Pia19 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL Registration

QTL: Pia19 (Pristane induced arthritis QTL 19) Rattus norvegicus

Symbol: Pia19
Name: Pristane induced arthritis QTL 19
RGD ID: 634333
Previously known as: Pia15
Trait: joint integrity trait   (VT:0010548)    
Measurement Type: joint inflammation composite score   (CMO:0000919)    
LOD Score: 3.4
P Value: Not Available
Variance: Not Available
Inheritance Type: dominant
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21873,997,140 - 79,532,029RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01877,151,301 - 83,366,399RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01876,260,634 - 82,427,750RGDRnor5.0
RGSC_v3.41877,452,390 - 82,920,522RGDRGSC3.4
RGSC_v3.11877,525,664 - 82,993,972RGD
Cross Type: backcross
Strains Crossed: DA/ZtmRhd E3/ZtmRhd 
JBrowse: View Region in Genome Browser (JBrowse)
Model



Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
Experimental Data Annotations     Click to see Annotation Detail View

Clinical Measurement

Experimental Condition
pristane  (IDA)

Measurement Method

Vertebrate Trait

Rat Strain
DA/ZtmRhd  (IEA)
E3/ZtmRhd  (IEA)

References

References - curated
# Reference Title Reference Citation
1. Quest for arthritis-causative genetic factors in the rat. Joe B Physiol Genomics. 2006 Oct 3;27(1):1-11. Epub 2006 Jun 27.
2. Identification and isolation of dominant susceptibility loci for pristane-induced arthritis. Olofsson P, etal., J Immunol 2003 Jul 1;171(1):407-16.
3. The complexity in hunting for candidate genes within QTL that determine susceptibility to arthritis in rats. Xiong Q, etal., Crit Rev Immunol. 2008;28(2):127-57.
4. Genetic and molecular basis of quantitative trait loci of arthritis in rat: genes and polymorphisms. Xiong Q, etal., J Immunol. 2008 Jul 15;181(2):859-64.

Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
2319357Nfatc1nuclear factor of activated T-cells 1187404642274156041Rat
1563006Atp9bATPase phospholipid transporting 9B (putative)187417686374368993Rat
1310232Sall3spalt-like transcription factor 3187440606674425974Rat
11405714LOC108348827uncharacterized LOC108348827187442548874431245Rat
7512865LOC102548287uncharacterized LOC102548287187469983274719059Rat
41304392LOC120098157uncharacterized LOC120098157187475585674793734Rat
41372303LOC120098186uncharacterized LOC120098186187483225574857223Rat
41191342LOC120098146uncharacterized LOC120098146187495396774989789Rat
11501613LOC108348828uncharacterized LOC108348828187499015374994427Rat
11478883LOC108348829uncharacterized LOC108348829187504967575061260Rat
7718722LOC102548467uncharacterized LOC102548467187504985175055909Rat
41117594LOC120098224uncharacterized LOC120098224187507611775099832Rat
7609985LOC102548626uncharacterized LOC102548626187537026075385371Rat
41304264LOC120098378small nucleolar RNA SNORA17187545097875451108Rat
7541364LOC102548779uncharacterized LOC102548779187546472575480485Rat
7696337LOC102548851uncharacterized LOC102548851187558276975603131Rat
7601026LOC102548977uncharacterized LOC102548977187561534375618490Rat
2656Galr1galanin receptor 1187577202175787577Rat
3054Mbpmyelin basic protein187585587875966404Rat
11459726LOC108348833uncharacterized LOC108348833187593745175959368Rat
1309670Zfp236zinc finger protein 236187597647876072428Rat
40996510LOC120098255uncharacterized LOC120098255187608586176090941Rat
1562171Rpl9-ps18ribosomal protein L9, pseudogene 18187610926976109838Rat
41056581Trnat-agu23transfer RNA threonine (anticodon AGU) 23187615341476153494Rat
9118324LOC103694251uncharacterized LOC103694251187616644376170609Rat
7523197LOC102552357uncharacterized LOC102552357187617120576198741Rat
11489686LOC108348835uncharacterized LOC108348835187624305476254356Rat
1306817Zfp516zinc finger protein 516187628645376386526Rat
40981657LOC120098250uncharacterized LOC120098250187672163776731166Rat
7738973LOC102552707uncharacterized LOC102552707187682367776880809Rat
41050242LOC120098191uncharacterized LOC120098191187686848276900985Rat
7581516LOC102552776uncharacterized LOC102552776187732341677325848Rat
41193841LOC120098286uncharacterized LOC120098286187733087877332081Rat
1311684Tshz1teashirt zinc finger homeobox 1187737639977452815Rat
1309999Ptgr3prostaglandin reductase 3187745443577463785Rat
1310645Zfp407zinc finger protein 407187757114077970282Rat
1359493Cndp1carnosine dipeptidase 1187798488678030837Rat
1305827Cndp2carnosine dipeptidase 2187803992478057030Rat
1559694Dipk1cdivergent protein kinase domain 1C187808797278109910Rat
1585281Pramel7-ps3preferentially expressed antigen in melanoma-like 7, pseudogene 3187814252578145717Rat
2323488C18h18orf63similar to human chromosome 18 open reading frame 63187815933478202317Rat
620558Cyb5acytochrome b5 type A187821306778245677Rat
1307279Timm21translocase of inner mitochondrial membrane 21187831490078319362Rat
1310628Fbxo15F-box protein 15187831957778634695Rat
40957615Pqbp1-ps1polyglutamine binding protein 1, pseudogene 1187834071978341543Rat

Markers in Region
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolExpected SizeChrStartStopSpeciesMatch
33814D18Mit9180187720969477209844Ratregion
34290D18Mgh4126187647781476477940Ratregion
33715D18Mit6147187953188679532029Ratregion
37586D18Rat74172187518195575182127Ratregion
35282D18Rat5162187399714073997283Ratregion
36642D18Rat4176187564109175641261Ratregion
36763D18Rat33175187475698574757160Ratregion
39904D18Rat78201187654164076541851Ratregion
40566D18Rat119141187740435177404482Ratregion
39098D18Rat45131187405561974055742Ratregion
41180D18Rat79139187569796975698109Ratregion
41022D18Rat81224187572232075722544Ratregion
45519D18Got70186187670964076709826Ratregion
45522D18Got67224187693902976939253Ratregion
45526D18Got66189187762917277629361Ratregion
45528D18Got69239187720968777209925Ratregion
629590D18Hmgc1142187652910676529238Ratregion
62466D18Uia6200187610418476104388Ratregion
1578815D18Chm68184187567983975680023Ratregion
1578824D18Chm67164187567591775676081Ratregion
1578833D18Chm71181187574617975746360Ratregion
1578876D18Chm83199187604731076047509Ratregion
1578894D18Chm69159187568332375683482Ratregion
1578925D18Chm82158187601786576018023Ratregion
1578943D18Chm70167187571105675711223Ratregion
1578958D18Chm78206187586933675869542Ratregion
1578989D18Chm77203187586678675866989Ratregion
1579002D18Chm72182187575642175756603Ratregion
1579030D18Chm66195187565368975653886Ratregion
1579038D18Chm80186187592730075927488Ratregion
1579045D18Chm79211187592256775922778Ratregion
1579063D18Chm65249187564717475647423Ratregion
1579082D18Chm76177187583308875833265Ratregion
1579085D18Chm74190187578159375781783Ratregion
1579087D18Chm81209187599611375996322Ratregion
1579106D18Chm73192187577839675778588Ratregion
1579178D18Chm75177187582995675830135Ratregion
1633007D18Got119165187613975876139923Ratregion
1636968D18M18Mit1158187712681077126968Ratregion
7206768ha31020187739784477399331Ratregion
5036727AU049012140187524037175240511Ratregion
5031430AU048350299187446585874466157Ratregion
5031776AU047181157187898189978982058Ratregion
5033597RH139406151187745597677456127Ratregion
5031197RH102961199187737640077376599Ratregion
5056431RH144374158187835335078353508Ratregion
5051919RH94734125187577309475773219Ratregion
5057940BF392934219187486216374862382Ratregion
5058788BE102437154187593972375939877Ratregion
5058196BF386790151187863405978634210Ratregion
5059740BE097717150187752682977526979Ratregion
5050190RH133913190187505515575055345Ratregion
5057746BI283655201187804025478040455Ratregion
5053777RH142845100187810972678109826Ratregion
5046202RH131617216187408835374088569Ratregion
5044300RH130523209187593926275939471Ratregion
5049682RH133621183187733175177331934Ratregion
5042486RH129463193187834069778340885Ratregion
5048604RH132999217187597666575976882Ratregion
5040456RH128293218187746095777461175Ratregion
5040520RH128330201187417753074177731Ratregion
5041318RH128788214187596614375966357Ratregion
5075318RH138525153187638448676384639Ratregion
5074454RH138026210187779020877790418Ratregion
5075304RH138517156187414574974145905Ratregion
5077398RH139733219187805632878056547Ratregion
5072968RH137158194187638626176386455Ratregion
5080542RH141640155187593717675937331Ratregion
5071674RH135219182187404715474047336Ratregion
5061700BF402482157187595194775952104Ratregion
5063332BF40410992187756782077567912Ratregion
5065076BF405689141187596304075963181Ratregion
5067054AU047992161187725299377253154Ratregion
5067218AU047890215187741154577411747Ratregion
5068538AU047085174187515663075156804Ratregion
5060592BE098524201187810495778105158Ratregion
5064244BE120868153187737659777376750Ratregion
5082137BF409889174187744373477443908Ratregion
5087078BE106956159187594450375944662Ratregion
5087205BM387980215187504976675049981Ratregion
5088547AU048635232187796916277969393Ratregion
5083976AA892769186187443504074435226Ratregion
5085294BQ195828152187512483575124987Ratregion
5082499BE119560192187863446578634657Ratregion
5085982AW529377168187440768174407849Ratregion
5082967BF390509190187460021574600405Ratregion
5504871ha27641130187925632479257454Ratregion
5506863G46819230187713730277137532Ratregion
5500167D18Mit216611187675908876759699Ratregion
Position Markers

Flank 1: (D18Rat5)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21873,997,140 - 73,997,283 (+)MAPPER
Rnor_6.01877,151,301 - 77,151,443NCBI
Rnor_5.01876,260,634 - 76,260,776UniSTS
RGSC_v3.41877,452,390 - 77,452,533RGD
RGSC_v3.41877,452,391 - 77,452,533UniSTS
RGSC_v3.11877,525,664 - 77,525,806RGD
Celera1872,654,840 - 72,654,982UniSTS
RH 3.4 Map18796.8UniSTS
RH 3.4 Map18796.8RGD
RH 2.0 Map18106.3RGD
SHRSP x BN Map1847.8599RGD
FHH x ACI Map1858.5499RGD
Peak: (D18Mit6)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21879,531,886 - 79,532,029 (+)MAPPER
Rnor_6.01883,366,257 - 83,366,399NCBI
Rnor_5.01882,427,608 - 82,427,750UniSTS
RGSC_v3.41882,920,379 - 82,920,522RGD
RGSC_v3.41882,920,380 - 82,920,522UniSTS
RGSC_v3.11882,993,830 - 82,993,972RGD
Celera1878,116,960 - 78,117,102UniSTS
RH 3.4 Map18768.3UniSTS
RH 3.4 Map18768.3RGD
SHRSP x BN Map1851.2799UniSTS
SHRSP x BN Map1851.2799RGD
Cytogenetic Map18q13UniSTS
Flank 2: (D18Mit6)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21879,531,886 - 79,532,029 (+)MAPPER
Rnor_6.01883,366,257 - 83,366,399NCBI
Rnor_5.01882,427,608 - 82,427,750UniSTS
RGSC_v3.41882,920,379 - 82,920,522RGD
RGSC_v3.41882,920,380 - 82,920,522UniSTS
RGSC_v3.11882,993,830 - 82,993,972RGD
Celera1878,116,960 - 78,117,102UniSTS
RH 3.4 Map18768.3UniSTS
RH 3.4 Map18768.3RGD
SHRSP x BN Map1851.2799UniSTS
SHRSP x BN Map1851.2799RGD
Cytogenetic Map18q13UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182479697779788953Rat
12904069Cm123Cardiac mass QTL 1230.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)185253976376104388Rat
12904070Cm124Cardiac mass QTL 1240.01heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)185253976376104388Rat
2303584Gluco55Glucose level QTL 552blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)184852004483828827Rat
12904071Am18Aortic mass QTL 180.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)185253976376104388Rat
12904067Cm122Cardiac mass QTL 1220.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)185253976376104388Rat
61384Bp48Blood pressure QTL 4819.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)186062231177209844Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182137289383213037Rat
2301417Bp319Blood pressure QTL 3190.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185253976376104388Rat
1298072Cia26Collagen induced arthritis QTL 263.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)185470976983828827Rat
12904073Kidm71Kidney mass QTL 710.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)185253976376104388Rat
6903353Bp353Blood pressure QTL 3532.8arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)185979647883828827Rat
738008Hcar14Hepatocarcinoma resistance QTL 144.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion number (CMO:0001462)185146473383218561Rat
634333Pia19Pristane induced arthritis QTL 193.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)187399714079532029Rat
6903356Bp354Blood pressure QTL 3544.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185979647883828827Rat
631518Bw11Body weight QTL 112.8body mass (VT:0001259)body weight (CMO:0000012)183587072380870723Rat
6893683Bw110Body weight QTL 1102.70.002body mass (VT:0001259)body weight (CMO:0000012)184334502283828827Rat
8694366Abfw8Abdominal fat weight QTL 86.380.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)184664067583828827Rat
70172Eae15Experimental allergic encephalomyelitis QTL 150.001nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)187647781477209844Rat
738005Anxrr11Anxiety related response QTL 113.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)183003981375039813Rat
631274Sprol1Serum protein level QTL 15.3blood total protein amount (VT:0005567)serum total protein level (CMO:0000661)183139332077209694Rat
9589041Epfw12Epididymal fat weight QTL 1217.080.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)184664067583828827Rat
8694432Bw165Body weight QTL 1653.810.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)184664067583828827Rat
70185BpQTLcluster15Blood pressure QTL cluster 154.61arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)185971241776477814Rat
9589816Gluco68Glucose level QTL 687.250.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)182979296574792965Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181927890183218561Rat
8694378Bw157Body weight QTL 1573.590.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)182979296574792965Rat
2303571Bw92Body weight QTL 923body mass (VT:0001259)body weight (CMO:0000012)184852004483828827Rat
1598826Anxrr20Anxiety related response QTL 203.04body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)184143297183828827Rat
2301969Bp324Blood pressure QTL 3244.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)185971241776477814Rat
631675Iddm15Insulin dependent diabetes mellitus QTL 15urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)186062231177209844Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181179151883218561Rat
2303120Mamtr8Mammary tumor resistance QTL 80.001mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)183135940883218561Rat
12880368Bw187Body weight QTL 1870.045body mass (VT:0001259)body weight (CMO:0000012)185253976376104388Rat
724542Kidm2Kidney mass QTL 22.6kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)185917211583828827Rat
61367Iddm4Insulin dependent diabetes mellitus QTL 42.330.0074blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)183819245583192455Rat
1359020Ppulsi2Prepulse inhibition QTL 22.71prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)185229287573997283Rat
9590318Scort22Serum corticosterone level QTL 227.640.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)182979296574792965Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181179151883218561Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182979296574792965Rat


Additional Information

Database Acc Id Source(s)
NCBI Gene Pia19

RGD Curation Notes
Note Type Note Reference
qtl_cross_type backcross  
qtl_gene 67 known and 37 novel genes were found in an analysis based on PubMed and OMIM data 2307198
qtl_gene whole genome analysis using PGMapper revealed Dcc as RA associated gene 2300074
qtl_general E3 allele associates with increased incidences of arthritis; also linked to ankle (paw) swelling 631850