EP300 (E1A binding protein p300) - Rat Genome Database

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Gene: EP300 (E1A binding protein p300) Sus scrofa
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Symbol: EP300
Name: E1A binding protein p300
RGD ID: 14039818
Description: ENCODES a protein that exhibits acetyltransferase activity (ortholog); acyltransferase activity (ortholog); antigen binding (ortholog); INVOLVED IN animal organ morphogenesis (ortholog); apoptotic process (ortholog); B cell differentiation (ortholog); PARTICIPATES IN androgen signaling pathway; cortisol signaling pathway; estrogen signaling pathway; ASSOCIATED WITH adenoid cystic carcinoma (ortholog); Agenesis of Corpus Callosum (ortholog); Alzheimer's disease (ortholog); FOUND IN chromatin (ortholog); cytoplasm (ortholog); nucleoplasm (ortholog); INTERACTS WITH warfarin
Type: protein-coding
RefSeq Status: MODEL
Also known as: LOW QUALITY PROTEIN: histone acetyltransferase p300
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl57,311,171 - 7,393,760 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.157,311,165 - 7,394,515 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.254,574,025 - 4,656,181 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
adenoid cystic carcinoma  (ISO)
Agenesis of Corpus Callosum  (ISO)
Alzheimer's disease  (ISO)
Brain Hypoxia  (ISO)
breast carcinoma  (ISO)
Breast Neoplasms  (ISO)
cardiac arrest  (ISO)
Cardiomegaly  (ISO)
cardiomyopathy  (ISO)
CHARGE syndrome  (ISO)
clear cell renal cell carcinoma  (ISO)
colon carcinoma  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
congenital diaphragmatic hernia  (ISO)
congestive heart failure  (ISO)
Craniofacial Abnormalities  (ISO)
Developmental Disabilities  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
Dwarfism  (ISO)
Endometrial Neoplasms  (ISO)
Endotoxemia  (ISO)
esophageal carcinoma  (ISO)
esophagus squamous cell carcinoma  (ISO)
Experimental Diabetes Mellitus  (ISO)
genetic disease  (ISO)
glomerulonephritis  (ISO)
head and neck squamous cell carcinoma  (ISO)
heart disease  (ISO)
hepatocellular carcinoma  (ISO)
hereditary breast ovarian cancer syndrome  (ISO)
Huntington's disease  (ISO)
Hyperalgesia  (ISO)
hypertension  (ISO)
intellectual disability  (ISO)
Kidney Reperfusion Injury  (ISO)
Lead Poisoning, Nervous System  (ISO)
lung adenocarcinoma  (ISO)
lung small cell carcinoma  (ISO)
lung squamous cell carcinoma  (ISO)
medulloblastoma  (ISO)
melanoma  (ISO)
membranoproliferative glomerulonephritis  (ISO)
Menke-Hennekam Syndrome 2  (ISO)
microcephaly  (ISO)
Micrognathism  (ISO)
Multicystic Dysplastic Kidney  (ISO)
Multiple Abnormalities  (ISO)
nephronophthisis-like nephropathy 1  (ISO)
Neurodevelopmental Disorders  (ISO)
obesity  (ISO)
Optic Nerve Injuries  (ISO)
Painful Neuropathy  (ISO)
prostate cancer  (ISO)
Reperfusion Injury  (ISO)
Retrognathia  (ISO)
Rubinstein-Taybi syndrome  (ISO)
Sepsis  (ISO)
squamous cell carcinoma  (ISO)
Stevens-Johnson syndrome  (ISO)
T-Cell Lymphoma  (ISO)
Thumb Deformity  (ISO)
transient cerebral ischemia  (ISO)
transitional cell carcinoma  (ISO)
type 2 diabetes mellitus  (ISO)
urinary bladder cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
warfarin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ morphogenesis  (IEA,ISO)
apoptotic process  (ISO)
B cell differentiation  (IEA,ISO)
behavioral defense response  (IEA)
cellular response to antibiotic  (ISO)
cellular response to cAMP  (ISO)
cellular response to dexamethasone stimulus  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to hydrogen peroxide  (ISO)
cellular response to mineralocorticoid stimulus  (ISO)
cellular response to nerve growth factor stimulus  (ISO)
cellular response to organic cyclic compound  (ISO)
cellular response to retinoic acid  (ISO)
cellular response to trichostatin A  (ISO)
cellular response to UV  (IEA)
cellular response to xenobiotic stimulus  (ISO)
circadian rhythm  (IEA)
digestive tract development  (ISO)
face morphogenesis  (IEA)
fat cell differentiation  (IEA)
heart development  (IEA,ISO)
histone acetylation  (IBA,ISO)
histone H2B acetylation  (IEA)
histone H3 acetylation  (ISO)
histone H3-K56 acetylation  (IEA,ISO)
histone H4 acetylation  (IEA)
internal peptidyl-lysine acetylation  (ISO)
internal protein amino acid acetylation  (ISO)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  (IEA)
learning or memory  (IEA)
lung development  (IEA,ISO)
macrophage derived foam cell differentiation  (IEA)
megakaryocyte development  (IEA,ISO)
memory  (ISO)
multicellular organism growth  (IEA)
N-terminal peptidyl-lysine acetylation  (IEA)
negative regulation of cell death  (ISO)
negative regulation of cellular metabolic process  (ISO)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
negative regulation of gluconeogenesis  (IEA)
negative regulation of miRNA metabolic process  (ISO)
negative regulation of protein-containing complex assembly  (IEA)
negative regulation of transcription by RNA polymerase II  (IEA)
peptidyl-lysine acetylation  (ISO)
peptidyl-lysine butyrylation  (IEA)
peptidyl-lysine crotonylation  (IEA)
peptidyl-lysine propionylation  (IEA)
platelet formation  (IEA,ISO)
positive regulation by host of viral transcription  (IEA)
positive regulation of axon extension  (ISO)
positive regulation of cell death  (ISO)
positive regulation of cell growth  (ISO)
positive regulation of cell growth involved in cardiac muscle cell development  (ISO)
positive regulation of cell size  (ISO)
positive regulation of cellular metabolic process  (ISO)
positive regulation of collagen biosynthetic process  (ISO)
positive regulation of DNA binding  (ISO)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of gene expression, epigenetic  (IEA)
positive regulation of glycoprotein biosynthetic process  (ISO)
positive regulation of histone acetylation  (ISO)
positive regulation of muscle atrophy  (ISO)
positive regulation of neuron projection development  (IEA)
positive regulation of NF-kappaB transcription factor activity  (IEA)
positive regulation of NIK/NF-kappaB signaling  (IEA)
positive regulation of protein acetylation  (ISO)
positive regulation of protein binding  (IEA,ISO)
positive regulation of protein import into nucleus  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of protein secretion  (ISO)
positive regulation of proteolysis  (ISO)
positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding  (IEA)
positive regulation of sarcomere organization  (ISO)
positive regulation of transcription by RNA polymerase II  (IBA,ISO)
positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response  (IEA)
positive regulation of transcription, DNA-templated  (ISO)
positive regulation of transforming growth factor beta receptor signaling pathway  (IEA)
positive regulation of translation  (ISO)
protein acetylation  (ISO)
protein destabilization  (IEA)
protein kinase B signaling  (ISO)
protein stabilization  (IEA)
protein-DNA complex assembly  (ISO)
regulation of androgen receptor signaling pathway  (IEA)
regulation of angiotensin metabolic process  (ISO)
regulation of glycolytic process  (IEA)
regulation of mitochondrion organization  (IEA)
regulation of transcription by RNA polymerase II  (ISO)
regulation of tubulin deacetylation  (IEA)
response to calcium ion  (ISO)
response to cobalt ion  (ISO)
response to dexamethasone  (ISO)
response to estrogen  (IEA,ISO)
response to ethanol  (ISO)
response to fatty acid  (ISO)
response to glucose  (ISO)
response to hydrogen peroxide  (ISO)
response to hypoxia  (IEA,ISO)
response to organic cyclic compound  (ISO)
response to retinoic acid  (ISO)
response to tumor necrosis factor  (ISO)
response to xenobiotic stimulus  (ISO)
skeletal muscle tissue development  (IEA,ISO)
somitogenesis  (IEA,ISO)
swimming  (IEA)
thigmotaxis  (IEA)

Cellular Component

Molecular Function
acetyltransferase activity  (ISO)
acyltransferase activity  (ISO)
androgen receptor binding  (IEA)
antigen binding  (ISO)
beta-catenin binding  (IEA)
bHLH transcription factor binding  (ISO)
chromatin binding  (ISO)
chromatin DNA binding  (IBA,ISO)
cis-regulatory region sequence-specific DNA binding  (ISO)
damaged DNA binding  (IEA)
DNA binding  (ISO)
DNA-binding transcription activator activity  (IEA)
DNA-binding transcription factor binding  (ISO)
glucocorticoid receptor binding  (ISO)
H3 histone acetyltransferase activity  (IEA)
H4 histone acetyltransferase activity  (IEA)
histone acetyltransferase activity  (IBA,ISO)
histone butyryltransferase activity  (IEA)
histone crotonyltransferase activity  (IEA)
histone lactyltransferase activity  (IEA)
lysine N-acetyltransferase activity, acting on acetyl phosphate as donor  (IEA)
mitogen-activated protein kinase binding  (ISO)
NF-kappaB binding  (IEA,ISO)
nuclear receptor binding  (ISO)
p53 binding  (IEA,ISO)
peptide butyryltransferase activity  (ISO)
peptide-lysine-N-acetyltransferase activity  (ISO)
peroxisome proliferator activated receptor binding  (ISO)
pre-mRNA intronic binding  (IEA)
promoter-specific chromatin binding  (ISO)
protein antigen binding  (ISO)
protein binding  (ISO)
protein C-terminus binding  (IEA)
protein kinase binding  (ISO)
protein propionyltransferase activity  (IEA)
protein-containing complex binding  (ISO)
RNA polymerase II cis-regulatory region sequence-specific DNA binding  (ISO)
RNA polymerase II-specific DNA-binding transcription factor binding  (ISO)
SMAD binding  (ISO)
STAT family protein binding  (IEA)
transcription coactivator activity  (IBA)
transcription coactivator binding  (IEA)
transcription coregulator binding  (ISO)
transcription factor binding  (ISO)
zinc ion binding  (IEA)

References

Genomics

Comparative Map Data
EP300
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl57,311,171 - 7,393,760 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.157,311,165 - 7,394,515 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.254,574,025 - 4,656,181 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EP300
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2241,092,592 - 41,180,077 (+)EnsemblGRCh38hg38GRCh38
GRCh382241,092,592 - 41,180,077 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372241,488,596 - 41,576,081 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362239,818,553 - 39,906,024 (+)NCBINCBI36hg18NCBI36
Build 342239,813,106 - 39,900,578NCBI
Celera2225,294,977 - 25,382,428 (+)NCBI
Cytogenetic Map22q13.2NCBI
HuRef2224,453,007 - 24,540,433 (+)NCBIHuRef
CHM1_12241,448,337 - 41,535,740 (+)NCBICHM1_1
Ep300
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391581,470,329 - 81,536,278 (+)NCBIGRCm39mm39
GRCm39 Ensembl1581,469,552 - 81,536,278 (+)Ensembl
GRCm381581,586,209 - 81,652,077 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1581,585,351 - 81,652,077 (+)EnsemblGRCm38mm10GRCm38
MGSCv371581,416,644 - 81,482,507 (+)NCBIGRCm37mm9NCBIm37
MGSCv361581,413,469 - 81,479,332 (+)NCBImm8
Celera1583,704,343 - 83,770,860 (+)NCBICelera
Cytogenetic Map15E1NCBI
Ep300
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27113,108,476 - 113,178,529 (+)NCBImRatBN7.2
Rnor_6.0 Ensembl7122,818,975 - 122,861,296 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.07122,818,194 - 122,889,055 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.07122,792,742 - 122,863,551 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47119,938,507 - 120,008,886 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17119,972,736 - 120,000,026 (+)NCBI
Celera7109,426,729 - 109,497,522 (+)NCBICelera
Cytogenetic Map7q34NCBI
Ep300
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541326,648,339 - 26,727,933 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541326,647,553 - 26,727,875 (+)NCBIChiLan1.0ChiLan1.0
EP300
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12240,079,214 - 40,168,936 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2240,079,503 - 40,168,604 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02221,986,467 - 22,076,921 (+)NCBIMhudiblu_PPA_v0panPan3
ZC3H7B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11023,882,379 - 23,944,850 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1023,884,981 - 23,920,131 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1023,814,502 - 23,876,996 (-)NCBI
ROS_Cfam_1.01024,626,532 - 24,689,038 (-)NCBI
UMICH_Zoey_3.11024,343,251 - 24,405,735 (-)NCBI
UNSW_CanFamBas_1.01024,664,137 - 24,726,628 (-)NCBI
UU_Cfam_GSD_1.01024,838,614 - 24,901,106 (-)NCBI
Ep300
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049457,686,568 - 7,767,718 (-)NCBI
SpeTri2.0NW_004936492696,982 - 778,132 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EP300
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11923,634,132 - 23,726,095 (+)NCBI
ChlSab1.1 Ensembl1923,634,571 - 23,724,979 (+)Ensembl
Vero_WHO_p1.0NW_023666045101,701,940 - 101,792,946 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 10 2 3 5 2 14 2 3 3
Low 2 9
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000026332   ⟹   ENSSSCP00000020812
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl57,311,171 - 7,393,760 (-)Ensembl
RefSeq Acc Id: XM_001929213   ⟹   XP_001929248
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.157,311,165 - 7,394,515 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_001929248 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_001929248   ⟸   XM_001929213
- Sequence:
RefSeq Acc Id: ENSSSCP00000020812   ⟸   ENSSSCT00000026332
Protein Domains
Bromo   CBP/p300-type HAT   KIX   TAZ-type   ZZ-type


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000000068 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000020812 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000026332 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 1.10.1630.10 UniProtKB/TrEMBL
  1.10.246.20 UniProtKB/TrEMBL
  1.20.1020.10 UniProtKB/TrEMBL
  1.20.920.10 UniProtKB/TrEMBL
  2.10.110.40 UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/TrEMBL
  3.30.60.90 UniProtKB/TrEMBL
InterPro Bromodomain UniProtKB/TrEMBL
  Bromodomain-like_sf UniProtKB/TrEMBL
  Bromodomain_CS UniProtKB/TrEMBL
  CBP_P300_HAT UniProtKB/TrEMBL
  Histone_AcTrfase_Rtt109/CBP UniProtKB/TrEMBL
  KIX_dom UniProtKB/TrEMBL
  KIX_dom_sf UniProtKB/TrEMBL
  Nuc_rcpt_coact UniProtKB/TrEMBL
  Nuc_rcpt_coact_CREBbp UniProtKB/TrEMBL
  Nuc_rcpt_coact_CREBbp_sf UniProtKB/TrEMBL
  RING_CBP-p300 UniProtKB/TrEMBL
  RING_CBP-p300_sf UniProtKB/TrEMBL
  TAZ_dom_sf UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
  Znf_TAZ UniProtKB/TrEMBL
  Znf_ZZ UniProtKB/TrEMBL
  Znf_ZZ_sf UniProtKB/TrEMBL
KEGG Report ssc:100156226 UniProtKB/TrEMBL
NCBI Gene EP300 ENTREZGENE
Pfam Bromodomain UniProtKB/TrEMBL
  Creb_binding UniProtKB/TrEMBL
  DUF902 UniProtKB/TrEMBL
  HAT_KAT11 UniProtKB/TrEMBL
  KIX UniProtKB/TrEMBL
  PF00569 UniProtKB/TrEMBL
  zf-TAZ UniProtKB/TrEMBL
PRINTS BROMODOMAIN UniProtKB/TrEMBL
PROSITE BROMODOMAIN_1 UniProtKB/TrEMBL
  BROMODOMAIN_2 UniProtKB/TrEMBL
  CBP_P300_HAT UniProtKB/TrEMBL
  KIX UniProtKB/TrEMBL
  ZF_TAZ UniProtKB/TrEMBL
  ZF_ZZ_1 UniProtKB/TrEMBL
  ZF_ZZ_2 UniProtKB/TrEMBL
SMART BROMO UniProtKB/TrEMBL
  KAT11 UniProtKB/TrEMBL
  ZnF_TAZ UniProtKB/TrEMBL
  ZnF_ZZ UniProtKB/TrEMBL
Superfamily-SCOP SSF47040 UniProtKB/TrEMBL
  SSF47370 UniProtKB/TrEMBL
  SSF57933 UniProtKB/TrEMBL
  SSF69125 UniProtKB/TrEMBL
UniProt A0A480QJT4_PIG UniProtKB/TrEMBL
  I3L9U8_PIG UniProtKB/TrEMBL
VGNC ID VGNC:87720 ENTREZGENE