Smad1 (SMAD family member 1) - Rat Genome Database

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Gene: Smad1 (SMAD family member 1) Mus musculus
Analyze
Symbol: Smad1
Name: SMAD family member 1
RGD ID: 734156
MGI Page MGI
Description: Enables DNA-binding transcription factor activity, RNA polymerase II-specific; identical protein binding activity; and nucleic acid binding activity. Involved in several processes, including SMAD protein signal transduction; osteoblast differentiation; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including animal organ development; osteoblast fate commitment; and positive regulation of macromolecule metabolic process. Located in cytoplasm and nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; nervous system; and sensory organ. Orthologous to human SMAD1 (SMAD family member 1); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; the extracellular signal-regulated Raf/Mek/Erk signaling pathway; transforming growth factor-beta superfamily mediated signaling pathway; INTERACTS WITH (S)-nicotine; 1,2-dichloroethane; 1,2-dimethylhydrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI528653; dwarfin-A; dwf-A; Mad; MAD homolog 1; mad-related protein 1; Mad1; Madh; Madh1; Madr1; Mlp1; mMad1; mothers against decapentaplegic homolog 1; mothers against DPP homolog 1; mothers-against-DPP-related 1; MusMLP; Smad 1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39880,065,024 - 80,126,057 (-)NCBIGRCm39mm39
GRCm39 Ensembl880,065,024 - 80,126,147 (-)Ensembl
GRCm38879,338,395 - 79,399,428 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl879,338,395 - 79,399,518 (-)EnsemblGRCm38mm10GRCm38
MGSCv37881,862,294 - 81,923,367 (-)NCBIGRCm37mm9NCBIm37
MGSCv36882,234,467 - 82,295,540 (-)NCBImm8
Celera883,615,361 - 83,676,406 (-)NCBICelera
Cytogenetic Map8C1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (EXP)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
17alpha-ethynylestradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4-dinitrotoluene  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroperoxycyclophosphamide  (EXP)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (EXP)
5-methoxypsoralen  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP)
ammonium chloride  (ISO)
antirheumatic drug  (ISO)
aristolochic acid  (ISO)
Aroclor 1254  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
aucubin  (ISO)
azadirachtin A  (EXP)
benzo[a]pyrene  (EXP)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
caffeine  (EXP)
calciol  (EXP)
captan  (EXP)
carbon nanotube  (EXP)
casticin  (ISO)
chlordecone  (EXP)
clofibrate  (EXP)
clofibric acid  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (EXP)
cytochalasin D  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
dichlorine  (ISO)
diclofenac  (EXP)
divanadium pentaoxide  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
enzyme inhibitor  (ISO)
fluoxetine  (ISO)
folic acid  (EXP)
folpet  (EXP)
galangin  (ISO)
glycerol 2-phosphate  (EXP)
glyphosate  (ISO)
imperatorin  (EXP)
indometacin  (ISO)
isoprenaline  (EXP)
L-ascorbic acid  (EXP)
lead diacetate  (EXP)
leflunomide  (ISO)
lipopolysaccharide  (EXP)
monocrotaline  (ISO)
N-nitrosodiethylamine  (ISO)
nickel dichloride  (ISO)
nicotine  (EXP)
nonanoic acid  (EXP)
oxaliplatin  (ISO)
ozone  (ISO)
paracetamol  (EXP)
paraquat  (EXP)
phenobarbital  (EXP)
picrotoxin  (ISO)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
propiconazole  (EXP)
resveratrol  (ISO)
Salidroside  (EXP)
SB 431542  (ISO)
simvastatin  (EXP)
sirtinol  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
Soman  (ISO)
streptozocin  (ISO)
tamoxifen  (EXP)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
toluene 2,4-diisocyanate  (EXP)
topotecan  (ISO)
trichostatin A  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
vincristine  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anatomical structure morphogenesis  (IBA)
BMP signaling pathway  (IBA,IDA,IGI,IMP,ISO,TAS)
bone development  (IGI)
cardiac muscle cell proliferation  (IGI,IMP)
cartilage development  (IGI)
cell differentiation  (IBA)
cellular response to BMP stimulus  (IGI)
cellular response to organic cyclic compound  (IDA)
gamete generation  (IMP)
hindbrain development  (IMP)
homeostatic process  (IMP)
inflammatory response  (IEP)
kidney development  (ISO)
MAPK cascade  (IMP,ISO)
mesodermal cell fate commitment  (IGI)
midbrain development  (IMP)
negative regulation of cell population proliferation  (IMP)
negative regulation of muscle cell apoptotic process  (ISO)
negative regulation of muscle cell differentiation  (IDA)
osteoblast differentiation  (IDA)
osteoblast fate commitment  (IGI)
positive regulation of cartilage development  (IDA)
positive regulation of cell differentiation  (ISO)
positive regulation of dendrite morphogenesis  (ISO)
positive regulation of gene expression  (IMP,ISO)
positive regulation of osteoblast differentiation  (IGI)
positive regulation of pri-miRNA transcription by RNA polymerase II  (IMP)
positive regulation of sprouting angiogenesis  (ISO)
positive regulation of transcription by RNA polymerase II  (IDA,IGI,ISO)
positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus  (IGI)
protein phosphorylation  (IDA)
regulation of transcription by RNA polymerase II  (IBA,IDA)
regulation of transcription, DNA-templated  (IEA)
response to organonitrogen compound  (ISO)
response to xenobiotic stimulus  (ISO)
SMAD protein complex assembly  (ISO)
SMAD protein signal transduction  (IBA,IGI)
transcription, DNA-templated  (ISO)
transforming growth factor beta receptor signaling pathway  (IBA,ISO)
ureteric bud development  (IEP)
wound healing  (ISO)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal allantois morphology  (IAGP)
abnormal cell morphology  (IAGP)
abnormal chorioallantoic fusion  (IAGP)
abnormal chorion morphology  (IAGP)
abnormal cranial nerve morphology  (IAGP)
abnormal direction of heart looping  (IAGP)
abnormal embryo development  (IAGP)
abnormal embryo turning  (IAGP)
abnormal embryonic epiblast morphology  (IAGP)
abnormal embryonic growth/weight/body size  (IAGP)
abnormal embryonic tissue morphology  (IAGP)
abnormal extraembryonic ectoderm morphology  (IAGP)
abnormal extraembryonic tissue morphology  (IAGP)
abnormal forebrain morphology  (IAGP)
abnormal gastric chief cell morphology  (IAGP)
abnormal gastric parietal cell morphology  (IAGP)
abnormal heart development  (IAGP)
abnormal heart looping  (IAGP)
abnormal heart tube morphology  (IAGP)
abnormal hindbrain morphology  (IAGP)
abnormal left-right axis patterning  (IAGP)
abnormal male reproductive system morphology  (IAGP)
abnormal mesenchyme morphology  (IAGP)
abnormal mesoderm development  (IAGP)
abnormal midbrain morphology  (IAGP)
abnormal nervous system development  (IAGP)
abnormal neural tube morphology  (IAGP)
abnormal neurocranium morphology  (IAGP)
abnormal pharyngeal arch morphology  (IAGP)
abnormal placenta morphology  (IAGP)
abnormal rostral-caudal axis patterning  (IAGP)
abnormal skeleton development  (IAGP)
abnormal somite development  (IAGP)
abnormal spinal nerve morphology  (IAGP)
abnormal stomach epithelium morphology  (IAGP)
abnormal stomach morphology  (IAGP)
abnormal stomach muscularis externa morphology  (IAGP)
abnormal trabecular bone morphology  (IAGP)
abnormal ventral body wall morphology  (IAGP)
abnormal visceral endoderm morphology  (IAGP)
absent primordial germ cells  (IAGP)
absent second pharyngeal arch  (IAGP)
absent third pharyngeal arch  (IAGP)
absent umbilical cord  (IAGP)
caudal body truncation  (IAGP)
decreased bone trabecula number  (IAGP)
decreased embryo size  (IAGP)
decreased osteoblast cell number  (IAGP)
decreased osteoblast proliferation  (IAGP)
decreased primordial germ cell number  (IAGP)
decreased trabecular bone connectivity density  (IAGP)
decreased trabecular bone thickness  (IAGP)
decreased trabecular bone volume  (IAGP)
delayed allantois development  (IAGP)
delayed bone ossification  (IAGP)
disorganized embryonic tissue  (IAGP)
disorganized testis cords  (IAGP)
distended pericardium  (IAGP)
early reproductive senescence  (IAGP)
embryonic lethality during organogenesis  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
enlarged pericardium  (IAGP)
excessive folding of visceral yolk sac  (IAGP)
failure of chorioallantoic fusion  (IAGP)
failure of heart looping  (IAGP)
heart right ventricle hypertrophy  (IAGP)
hemoperitoneum  (IAGP)
impaired osteoblast differentiation  (IAGP)
incomplete embryo turning  (IAGP)
incomplete rostral neuropore closure  (IAGP)
increased bone trabecular spacing  (IAGP)
increased granulosa cell tumor incidence  (IAGP)
increased ovarian carcinoma incidence  (IAGP)
increased ovary tumor incidence  (IAGP)
increased right ventricle systolic pressure  (IAGP)
increased testis tumor incidence  (IAGP)
male infertility  (IAGP)
meteorism  (IAGP)
no abnormal phenotype detected  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
postnatal lethality  (IAGP)
premature death  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
reduced fertility  (IAGP)
rostral body truncation  (IAGP)
small testis  (IAGP)
suppressed circulating follicle stimulating hormone level  (IAGP)
References

Additional References at PubMed
PMID:7798324   PMID:8799132   PMID:9076678   PMID:9076683   PMID:9451002   PMID:9529255   PMID:9566949   PMID:10079220   PMID:10205054   PMID:10224145   PMID:10349636   PMID:10376010  
PMID:10400677   PMID:11025211   PMID:11042159   PMID:11076861   PMID:11090449   PMID:11094085   PMID:11111041   PMID:11160896   PMID:11163184   PMID:11169847   PMID:11566864   PMID:11711431  
PMID:11714671   PMID:11784053   PMID:11788714   PMID:11811554   PMID:11850197   PMID:11857782   PMID:12082094   PMID:12117821   PMID:12151307   PMID:12217322   PMID:12223402   PMID:12270938  
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PMID:17628518   PMID:17662325   PMID:17670744   PMID:17693062   PMID:17693602   PMID:17698011   PMID:17699604   PMID:17804806   PMID:17823941   PMID:17919533   PMID:17967138   PMID:18000065  
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PMID:18776146   PMID:18787044   PMID:18789316   PMID:18799693   PMID:18832392   PMID:18832393   PMID:18927151   PMID:18927156   PMID:18952608   PMID:18974875   PMID:18981480   PMID:18985738  
PMID:18997172   PMID:19096363   PMID:19103752   PMID:19116164   PMID:19116665   PMID:19141668   PMID:19153222   PMID:19170762   PMID:19201948   PMID:19224917   PMID:19224984   PMID:19251632  
PMID:19251704   PMID:19252488   PMID:19272526   PMID:19299468   PMID:19369394   PMID:19379695   PMID:19389368   PMID:19410550   PMID:19416967   PMID:19474151   PMID:19501582   PMID:19505455  
PMID:19509466   PMID:19536134   PMID:19556507   PMID:19631205   PMID:19661464   PMID:19717565   PMID:19733164   PMID:19762422   PMID:19769959   PMID:19782070   PMID:19793887   PMID:19793891  
PMID:19796622   PMID:19797899   PMID:19819941   PMID:19850029   PMID:19906857   PMID:19914168   PMID:19914233   PMID:19918795   PMID:19922873   PMID:19923727   PMID:19926752   PMID:19934017  
PMID:19955426   PMID:19956733   PMID:20007850   PMID:20007998   PMID:20019329   PMID:20042635   PMID:20043899   PMID:20059953   PMID:20059955   PMID:20065295   PMID:20110314   PMID:20130285  
PMID:20147459   PMID:20211142   PMID:20308569   PMID:20346939   PMID:20359476   PMID:20371744   PMID:20375015   PMID:20398647   PMID:20404326   PMID:20412781   PMID:20417197   PMID:20445055  
PMID:20454682   PMID:20508035   PMID:20522595   PMID:20530870   PMID:20534673   PMID:20534695   PMID:20585044   PMID:20651281   PMID:20660756   PMID:20727875   PMID:20727876   PMID:20730911  
PMID:20807528   PMID:20826310   PMID:20837004   PMID:20843790   PMID:20847311   PMID:20875817   PMID:20881014   PMID:20889504   PMID:20956305   PMID:20962035   PMID:21034733   PMID:21068065  
PMID:21068310   PMID:21145505   PMID:21185280   PMID:21187450   PMID:21239498   PMID:21246655   PMID:21247964   PMID:21267068   PMID:21270055   PMID:21273545   PMID:21281623   PMID:21297990  
PMID:21303850   PMID:21308777   PMID:21311046   PMID:21381028   PMID:21420501   PMID:21453705   PMID:21482757   PMID:21518886   PMID:21533152   PMID:21536023   PMID:21538804   PMID:21571370  
PMID:21613322   PMID:21681813   PMID:21693521   PMID:21723296   PMID:21724602   PMID:21731673   PMID:21778144   PMID:21856951   PMID:21873635   PMID:21880664   PMID:21896628   PMID:21907140  
PMID:21937600   PMID:21939397   PMID:21953618   PMID:21957238   PMID:21976273   PMID:22072987   PMID:22084104   PMID:22114682   PMID:22116936   PMID:22144916   PMID:22190459   PMID:22240098  
PMID:22253716   PMID:22300732   PMID:22302143   PMID:22364862   PMID:22365545   PMID:22366192   PMID:22370000   PMID:22426104   PMID:22438570   PMID:22474288   PMID:22474292   PMID:22485132  
PMID:22508726   PMID:22509524   PMID:22510377   PMID:22535663   PMID:22536403   PMID:22547067   PMID:22560297   PMID:22588298   PMID:22609550   PMID:22632802   PMID:22698281   PMID:22701694  
PMID:22711842   PMID:22723422   PMID:22753148   PMID:22783020   PMID:22819676   PMID:22828627   PMID:22833130   PMID:22865640   PMID:22964636   PMID:22996691   PMID:23011393   PMID:23028455  
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PMID:23458899   PMID:23459943   PMID:23466739   PMID:23469192   PMID:23478097   PMID:23546880   PMID:23559326   PMID:23560048   PMID:23584254   PMID:23592779   PMID:23595735   PMID:23610558  
PMID:23620745   PMID:23665221   PMID:23676271   PMID:23680673   PMID:23712751   PMID:23717575   PMID:23720040   PMID:23754280   PMID:23776616   PMID:23793844   PMID:23804438   PMID:23863482  
PMID:23891934   PMID:23933588   PMID:23946498   PMID:23969857   PMID:23974041   PMID:23993924   PMID:23994637   PMID:24023003   PMID:24055172   PMID:24067355   PMID:24142423   PMID:24162165  
PMID:24211589   PMID:24269886   PMID:24284212   PMID:24293546   PMID:24297369   PMID:24336726   PMID:24347165   PMID:24373957   PMID:24501377   PMID:24523460   PMID:24524909   PMID:24583261  
PMID:24680892   PMID:24698271   PMID:24715462   PMID:24816837   PMID:24835278   PMID:24912677   PMID:24932701   PMID:24933422   PMID:24948604   PMID:24951251   PMID:24952961   PMID:25028519  
PMID:25031030   PMID:25034710   PMID:25057208   PMID:25082703   PMID:25100727   PMID:25141865   PMID:25155999   PMID:25165122   PMID:25182747   PMID:25243859   PMID:25249463   PMID:25274628  
PMID:25300579   PMID:25312496   PMID:25318679   PMID:25329657   PMID:25331953   PMID:25336743   PMID:25376721   PMID:25378163   PMID:25406396   PMID:25428115   PMID:25428587   PMID:25446538  
PMID:25470749   PMID:25488669   PMID:25514040   PMID:25536014   PMID:25546423   PMID:25605781   PMID:25615642   PMID:25670795   PMID:25755279   PMID:25758226   PMID:25762570   PMID:25810530  
PMID:25820239   PMID:25870111   PMID:25896202   PMID:25995358   PMID:26023097   PMID:26058470   PMID:26076038   PMID:26113728   PMID:26116174   PMID:26116176   PMID:26120030   PMID:26173459  
PMID:26284287   PMID:26313916   PMID:26317208   PMID:26367869   PMID:26391659   PMID:26407529   PMID:26466345   PMID:26552887   PMID:26586223   PMID:26658320   PMID:26661618   PMID:26671461  
PMID:26681395   PMID:26711875   PMID:26735394   PMID:26765568   PMID:26771354   PMID:26776318   PMID:26821812   PMID:26826495   PMID:26896753   PMID:26952187   PMID:27019229   PMID:27030100  
PMID:27048518   PMID:27056911   PMID:27068110   PMID:27076431   PMID:27113717   PMID:27188281   PMID:27190064   PMID:27217206   PMID:27225772   PMID:27234308   PMID:27250101   PMID:27302476  
PMID:27320915   PMID:27335065   PMID:27355685   PMID:27381227   PMID:27483343   PMID:27492138   PMID:27568519   PMID:27596755   PMID:27606421   PMID:27612439   PMID:27633990   PMID:27633992  
PMID:27647853   PMID:27680501   PMID:27713395   PMID:27720610   PMID:27741240   PMID:27803996   PMID:27827819   PMID:27835665   PMID:27890611   PMID:28029182   PMID:28128304   PMID:28190640  
PMID:28254784   PMID:28288971   PMID:28298362   PMID:28327634   PMID:28370465   PMID:28401685   PMID:28438754   PMID:28457943   PMID:28501478   PMID:28574994   PMID:28576771   PMID:28641928  
PMID:28642261   PMID:28650075   PMID:28655168   PMID:28692808   PMID:28763805   PMID:28807898   PMID:28922976   PMID:29093060   PMID:29126155   PMID:29184513   PMID:29232368   PMID:29247325  
PMID:29253505   PMID:29273814   PMID:29317485   PMID:29321139   PMID:29411501   PMID:29412136   PMID:29463648   PMID:29467244   PMID:29618652   PMID:29637597   PMID:29638158   PMID:29665134  
PMID:29677202   PMID:29700203   PMID:29771958   PMID:29852132   PMID:29853617   PMID:29891551   PMID:29934521   PMID:29950483   PMID:29975682   PMID:29981310   PMID:29986157   PMID:30002389  
PMID:30125728   PMID:30134160   PMID:30188920   PMID:30201295   PMID:30230914   PMID:30235284   PMID:30352686   PMID:30413887   PMID:30446626   PMID:30638444   PMID:30653268   PMID:30664861  
PMID:30692543   PMID:30735122   PMID:30770380   PMID:30840660   PMID:30842446   PMID:30898767   PMID:30936179   PMID:30958854   PMID:30963569   PMID:31038803   PMID:31127639   PMID:31201465  
PMID:31221640   PMID:31311865   PMID:31539501   PMID:31586065   PMID:31618630   PMID:31670387   PMID:31729356   PMID:31767619   PMID:32105214   PMID:32106289   PMID:32156757   PMID:32187534  
PMID:32210087   PMID:32324134   PMID:32369449   PMID:32374006   PMID:32467233   PMID:32541003   PMID:32600616   PMID:32616504   PMID:32662771   PMID:32664967   PMID:32698004   PMID:32747435  
PMID:32855417   PMID:32866472   PMID:33046507   PMID:33217406   PMID:33248111   PMID:33308444   PMID:33393086   PMID:33436499   PMID:33436697   PMID:33723039   PMID:33787491   PMID:33846290  
PMID:34010654   PMID:34099644   PMID:34107258   PMID:34157307   PMID:34184027  


Genomics

Comparative Map Data
Smad1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39880,065,024 - 80,126,057 (-)NCBIGRCm39mm39
GRCm39 Ensembl880,065,024 - 80,126,147 (-)Ensembl
GRCm38879,338,395 - 79,399,428 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl879,338,395 - 79,399,518 (-)EnsemblGRCm38mm10GRCm38
MGSCv37881,862,294 - 81,923,367 (-)NCBIGRCm37mm9NCBIm37
MGSCv36882,234,467 - 82,295,540 (-)NCBImm8
Celera883,615,361 - 83,676,406 (-)NCBICelera
Cytogenetic Map8C1NCBI
SMAD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl4145,481,194 - 145,559,176 (+)EnsemblGRCh38hg38GRCh38
GRCh384145,481,306 - 145,559,176 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh374146,402,458 - 146,480,328 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364146,622,401 - 146,699,778 (+)NCBINCBI36hg18NCBI36
Build 344146,760,555 - 146,837,928NCBI
Celera4143,730,483 - 143,807,862 (+)NCBI
Cytogenetic Map4q31.21NCBI
HuRef4142,134,622 - 142,210,284 (+)NCBIHuRef
CHM1_14146,379,527 - 146,456,909 (+)NCBICHM1_1
Smad1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21928,513,130 - 28,573,665 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1928,513,131 - 28,573,651 (+)Ensembl
Rnor_6.01932,182,942 - 32,248,694 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1932,188,267 - 32,248,684 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01943,079,695 - 43,145,300 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41930,348,886 - 30,409,345 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11930,353,711 - 30,414,170 (+)NCBI
Celera1928,023,055 - 28,083,575 (+)NCBICelera
Cytogenetic Map19q11NCBI
Smad1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554281,361,085 - 1,429,948 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554281,357,398 - 1,429,521 (+)NCBIChiLan1.0ChiLan1.0
SMAD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.14149,481,819 - 149,558,135 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4149,481,836 - 149,558,135 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v04137,822,269 - 137,899,700 (+)NCBIMhudiblu_PPA_v0panPan3
SMAD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11544,093,491 - 44,171,177 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1544,095,497 - 44,170,098 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1544,485,533 - 44,563,273 (+)NCBI
ROS_Cfam_1.01544,761,101 - 44,839,209 (+)NCBI
UMICH_Zoey_3.11544,034,585 - 44,112,489 (+)NCBI
UNSW_CanFamBas_1.01544,121,557 - 44,199,409 (+)NCBI
UU_Cfam_GSD_1.01544,386,546 - 44,464,496 (+)NCBI
Smad1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530146,145,177 - 46,219,936 (-)NCBI
SpeTri2.0NW_0049365353,582,512 - 3,626,312 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SMAD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl882,908,527 - 82,968,994 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1882,907,557 - 82,987,909 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SMAD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1792,047,273 - 92,123,451 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl792,079,914 - 92,123,429 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603771,693,446 - 71,769,726 (+)NCBIVero_WHO_p1.0
Smad1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248534,415,816 - 4,503,317 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
Smad1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38879,371,833 - 79,372,183UniSTSGRCm38
MGSCv37881,895,732 - 81,896,082UniSTSGRCm37
Celera883,648,866 - 83,649,216UniSTS
Cytogenetic Map8C2UniSTS
cM Map8 UniSTS
AI528653  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38879,339,546 - 79,339,627UniSTSGRCm38
MGSCv37881,863,445 - 81,863,526UniSTSGRCm37
Celera883,616,512 - 83,616,593UniSTS
Cytogenetic Map8C2UniSTS
Whitehead/MRC_RH8945.87UniSTS
17.MMHAP23FLF2.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38879,365,903 - 79,366,057UniSTSGRCm38
MGSCv37881,889,802 - 81,889,956UniSTSGRCm37
Celera883,642,936 - 83,643,090UniSTS
Cytogenetic Map8C2UniSTS
Whitehead_YAC8 UniSTS
U74359  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38879,339,290 - 79,339,386UniSTSGRCm38
MGSCv37881,863,189 - 81,863,285UniSTSGRCm37
Celera883,616,256 - 83,616,352UniSTS
Cytogenetic Map8C2UniSTS
Whitehead/MRC_RH8946.99UniSTS
Smad1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38879,355,419 - 79,355,883UniSTSGRCm38
MGSCv37881,879,318 - 81,879,782UniSTSGRCm37
Celera883,632,384 - 83,632,848UniSTS
Cytogenetic Map8C2UniSTS
Smad1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8C2UniSTS
Smad1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8C2UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832016544117238700Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined834642776114837007Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83616300092728652Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837400000109600000Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)83970925694689598Mouse
1301717Adip4_madiposity 4 (mouse)Not determined84763703081637146Mouse
10766453Char11_mP. chabaudi malaria resistance QTL 11 (mouse)84763703081637146Mouse
1301441Skull11_mskull morphology 11 (mouse)Not determined84773713481737254Mouse
1357715Alaa3_malopecia areata 3 (mouse)Not determined84879293982793021Mouse
14746987Manh64_mmandible shape 64 (mouse)85005330684053306Mouse
14747005Mancz7_mmandible centroid size 7 (mouse)85005330684053306Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85188219185882191Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85428781788287993Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85470661488706763Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85554502889545028Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85820147992201479Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85840977692409776Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86078685094786976Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6346010797460107Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86393954797939696Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined86535776899357920Mouse
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined86560020799600347Mouse
10766466Char12_mP. chabaudi malaria resistance QTL 12 (mouse)86826982782600347Mouse
1301767Fcsa2_mfemoral cross-sectional area 2 (mouse)Not determined870305375104305495Mouse
4142283Imraq2_mimmune response to AAV2 QTL 2 (mouse)Not determined870305375104305495Mouse
1558780Idd22_minsulin dependent diabetes susceptibility 22 (mouse)Not determined871102903105103009Mouse
4141395Char2a_mP. chabaudi malaria resistance QTL 2a (mouse)Not determined7113678390202598Mouse
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71287817123895615Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871287817123895615Mouse
1301872Cd4ts3_mCD4 T cell subset 3 (mouse)Not determined871396181105396393Mouse
1300920Pitm3_mprion incubation time 3 (mouse)Not determined873202495107202598Mouse
27095912Pglq14_mpelvic girdle length QTL 14, 16 week (mouse)873400000126100000Mouse
1558890Lith18_mlithogenic gene 18 (mouse)Not determined875675517109675623Mouse
1357470Obq16_mobesity QTL 16 (mouse)Not determined875685348109685497Mouse
1301808Nhdlq1_mnon-HDL QTL 1 (mouse)Not determined875685348109685497Mouse
1301874Hdlq16_mHDL QTL 16 (mouse)Not determined875685348109685497Mouse
10412234Nhdlq14_mnon-HDL QTL 14 (mouse)Not determined875685348109685497Mouse
1301099Cbm2_mcerebellum weight 2 (mouse)Not determined878518613112518703Mouse
1301581Char2_mP. chabaudi malaria resistance QTL 2 (mouse)Not determined879082178113082403Mouse

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir199a-1mmu-miR-199a-3pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI19251704
Mir199a-1mmu-miR-199a-3pMirecordsexternal_infoNANA19251704

Predicted Target Of
Summary Value
Count of predictions:1206
Count of miRNA genes:650
Interacting mature miRNAs:818
Transcripts:ENSMUST00000066081, ENSMUST00000066091, ENSMUST00000109885
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000066081
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl880,081,985 - 80,126,147 (-)Ensembl
GRCm38.p6 Ensembl879,355,356 - 79,399,518 (-)Ensembl
RefSeq Acc Id: ENSMUST00000066091   ⟹   ENSMUSP00000071035
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl880,065,024 - 80,126,147 (-)Ensembl
GRCm38.p6 Ensembl879,338,395 - 79,399,518 (-)Ensembl
RefSeq Acc Id: ENSMUST00000109885   ⟹   ENSMUSP00000105511
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl880,068,209 - 80,126,147 (-)Ensembl
GRCm38.p6 Ensembl879,341,580 - 79,399,518 (-)Ensembl
RefSeq Acc Id: ENSMUST00000210678
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl880,070,302 - 80,076,680 (-)Ensembl
GRCm38.p6 Ensembl879,343,673 - 79,350,051 (-)Ensembl
RefSeq Acc Id: ENSMUST00000215983
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl880,076,356 - 80,083,307 (-)Ensembl
GRCm38.p6 Ensembl879,349,727 - 79,356,678 (-)Ensembl
RefSeq Acc Id: NM_008539   ⟹   NP_032565
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39880,065,024 - 80,126,057 (-)NCBI
GRCm38879,338,395 - 79,399,428 (-)NCBI
MGSCv37881,862,294 - 81,923,367 (-)RGD
Celera883,615,361 - 83,676,406 (-)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006530746   ⟹   XP_006530809
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39880,065,024 - 80,099,299 (-)NCBI
GRCm38879,338,409 - 79,372,673 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_032565   ⟸   NM_008539
- UniProtKB: P70340 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006530809   ⟸   XM_006530746
- Peptide Label: isoform X1
- UniProtKB: P70340 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000071035   ⟸   ENSMUST00000066091
RefSeq Acc Id: ENSMUSP00000105511   ⟸   ENSMUST00000109885
Protein Domains
MH1   MH2

Promoters
RGD ID:8667551
Promoter ID:EPDNEW_M11806
Type:initiation region
Name:Smad1_1
Description:Mus musculus SMAD family member 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38879,399,428 - 79,399,488EPDNEW
RGD ID:6848896
Promoter ID:MM_TRO:9579
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:MTR002193.8.1414.3
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36881,879,991 - 81,880,491 (-)MPROMDB
RGD ID:6843741
Promoter ID:MM_KWN:54949
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   Spleen
Transcripts:ENSMUST00000109885,   OTTMUST00000049956,   OTTMUST00000049958
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36881,923,124 - 81,923,624 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:109452 AgrOrtholog
Ensembl Genes ENSMUSG00000031681 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000071035 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000105511 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000066091 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000109885 UniProtKB/TrEMBL
Gene3D-CATH 2.60.200.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.520.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Dwarfin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAD_homology1_Dwarfin-type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAD_homology_MH1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMAD-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMAD_dom_Dwarfin-type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMAD_FHA_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMAD_MH1_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:17125 UniProtKB/Swiss-Prot
MGD MGI:109452 ENTREZGENE
NCBI Gene 17125 ENTREZGENE
PANTHER PTHR13703 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam MH1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Smad1 PhenoGen
PROSITE MH1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART DWA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DWB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49879 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56366 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt P70340 ENTREZGENE
  Q8C3Y6_MOUSE UniProtKB/TrEMBL
  SMAD1_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary P70442 UniProtKB/Swiss-Prot
  Q6GT95 UniProtKB/Swiss-Prot
  Q9CYK6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-07-10 Smad1  SMAD family member 1  Smad1  MAD homolog 1 (Drosophila)  Symbol and/or name change 5135510 APPROVED