Smad3 (SMAD family member 3) - Rat Genome Database

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Gene: Smad3 (SMAD family member 3) Ictidomys tridecemlineatus
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Symbol: Smad3
Name: SMAD family member 3
RGD ID: 12522790
Description: ENCODES a protein that exhibits beta-catenin binding (ortholog); bHLH transcription factor binding (ortholog); chromatin binding (ortholog); INVOLVED IN activation of cysteine-type endopeptidase activity involved in apoptotic process (ortholog); activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway (ortholog); activin receptor signaling pathway (ortholog); PARTICIPATES IN activin signaling pathway; altered transforming growth factor-beta Smad dependent signaling pathway; colorectal cancer pathway; ASSOCIATED WITH alcoholic liver cirrhosis (ortholog); Aneurysm (ortholog); aortic aneurysm (ortholog); FOUND IN chromatin (ortholog); cytoplasm (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: mothers against decapentaplegic homolog 3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640109,232,767 - 109,341,735 (+)NCBI
SpeTri2.0NW_00493647127,080,662 - 27,185,861 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway  (ISO)
activin receptor signaling pathway  (ISO)
adrenal gland development  (ISO)
cell-cell junction organization  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
developmental growth  (ISO)
embryonic cranial skeleton morphogenesis  (ISO)
embryonic foregut morphogenesis  (ISO)
embryonic pattern specification  (ISO)
endoderm development  (ISO)
extrinsic apoptotic signaling pathway  (ISO)
gastrulation  (ISO)
heart looping  (ISO)
immune response  (ISO)
immune system development  (ISO)
in utero embryonic development  (ISO)
lens fiber cell differentiation  (ISO)
liver development  (ISO)
mesoderm formation  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cardiac muscle hypertrophy in response to stress  (ISO)
negative regulation of cell growth  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of cytosolic calcium ion concentration  (ISO)
negative regulation of fat cell differentiation  (ISO)
negative regulation of inflammatory response  (ISO)
negative regulation of lung blood pressure  (ISO)
negative regulation of mitotic cell cycle  (ISO)
negative regulation of osteoblast differentiation  (ISO)
negative regulation of osteoblast proliferation  (ISO)
negative regulation of protein catabolic process  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of wound healing  (ISO)
nodal signaling pathway  (ISO)
osteoblast development  (ISO)
osteoblast differentiation  (ISO)
paraxial mesoderm morphogenesis  (ISO)
pericardium development  (ISO)
positive regulation of alkaline phosphatase activity  (ISO)
positive regulation of bone mineralization  (ISO)
positive regulation of canonical Wnt signaling pathway  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of chondrocyte differentiation  (ISO)
positive regulation of epithelial to mesenchymal transition  (ISO)
positive regulation of extracellular matrix assembly  (ISO)
positive regulation of focal adhesion assembly  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of interleukin-1 beta production  (ISO)
positive regulation of nitric oxide biosynthetic process  (ISO)
positive regulation of positive chemotaxis  (ISO)
positive regulation of pri-miRNA transcription by RNA polymerase II  (ISO)
positive regulation of stress fiber assembly  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
positive regulation of transforming growth factor beta3 production  (ISO)
protein stabilization  (ISO)
regulation of binding  (ISO)
regulation of cell cycle  (ISO)
regulation of epithelial cell proliferation  (ISO)
regulation of immune response  (ISO)
regulation of striated muscle tissue development  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
regulation of transforming growth factor beta receptor signaling pathway  (ISO)
regulation of transforming growth factor beta2 production  (ISO)
response to hypoxia  (ISO)
signal transduction involved in regulation of gene expression  (ISO)
skeletal system development  (ISO)
SMAD protein complex assembly  (ISO)
SMAD protein signal transduction  (ISO)
somitogenesis  (ISO)
T cell activation  (ISO)
thyroid gland development  (ISO)
transdifferentiation  (ISO)
transforming growth factor beta receptor signaling pathway  (ISO)
ureteric bud development  (ISO)

Cellular Component

References

Genomics

Comparative Map Data
Smad3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640109,232,767 - 109,341,735 (+)NCBI
SpeTri2.0NW_00493647127,080,662 - 27,185,861 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SMAD3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1567,063,763 - 67,195,173 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl1567,063,763 - 67,195,169 (+)EnsemblGRCh38hg38GRCh38
GRCh381567,065,602 - 67,195,195 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371567,357,940 - 67,487,507 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361565,145,249 - 65,274,587 (+)NCBINCBI36hg18NCBI36
Build 341565,145,248 - 65,274,586NCBI
Celera1544,246,635 - 44,375,039 (+)NCBI
Cytogenetic Map15q22.33NCBI
HuRef1544,193,465 - 44,321,904 (+)NCBIHuRef
CHM1_11567,476,260 - 67,605,488 (+)NCBICHM1_1
Smad3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39963,554,048 - 63,665,276 (-)NCBIGRCm39mm39
GRCm39 Ensembl963,554,049 - 63,665,276 (-)Ensembl
GRCm38963,646,766 - 63,757,994 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl963,646,767 - 63,757,994 (-)EnsemblGRCm38mm10GRCm38
MGSCv37963,494,574 - 63,605,801 (-)NCBIGRCm37mm9NCBIm37
MGSCv36963,444,773 - 63,556,000 (-)NCBImm8
Celera960,869,117 - 60,980,879 (-)NCBICelera
Cytogenetic Map9CNCBI
Smad3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2864,126,829 - 64,236,960 (-)NCBI
Rnor_6.0 Ensembl868,569,530 - 68,678,349 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0868,569,530 - 68,678,349 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0868,290,927 - 68,397,727 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4867,803,909 - 67,952,056 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1867,822,964 - 67,971,110 (-)NCBI
Celera863,537,497 - 63,647,062 (-)NCBICelera
Cytogenetic Map8q24NCBI
Smad3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554508,747,651 - 8,842,136 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554508,747,651 - 8,842,003 (-)NCBIChiLan1.0ChiLan1.0
SMAD3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11564,284,949 - 64,414,185 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1564,284,949 - 64,414,185 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01546,013,764 - 46,143,126 (+)NCBIMhudiblu_PPA_v0panPan3
SMAD3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13031,246,313 - 31,360,098 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3031,245,657 - 31,363,337 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3031,175,971 - 31,289,442 (+)NCBI
ROS_Cfam_1.03031,444,224 - 31,557,937 (+)NCBI
UMICH_Zoey_3.13031,371,657 - 31,485,227 (+)NCBI
UNSW_CanFamBas_1.03031,431,846 - 31,545,247 (+)NCBI
UU_Cfam_GSD_1.03031,673,713 - 31,787,293 (+)NCBI
SMAD3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1164,998,083 - 165,124,454 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11164,998,457 - 165,124,455 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21182,902,348 - 182,926,370 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SMAD3
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12616,319,959 - 16,446,472 (-)NCBI
ChlSab1.1 Ensembl2616,320,933 - 16,446,527 (-)Ensembl
Vero_WHO_p1.0NW_023666048125,021,354 - 125,151,320 (+)NCBI
Smad3
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247815,795,652 - 5,890,047 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_005316724   ⟹   XP_005316781
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024408640109,232,767 - 109,341,734 (+)NCBI
SpeTri2.0NW_00493647127,080,662 - 27,185,861 (+)NCBI
Sequence:
RefSeq Acc Id: XM_040275167   ⟹   XP_040131101
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024408640109,270,174 - 109,341,735 (+)NCBI
RefSeq Acc Id: XM_040275168   ⟹   XP_040131102
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024408640109,233,131 - 109,341,735 (+)NCBI
Protein Sequences
Protein RefSeqs XP_005316781 (Get FASTA)   NCBI Sequence Viewer  
  XP_040131101 (Get FASTA)   NCBI Sequence Viewer  
  XP_040131102 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005316781   ⟸   XM_005316724
- Peptide Label: isoform X1
- UniProtKB: I3MF72 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040131102   ⟸   XM_040275168
- Peptide Label: isoform X3
RefSeq Acc Id: XP_040131101   ⟸   XM_040275167
- Peptide Label: isoform X2
Protein Domains
MH1   MH2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000010286 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSTOP00000009229 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000010285 UniProtKB/TrEMBL
Gene3D-CATH 2.60.200.10 UniProtKB/TrEMBL
  3.90.520.10 UniProtKB/TrEMBL
InterPro Dwarfin UniProtKB/TrEMBL
  MAD_homology1_Dwarfin-type UniProtKB/TrEMBL
  MAD_homology_MH1 UniProtKB/TrEMBL
  SMAD_dom-like UniProtKB/TrEMBL
  SMAD_dom_Dwarfin-type UniProtKB/TrEMBL
  SMAD_FHA_domain UniProtKB/TrEMBL
  SMAD_MH1_sf UniProtKB/TrEMBL
NCBI Gene Smad3 ENTREZGENE
PANTHER PTHR13703 UniProtKB/TrEMBL
Pfam MH1 UniProtKB/TrEMBL
  MH2 UniProtKB/TrEMBL
PROSITE MH1 UniProtKB/TrEMBL
  MH2 UniProtKB/TrEMBL
SMART DWA UniProtKB/TrEMBL
  DWB UniProtKB/TrEMBL
Superfamily-SCOP SSF49879 UniProtKB/TrEMBL
  SSF56366 UniProtKB/TrEMBL
UniProt I3MF72 ENTREZGENE, UniProtKB/TrEMBL