 (+)NCBIHuRef
CHM1_1645,298,649 - 45,521,390 (+)NCBICHM1_1
T2T-CHM13v2.0645,163,134 - 45,385,899 (+)NCBIT2T-CHM13v2.0
Runx2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391744,806,873 - 45,125,518 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1744,806,874 - 45,125,684 (-)EnsemblGRCm39 Ensembl
GRCm381744,495,987 - 44,814,797 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1744,495,987 - 44,814,797 (-)EnsemblGRCm38mm10GRCm38
MGSCv371744,740,950 - 44,951,746 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361744,067,056 - 44,277,682 (-)NCBIMGSCv36mm8
Celera1748,040,272 - 48,252,046 (-)NCBICelera
Cytogenetic Map17B3NCBI
cM Map1721.33NCBI
Runx2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8923,661,278 - 23,990,248 (+)NCBIGRCr8
mRatBN7.2916,167,504 - 16,492,826 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl916,167,482 - 16,492,167 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx924,761,163 - 24,969,039 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0929,823,843 - 30,032,066 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0928,124,579 - 28,332,468 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0918,564,743 - 18,773,092 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl918,564,927 - 18,773,092 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0917,448,142 - 17,658,373 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4911,869,234 - 12,025,219 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1911,867,896 - 11,943,304 (+)NCBI
Celera913,904,221 - 14,111,920 (+)NCBICelera
Cytogenetic Map9q13NCBI
RUNX2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2559,818,489 - 60,045,725 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1655,684,505 - 55,911,773 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0645,003,962 - 45,133,148 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1646,189,426 - 46,411,889 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl646,189,432 - 46,524,389 (+)Ensemblpanpan1.1panPan2
RUNX2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11213,723,535 - 13,842,565 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1213,628,539 - 13,840,785 (+)NCBICanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1213,628,539 - 13,840,785 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1213,657,403 - 13,875,716 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01214,116,775 - 14,343,464 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1214,117,254 - 14,450,732 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11213,641,535 - 13,967,483 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01213,729,537 - 14,055,648 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01213,825,170 - 14,151,515 (+)NCBIUU_Cfam_GSD_1.0
Runx2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494649,141,956 - 49,373,718 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647614,695,965 - 14,905,157 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647614,695,965 - 14,818,246 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RUNX2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl740,106,532 - 40,460,687 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1740,106,581 - 40,353,304 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2746,278,416 - 46,417,291 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RUNX2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11726,679,386 - 26,807,812 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1726,683,175 - 26,807,319 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604445,423,449 - 45,552,140 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Runx2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475414,679,974 - 14,867,729 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475414,601,574 - 14,868,469 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCLAT00000015717   ⟹   ENSCLAP00000015555
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495543710,598,145 - 10,800,560 (+)Ensembl
Ensembl Acc Id: ENSCLAT00000015718   ⟹   ENSCLAP00000015556
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495543710,598,670 - 10,800,376 (+)Ensembl
Ensembl Acc Id: ENSCLAT00000015719   ⟹   ENSCLAP00000015557
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495543710,685,641 - 10,796,587 (+)Ensembl
RefSeq Acc Id: XM_005389822   ⟹   XP_005389879
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495543710,598,145 - 10,800,376 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005389823   ⟹   XP_005389880
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495543710,598,322 - 10,800,376 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005389831   ⟹   XP_005389888
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495543710,682,760 - 10,800,376 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013516854   ⟹   XP_013372308
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495543710,598,670 - 10,800,376 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013516855   ⟹   XP_013372309
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495543710,598,670 - 10,885,858 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013516856   ⟹   XP_013372310
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495543710,598,670 - 10,800,376 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013516857   ⟹   XP_013372311
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495543710,598,670 - 10,800,376 (+)NCBI
Sequence:
RefSeq Acc Id: XP_005389879   ⟸   XM_005389822
- Peptide Label: isoform X1
- UniProtKB: A0A8C2VHG6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005389880   ⟸   XM_005389823
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_005389888   ⟸   XM_005389831
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_013372309   ⟸   XM_013516855
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_013372308   ⟸   XM_013516854
- Peptide Label: isoform X2
- UniProtKB: A0A8C2VPD3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013372310   ⟸   XM_013516856
- Peptide Label: isoform X5
- UniProtKB: A0A8C2VJ77 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013372311   ⟸   XM_013516857
- Peptide Label: isoform X6
- UniProtKB: A0A8C2VJ77 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCLAP00000015557   ⟸   ENSCLAT00000015719
Ensembl Acc Id: ENSCLAP00000015556   ⟸   ENSCLAT00000015718
Ensembl Acc Id: ENSCLAP00000015555   ⟸   ENSCLAT00000015717
Protein Domains
Runt


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000010695 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000015717 ENTREZGENE
  ENSCLAT00000015717.1 UniProtKB/TrEMBL
  ENSCLAT00000015718 ENTREZGENE
  ENSCLAT00000015718.1 UniProtKB/TrEMBL
  ENSCLAT00000015719 ENTREZGENE
  ENSCLAT00000015719.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.720 UniProtKB/TrEMBL
  Signal Protein Aml-1b, Chain A, domain 3 UniProtKB/TrEMBL
InterPro AML1_Runt UniProtKB/TrEMBL
  p53-like_TF_DNA-bd UniProtKB/TrEMBL
  p53/RUNT-type_TF_DNA-bd_sf UniProtKB/TrEMBL
  Runt_dom UniProtKB/TrEMBL
  Runx_central_dom_sf UniProtKB/TrEMBL
  RunxI_C_dom UniProtKB/TrEMBL
  TF_Runt-rel_RUNX UniProtKB/TrEMBL
NCBI Gene Runx2 ENTREZGENE
PANTHER PTHR11950 UniProtKB/TrEMBL
  RUNT-RELATED TRANSCRIPTION FACTOR 2 UniProtKB/TrEMBL
Pfam Runt UniProtKB/TrEMBL
  RunxI UniProtKB/TrEMBL
PIRSF TF_Runt-rel_RUNX UniProtKB/TrEMBL
PRINTS ONCOGENEAML1 UniProtKB/TrEMBL
PROSITE RUNT UniProtKB/TrEMBL
Superfamily-SCOP SSF49417 UniProtKB/TrEMBL
UniProt A0A8C2VHG6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2VJ77 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2VPD3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-09 Runx2  RUNX family transcription factor 2    runt related transcription factor 2  Symbol and/or name change 5135510 APPROVED
2016-08-03 Runx2  runt related transcription factor 2    runt-related transcription factor 2  Symbol and/or name change 5135510 APPROVED