RGD Reference Report - The complexity in hunting for candidate genes within QTL that determine susceptibility to arthritis in rats. - Rat Genome Database

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The complexity in hunting for candidate genes within QTL that determine susceptibility to arthritis in rats.

Authors: Xiong, Q  Zhu, J  Hasty, KA  Canale, ST  Stuart, J  Gu, W 
Citation: Xiong Q, etal., Crit Rev Immunol. 2008;28(2):127-57.
RGD ID: 2307198
Pubmed: PMID:18540828   (View Abstract at PubMed)

Quantitative trait loci (QTL) often span large genomic regions that contain from dozens to hundreds of genes. Over the last decade, a large number of QTL that regulate arthritis have been identified using rodent models of inflammatory arthritis. To examine the relationship between genes in those QTL and arthritis, we conducted a literature search using the key words arthritis and QTL in PubMed for publications up to January 2007 and obtained 60 QTL identified from experimental arthritis in rats. We then ascertained the identity of genes within those QTL regions based on data from the Ensembl database. We found a potential total of 17,012 genes within 60 arthritis QTL covering 1,607,804,390 base pairs of genomic sequences. The potential of every gene to be involved in arthritis was evaluated using all available reports from Online Mendelian Inheritance in Man (OMIM) and PubMed. On the basis of this analysis, 162 genes were identified as candidate genes of arthritis QTL. Importantly, associations between polymorphisms of some of these candidate genes and human arthritis have been reported in previous studies. These data suggest that the relationship between the candidate genes that we identified and arthritis QTL should be investigated in more detail. This comprehensive search should provide assistance in the identification of causative genes underlying arthritis QTL.

Objects referenced in this article
QTL Aia1 Adjuvant induced arthritis QTL 1 Rattus norvegicus
QTL Aia2 Adjuvant induced arthritis QTL 2 Rattus norvegicus
QTL Aia3 Adjuvant induced arthritis QTL 3 Rattus norvegicus
QTL Aia4 Adjuvant induced arthritis QTL 4 Rattus norvegicus
QTL Apr1 Acute phase response QTL 1 Rattus norvegicus
QTL Apr2 Acute phase response QTL 2 Rattus norvegicus
QTL Cia1 Collagen induced arthritis QTL 1 Rattus norvegicus
QTL Cia10 Collagen induced arthritis QTL 10 Rattus norvegicus
QTL Cia11 Collagen induced arthritis QTL 11 Rattus norvegicus
QTL Cia12 Collagen induced arthritis QTL 12 Rattus norvegicus
QTL Cia13 Collagen induced arthritis QTL 13 Rattus norvegicus
QTL Cia14 Collagen induced arthritis QTL 14 Rattus norvegicus
QTL Cia15 Collagen induced arthritis QTL 15 Rattus norvegicus
QTL Cia16 Collagen induced arthritis QTL 16 Rattus norvegicus
QTL Cia17 Collagen induced arthritis QTL 17 Rattus norvegicus
QTL Cia18 Collagen induced arthritis QTL 18 Rattus norvegicus
QTL Cia19 Collagen induced arthritis QTL 19 Rattus norvegicus
QTL Cia2 Collagen induced arthritis QTL 2 Rattus norvegicus
QTL Cia24 Collagen induced arthritis QTL 24 Rattus norvegicus
QTL Cia25 Collagen induced arthritis QTL 25 Rattus norvegicus
QTL Cia26 Collagen induced arthritis QTL 26 Rattus norvegicus
QTL Cia27 Collagen induced arthritis QTL 27 Rattus norvegicus
QTL Cia28 Collagen induced arthritis QTL 28 Rattus norvegicus
QTL Cia3 Collagen induced arthritis QTL 3 Rattus norvegicus
QTL Cia4 Collagen induced arthritis QTL 4 Rattus norvegicus
QTL Cia6 Collagen induced arthritis QTL 6 Rattus norvegicus
QTL Cia7 Collagen induced arthritis QTL 7 Rattus norvegicus
QTL Cia8 Collagen induced arthritis QTL 8 Rattus norvegicus
QTL Ciaa1 CIA Autoantibody QTL 1 Rattus norvegicus
QTL Ciaa2 CIA Autoantibody QTL 2 Rattus norvegicus
QTL Ciaa3 CIA Autoantibody QTL 3 Rattus norvegicus
QTL Ciaa4 CIA Autoantibody QTL 4 Rattus norvegicus
QTL Ciaa5 CIA Autoantibody QTL 5 Rattus norvegicus
QTL Oia3 Oil induced arthritis QTL 3 Rattus norvegicus
QTL Oia4 Oil induced arthritis QTL 4 Rattus norvegicus
QTL Oia5 Oil induced arthritis QTL 5 Rattus norvegicus
QTL Oia6 Oil induced arthritis QTL 6 Rattus norvegicus
QTL Oia7 Oil induced arthritis QTL 7 Rattus norvegicus
QTL Pia11 Pristane induced arthritis QTL 11 Rattus norvegicus
QTL Pia13 Pristane induced arthritis QTL 13 Rattus norvegicus
QTL Pia14 Pristane induced arthritis QTL 14 Rattus norvegicus
QTL Pia15 Pristane induced arthritis QTL 15 Rattus norvegicus
QTL Pia16 Pristane induced arthritis QTL 16 Rattus norvegicus
QTL Pia17 Pristane induced arthritis QTL 17 Rattus norvegicus
QTL Pia18 Pristane induced arthritis QTL 18 Rattus norvegicus
QTL Pia19 Pristane induced arthritis QTL 19 Rattus norvegicus
QTL Pia2 Pristane induced arthritis QTL 2 Rattus norvegicus
QTL Pia21 Pristane induced arthritis QTL 21 Rattus norvegicus
QTL Pia26 Pristane induced arthritis QTL 26 Rattus norvegicus
QTL Pia3 Pristane induced arthritis QTL 3 Rattus norvegicus
QTL Pia4 Pristane induced arthritis QTL 4 Rattus norvegicus
QTL Pia5 Pristane induced arthritis QTL 5 Rattus norvegicus
QTL Pia6 Pristane induced arthritis QTL 6 Rattus norvegicus
QTL Pia7 Pristane induced arthritis QTL 7 Rattus norvegicus
QTL Pia8 Pristane induced arthritis QTL 8 Rattus norvegicus
QTL Pia9 Pristane induced arthritis QTL 9 Rattus norvegicus
QTL Scwia1 Streptococcal cell wall induced arthritis QTL 1 Rattus norvegicus

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