Nfatc1 (nuclear factor of activated T-cells 1) - Rat Genome Database

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Gene: Nfatc1 (nuclear factor of activated T-cells 1) Rattus norvegicus
Analyze
Symbol: Nfatc1
Name: nuclear factor of activated T-cells 1
RGD ID: 2319357
Description: Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity and transcription coactivator binding activity. Involved in several processes, including cellular response to transforming growth factor beta stimulus; cellular response to tumor necrosis factor; and positive regulation of nucleobase-containing compound metabolic process. Located in nucleus; perinuclear region of cytoplasm; and sarcoplasm. Biomarker of kidney disease and osteoarthritis. Human ortholog(s) of this gene implicated in congenital heart disease and ventricular septal defect. Orthologous to human NFATC1 (nuclear factor of activated T cells 1); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; alpha-Zearalanol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC100361818; nuclear factor of activated T-cells, cytoplasmic 1; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81876,321,386 - 76,430,997 (-)NCBIGRCr8
mRatBN7.21874,046,422 - 74,156,041 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1874,046,904 - 74,156,028 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1876,149,324 - 76,258,603 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01876,818,657 - 76,927,924 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01874,664,215 - 74,773,420 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01877,203,517 - 77,322,690 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1877,203,525 - 77,322,690 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01876,309,900 - 76,426,095 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41877,498,654 - 77,581,231 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1872,704,426 - 72,813,069 (-)NCBICelera
Cytogenetic Map18q12.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-matairesinol  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-aminopurine  (ISO)
2-tert-butylhydroquinone  (ISO)
3'-O-(4-Benzoyl)benzoyl ATP  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxybenzamide  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
8-bromo-3',5'-cyclic GMP  (ISO)
9-phenanthrol  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
Alisol B  (ISO)
all-trans-retinoic acid  (ISO)
alpha-naphthoflavone  (ISO)
alpha-Zearalanol  (EXP)
apocynin  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP)
ATP  (EXP,ISO)
atrazine  (EXP)
azetidine  (ISO)
benzamide  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
benzyl isothiocyanate  (ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (ISO)
cadmium atom  (ISO)
Calcimycin  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
chlorpromazine  (ISO)
choline  (ISO)
chromium(3+) trichloride  (ISO)
chrysene  (ISO)
cisapride  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
coenzyme Q10  (ISO)
copper(II) sulfate  (ISO)
corilagin  (ISO)
CU-O LINKAGE  (ISO)
cyclosporin A  (EXP,ISO)
decabromodiphenyl ether  (EXP)
deoxynivalenol  (ISO)
diarsenic trioxide  (EXP)
dibenziodolium  (ISO)
diosmetin  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ellagic acid  (ISO)
entinostat  (ISO)
ethanol  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
formononetin  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
ginsenoside Rb1  (ISO)
glyburide  (ISO)
harmine  (ISO)
hydrogen peroxide  (ISO)
hydroxychloroquine  (ISO)
hypoxanthine  (ISO)
inulin  (ISO)
ionomycin  (ISO)
isoprenaline  (EXP)
KN-93  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
methapyrilene  (ISO)
methoxychlor  (EXP)
methylglyoxal  (ISO)
Morroniside  (ISO)
N-acetyl-L-cysteine  (ISO)
niclosamide  (ISO)
ochratoxin A  (ISO)
oxaliplatin  (EXP)
p-menthan-3-ol  (ISO)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenylephrine  (EXP)
phloretin  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
platycodin D  (EXP,ISO)
quercetin  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
Ro 41-5253  (ISO)
rotenone  (ISO)
ruxolitinib  (ISO)
Sanggenon C  (EXP,ISO)
SB 203580  (ISO)
SB 431542  (ISO)
sclareol  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
SKF-96365 hydrochloride  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
streptozocin  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
tetraphene  (ISO)
thapsigargin  (ISO)
thymol  (ISO)
thymol sulfate(1-)  (ISO)
titanium dioxide  (ISO)
tofacitinib  (ISO)
topotecan  (EXP)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
triphenylstannane  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
xanthohumol  (ISO)
zinc atom  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aortic valve development  (ISO)
aortic valve morphogenesis  (ISO)
B-1a B cell differentiation  (ISO)
branching involved in lymph vessel morphogenesis  (ISO)
calcineurin-NFAT signaling cascade  (IBA,ISO)
calcium ion transport  (ISO)
cellular response to calcium ion  (ISO)
cellular response to transforming growth factor beta stimulus  (IEP)
cellular response to tumor necrosis factor  (IEP)
endocardial cushion development  (ISO)
epithelial to mesenchymal transition  (ISO)
G1/S transition of mitotic cell cycle  (ISO)
gene expression  (ISO)
heart development  (ISO)
heart trabecula morphogenesis  (ISO)
heart valve development  (ISO)
heart valve morphogenesis  (ISO)
intracellular signal transduction  (ISO)
keratinocyte proliferation  (ISO)
lymphangiogenesis  (ISO)
mononuclear cell differentiation  (IEP)
negative regulation of keratinocyte proliferation  (ISO)
negative regulation of osteoblast differentiation  (ISO)
negative regulation of stem cell proliferation  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of vascular associated smooth muscle cell differentiation  (ISO)
osteoclast differentiation  (ISO)
positive regulation of DNA biosynthetic process  (IMP)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of transcription by RNA polymerase II  (IBA,IMP,ISO)
pulmonary valve development  (ISO)
pulmonary valve morphogenesis  (ISO)
regulation of hair cycle  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
response to muscle activity  (IEP)
semi-lunar valve development  (ISO)
skeletal muscle adaptation  (IEP)
stem cell proliferation  (ISO)
transcription by RNA polymerase II  (ISO)
transition between fast and slow fiber  (ISO)
ventricular septum morphogenesis  (ISO)
wound healing  (IMP)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Co-operative interactions between NFAT (nuclear factor of activated T cells) c1 and the zinc finger transcription factors Sp1/Sp3 and Egr-1 regulate MT1-MMP (membrane type 1 matrix metalloproteinase) transcription by glomerular mesangial cells. Alfonso-Jaume MA, etal., Biochem J. 2004 Jun 15;380(Pt 3):735-47.
2. Inhibition of calcineurin/NFAT pathway plays an essential role in renoprotective effect of tropisetron in early stage of diabetic nephropathy. Barzegar-Fallah A, etal., Eur J Pharmacol. 2015 Nov 15;767:152-9. doi: 10.1016/j.ejphar.2015.10.019. Epub 2015 Oct 21.
3. Upregulation of nuclear factor of activated T-cells by nerve injury contributes to development of neuropathic pain. Cai YQ, etal., J Pharmacol Exp Ther. 2013 Apr;345(1):161-8. doi: 10.1124/jpet.112.202192. Epub 2013 Feb 5.
4. Glycogen synthase kinase 3beta regulation of nuclear factor of activated T-cells isoform c1 in the vascular smooth muscle cell response to injury. Chow W, etal., Exp Cell Res. 2008 Oct 1;314(16):2919-29. doi: 10.1016/j.yexcr.2008.07.010. Epub 2008 Jul 22.
5. Dihydroartemisinin attenuates osteoclast formation and bone resorption via inhibiting the NF‑κB, MAPK and NFATc1 signaling pathways and alleviates osteoarthritis. Ding D, etal., Int J Mol Med. 2022 Jan;49(1):4. doi: 10.3892/ijmm.2021.5059. Epub 2021 Nov 5.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Association of a tandem repeat polymorphism in NFATc1 with increased risk of perimembranous ventricular septal defect in a Chinese population. Gu H, etal., Biochem Genet. 2011 Oct;49(9-10):592-600. doi: 10.1007/s10528-011-9434-8. Epub 2011 Apr 17.
8. NFATc1 targets cyclin A in the regulation of vascular smooth muscle cell multiplication during restenosis. Karpurapu M, etal., J Biol Chem. 2008 Sep 26;283(39):26577-90. doi: 10.1074/jbc.M800423200. Epub 2008 Jul 29.
9. Endothelin-1-dependent nuclear factor of activated T lymphocyte signaling associates with transcriptional coactivator p300 in the activation of the B cell leukemia-2 promoter in cardiac myocytes. Kawamura T, etal., Circ Res. 2004 Jun 11;94(11):1492-9. Epub 2004 Apr 29.
10. Novel interactions between NFATc1 (Nuclear Factor of Activated T cells c1) and STAT-3 (Signal Transducer and Activator of Transcription-3) mediate G protein-coupled receptor agonist, thrombin-induced biphasic expression of cyclin D1, with first phase influencing cell migration and second phase directing cell proliferation. Kundumani-Sridharan V, etal., J Biol Chem. 2012 Jun 29;287(27):22463-82. doi: 10.1074/jbc.M112.362996. Epub 2012 May 6.
11. Water extract of Cnidii Rhizoma suppresses RANKL-induced osteoclastogenesis in RAW 264.7 cell by inhibiting NFATc1/c-Fos signaling and prevents ovariectomized bone loss in SD-rat. Lee KY, etal., BMC Complement Altern Med. 2019 Aug 9;19(1):207. doi: 10.1186/s12906-019-2611-8.
12. Correlation between NFATC1 gene polymorphisms and congenital heart disease in children. Li CL, etal., Eur Rev Med Pharmacol Sci. 2017 Aug;21(15):3441-3446.
13. Recombinant human erythropoietin pretreatment alleviates renal glomerular injury induced by cardiopulmonary bypass by reducing transient receptor potential channel 6-nuclear factor of activated T-cells pathway activation. Liu X, etal., J Thorac Cardiovasc Surg. 2013 Mar 24. pii: S0022-5223(13)00274-2. doi: 10.1016/j.jtcvs.2013.02.076.
14. PIAS1 Alleviates Hepatic Ischemia-Reperfusion Injury in Mice through a Mechanism Involving NFATc1 SUMOylation. Luo J, etal., Dis Markers. 2022 Aug 31;2022:4988539. doi: 10.1155/2022/4988539. eCollection 2022.
15. Increased myofiber remodelling and NFATc1-myonuclear translocation in rat postural skeletal muscle after experimental vestibular deafferentation. Luxa N, etal., J Vestib Res. 2013;23(4-5):187-93. doi: 10.3233/VES-130499.
16. Characterization and identification of subpopulations of mononuclear preosteoclasts induced by TNF-α in combination with TGF-β in rats. Matsubara R, etal., PLoS One. 2012;7(10):e47930. doi: 10.1371/journal.pone.0047930. Epub 2012 Oct 24.
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Calcineurin is a potent regulator for skeletal muscle regeneration by association with NFATc1 and GATA-2. Sakuma K, etal., Acta Neuropathol. 2003 Mar;105(3):271-80. Epub 2002 Dec 19.
20. Association of NFATc1 gene polymorphism with ventricular septal defect in the Chinese Han population. Shen L, etal., Chin Med J (Engl). 2013 Jan;126(1):78-81.
21. Acute Skeletal Muscle Contractions Orchestrate Signaling Mechanisms to Trigger Nuclear NFATc1 Shuttling and Epigenetic Histone Modifications. Suhr F, etal., Cell Physiol Biochem. 2019;52(3):633-652. doi: 10.33594/000000045.
22. [Histopathologic features of degenerative aortic valve and its mechanisms]. Sun J, etal., Zhonghua Yi Xue Za Zhi. 2013 Jan 22;93(4):280-4.
Additional References at PubMed
PMID:7650004   PMID:9515963   PMID:9515964   PMID:10903175   PMID:11782539   PMID:11889139   PMID:12091710   PMID:12370307   PMID:12469121   PMID:12660151   PMID:12808150   PMID:12970181  
PMID:14595020   PMID:14749367   PMID:15058383   PMID:15304486   PMID:15339668   PMID:15850572   PMID:17125834   PMID:17430895   PMID:17442941   PMID:17882263   PMID:17965140   PMID:18243104  
PMID:18408153   PMID:18625840   PMID:18978355   PMID:19233265   PMID:19463978   PMID:19561615   PMID:19961855   PMID:21464233   PMID:21701818   PMID:21982707   PMID:22019888   PMID:22451653  
PMID:22688515   PMID:23044922   PMID:23853098   PMID:23980096   PMID:23994523   PMID:24039232   PMID:24043548   PMID:24301466   PMID:24415751   PMID:26644563   PMID:27122093   PMID:28478803  
PMID:30213522   PMID:31046517   PMID:32372426   PMID:32686149   PMID:37002575   PMID:37501148  


Genomics

Comparative Map Data
Nfatc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81876,321,386 - 76,430,997 (-)NCBIGRCr8
mRatBN7.21874,046,422 - 74,156,041 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1874,046,904 - 74,156,028 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1876,149,324 - 76,258,603 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01876,818,657 - 76,927,924 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01874,664,215 - 74,773,420 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01877,203,517 - 77,322,690 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1877,203,525 - 77,322,690 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01876,309,900 - 76,426,095 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41877,498,654 - 77,581,231 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1872,704,426 - 72,813,069 (-)NCBICelera
Cytogenetic Map18q12.3NCBI
NFATC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381879,395,930 - 79,529,323 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1879,395,856 - 79,529,325 (+)EnsemblGRCh38hg38GRCh38
GRCh371877,155,930 - 77,289,323 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361875,256,760 - 75,390,311 (+)NCBINCBI36Build 36hg18NCBI36
Build 341875,256,759 - 75,329,165NCBI
Celera1873,929,368 - 74,061,687 (+)NCBICelera
Cytogenetic Map18q23NCBI
HuRef1873,783,058 - 73,914,637 (+)NCBIHuRef
CHM1_11877,150,992 - 77,284,501 (+)NCBICHM1_1
T2T-CHM13v2.01879,649,928 - 79,782,943 (+)NCBIT2T-CHM13v2.0
Nfatc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391880,649,418 - 80,756,286 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1880,649,420 - 80,756,286 (-)EnsemblGRCm39 Ensembl
GRCm381880,606,205 - 80,713,071 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1880,606,205 - 80,713,071 (-)EnsemblGRCm38mm10GRCm38
MGSCv371880,802,944 - 80,909,810 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361880,768,264 - 80,875,117 (-)NCBIMGSCv36mm8
Celera1881,715,612 - 81,822,471 (-)NCBICelera
Cytogenetic Map18E3NCBI
cM Map1853.66NCBI
Nfatc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540262,558,286 - 62,674,457 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540262,558,392 - 62,674,347 (+)NCBIChiLan1.0ChiLan1.0
NFATC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21796,966,431 - 97,102,776 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11882,659,055 - 82,795,399 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01872,948,067 - 73,083,180 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11876,020,443 - 76,133,790 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1876,017,454 - 76,094,453 (+)Ensemblpanpan1.1panPan2
NFATC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.111,027,021 - 1,121,362 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl11,028,695 - 1,121,588 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha12,030,800 - 2,126,866 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01826,991 - 923,076 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1827,017 - 923,153 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11879,585 - 975,578 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01825,423 - 922,065 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01996,485 - 1,092,567 (-)NCBIUU_Cfam_GSD_1.0
Nfatc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494415,162,918 - 15,264,081 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936616484,045 - 587,891 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936616484,062 - 584,950 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NFATC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1145,911,046 - 146,008,139 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11145,940,099 - 146,002,897 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21161,528,147 - 161,632,555 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NFATC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.118690,313 - 815,804 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl18689,671 - 811,100 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606025,265,195 - 25,449,498 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nfatc1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624806905,174 - 1,022,800 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624806905,487 - 1,022,784 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:44
Count of miRNA genes:42
Interacting mature miRNAs:43
Transcripts:ENSRNOT00000058382
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182507112683910656Rat
12904069Cm123Cardiac mass QTL 1230.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)183337915878379158Rat
1331798Bp224Blood pressure QTL 2243.53873arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
12904070Cm124Cardiac mass QTL 1240.01heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)183337915878379158Rat
12904071Am18Aortic mass QTL 180.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)183337915878379158Rat
2303584Gluco55Glucose level QTL 552blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)185079521286134022Rat
1331730Scl27Serum cholesterol level QTL 273.826blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)185449080186134022Rat
61383Bp47Blood pressure QTL 4717.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)183152278376522783Rat
12904067Cm122Cardiac mass QTL 1220.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)183337915878379158Rat
61384Bp48Blood pressure QTL 4819.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)186289225779484461Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182349405785487725Rat
1331742Bp228Blood pressure QTL 2283.88752arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
2301417Bp319Blood pressure QTL 3190.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183337915878379158Rat
1298072Cia26Collagen induced arthritis QTL 263.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)186438376279484311Rat
12904073Kidm71Kidney mass QTL 710.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)183337915878379158Rat
631834Sach3Saccharin preference QTL 33.90.01consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)183857591983575919Rat
738008Hcar14Hepatocarcinoma resistance QTL 144.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion number (CMO:0001462)185782524385493247Rat
1331776Bp225Blood pressure QTL 2252.829arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)183161050577371277Rat
634333Pia19Pristane induced arthritis QTL 193.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)187627210481806852Rat
631518Bw11Body weight QTL 112.8body mass (VT:0001259)body weight (CMO:0000012)183612162681121626Rat
1641923Colcr8Colorectal carcinoma resistance QTL 83.10.0014intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)183199089176990891Rat
6893683Bw110Body weight QTL 1102.70.002body mass (VT:0001259)body weight (CMO:0000012)184562030686134022Rat
8694366Abfw8Abdominal fat weight QTL 86.380.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)184891573786134022Rat
7794793Mcs34Mammary carcinoma susceptibility QTL 341.54mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)186563556785897775Rat
631274Sprol1Serum protein level QTL 15.3blood total protein amount (VT:0005567)serum total protein level (CMO:0000661)183164450879484311Rat
9589041Epfw12Epididymal fat weight QTL 1217.080.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)184891573786134022Rat
8694432Bw165Body weight QTL 1653.810.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)184891573786134022Rat
1358193Emca2Estrogen-induced mammary cancer QTL 21.6mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)186584644786134022Rat
1598832Glom11Glomerulus QTL 112.9kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)185326667186134022Rat
1331774Bp226Blood pressure QTL 2264.41065arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
9589816Gluco68Glucose level QTL 687.250.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)183199089176990891Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181955353285493247Rat
8694378Bw157Body weight QTL 1573.590.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)183199089176990891Rat
1331770Bp234Blood pressure QTL 2343.807arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184562030686134022Rat
2303571Bw92Body weight QTL 923body mass (VT:0001259)body weight (CMO:0000012)185079521286134022Rat
2301969Bp324Blood pressure QTL 3244.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)186198220476619168Rat
631675Iddm15Insulin dependent diabetes mellitus QTL 15urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)186289225779484461Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181206648285493247Rat
2303120Mamtr8Mammary tumor resistance QTL 80.001mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)183161050585493247Rat
12880368Bw187Body weight QTL 1870.045body mass (VT:0001259)body weight (CMO:0000012)183337915878379158Rat
724542Kidm2Kidney mass QTL 22.6kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)186144685386134022Rat
61367Iddm4Insulin dependent diabetes mellitus QTL 42.330.0074blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)184046238385462383Rat
9590318Scort22Serum corticosterone level QTL 227.640.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)183199089176990891Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181206648285493247Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181564228086134022Rat

Markers in Region
D18Rat45  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81876,330,583 - 76,330,704 (+)Marker Load Pipeline
mRatBN7.21874,055,619 - 74,055,742 (+)MAPPERmRatBN7.2
Rnor_6.01877,212,212 - 77,212,332NCBIRnor6.0
Rnor_5.01876,318,595 - 76,318,715UniSTSRnor5.0
RGSC_v3.41877,510,828 - 77,511,190RGDRGSC3.4
RGSC_v3.41877,510,855 - 77,510,975UniSTSRGSC3.4
RGSC_v3.11877,584,128 - 77,584,248RGD
Celera1872,713,123 - 72,713,243UniSTS
RH 3.4 Map18794.7RGD
RH 3.4 Map18794.7UniSTS
RH 2.0 Map18106.0RGD
SHRSP x BN Map1847.8399RGD
FHH x ACI Map1858.5499RGD
Cytogenetic Map18q12.3UniSTS
RH131617  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21874,088,353 - 74,088,569 (+)MAPPERmRatBN7.2
Rnor_6.01877,245,143 - 77,245,358NCBIRnor6.0
Rnor_5.01876,351,526 - 76,351,741UniSTSRnor5.0
RGSC_v3.41877,543,588 - 77,543,803UniSTSRGSC3.4
Celera1872,746,026 - 72,746,241UniSTS
RH 3.4 Map18794.7UniSTS
Cytogenetic Map18q12.3UniSTS
RH135219  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21874,047,154 - 74,047,336 (+)MAPPERmRatBN7.2
Rnor_6.01877,203,748 - 77,203,929NCBIRnor6.0
Rnor_5.01876,310,131 - 76,310,312UniSTSRnor5.0
RGSC_v3.41877,502,389 - 77,502,570UniSTSRGSC3.4
Celera1872,704,657 - 72,704,838UniSTS
RH 3.4 Map18798.2UniSTS
Cytogenetic Map18q12.3UniSTS
RH138517  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21874,145,749 - 74,145,905 (+)MAPPERmRatBN7.2
Rnor_6.01877,312,412 - 77,312,567NCBIRnor6.0
Rnor_5.01876,415,817 - 76,415,972UniSTSRnor5.0
RGSC_v3.41877,583,577 - 77,583,732UniSTSRGSC3.4
Celera1872,802,791 - 72,802,946UniSTS
RH 3.4 Map18813.4UniSTS
Cytogenetic Map18q12.3UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000058382   ⟹   ENSRNOP00000055183
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1874,046,904 - 74,156,028 (-)Ensembl
Rnor_6.0 Ensembl1877,203,525 - 77,322,690 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000090369   ⟹   ENSRNOP00000070317
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1874,046,904 - 74,151,335 (-)Ensembl
Rnor_6.0 Ensembl1877,250,850 - 77,317,969 (-)Ensembl
RefSeq Acc Id: NM_001244933   ⟹   NP_001231862
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81876,321,386 - 76,430,990 (-)NCBI
mRatBN7.21874,046,422 - 74,156,030 (-)NCBI
Rnor_6.01877,203,517 - 77,322,690 (-)NCBI
Rnor_5.01876,309,900 - 76,426,095 (-)NCBI
Celera1872,704,426 - 72,813,069 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001415721   ⟹   NP_001402650
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81876,321,386 - 76,430,990 (-)NCBI
mRatBN7.21874,046,422 - 74,156,030 (-)NCBI
RefSeq Acc Id: XM_063277044   ⟹   XP_063133114
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81876,321,386 - 76,426,309 (-)NCBI
RefSeq Acc Id: XM_063277045   ⟹   XP_063133115
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81876,321,386 - 76,426,309 (-)NCBI
RefSeq Acc Id: XM_063277046   ⟹   XP_063133116
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81876,321,386 - 76,426,309 (-)NCBI
RefSeq Acc Id: XR_010059532
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81876,321,386 - 76,430,997 (-)NCBI
RefSeq Acc Id: XR_010059533
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81876,321,386 - 76,426,309 (-)NCBI
RefSeq Acc Id: XR_010059534
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81876,321,386 - 76,430,997 (-)NCBI
RefSeq Acc Id: NP_001231862   ⟸   NM_001244933
- Peptide Label: isoform 1
- Sequence:
Ensembl Acc Id: ENSRNOP00000070317   ⟸   ENSRNOT00000090369
Ensembl Acc Id: ENSRNOP00000055183   ⟸   ENSRNOT00000058382
RefSeq Acc Id: NP_001402650   ⟸   NM_001415721
- Peptide Label: isoform 2
- UniProtKB: D3ZE20 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063133116   ⟸   XM_063277046
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063133115   ⟸   XM_063277045
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063133114   ⟸   XM_063277044
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JXL2 (UniProtKB/TrEMBL)
Protein Domains
RHD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZE20-F1-model_v2 AlphaFold D3ZE20 1-827 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700899
Promoter ID:EPDNEW_R11413
Type:multiple initiation site
Name:Nfatc1_2
Description:nuclear factor of activated T-cells 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R11414  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01877,317,955 - 77,318,015EPDNEW
RGD ID:13700890
Promoter ID:EPDNEW_R11414
Type:multiple initiation site
Name:Nfatc1_1
Description:nuclear factor of activated T-cells 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R11413  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01877,322,692 - 77,322,752EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2319357 AgrOrtholog
BioCyc Gene G2FUF-6851 BioCyc
Ensembl Genes ENSRNOG00000017146 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000058382.5 UniProtKB/TrEMBL
  ENSRNOT00000090369.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
  2.60.40.340 UniProtKB/TrEMBL
InterPro Ig-like_fold UniProtKB/TrEMBL
  Ig_E-set UniProtKB/TrEMBL
  IPT UniProtKB/TrEMBL
  NFAT UniProtKB/TrEMBL
  p53-like_TF_DNA-bd UniProtKB/TrEMBL
  RHD_dimer UniProtKB/TrEMBL
  RHD_DNA_bind_dom UniProtKB/TrEMBL
  RHD_DNA_bind_dom_sf UniProtKB/TrEMBL
NCBI Gene 100361818 ENTREZGENE
PANTHER PTHR12533 UniProtKB/TrEMBL
  PTHR12533:SF5 UniProtKB/TrEMBL
Pfam RHD_dimer UniProtKB/TrEMBL
  RHD_DNA_bind UniProtKB/TrEMBL
PhenoGen Nfatc1 PhenoGen
PRINTS NUCFACTORATC UniProtKB/TrEMBL
PROSITE REL_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017146 RatGTEx
SMART IPT UniProtKB/TrEMBL
Superfamily-SCOP SSF49417 UniProtKB/TrEMBL
  SSF81296 UniProtKB/TrEMBL
UniProt A0A0G2JXL2 ENTREZGENE, UniProtKB/TrEMBL
  D3ZE20 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-29 Nfatc1  nuclear factor of activated T-cells 1  Nfatc1  nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-12-13 Nfatc1  nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1  LOC100361818  nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-05 LOC100361818  nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1      Symbol and Name status set to provisional 70820 PROVISIONAL