Foxo4 (forkhead box O4) - Rat Genome Database

Name: Foxo4
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Foxo4 (forkhead box O4) Rattus norvegicus

Analyze

Symbol:

Foxo4

Name:

forkhead box O4

RGD ID:

1561201

Description:

Enables promoter-specific chromatin binding activity. Involved in positive regulation of smooth muscle cell migration; response to nutrient levels; and response to water-immersion restraint stress. Predicted to be located in cytosol and nuclear speck. Predicted to be active in nucleus. Biomarker of alcohol-induced mental disorder; gastric ulcer; and paraplegia. Orthologous to human FOXO4 (forkhead box O4); PARTICIPATES IN phosphatidylinositol 3-kinase-Akt signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; acrylamide.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

forkhead box protein O4; LOC302415; RGD1561201; similar to forkhead protein AFXH

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	FOXO4 (forkhead box O4)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Mus musculus (house mouse):	Foxo4 (forkhead box O4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Foxo4 (forkhead box O4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	FOXO4 (forkhead box O4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	FOXO4 (forkhead box O4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Foxo4 (forkhead box O4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	FOXO4 (forkhead box O4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	FOXO4 (forkhead box O4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Foxo4 (forkhead box O4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	FOXO4 (forkhead box O4)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Foxo4 (forkhead box O4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	foxo4 (forkhead box O4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	daf-16	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	foxo	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	foxo4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	X	66,385,241 - 66,392,115 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	66,385,558 - 66,392,115 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	67,868,914 - 67,875,471 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	X	71,369,302 - 71,375,859 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	X	68,930,209 - 68,936,766 (+)	NCBI	Rnor_WKY
Rnor_6.0	X	71,155,284 - 71,162,158 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	71,155,601 - 71,162,158 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	72,007,762 - 72,014,636 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	89,332,278 - 89,338,835 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	X	66,741,475 - 66,748,019 (+)	NCBI		Celera
Cytogenetic Map	X	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

alcohol-induced mental disorder (IEP)

autistic disorder (ISO)

FG Syndrome 1 (ISO)

gastric ulcer (IEP)

genetic disease (ISO)

hemangioma (ISO)

intellectual disability (ISO)

lymphoblastic lymphoma (ISO)

Neointima (ISO)

paraplegia (IEP)

Sarcopenia (IEP)

syndromic X-linked intellectual disability Lubs type (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(1->4)-beta-D-glucan (ISO)

1,2-dichloroethane (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3-Nitrobenzanthrone (ISO)

4,4'-sulfonyldiphenol (ISO)

4-nitrophenol (ISO)

5-aza-2'-deoxycytidine (ISO)

acrylamide (EXP,ISO)

aflatoxin B1 (EXP)

Aflatoxin B2 alpha (ISO)

all-trans-retinoic acid (EXP,ISO)

antimycin A (ISO)

arsenous acid (ISO)

atrazine (ISO)

azoxystrobin (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

cadmium dichloride (ISO)

calcitriol (ISO)

choline (ISO)

cisplatin (ISO)

clothianidin (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

DDE (ISO)

deguelin (ISO)

dextran sulfate (ISO)

diarsenic trioxide (ISO)

dibutyl phthalate (EXP)

dioxygen (ISO)

doxorubicin (ISO)

ethanol (ISO)

fipronil (EXP)

folic acid (ISO)

fonofos (ISO)

fulvestrant (ISO)

gentamycin (EXP)

geraniol (ISO)

L-methionine (ISO)

LY294002 (ISO)

malathion (ISO)

nickel atom (ISO)

NMN zwitterion (ISO)

ozone (ISO)

paracetamol (EXP,ISO)

parathion (ISO)

perfluorononanoic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

picoxystrobin (ISO)

pirinixic acid (ISO)

propiconazole (ISO)

resveratrol (EXP,ISO)

rotenone (ISO)

silicon dioxide (ISO)

sodium dodecyl sulfate (ISO)

sunitinib (ISO)

tamibarotene (ISO)

terbufos (ISO)

testosterone (ISO)

tetrachloromethane (EXP)

thapsigargin (ISO)

titanium dioxide (ISO)

toluene (EXP)

trichostatin A (ISO)

tris(2-butoxyethyl) phosphate (ISO)

tungsten (ISO)

urethane (ISO)

wortmannin (ISO)

zinc atom (ISO)

zinc sulfate (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

insulin receptor signaling pathway (ISO)

mitotic G2 DNA damage checkpoint signaling (ISO)

negative regulation of angiogenesis (ISO)

negative regulation of cell population proliferation (ISO)

negative regulation of G0 to G1 transition (ISO)

negative regulation of smooth muscle cell differentiation (ISO)

positive regulation of DNA-templated transcription (ISO)

positive regulation of smooth muscle cell migration (IMP)

positive regulation of transcription by RNA polymerase II (ISO)

regulation of DNA-templated transcription (ISO)

regulation of transcription by RNA polymerase II (IBA)

response to nutrient levels (IEP)

response to oxidative stress (IEA,ISO)

response to water-immersion restraint stress (IEP)

stem cell differentiation (ISO)

Cellular Component

cytoplasm (ISO)

cytosol (ISO)

nuclear speck (IEA,ISO)

nucleus (IBA,ISO)

Molecular Function

beta-catenin binding (ISO)

DNA binding (ISO)

DNA-binding transcription activator activity, RNA polymerase II-specific (ISO)

DNA-binding transcription factor activity (ISO)

DNA-binding transcription factor activity, RNA polymerase II-specific (IBA)

DNA-binding transcription factor binding (ISO)

enzyme binding (ISO)

identical protein binding (ISO)

nucleic acid binding (ISO)

promoter-specific chromatin binding (IDA)

protein binding (IPI,ISO)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IBA)

sequence-specific DNA binding (ISO)

sequence-specific double-stranded DNA binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

phosphatidylinositol 3-kinase-Akt signaling pathway (ISO)

transforming growth factor-beta Smad dependent signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	The role of FoxO4 in the relationship between alcohol-induced intestinal barrier dysfunction and liver injury.	Chang B, etal., Int J Mol Med. 2013 Mar;31(3):569-76. doi: 10.3892/ijmm.2013.1229. Epub 2013 Jan 4.
2.	Gene and protein expression associated with protein synthesis and breakdown in paraplegic skeletal muscle.	Drummond MJ, etal., Muscle Nerve. 2008 Apr;37(4):505-13.
3.	Atrogin-1/MAFbx and MuRF1 are downregulated in aging-related loss of skeletal muscle.	Edstrom E, etal., J Gerontol A Biol Sci Med Sci. 2006 Jul;61(7):663-74.
4.	Effects of aging and caloric restriction on the gene expression of Foxo1, 3, and 4 (FKHR, FKHRL1, and AFX) in the rat skeletal muscles.	Furuyama T, etal., Microsc Res Tech. 2002 Nov 15;59(4):331-4.
5.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6.	Effect of the IGF-1/PTEN/Akt/FoxO signaling pathway in the duodenal mucosa of rats subjected to water immersion and restraint stress.	Huang P, etal., Genet Mol Res. 2012 Sep 19;11(4):4775-88. doi: 10.4238/2012.September.19.2.
7.	Effect of the IGF-1/PTEN/Akt/FoxO signaling pathway on the development and healing of water immersion and restraint stress-induced gastric ulcers in rats.	Huang P, etal., Int J Mol Med. 2012 Sep;30(3):650-8. doi: 10.3892/ijmm.2012.1041. Epub 2012 Jun 20.
8.	Age-dependent expression of forkhead box O proteins in the duodenum of rats.	Huang P, etal., J Zhejiang Univ Sci B. 2011 Sep;12(9):730-5. doi: 10.1631/jzus.B1000298.
9.	FoxO4 regulates tumor necrosis factor alpha-directed smooth muscle cell migration by activating matrix metalloproteinase 9 gene transcription.	Li H, etal., Mol Cell Biol. 2007 Apr;27(7):2676-86. Epub 2007 Jan 22.
10.	Phenotypic modulation of smooth muscle cells through interaction of Foxo4 and myocardin.	Liu ZP, etal., Dev Cell. 2005 Aug;9(2):261-70.
11.	Smad transcription factors.	Massagué J, etal., Genes Dev. 2005 Dec 1;19(23):2783-810.
12.	Antioxidant administration attenuates mechanical ventilation-induced rat diaphragm muscle atrophy independent of protein kinase B (PKB Akt) signalling.	McClung JM, etal., J Physiol. 2007 Nov 15;585(Pt 1):203-15. Epub 2007 Oct 4.
13.	FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis.	Paik JH, etal., Cell. 2007 Jan 26;128(2):309-23. doi: 10.1016/j.cell.2006.12.029.
14.	PID Annotation Import Pipeline	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
15.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
16.	How the Smads regulate transcription.	Ross S and Hill CS, Int J Biochem Cell Biol. 2008;40(3):383-408. Epub 2007 Oct 7.

Additional References at PubMed

PMID:10217147	PMID:10783894	PMID:11353388	PMID:11689711	PMID:12048180	PMID:12761217	PMID:14966295	PMID:15126506	PMID:15905404	PMID:16272144	PMID:16964248	PMID:19932102
PMID:22972301	PMID:23332764	PMID:24663349	PMID:25609649	PMID:29409329	PMID:31044535	PMID:33390770	PMID:34251583	PMID:34549304	PMID:35089807	PMID:36607602

Genomics

Comparative Map Data

Foxo4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	X	66,385,241 - 66,392,115 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	66,385,558 - 66,392,115 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	67,868,914 - 67,875,471 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	X	71,369,302 - 71,375,859 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	X	68,930,209 - 68,936,766 (+)	NCBI	Rnor_WKY
Rnor_6.0	X	71,155,284 - 71,162,158 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	71,155,601 - 71,162,158 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	72,007,762 - 72,014,636 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	89,332,278 - 89,338,835 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	X	66,741,475 - 66,748,019 (+)	NCBI		Celera
Cytogenetic Map	X	q22	NCBI

FOXO4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	71,095,851 - 71,103,532 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	X	71,095,851 - 71,103,532 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	X	70,315,701 - 70,323,382 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	70,232,751 - 70,240,109 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	X	70,099,230 - 70,106,405	NCBI
Celera	X	70,670,001 - 70,677,287 (+)	NCBI		Celera
Cytogenetic Map	X	q13.1	NCBI
HuRef	X	64,135,718 - 64,143,103 (+)	NCBI		HuRef
CHM1_1	X	70,208,338 - 70,215,723 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	X	69,529,947 - 69,537,628 (+)	NCBI		T2T-CHM13v2.0

Foxo4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	100,297,855 - 100,304,479 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	100,298,134 - 100,304,479 (+)	Ensembl		GRCm39 Ensembl
GRCm38	X	101,254,261 - 101,260,873 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	101,254,528 - 101,260,873 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	98,449,867 - 98,456,212 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	X	97,457,247 - 97,462,413 (+)	NCBI		MGSCv36	mm8
Celera	X	88,170,853 - 88,177,001 (+)	NCBI		Celera
Cytogenetic Map	X	D	NCBI
cM Map	X	43.89	NCBI

Foxo4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955475	10,665,987 - 10,674,110 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955475	10,666,024 - 10,673,717 (+)	NCBI	ChiLan1.0	ChiLan1.0

FOXO4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	X	70,777,460 - 70,784,897 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	60,364,466 - 60,372,147 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	70,422,504 - 70,429,971 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	70,422,504 - 70,429,971 (+)	Ensembl	panpan1.1		panPan2

FOXO4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	55,469,738 - 55,477,699 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	55,469,382 - 55,477,699 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	X	46,296,815 - 46,304,773 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	X	56,438,647 - 56,446,613 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	X	56,438,272 - 56,446,607 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	X	54,406,889 - 54,414,846 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	55,738,314 - 55,746,276 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	55,665,450 - 55,673,416 (+)	NCBI		UU_Cfam_GSD_1.0

Foxo4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	46,731,760 - 46,739,080 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936762	493,910 - 501,531 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936762	495,271 - 501,278 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

FOXO4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	57,132,548 - 57,140,356 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	X	57,132,549 - 57,140,377 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	X	64,662,694 - 64,670,530 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

FOXO4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	60,893,711 - 60,901,134 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	X	60,893,526 - 60,902,844 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666065	2,753,315 - 2,760,992 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Foxo4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624903	1,391,910 - 1,399,949 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624903	1,390,899 - 1,399,745 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Foxo4
5 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	689
Count of miRNA genes:	282
Interacting mature miRNAs:	369
Transcripts:	ENSRNOT00000048521
Prediction methods:	Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
61430	Cia18	Collagen induced arthritis QTL 18	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	X	14843113	120568734	Rat
1598837	Memor13	Memory QTL 13	3.2		exploratory behavior trait (VT:0010471)	difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)	X	41052407	146860749	Rat
738035	Stresp1	Stress response QTL 1	4.96	0.000011	stress-related behavior trait (VT:0010451)	defensive burying - coping	X	41304447	112935181	Rat
61431	Cia19	Collagen induced arthritis QTL 19	4.4		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	X	65612192	120568734	Rat

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	35	25	18	18	18	8	11	54	29	35	11	8
Low		8	32	23	1	23			20	6	6
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001106943	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017601967	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473966	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000420	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000048521 ⟹ ENSRNOP00000042383

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	X	66,385,558 - 66,392,115 (+)	Ensembl
Rnor_6.0 Ensembl	X	71,155,601 - 71,162,158 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000076453 ⟹ ENSRNOP00000068509

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	X	71,155,601 - 71,160,837 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000076479 ⟹ ENSRNOP00000068105

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	X	66,385,851 - 66,392,115 (+)	Ensembl
Rnor_6.0 Ensembl	X	71,155,894 - 71,160,371 (+)	Ensembl

RefSeq Acc Id:

NM_001106943 ⟹ NP_001100413

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	X	66,385,558 - 66,392,115 (+)	NCBI
Rnor_6.0	X	71,155,601 - 71,162,158 (+)	NCBI
Rnor_5.0	X	72,007,762 - 72,014,636 (+)	NCBI
RGSC_v3.4	X	89,332,278 - 89,338,835 (+)	RGD
Celera	X	66,741,475 - 66,748,019 (+)	RGD

Sequence:

show sequence

GCCTCAGGTTTAAAAGAGCAGGAAGCTGAGTGAGAGGGTGCAGAAAAACTGGAAAGAATGTGTT
TCCCCCCTTGGGGGAGGCATGGTGAGGGACTGTGGCAGGCTCCACTGAACGCTGAGCTGCAGAG
GTTCGACCCCACGTATGGAGCCAGAGAATAAGAAGTCAGCCACAGAGGCTGCCGCGATCATAGA
CCTCGATCCCGACTTCGAACCCCAGAGCCGTCCGCGGTCCTGCACCTGGCCCCTTCCTCGACCA
GAGCTCGCTACGGAGCCACCCGAACCGTCCGAGGTGGAGCCCAGTCTGGGACAGAAGGTACCCA
CGGAGGGACACTCCGAACCGACCCTGTTGCCCTCTCGGCTCCCAGAGCCGGCAGGGGGCCCCCA
GCCGGAAATCCTGGGGGCTGTAACAGGTCCTCGGAAGGGAGGCTCCCGCCGGAATGCCTGGGGA
AATCAGTCATATGCAGAACTCATCAGCCAGGCCATTGAAAGCGCCCCGGAGAAGCGGCTGACAC
TCGCCCAGATATACGAATGGATGGTCCGCACGGTGCCCTACTTCAAGGACAAGGGTGACAGCAA
CAGCTCGGCAGGATGGAAGAACTCCATCCGTCACAACCTGTCTTTGCACAGCAAGTTCATCAAG
GTACATAACGAGGCCACCGGCAAGAGCTCTTGGTGGATGCTGAACCCCGATGGCGGCAAGGGTG
GCAAGGCACCCCGGCGCAGGGCTGCCTCCATGGATAGCAGCAGCAAGCTGCTCCGGGGCCGCAG
CAAAGGCCCCAAGAAGAAGCCATCTGTCCTGCCAGCTCCACCTGAAGGTGCCACTCCAAGGAGC
CCTCTGGGCCACTTTGCCAAGTGGTCGAGCAGTCCTTGTCCTCGAAATCGAGAAGAAGCTGATG
TGTGGACCACTTTCCGTCCACGAAGCAGTTCAAATGCTAGCACTGTCAGCACTCGGCTGTCCCC
AATGAGGCCGGAGTCTGAGGTGCTAGCAGAAGAGGAAATGCCAGCCTCAGCCAGCAGCTATGCA
GGGGGTGTCCCTCCCACCCTCAGTGAAGATCTAGAGCTGCTGGATGGGCTCAATCTTGCATCTC
CCCATTCCTTGCTGTCCAGGAGCAATCTCTCCAGCTTCTCTTTGCAGCATCCTGGGCTTGCTGG
CCCCTTACATAGCTATGGCGCCTCCCTCTTTGGCCCAATAGATGGGTCTTTGTCAGCAGGAGAA
GGGTGCTTCTCGAGTTCCCAGTCTCTAGAGGCTCTGCTCACCTCTGATACACCACCACCTCCTG
CTGATGTTCTCATGACCCAGGTAGATCCTATCCTGTCTCAGGCTCCTACACTTCTGTTACTGGG
AGGAATGCCTTCCTCTAGCAAGCTGGCCACAGGAGTCAGCCTGTGTCCTACGCCGCTAGAGGGT
CCTGGTCCCAGCAACCTGGTTCCCACCCTTTCTGTGATGGCACCACCTCCAGTCATGCCAGGTG
CTCCCATCCCTAAGGTCCTGGGAACCCCTGTGCTTGCATCTCCTACTGAAGATTTCAGCCATGA
CAGAATGCCTCAGGATCTGGATCTTGATATGTACATGGAGAACCTGGAGTGTGACATGGATAAC
ATCATCAGTGACCTCATGGATGGTGAGGGACTGGACTTCAACTTTGAGCCAGATCCCTGAGTCA
CAGCAAGAAGCTTTGTCCCCTGCTTCAGAGGTGGAGCCGGAGCCGAGCCTGTCCTTATCCACTT
TTCCCCCTTGAGCCCTCCCCAGGAGTCTGGGACCCTACGTTAGAGCTAGGGATAGGTGGTCACA
CACTCAAGTGTTGAGGAAATTATAAAGATACATCAATGACAGTAGGGATTGTGAAGGAGGGTGA
TGGGAGGAAGGAGGGAAAGGCTTATTCTCACTGTGCCAATTAGGGGGTAATTATGGTCCTTTCT
CAGGGGCCACCATTGATTTCCCCATTACACCTCCTAGGCCTTGAAGCAGGGGCCAGCAATGCTG
TTGGAAATGTGAAGTCACCAGTGGCCTTATTACCCTGCCTTTGGGAGCAGGATCATTATTATTA
TTATTATTATTTTTGGTAGAGAGAGTCTTACTAGAGCTGGGCCAGGCTGGGTTGAGCCTGGATT
TTTATGCAGTGGGGTGGGTGGGTGGGGGTTGGGGACCTAGAAGGGCCAAGTTTTGAGCACTGGA
GTGGCTCACCAGGCCAAATCACTTTTGAAAGGATGCAGATAACAGACAGGCTTTTTATAAACTT
TTAAAGAAATATAAACACAAATATAGAGATTTTTAACAGTGGTGAGGTGCTAGTGAGGGGGAGA
AGGCTTTTTTTCTTTCCGAAGGCTTTGTCATAGTGACATGATACAAACACTACAGACTCTTACG
GAGGAGACACAGGAAGCTAGGGAAAGGTGGGTAGCAAGAGTGACTGGAAGGAAGCGTTCCCCCT
TGGACCAGGTCTAGAAAAAGCTCTATACATAGTTTTAAGCACAGAAACCTAAGCCAGGTCTCTG
CATTCTGTCCACTAGTGCCTAGAAGAGGGTGCTGTTGTGGGGCAAGCACACTCTTGTTTCACCA
GTGCGGGTTAGTGCTCCCAGAGAGAGCATCCAAAGCCTGAAATTGGCTTGGGGCCTGGGAGGGG
CGTGAAAGAAGGAAGGATTTAGGGTAGTAAAGTTAGGTACAGAGACCTCCCTGTTCAAGGCCTG
GGACAGCTGTCCCTGCCCTTCTTCCCAGTCCTGGTCTGCCAGGGTTATGTGAAGACCATAGTGG
CAGGCAGGGTTGTGGGGAGGAACAGGGAAGGGGGAGCTTGGGGAGTTTGGCTGAGGGTCTGGGA
AATGAGCAGGGATGGGGGGAATGTGGATCAGGTTTACTAGCACCTGCCAGAGAGGCCATCTGGG
GCTCCTCCACCCCAGCCCCCAAGCAGCCCCTCCCCCAGCGCCCTTTGCATTGTCCCCTCCCCCA
CTCCTGCTGTGGGTTCCCATCATTTCCTGTGTCAGCGCCTGGCCTACCCAGATTGTATCATGTG
CTAGATTGGAGTGGGGAAGTGTGTCAAATCAATAAGTGAGTTCAATAAATGTCTATAATCAGAT
CTGGTTTCTGGTTTCTGCTGCCTTGCTGCCCCCCTCCAATATGGGGGAGGGAGAGAGGCGGAAA
GTCGAAGGGCAGTTAGTTGACTG

hide sequence

RefSeq Acc Id:

XM_017601967 ⟹ XP_017457456

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	X	66,385,241 - 66,392,027 (+)	NCBI
Rnor_6.0	X	71,155,284 - 71,162,070 (+)	NCBI

Sequence:

show sequence

ACGTCAGGCGGGGGCTGCTGCTTGGAGCAAAACAAAAGGGAAACCCGGGGGGCGGGGGGTGGGG
GGGTCCGATAGGGGATTCAGTTCTGGAGTAGGGGAACCTTGACCCTATCAAGAGTGACCTGGAG
GGAAGAGGCGAGGGGAGGGAGAGCCAGGGGAGGGACAAGTGACGCCCGGGAGCGGGGCGTGGGG
GAGGGCAGCGATCCGGGTGGAGGAAATTTGGGAGGAGTGTCCGGGGGGCAGCAACTTGAAAGGG
GGAGGGAACTTCGCTGAGGAGACGTTCGGTGATGGGAGCGCAATGTATGAGGGGATACGGTGCC
TCAGGTTTAAAAGAGCAGGAAGCTGAGTGAGAGGGTGCAGAAAGTGCCTTCGCTAGGCGGAGGT
TACAGGTGGTGCCTCAGAGCGCTACTCTGAGGCTGCAGCCTGTAGTCCGGAGGGGATCGAAGCA
CCGAGTGGAAGGGACAGTTTAGGGGCTGGAGTCCTGAGAGGAGGGAGAAGTTCGTGACTTTCTG
AGAACTGGAAAGAATGTGTTTCCCCCCTTGGGGGAGGCATGGTGAGGGACTGTGGCAGGCTCCA
CTGAACGCTGAGCTGCAGAGGTTCGACCCCACGTATGGAGCCAGAGAATAAGAAGTCAGCCACA
GAGGCTGCCGCGATCATAGACCTCGATCCCGACTTCGAACCCCAGAGCCGTCCGCGGTCCTGCA
CCTGGCCCCTTCCTCGACCAGAGCTCGCTACGGAGCCACCCGAACCGTCCGAGGTGGAGCCCAG
TCTGGGACAGAAGGTACCCACGGAGGGACACTCCGAACCGACCCTGTTGCCCTCTCGGCTCCCA
GAGCCGGCAGGGGGCCCCCAGCCGGAAATCCTGGGGGCTGTAACAGGTCCTCGGAAGGGAGGCT
CCCGCCGGAATGCCTGGGGAAATCAGTCATATGCAGAACTCATCAGCCAGGCCATTGAAAGCGC
CCCGGAGAAGCGGCTGACACTCGCCCAGATATACGAATGGATGGTCCGCACGGTGCCCTACTTC
AAGGACAAGGGTGACAGCAACAGCTCGGCAGGATGGAAGAACTCCATCCGTCACAACCTGTCTT
TGCACAGCAAGTTCATCAAGGTACATAACGAGGCCACCGGCAAGAGCTCTTGGTGGATGCTGAA
CCCCGATGGCGGCAAGGGTGGCAAGGCACCCCGGCGCAGGGCTGCCTCCATGGATAGCAGCAGC
AAGCTGCTCCGGGGCCGCAGCAAAGGCCCCAAGAAGAAGCCATCTGTCCTGCCAGCTCCACCTG
AAGGTGCCACTCCAAGGAGCCCTCTGGGCCACTTTGCCAAGTGGTCGAGCAGTCCTTGTCCTCG
AAATCGAGAAGAAGCTGATGTGTGGACCACTTTCCGTCCACGAAGCAGTTCAAATGCTAGCACT
GTCAGCACTCGGCTGTCCCCAATGAGGCCGGAGTCTGAGGTGCTAGCAGAAGAGGAAATGCCAG
CCTCAGCCAGCAGCTATGCAGGGGGTGTCCCTCCCACCCTCAGTGAAGATCTAGAGCTGCTGGA
TGGGCTCAATCTTGCATCTCCCCATTCCTTGCTGTCCAGGAGCAATCTCTCCAGCTTCTCTTTG
CAGCATCCTGGGCTTGCTGGCCCCTTACATAGCTATGGCGCCTCCCTCTTTGGCCCAATAGATG
GGTCTTTGTCAGCAGGAGAAGGGTGCTTCTCGAGTTCCCAGTCTCTAGAGGCTCTGCTCACCTC
TGATACACCACCACCTCCTGCTGATGTTCTCATGACCCAGGTAGATCCTATCCTGTCTCAGGCT
CCTACACTTCTGTTACTGGGAGGAATGCCTTCCTCTAGCAAGCTGGCCACAGGAGTCAGCCTGT
GTCCTACGCCGCTAGAGGGTCCTGGTCCCAGCAACCTGGTTCCCACCCTTTCTGTGATGGCACC
ACCTCCAGTCATGCCAGGTGCTCCCATCCCTAAGGTCCTGGGAACCCCTGTGCTTGCATCTCCT
ACTGAAGATTTCAGCCATGACAGAATGCCTCAGGATCTGGATCTTGATATGTACATGGAGAACC
TGGAGTGTGACATGGATAACATCATCAGTGACCTCATGGATGGTGAGGGACTGGACTTCAACTT
TGAGCCAGATCCCTGAGTCACAGCAAGAAGCTTTGTCCCCTGCTTCAGAGGTGGAGCCGGAGCC
GAGCCTGTCCTTATCCACTTTTCCCCCTTGAGCCCTCCCCAGGAGTCTGGGACCCTACGTTAGA
GCTAGGGATAGGTGGTCACACACTCAAGTGTTGAGGAAATTATAAAGATACATCAATGACAGTA
GGGATTGTGAAGGAGGGTGATGGGAGGAAGGAGGGAAAGGCTTATTCTCACTGTGCCAATTAGG
GGGTAATTATGGTCCTTTCTCAGGGGCCACCATTGATTTCCCCATTACACCTCCTAGGCCTTGA
AGCAGGGGCCAGCAATGCTGTTGGAAATGTGAAGTCACCAGTGGCCTTATTACCCTGCCTTTGG
GAGCAGGATCATTATTATTATTATTATTATTTTTGGTAGAGAGAGTCTTACTAGAGCTGGGCCA
GGCTGGGTTGAGCCTGGATTTTTATGCAGTGGGGTGGGTGGGTGGGGGTTGGGGACCTAGAAGG
GCCAAGTTTTGAGCACTGGAGTGGCTCACCAGGCCAAATCACTTTTGAAAGGATGCAGATAACA
GACAGGCTTTTTATAAACTTTTAAAGAAATATAAACACAAATATAGAGATTTTTAACAGTGGTG
AGGTGCTAGTGAGGGGGAGAAGGCTTTTTTTCTTTCCGAAGGCTTTGTCATAGTGACATGATAC
AAACACTACAGACTCTTACGGAGGAGACACAGGAAGCTAGGGAAAGGTGGGTAGCAAGAGTGAC
TGGAAGGAAGCGTTCCCCCTTGGACCAGGTCTAGAAAAAGCTCTATACATAGTTTTAAGCACAG
AAACCTAAGCCAGGTCTCTGCATTCTGTCCACTAGTGCCTAGAAGAGGGTGCTGTTGTGGGGCA
AGCACACTCTTGTTTCACCAGTGCGGGTTAGTGCTCCCAGAGAGAGCATCCAAAGCCTGAAATT
GGCTTGGGGCCTGGGAGGGGCGTGAAAGAAGGAAGGATTTAGGGTAGTAAAGTTAGGTACAGAG
ACCTCCCTGTTCAAGGCCTGGGACAGCTGTCCCTGCCCTTCTTCCCAGTCCTGGTCTGCCAGGG
TTATGTGAAGACCATAGTGGCAGGCAGGGTTGTGGGGAGGAACAGGGAAGGGGGAGCTTGGGGA
GTTTGGCTGAGGGTCTGGGAAATGAGCAGGGATGGGGGGAATGTGGATCAGGTTTACTAGCACC
TGCCAGAGAGGCCATCTGGGGCTCCTCCACCCCAGCCCCCAAGCAGCCCCTCCCCCAGCGCCCT
TTGCATTGTCCCCTCCCCCACTCCTGCTGTGGGTTCCCATCATTTCCTGTGTCAGCGCCTGGCC
TACCCAGATTGTATCATGTGCTAGATTGGAGTGGGGAAGTGTGTCAAATCAATAAGTGAGTTCA
ATAAATGTCTATAATCAGA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001100413	(Get FASTA)	NCBI Sequence Viewer
	XP_017457456	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL95908	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_001100413 ⟸ NM_001106943

- UniProtKB:

D4A433 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MEPENKKSATEAAAIIDLDPDFEPQSRPRSCTWPLPRPELATEPPEPSEVEPSLGQKVPTEGHS
EPTLLPSRLPEPAGGPQPEILGAVTGPRKGGSRRNAWGNQSYAELISQAIESAPEKRLTLAQIY
EWMVRTVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIKVHNEATGKSSWWMLNPDGGKGGKAPR
RRAASMDSSSKLLRGRSKGPKKKPSVLPAPPEGATPRSPLGHFAKWSSSPCPRNREEADVWTTF
RPRSSSNASTVSTRLSPMRPESEVLAEEEMPASASSYAGGVPPTLSEDLELLDGLNLASPHSLL
SRSNLSSFSLQHPGLAGPLHSYGASLFGPIDGSLSAGEGCFSSSQSLEALLTSDTPPPPADVLM
TQVDPILSQAPTLLLLGGMPSSSKLATGVSLCPTPLEGPGPSNLVPTLSVMAPPPVMPGAPIPK
VLGTPVLASPTEDFSHDRMPQDLDLDMYMENLECDMDNIISDLMDGEGLDFNFEPDP

hide sequence

RefSeq Acc Id:	XP_017457456 ⟸ XM_017601967
- Peptide Label:	isoform X1
- UniProtKB:	D4A433 (UniProtKB/TrEMBL)
- Sequence:	show sequence MEPENKKSATEAAAIIDLDPDFEPQSRPRSCTWPLPRPELATEPPEPSEVEPSLGQKVPTEGHS EPTLLPSRLPEPAGGPQPEILGAVTGPRKGGSRRNAWGNQSYAELISQAIESAPEKRLTLAQIY EWMVRTVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIKVHNEATGKSSWWMLNPDGGKGGKAPR RRAASMDSSSKLLRGRSKGPKKKPSVLPAPPEGATPRSPLGHFAKWSSSPCPRNREEADVWTTF RPRSSSNASTVSTRLSPMRPESEVLAEEEMPASASSYAGGVPPTLSEDLELLDGLNLASPHSLL SRSNLSSFSLQHPGLAGPLHSYGASLFGPIDGSLSAGEGCFSSSQSLEALLTSDTPPPPADVLM TQVDPILSQAPTLLLLGGMPSSSKLATGVSLCPTPLEGPGPSNLVPTLSVMAPPPVMPGAPIPK VLGTPVLASPTEDFSHDRMPQDLDLDMYMENLECDMDNIISDLMDGEGLDFNFEPDP hide sequence

RefSeq Acc Id:

ENSRNOP00000042383 ⟸ ENSRNOT00000048521

RefSeq Acc Id:

ENSRNOP00000068105 ⟸ ENSRNOT00000076479

RefSeq Acc Id:

ENSRNOP00000068509 ⟸ ENSRNOT00000076453

Protein Domains

Fork-head

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4A433-F1-model_v2	AlphaFold	D4A433	1-505	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13701871

Promoter ID:

EPDNEW_R12395

Type:

single initiation site

Name:

Foxo4_1

Description:

forkhead box O4

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	X	71,155,640 - 71,155,700	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1561201	AgrOrtholog
BioCyc Gene	G2FUF-2106	BioCyc
Ensembl Genes	ENSRNOG00000033316	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000042383	ENTREZGENE
	ENSRNOP00000042383.3	UniProtKB/TrEMBL
	ENSRNOP00000068105	ENTREZGENE
	ENSRNOP00000068105.2	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000048521	ENTREZGENE
	ENSRNOT00000048521.4	UniProtKB/TrEMBL
	ENSRNOT00000076479	ENTREZGENE
	ENSRNOT00000076479.2	UniProtKB/TrEMBL
Gene3D-CATH	1.10.10.10	UniProtKB/TrEMBL
InterPro	FH_FOXO4	UniProtKB/TrEMBL
	FOXO-TAD	UniProtKB/TrEMBL
	TF_fork_head	UniProtKB/TrEMBL
	TF_fork_head_CS_2	UniProtKB/TrEMBL
	WH-like_DNA-bd_sf	UniProtKB/TrEMBL
	WH_DNA-bd_sf	UniProtKB/TrEMBL
KEGG Report	rno:302415	UniProtKB/TrEMBL
NCBI Gene	302415	ENTREZGENE
PANTHER	FORKHEAD BOX PROTEIN O	UniProtKB/TrEMBL
	FORKHEAD BOX PROTEIN O4	UniProtKB/TrEMBL
Pfam	Fork_head	UniProtKB/TrEMBL
	FOXO-TAD	UniProtKB/TrEMBL
PhenoGen	Foxo4	PhenoGen
PRINTS	FORKHEAD	UniProtKB/TrEMBL
PROSITE	FORK_HEAD_2	UniProtKB/TrEMBL
	FORK_HEAD_3	UniProtKB/TrEMBL
SMART	SM00339	UniProtKB/TrEMBL
Superfamily-SCOP	SSF46785	UniProtKB/TrEMBL
UniProt	A0A096MJF0_RAT	UniProtKB/TrEMBL
	D4A433	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-02-28	Foxo4	forkhead box O4	RGD1561201_predicted	similar to forkhead protein AFXH (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-07	RGD1561201_predicted	similar to forkhead protein AFXH (predicted)	LOC302415	similar to forkhead protein AFXH	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC302415	similar to forkhead protein AFXH			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - PID (archival)