RNA POLYMERASE I TRANSCRIPTION PATHWAY (PW:0000126)

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Description

The three eukaryotic RNA polymerases (RNAPs)- Pol I, II and III, transcribe different sets of genes and require distinct sets of factors to assemble a specific initiation complex which recruits them on gene promoters. The multi-subunit enzymes are composed of 14 (RNAPI), 12 (RNAPII) and 17 (RNAPIII) sub-units of which some are shared and others are unique, yet converging on an overall similar structural topology. Complexes specific to each of the three systems share the universal transcription

Pathway Diagram:

Elsevier Inc. ribosome biogenesis pathway rRNA maturation pathway pre-rRNA transcript Sirt1 Sirt7 Sirt7 --+> RNA polymerase I normal conditions --+> RNA polymerase I Ncl ---> pre-rRNA transcript Crebbp ---| RNA polymerase I nucleolar stress --+> p53 signaling pathway nutrients stress conditions stress conditions ---| SL1 complex Sirt1 ---| SL1 complex stress conditions ---| Sirt7 stress conditions --+> adenosine monophosphate-activated protein kinase (AMPK) signaling pathway nutrients --+> mTOR signaling pathway nutrients --+> the extracellular signal-regulated Raf/Mek/Erk signaling pathway adenosine monophosphate-activated protein kinase (AMPK) signaling pathway ---| SL1 complex mTOR signaling pathway --+> SL1 complex the extracellular signal-regulated Raf/Mek/Erk signaling pathway --+> SL1 complex Ncl ---> ribosome biogenesis pathway Ncl ---> rRNA maturation pathway RNA polymerase I mTOR signaling pathway FACT complex Ncl chromatin modification/remodeling pathway Ptrf Ttf1 Supt4h1 Supt5h Crebbp Rrn3 Ubtf P- P+ SL1 complex Paf1 complex nucleolar stress Rrn3 ---- SL1 complex SL1 complex ---- Ubtf normal conditions RNA polymerase I ---> pre-rRNA transcript RNA polymerase I ---- Supt5h RNA polymerase I ---- Rrn3 Ptrf ---- Ttf1 Paf1 complex ---- Supt4h1 Paf1 complex ---- Supt5h Supt4h1 ---- Supt5h Supt5h ---> pre-rRNA transcript chromatin modification/remodeling pathway ---> pre-rRNA transcript FACT complex ---> pre-rRNA transcript p53 signaling pathway adenosine monophosphate-activated protein kinase (AMPK) signaling pathway the extracellular signal-regulated Raf/Mek/Erk signaling pathway
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Genes in Pathway:

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RNA polymerase I transcription pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cavin1 caveolae associated protein 1 JBrowse link 10 88,862,513 88,874,495 RGD:9588249
G Cd3eap CD3e molecule associated protein JBrowse link 1 80,267,725 80,271,001 RGD:9588244
RGD:9588262
G Cdc73 cell division cycle 73 JBrowse link 13 60,403,771 60,496,511 RGD:9588246
G Crebbp CREB binding protein JBrowse link 10 11,590,994 11,721,039 RGD:9588250
G Ctr9 CTR9 homolog, Paf1/RNA polymerase II complex component JBrowse link 1 175,839,140 175,869,167 RGD:9588246
G Leo1 LEO1 homolog, Paf1/RNA polymerase II complex component JBrowse link 8 82,380,906 82,405,293 RGD:9588246
G Ncl nucleolin JBrowse link 9 93,369,119 93,377,643 RGD:9588244
RGD:9588251
G Paf1 PAF1 homolog, Paf1/RNA polymerase II complex component JBrowse link 1 85,362,421 85,367,999 RGD:9588246
G Polr1a RNA polymerase I subunit A JBrowse link 4 99,822,964 99,903,969 RGD:9588244
RGD:9588262
G Polr1b RNA polymerase I subunit B JBrowse link 3 121,632,043 121,656,506 RGD:9588244
RGD:9588262
G Polr1c RNA polymerase I and III subunit C JBrowse link 9 17,120,759 17,124,871 RGD:9588244
RGD:9588262
G Polr1e RNA polymerase I subunit E JBrowse link 5 60,572,573 60,588,097 RGD:9588244
RGD:9588262
G Polr2e RNA polymerase II subunit E JBrowse link 7 12,532,785 12,536,797 RGD:9588244
RGD:9588262
G Polr2f RNA polymerase II subunit F JBrowse link 7 120,380,543 120,392,214 RGD:9588244
RGD:9588262
G Polr2k RNA polymerase II subunit K JBrowse link 7 74,939,010 74,992,594 RGD:9588244
RGD:9588262
G Rrn3 RRN3 homolog, RNA polymerase I transcription factor JBrowse link 10 3,170,387 3,214,648 RGD:9588243
RGD:9588244
G Rtf1 Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) JBrowse link 3 111,478,350 111,537,941 RGD:9588246
G Sirt1 sirtuin 1 JBrowse link 20 26,831,971 26,851,587 RGD:9588250
G Sirt7 sirtuin 7 JBrowse link 10 109,796,046 109,802,821 RGD:9588250
G Ssrp1 structure specific recognition protein 1 JBrowse link 3 72,447,516 72,457,621 RGD:9588245
G Supt16h SPT16 homolog, facilitates chromatin remodeling subunit JBrowse link 15 28,574,841 28,611,959 RGD:9588245
G Supt4h1 SPT4 homolog, DSIF elongation factor subunit JBrowse link 10 75,032,365 75,038,547 RGD:9588244
G Supt5h SPT5 homolog, DSIF elongation factor subunit JBrowse link 1 85,437,780 85,466,854 RGD:9588244
G Taf12 TATA-box binding protein associated factor 12 JBrowse link 5 150,459,701 150,476,521 RGD:9588243
RGD:9588244
G Taf1a TATA-box binding protein associated factor, RNA polymerase I subunit A JBrowse link 13 101,770,278 101,807,975 RGD:9588243
RGD:9588244
G Taf1b TATA-box binding protein associated factor, RNA polymerase I subunit B JBrowse link 6 43,644,931 43,722,124 RGD:9588243
RGD:9588244
G Taf1c TATA-box binding protein associated factor, RNA polymerase 1 subunit C JBrowse link 19 52,246,061 52,252,642 RGD:9588243
RGD:9588244
G Taf1d TATA-box binding protein associated factor, RNA polymerase I subunit D JBrowse link 8 13,861,242 13,871,508 RGD:9588243
RGD:9588244
G Tbp TATA box binding protein JBrowse link 1 57,491,381 57,509,335 RGD:9588243
RGD:9588244
G Ttf1 transcription termination factor 1 JBrowse link 3 7,635,630 7,660,153 RGD:9588249
G Twistnb TWIST neighbor JBrowse link 6 52,751,106 52,768,574 RGD:9588244
RGD:9588262
G Ubtf upstream binding transcription factor JBrowse link 10 90,250,275 90,265,772 RGD:9588243
RGD:9588244
G Wdr61 WD repeat domain 61 JBrowse link 8 59,296,339 59,313,663 RGD:9588246
G Znrd1 zinc ribbon domain containing 1 JBrowse link 20 2,088,518 2,092,436 RGD:9588244
RGD:9588262

Pathway Gene Annotations

Disease Annotations Associated with Genes in the RNA polymerase I transcription pathway
Disease TermsGene Symbols
acrofacial dysostosis Cincinnati typePolr1a
acute kidney failureSirt1
acute myeloid leukemiaCrebbp
adenoid cystic carcinomaCrebbp
Alzheimer's diseaseCrebbp , Sirt1 , Tbp
amyotrophic lateral sclerosisSirt1
amyotrophic lateral sclerosis type 1Crebbp
Animal Disease ModelsNcl
Arsenic PoisoningTaf1d
atherosclerosisSirt1
atrial fibrillationSirt1
atrial heart septal defectCrebbp
attention deficit hyperactivity disorderCrebbp
autistic disorderCrebbp , Taf1c
Autoimmune DiseasesSirt1
Binge DrinkingSirt1
bladder urothelial carcinomaCrebbp
brain infarctionSirt1
Brain InjuriesSirt1
Brain NeoplasmsSirt1
Brain-Lung-Thyroid SyndromeTtf1
Breast NeoplasmsSirt1
CardiomegalySirt1 , Ubtf
Carotid AtherosclerosisSirt1
central nervous system diseaseCrebbp
choreatic diseaseTtf1
Ciliary Motility DisordersTaf1c
colitisSirt1
Colorectal NeoplasmsCrebbp
congenital generalized lipodystrophy type 4Cavin1
congestive heart failureSirt1
demyelinating diseaseSirt1
Developmental DisabilitiesCrebbp
diabetes mellitusCavin1 , Sirt1
Diabetes Mellitus, Experimental Sirt1
diabetic retinopathySirt1
epilepsySirt1
Experimental Autoimmune EncephalomyelitisSirt1
Experimental Autoimmune MyocarditisSirt1
Experimental Liver CirrhosisSirt1
Experimental NeoplasmsZnrd1
familial partial lipodystrophyCavin1
fatty liver diseaseSirt1 , Sirt7
FibrosisSirt1
follicular lymphomaCrebbp
gastric adenocarcinomaCrebbp
genetic diseaseCdc73 , Crebbp , Polr1a , Polr2f
Genomic InstabilitySirt1
glaucomaCrebbp
glioblastoma multiformeCrebbp
glucose intoleranceSirt1
head and neck squamous cell carcinomaCrebbp
heart diseaseSirt1
hepatocellular carcinomaCrebbp
Hirschsprung Disease 1Crebbp , Polr2f
human immunodeficiency virus infectious diseaseSirt1
Huntington's diseaseCrebbp , Sirt1 , Tbp
HyperparathyroidismCdc73
Hyperparathyroidism 1Cdc73
Hyperparathyroidism 2Cdc73
HypertrophySirt1
hypomyelinating leukodystrophy 11Polr1c
impotenceSirt1
Insulin ResistanceSirt1
Kartagener syndromePolr2k
Kidney Reperfusion InjurySirt1
late onset Parkinson's diseaseTbp
Left Ventricular HypertrophyNcl , Sirt1
liver cancerCrebbp
Liver InjurySirt1
Liver Reperfusion InjurySirt1
Lung InjurySirt1
lung small cell carcinomaCrebbp
lung squamous cell carcinomaCrebbp
macular degenerationSirt1
Mandibulofacial DysostosisPolr1c
Mandibulofacial Dysostosis, Treacher Collins Type, Autosomal RecessivePolr1c
medulloblastomaCrebbp
melanomaCrebbp
Metabolic SyndromeSirt1
methylmalonic acidemiaCavin1
middle cerebral artery infarctionSirt1
Multiple AbnormalitiesCrebbp
Muscle SpasticityCrebbp
myelodysplastic syndromeCrebbp
myocardial infarctionSirt1
Myocardial IschemiaNcl
Myocardial Reperfusion InjuryNcl , Sirt1
Neoplasm MetastasisSirt1
nephrogenic diabetes insipidusSirt1
Nerve DegenerationSirt1
NEURODEGENERATION, CHILDHOOD-ONSET, WITH BRAIN ATROPHYUbtf
neurodegenerative diseaseSirt1
neuronal ceroid lipofuscinosis 1Sirt1
nonalcoholic fatty liver diseaseSirt1
obesitySirt1
ossifying fibromaCdc73
osteoporosisSirt1
osteosarcomaSirt1
ParalysisSirt1
parathyroid adenomaCdc73
Parathyroid Adenomatosis, Familial CysticCdc73
parathyroid carcinomaCdc73
Parathyroid NeoplasmsCdc73
Parkinson's diseaseRrn3 , Tbp
PCWH syndromePolr2f
Peroxisome Biogenesis Disorder 3BPaf1
Peroxisome Biogenesis Disorder 5A (Zellweger)Paf1
Peroxisome Biogenesis Disorder 5BPaf1
Peutz-Jeghers syndromePolr2e
pleomorphic xanthoastrocytomaTwistnb
Pneumococcal PneumoniaSirt1
pneumoniaSirt1
precursor lymphoblastic lymphoma/leukemiaCrebbp
primary ciliary dyskinesiaTaf1c
primary ciliary dyskinesia 13Taf1c
primary ciliary dyskinesia 28Polr2k
Prostatic NeoplasmsCrebbp , Sirt1
pulmonary hypertensionCavin1
Reperfusion InjurySirt7
retinal diseaseSirt1
Rubinstein-Taybi syndromeCrebbp
schizophreniaRrn3 , Tbp
scoliosisCrebbp
senile cataractSirt1
Sezary's diseaseCrebbp
Shock, HemorrhagicSirt1
skin diseaseTaf1d
sleep apneaTbp
Smith-Magenis syndromeCavin1 , Sirt7 , Supt4h1 , Ubtf
spina bifidaCrebbp
Spinal Cord InjuriesTbp
spinocerebellar ataxia type 17Tbp
Spinocerebellar AtaxiasTbp
squamous cell carcinomaCrebbp
Stomach NeoplasmsZnrd1
systemic sclerodermaSirt1 , Sirt7
thrombosisSirt1
Thumb DeformityCrebbp
Thyroid Carcinoma, Nonmedullary 1Ttf1
transitional cell carcinomaCrebbp
Treacher Collins syndromePolr1c
type 1 diabetes mellitusTbp
type 2 diabetes mellitusSirt1
urinary bladder cancerCrebbp
Usher syndromeTaf1a
Uterine Cervical NeoplasmsCrebbp
Waardenburg syndrome type 2APolr2f
Waardenburg syndrome type 2EPolr2f
Waardenburg syndrome type 4APolr2f
Waardenburg syndrome type 4CPolr2f
Waardenburg's syndromePolr2f
Wallerian DegenerationSirt1
Weight GainCavin1
Pathway Annotations Associated with Genes in the RNA polymerase I transcription pathway
Pathway TermsGene Symbols
aldosterone signaling pathwayCrebbp
androgen signaling pathwayCrebbp
cell cycle pathway, mitoticCrebbp
cisplatin drug pathwaySsrp1 , Tbp , Ubtf
cortisol signaling pathwayCrebbp
estrogen signaling pathwayCrebbp
forkhead class A signaling pathwayCrebbp
Hedgehog signaling pathwayCrebbp
histone modification pathwayCrebbp , Sirt1 , Sirt7 , Ssrp1 , Supt16h
Huntington's disease pathwayCrebbp , Polr2e , Polr2f , Tbp
hypoxia inducible factor pathwayCrebbp
influenza A pathwayCrebbp
Jak-Stat signaling pathwayCrebbp
long term potentiationCrebbp
mTOR signaling pathwayRrn3
Notch signaling pathwayCrebbp
nuclear factor, erythroid 2 like 2 signaling pathwayCrebbp
nucleotide excision repair pathwayPolr1a
p53 signaling pathwayCrebbp , Sirt1
prostate cancer pathwayCrebbp
purine metabolic pathwayPolr1a , Polr1b , Polr1c , Polr1e , Polr2e , Polr2f , Znrd1
pyrimidine metabolic pathwayPolr1a , Polr1b , Polr1c , Polr1e , Polr2e , Polr2f , Znrd1
renal cell carcinoma pathwayCrebbp
RNA degradation pathwayWdr61
RNA polymerase I transcription pathwayCavin1 , Cd3eap , Cdc73 , Crebbp , Ctr9 , Leo1 , Ncl , Paf1 , Polr1a , Polr1b , Polr1c , Polr1e , Polr2e , Polr2f , Polr2k , Rrn3 , Rtf1 , Sirt1 , Sirt7 , Ssrp1 , Supt16h , Supt4h1 , Supt5h , Taf12 , Taf1a , Taf1b , Taf1c , Taf1d , Tbp , Ttf1 , Twistnb , Ubtf , Wdr61 , Znrd1
RNA polymerase II transcription elongation pathwayCdc73 , Ctr9 , Leo1 , Paf1 , Rtf1 , Ssrp1 , Supt16h , Supt4h1 , Supt5h , Wdr61
RNA polymerase II transcription initiation pathwayTaf12 , Tbp
RNA polymerase II transcription pathwayPolr2e , Polr2f , Polr2k
RNA polymerase III transcription pathwayPolr1c , Polr2e , Polr2f , Polr2k , Tbp
Sirtuin mediated pathwaySirt1 , Sirt7
transforming growth factor-beta Smad dependent signaling pathwayCrebbp
transforming growth factor-beta superfamily mediated signaling pathwayCrebbp
tuberculosis pathwayCrebbp
type II interferon signaling pathwayCrebbp
Wnt signaling pathwayCrebbp
Wnt signaling, canonical pathwayCrebbp
Phenotype Annotations Associated with Genes in the RNA polymerase I transcription pathway
Phenotype TermsGene Symbols
cardiac hypertrophyCrebbp

References Associated with the RNA polymerase I transcription pathway:

Ontology Path Diagram:

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