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Gene: Smad7 (SMAD family member 7) Rattus norvegicus
Symbol: Smad7
Name: SMAD family member 7
Description: Exhibits ubiquitin protein ligase binding activity. Involved in intracellular signal transduction; negative regulation of transcription, DNA-templated; and regulation of transforming growth factor beta receptor signaling pathway. Predicted to colocalize with adherens junction and catenin complex. Biomarker of nephritis and pulmonary hypertension. Human ortholog(s) of this gene implicated in colorectal cancer and pancreatic adenocarcinoma. Orthologous to human SMAD7 (SMAD family member 7); PARTICIPATES IN altered transforming growth factor-beta Smad dependent signaling pathway; Bone morphogenetic proteins signaling pathway; colorectal cancer pathway; INTERACTS WITH (+)-schisandrin B; 1,3-dinitrobenzene; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
Also known as: MAD (mothers against decapentaplegic Drosophila) homolog 7; MAD (mothers against decapentaplegic, Drosophila) homolog 7; MAD homolog 7; MAD homolog 7 (Drosophila); Madh7; mothers against decapentaplegic homolog 7; mothers against DPP homolog 7; SMAD 7
Homo sapiens (human) : SMAD7 (SMAD family member 7)  HGNC  Alliance
Mus musculus (house mouse) : Smad7 (SMAD family member 7)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Smad7 (SMAD family member 7)
Pan paniscus (bonobo/pygmy chimpanzee) : SMAD7 (SMAD family member 7)
Canis lupus familiaris (dog) : SMAD7 (SMAD family member 7)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Smad7 (SMAD family member 7)
Sus scrofa (pig) : SMAD7 (SMAD family member 7)
Chlorocebus sabaeus (African green monkey) : SMAD7 (SMAD family member 7)
Heterocephalus glaber (naked mole-rat) : Smad7 (SMAD family member 7)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01871,395,830 - 71,424,164 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1871,395,830 - 71,424,157 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01870,530,559 - 70,558,932 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41872,294,803 - 72,323,354 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11872,368,075 - 72,396,625 (+)NCBI
Celera1867,155,575 - 67,183,461 (+)NCBICelera
Cytogenetic Map18q12.2NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Smad7
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 69314
Created: 2001-11-14
Species: Rattus norvegicus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.