NFATC1 (nuclear factor of activated T cells 1) - Rat Genome Database

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Gene: NFATC1 (nuclear factor of activated T cells 1) Chlorocebus sabaeus
Analyze
Symbol: NFATC1
Name: nuclear factor of activated T cells 1
RGD ID: 18588211
Description: ENCODES a protein that exhibits chromatin binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); DNA-binding transcription factor binding (ortholog); INVOLVED IN aortic valve development (ortholog); aortic valve morphogenesis (ortholog); B-1a B cell differentiation (ortholog); ASSOCIATED WITH aortic valve stenosis (ortholog); Burn-McKeown syndrome (ortholog); chromosome 18q deletion syndrome (ortholog); FOUND IN chromatin (ortholog); cytoplasm (ortholog); nuclear body (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: nuclear factor of activated T-cells, cytoplasmic 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.118690,313 - 815,804 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl18689,671 - 811,100 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606025,265,195 - 25,449,498 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aortic valve development  (ISO)
aortic valve morphogenesis  (ISO)
B-1a B cell differentiation  (ISO)
branching involved in lymph vessel morphogenesis  (ISO)
calcineurin-NFAT signaling cascade  (IEA,ISO)
calcium ion transport  (ISO)
cellular response to calcium ion  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
cellular response to tumor necrosis factor  (ISO)
endocardial cushion development  (ISO)
epithelial to mesenchymal transition  (ISO)
G1/S transition of mitotic cell cycle  (ISO)
gene expression  (ISO)
heart development  (ISO)
heart trabecula morphogenesis  (ISO)
heart valve development  (ISO)
heart valve morphogenesis  (ISO)
intracellular signal transduction  (ISO)
keratinocyte proliferation  (ISO)
lymphangiogenesis  (ISO)
mononuclear cell differentiation  (ISO)
negative regulation of keratinocyte proliferation  (ISO)
negative regulation of osteoblast differentiation  (ISO)
negative regulation of stem cell proliferation  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of vascular associated smooth muscle cell differentiation  (ISO)
osteoclast differentiation  (ISO)
positive regulation of DNA biosynthetic process  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
pulmonary valve development  (ISO)
pulmonary valve morphogenesis  (ISO)
regulation of DNA-templated transcription  (IEA)
regulation of hair cycle  (ISO)
regulation of transcription by RNA polymerase II  (IEA)
response to muscle activity  (ISO)
semi-lunar valve development  (ISO)
skeletal muscle adaptation  (ISO)
stem cell proliferation  (ISO)
transcription by RNA polymerase II  (ISO)
transition between fast and slow fiber  (ISO)
ventricular septum morphogenesis  (ISO)
wound healing  (ISO)

Cellular Component

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
NFATC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.118690,313 - 815,804 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl18689,671 - 811,100 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606025,265,195 - 25,449,498 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
NFATC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381879,395,930 - 79,529,323 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1879,395,856 - 79,529,325 (+)EnsemblGRCh38hg38GRCh38
GRCh371877,155,930 - 77,289,323 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361875,256,760 - 75,390,311 (+)NCBINCBI36Build 36hg18NCBI36
Build 341875,256,759 - 75,329,165NCBI
Celera1873,929,368 - 74,061,687 (+)NCBICelera
Cytogenetic Map18q23NCBI
HuRef1873,783,058 - 73,914,637 (+)NCBIHuRef
CHM1_11877,150,992 - 77,284,501 (+)NCBICHM1_1
T2T-CHM13v2.01879,649,928 - 79,782,943 (+)NCBIT2T-CHM13v2.0
Nfatc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391880,649,418 - 80,756,286 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1880,649,420 - 80,756,286 (-)EnsemblGRCm39 Ensembl
GRCm381880,606,205 - 80,713,071 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1880,606,205 - 80,713,071 (-)EnsemblGRCm38mm10GRCm38
MGSCv371880,802,944 - 80,909,810 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361880,768,264 - 80,875,117 (-)NCBIMGSCv36mm8
Celera1881,715,612 - 81,822,471 (-)NCBICelera
Cytogenetic Map18E3NCBI
cM Map1853.66NCBI
Nfatc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81876,321,386 - 76,430,997 (-)NCBIGRCr8
mRatBN7.21874,046,422 - 74,156,041 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1874,046,904 - 74,156,028 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1876,149,324 - 76,258,603 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01876,818,657 - 76,927,924 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01874,664,215 - 74,773,420 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01877,203,517 - 77,322,690 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1877,203,525 - 77,322,690 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01876,309,900 - 76,426,095 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41877,498,654 - 77,581,231 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1872,704,426 - 72,813,069 (-)NCBICelera
Cytogenetic Map18q12.3NCBI
Nfatc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540262,558,286 - 62,674,457 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540262,558,392 - 62,674,347 (+)NCBIChiLan1.0ChiLan1.0
NFATC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21796,966,431 - 97,102,776 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11882,659,055 - 82,795,399 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01872,948,067 - 73,083,180 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11876,020,443 - 76,133,790 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1876,017,454 - 76,094,453 (+)Ensemblpanpan1.1panPan2
NFATC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.111,027,021 - 1,121,362 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl11,028,695 - 1,121,588 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha12,030,800 - 2,126,866 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01826,991 - 923,076 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1827,017 - 923,153 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11879,585 - 975,578 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01825,423 - 922,065 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01996,485 - 1,092,567 (-)NCBIUU_Cfam_GSD_1.0
Nfatc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494415,162,918 - 15,264,081 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936616484,045 - 587,891 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936616484,062 - 584,950 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NFATC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1145,911,046 - 146,008,139 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11145,940,099 - 146,002,897 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21161,528,147 - 161,632,555 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Nfatc1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624806905,174 - 1,022,800 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624806905,487 - 1,022,784 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 2 2
Low 34 20 58
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000016344   ⟹   ENSCSAP00000014262
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl18689,671 - 811,100 (-)Ensembl
RefSeq Acc Id: XM_008013721   ⟹   XP_008011912
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.118690,313 - 815,804 (-)NCBI
Vero_WHO_p1.0NW_02366606025,265,195 - 25,449,498 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008013722   ⟹   XP_008011913
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.118690,313 - 811,195 (-)NCBI
Vero_WHO_p1.0NW_02366606025,269,005 - 25,449,498 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008013723   ⟹   XP_008011914
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.118690,313 - 815,801 (-)NCBI
Vero_WHO_p1.0NW_02366606025,265,201 - 25,449,498 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008013724   ⟹   XP_008011915
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.118690,313 - 811,195 (-)NCBI
Vero_WHO_p1.0NW_02366606025,270,213 - 25,449,498 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_008011912 (Get FASTA)   NCBI Sequence Viewer  
  XP_008011913 (Get FASTA)   NCBI Sequence Viewer  
  XP_008011914 (Get FASTA)   NCBI Sequence Viewer  
  XP_008011915 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000014262.1
Reference Protein Sequences
RefSeq Acc Id: XP_008011912   ⟸   XM_008013721
- Peptide Label: isoform X1
- UniProtKB: A0A0D9S073 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_008011914   ⟸   XM_008013723
- Peptide Label: isoform X3
- UniProtKB: A0A0D9S073 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_008011915   ⟸   XM_008013724
- Peptide Label: isoform X4
- UniProtKB: A0A0D9S073 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_008011913   ⟸   XM_008013722
- Peptide Label: isoform X2
- UniProtKB: A0A0D9S073 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000014262   ⟸   ENSCSAT00000016344


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000018247 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000016344.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
  2.60.40.340 UniProtKB/TrEMBL
InterPro Ig-like_fold UniProtKB/TrEMBL
  Ig_E-set UniProtKB/TrEMBL
  IPT_dom UniProtKB/TrEMBL
  NFAT UniProtKB/TrEMBL
  p53-like_TF_DNA-bd UniProtKB/TrEMBL
  RHD_dimer UniProtKB/TrEMBL
  RHD_DNA_bind_dom UniProtKB/TrEMBL
  RHD_DNA_bind_dom_sf UniProtKB/TrEMBL
NCBI Gene NFATC1 ENTREZGENE
PANTHER PTHR12533 UniProtKB/TrEMBL
  PTHR12533:SF5 UniProtKB/TrEMBL
Pfam RHD_dimer UniProtKB/TrEMBL
  RHD_DNA_bind UniProtKB/TrEMBL
PRINTS NUCFACTORATC UniProtKB/TrEMBL
PROSITE REL_2 UniProtKB/TrEMBL
SMART IPT UniProtKB/TrEMBL
Superfamily-SCOP SSF49417 UniProtKB/TrEMBL
  SSF81296 UniProtKB/TrEMBL
UniProt A0A0D9S073 ENTREZGENE, UniProtKB/TrEMBL