RUNX2 (RUNX family transcription factor 2) - Rat Genome Database

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Gene: RUNX2 (RUNX family transcription factor 2) Sus scrofa
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Symbol: RUNX2
Name: RUNX family transcription factor 2
RGD ID: 14191035
Description: ENCODES a protein that exhibits DNA-binding transcription factor binding (ortholog); general transcription initiation factor binding (ortholog); histone deacetylase binding (ortholog); INVOLVED IN bone mineralization (ortholog); cell maturation (ortholog); cell population proliferation (ortholog); PARTICIPATES IN fibroblast growth factor signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; ASSOCIATED WITH Bone Fractures (ortholog); Breast Neoplasms (ortholog); cleidocranial dysplasia (ortholog); FOUND IN chromatin (inferred); cytoplasm (inferred); nucleoplasm (inferred); INTERACTS WITH ammonium chloride; Bisphenol A diglycidyl ether; deoxynivalenol
Type: protein-coding
RefSeq Status: MODEL
Previously known as: runt related transcription factor 2; runt-related transcription factor 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl740,106,532 - 40,460,687 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1740,106,581 - 40,353,304 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2746,278,416 - 46,417,291 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
BMP signaling pathway  (IEA)
bone mineralization  (IEA,ISO)
cell maturation  (IEA,ISO)
cell population proliferation  (IEA,ISO)
cellular response to fibroblast growth factor stimulus  (ISO)
cellular response to zinc ion starvation  (ISO)
chondrocyte development  (IEA,ISO)
chondrocyte differentiation  (IEA,ISO)
embryonic cranial skeleton morphogenesis  (IEA,ISO)
embryonic forelimb morphogenesis  (IEA,ISO)
endochondral ossification  (IEA,ISO)
epithelial cell proliferation  (IEA,ISO)
gene expression  (IEA,ISO)
ligamentous ossification  (IEA)
negative regulation of DNA-templated transcription  (IEA)
negative regulation of smoothened signaling pathway  (IEA,ISO)
odontogenesis of dentin-containing tooth  (IEA,ISO)
osteoblast development  (IEA,ISO)
osteoblast differentiation  (IEA,ISO)
osteoblast fate commitment  (IEA,ISO)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of chondrocyte differentiation  (IEA,ISO)
positive regulation of developmental process  (IEA)
positive regulation of DNA-templated transcription  (IEA,ISO)
positive regulation of epithelial cell proliferation  (IEA,ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of ossification  (ISO)
positive regulation of osteoblast differentiation  (IEA,ISO)
positive regulation of stem cell proliferation  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
regulation of DNA-templated transcription  (IEA)
regulation of fibroblast growth factor receptor signaling pathway  (IEA,ISO)
regulation of gene expression  (IEA,ISO)
regulation of odontogenesis of dentin-containing tooth  (IEA,ISO)
regulation of ossification  (IEA,ISO)
regulation of osteoblast differentiation  (IEA,ISO)
response to insulin  (ISO)
response to sodium phosphate  (IEA)
skeletal system development  (IEA,ISO)
skeletal system morphogenesis  (IEA,ISO)
SMAD protein signal transduction  (IEA)
smoothened signaling pathway  (IEA,ISO)
stem cell differentiation  (IEA,ISO)
stem cell proliferation  (IEA,ISO)
T cell differentiation  (IEA,ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:27242197   PMID:30032202  


Genomics

Comparative Map Data
RUNX2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl740,106,532 - 40,460,687 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1740,106,581 - 40,353,304 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2746,278,416 - 46,417,291 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RUNX2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38645,328,330 - 45,551,082 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl645,328,157 - 45,664,349 (+)EnsemblGRCh38hg38GRCh38
GRCh37645,296,067 - 45,518,819 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36645,404,032 - 45,626,797 (+)NCBINCBI36Build 36hg18NCBI36
Build 34645,498,291 - 45,623,020NCBI
Celera646,849,063 - 47,071,816 (+)NCBICelera
Cytogenetic Map6p21.1NCBI
HuRef645,018,738 - 45,241,794 (+)NCBIHuRef
CHM1_1645,298,649 - 45,521,390 (+)NCBICHM1_1
T2T-CHM13v2.0645,163,134 - 45,385,899 (+)NCBIT2T-CHM13v2.0
Runx2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391744,806,873 - 45,125,518 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1744,806,874 - 45,125,684 (-)EnsemblGRCm39 Ensembl
GRCm381744,495,987 - 44,814,797 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1744,495,987 - 44,814,797 (-)EnsemblGRCm38mm10GRCm38
MGSCv371744,740,950 - 44,951,746 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361744,067,056 - 44,277,682 (-)NCBIMGSCv36mm8
Celera1748,040,272 - 48,252,046 (-)NCBICelera
Cytogenetic Map17B3NCBI
cM Map1721.33NCBI
Runx2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8923,661,278 - 23,990,248 (+)NCBIGRCr8
mRatBN7.2916,167,504 - 16,492,826 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl916,167,482 - 16,492,167 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx924,761,163 - 24,969,039 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0929,823,843 - 30,032,066 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0928,124,579 - 28,332,468 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0918,564,743 - 18,773,092 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl918,564,927 - 18,773,092 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0917,448,142 - 17,658,373 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4911,869,234 - 12,025,219 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1911,867,896 - 11,943,304 (+)NCBI
Celera913,904,221 - 14,111,920 (+)NCBICelera
Cytogenetic Map9q13NCBI
Runx2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543710,598,145 - 10,800,560 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543710,598,145 - 10,885,858 (+)NCBIChiLan1.0ChiLan1.0
RUNX2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2559,818,489 - 60,045,725 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1655,684,505 - 55,911,773 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0645,003,962 - 45,133,148 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1646,189,426 - 46,411,889 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl646,189,432 - 46,524,389 (+)Ensemblpanpan1.1panPan2
RUNX2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11213,723,535 - 13,842,565 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1213,628,539 - 13,840,785 (+)NCBICanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1213,628,539 - 13,840,785 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1213,657,403 - 13,875,716 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01214,116,775 - 14,343,464 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1214,117,254 - 14,450,732 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11213,641,535 - 13,967,483 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01213,729,537 - 14,055,648 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01213,825,170 - 14,151,515 (+)NCBIUU_Cfam_GSD_1.0
Runx2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494649,141,956 - 49,373,718 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647614,695,965 - 14,905,157 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647614,695,965 - 14,818,246 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RUNX2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11726,679,386 - 26,807,812 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1726,683,175 - 26,807,319 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604445,423,449 - 45,552,140 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Runx2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475414,679,974 - 14,867,729 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475414,601,574 - 14,868,469 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in RUNX2
6000 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 22 3 2 5 14 12 22 3 6 3

Sequence


Ensembl Acc Id: ENSSSCT00000001910   ⟹   ENSSSCP00000001863
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl740,205,455 - 40,316,707 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000044704   ⟹   ENSSSCP00000040420
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl740,106,513 - 40,347,474 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000053493   ⟹   ENSSSCP00000032242
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl740,106,532 - 40,353,299 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000059192   ⟹   ENSSSCP00000050807
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl740,106,644 - 40,353,300 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000083673   ⟹   ENSSSCP00000073388
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl740,106,532 - 40,460,687 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000088700   ⟹   ENSSSCP00000067616
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl740,106,685 - 40,112,774 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000089878   ⟹   ENSSSCP00000070509
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl740,106,513 - 40,353,299 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000090875   ⟹   ENSSSCP00000068961
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl740,205,455 - 40,326,045 (+)Ensembl
RefSeq Acc Id: XM_003482203   ⟹   XP_003482251
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1740,106,581 - 40,353,304 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005666073   ⟹   XP_005666130
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1740,106,581 - 40,353,304 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005666074   ⟹   XP_005666131
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1740,106,581 - 40,353,304 (+)NCBI
Sequence:
RefSeq Acc Id: XP_003482251   ⟸   XM_003482203
- Peptide Label: isoform X1
- UniProtKB: A0A480XW93 (UniProtKB/TrEMBL),   A0A8D1KYV6 (UniProtKB/TrEMBL),   A0A286ZKW6 (UniProtKB/TrEMBL),   A0A8D1QYD0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005666130   ⟸   XM_005666073
- Peptide Label: isoform X2
- UniProtKB: A0A8D1R1Z5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005666131   ⟸   XM_005666074
- Peptide Label: isoform X3
- UniProtKB: A0A8D1QYD0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000067616   ⟸   ENSSSCT00000088700
Ensembl Acc Id: ENSSSCP00000073388   ⟸   ENSSSCT00000083673
Ensembl Acc Id: ENSSSCP00000040420   ⟸   ENSSSCT00000044704
Ensembl Acc Id: ENSSSCP00000070509   ⟸   ENSSSCT00000089878
Ensembl Acc Id: ENSSSCP00000068961   ⟸   ENSSSCT00000090875
Ensembl Acc Id: ENSSSCP00000050807   ⟸   ENSSSCT00000059192
Ensembl Acc Id: ENSSSCP00000001863   ⟸   ENSSSCT00000001910
Ensembl Acc Id: ENSSSCP00000032242   ⟸   ENSSSCT00000053493
Protein Domains
Runt   Runx C-terminal


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000001710 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015014884 UniProtKB/TrEMBL
  ENSSSCG00025024902 UniProtKB/TrEMBL
  ENSSSCG00030066019 UniProtKB/TrEMBL
  ENSSSCG00035079177 UniProtKB/TrEMBL
  ENSSSCG00040002901 UniProtKB/TrEMBL
  ENSSSCG00045019606 UniProtKB/TrEMBL
  ENSSSCG00050003674 UniProtKB/TrEMBL
  ENSSSCG00055016629 UniProtKB/TrEMBL
  ENSSSCG00060018768 UniProtKB/TrEMBL
  ENSSSCG00065060039 UniProtKB/TrEMBL
  ENSSSCG00070021695 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000053493 ENTREZGENE
  ENSSSCT00000053493.3 UniProtKB/TrEMBL
  ENSSSCT00000059192 ENTREZGENE
  ENSSSCT00000059192.3 UniProtKB/TrEMBL
  ENSSSCT00000083673.2 UniProtKB/TrEMBL
  ENSSSCT00015019681.1 UniProtKB/TrEMBL
  ENSSSCT00025033664.1 UniProtKB/TrEMBL
  ENSSSCT00025033823.1 UniProtKB/TrEMBL
  ENSSSCT00025033952.1 UniProtKB/TrEMBL
  ENSSSCT00030092360.1 UniProtKB/TrEMBL
  ENSSSCT00030092641.1 UniProtKB/TrEMBL
  ENSSSCT00035108319.1 UniProtKB/TrEMBL
  ENSSSCT00035108356.1 UniProtKB/TrEMBL
  ENSSSCT00035108414.1 UniProtKB/TrEMBL
  ENSSSCT00035108467.1 UniProtKB/TrEMBL
  ENSSSCT00040003652.1 UniProtKB/TrEMBL
  ENSSSCT00040003683.1 UniProtKB/TrEMBL
  ENSSSCT00040003706.1 UniProtKB/TrEMBL
  ENSSSCT00045033484.1 UniProtKB/TrEMBL
  ENSSSCT00045033845.1 UniProtKB/TrEMBL
  ENSSSCT00050004983.1 UniProtKB/TrEMBL
  ENSSSCT00050005081.1 UniProtKB/TrEMBL
  ENSSSCT00055033035.1 UniProtKB/TrEMBL
  ENSSSCT00055033127.1 UniProtKB/TrEMBL
  ENSSSCT00055033222.1 UniProtKB/TrEMBL
  ENSSSCT00055033290.1 UniProtKB/TrEMBL
  ENSSSCT00060025301.1 UniProtKB/TrEMBL
  ENSSSCT00065082254.1 UniProtKB/TrEMBL
  ENSSSCT00065082330.1 UniProtKB/TrEMBL
  ENSSSCT00070043083.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.720 UniProtKB/TrEMBL
InterPro AML1_Runt UniProtKB/TrEMBL
  p53-like_TF_DNA-bd UniProtKB/TrEMBL
  p53/RUNT-type_TF_DNA-bd_sf UniProtKB/TrEMBL
  Runt_dom UniProtKB/TrEMBL
  Runx_central_dom_sf UniProtKB/TrEMBL
  RunxI_C_dom UniProtKB/TrEMBL
  TF_Runt-rel_RUNX UniProtKB/TrEMBL
NCBI Gene RUNX2 ENTREZGENE
PANTHER PTHR11950 UniProtKB/TrEMBL
  RUNT-RELATED TRANSCRIPTION FACTOR 2 UniProtKB/TrEMBL
Pfam Runt UniProtKB/TrEMBL
  RunxI UniProtKB/TrEMBL
PIRSF TF_Runt-rel_RUNX UniProtKB/TrEMBL
PRINTS ONCOGENEAML1 UniProtKB/TrEMBL
PROSITE RUNT UniProtKB/TrEMBL
Superfamily-SCOP SSF49417 UniProtKB/TrEMBL
UniProt A0A286ZKW6 ENTREZGENE, UniProtKB/TrEMBL
  A0A287B3G3_PIG UniProtKB/TrEMBL
  A0A480XW93 ENTREZGENE
  A0A4X1V3U0_PIG UniProtKB/TrEMBL
  A0A5G2R7Z2_PIG UniProtKB/TrEMBL
  A0A8D1BHV3_PIG UniProtKB/TrEMBL
  A0A8D1KYV6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1QYD0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1R1Z5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D2CCT3_PIG UniProtKB/TrEMBL
  B3GBX6_PIG UniProtKB/TrEMBL
UniProt Secondary A0A480XW93 UniProtKB/TrEMBL
VGNC ID VGNC:92517 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-09 RUNX2  RUNX family transcription factor 2    runt related transcription factor 2  Symbol and/or name change 5135510 APPROVED