Oia7 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL: Oia7 (Oil induced arthritis QTL 7) Rattus norvegicus

Symbol: Oia7
Name: Oil induced arthritis QTL 7
RGD ID: 731178
Also known as: Oia2
Trait: joint integrity trait   (VT:0010548)    
Measurement Type: joint inflammation composite score   (CMO:0000919)    
LOD Score: Not Available
P Value: 1.0E-4
Variance: Not Available
Inheritance Type: additive
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24156,050,654 - 157,232,313RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.04155,657,051 - 156,945,571RGD_MAPPER_PIPELINERnor6.0
Rnor_5.04222,677,930 - 223,964,695RGDRnor5.0
RGSC_v3.44159,298,584 - 160,528,447RGDRGSC3.4
RGSC_v3.14159,543,521 - 160,773,383RGD
Cross Type: backcross
Strains Crossed: DA.PVG-(D4Rat141-D4Mgh11) 
JBrowse: View Region in Genome Browser (JBrowse)
Model



Candidate Gene Status
Klrc1 is a candidate Gene for Oia7
Klrc2 is a candidate Gene for Oia7
Klrd1 is a candidate Gene for Oia7
C1s is a candidate Gene for Oia7
C3ar1 is a candidate Gene for Oia7
Clec4a3 is a candidate Gene for Oia7

Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
joint swelling  (IAGP)
Experimental Data Annotations     Click to see Annotation Detail View

Clinical Measurement

Experimental Condition
pristane  (IDA)

Measurement Method

Vertebrate Trait

Rat Strain

References


Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
735022Vom2r52vomeronasal 2 receptor, 524156918262156956543Rat
620537C3ar1complement C3a receptor 14156074747156084680Rat
1303339Clec4dC-type lectin domain family 4, member D4156589591156598969Rat
1306053Necap1NECAP endocytosis associated 14156103935156119068Rat
1359354Clec4b2C-type lectin domain family 4, member B24156462742156486240Rat
1359163Clec4a2C-type lectin domain family 4, member A24156262438156321695Rat
1307916RGD1307916LOC3624334157157264157241805Rat
1310382Cd163CD163 molecule4157085080157118470Rat
1359505Clec6a-ps1C-type lectin domain family 6, member A, pseudogene 14156539408156559032Rat
1359109Clec4a1C-type lectin domain family 4, member A14156173894156186009Rat
1359298Clec4eC-type lectin domain family 4, member E4156606927156612911Rat
1559669RGD1559669similar to Slbp protein4156563058156563967Rat
1359528Clec4a3C-type lectin domain family 4, member A34156214030156224818Rat
1359662Clec4aC-type lectin domain family 4, member A4156340439156434212Rat
1563551RGD1563551similar to ribosomal protein L314156096896156097888Rat
1561712Vom2r51vomeronasal 2 receptor, 514156834644156884468Rat
1566165Vom2r50vomeronasal 2 receptor, 504156801318156823561Rat
1561715RGD1561715similar to complement component 1, s subcomponent4157059237157061211Rat
1565101Foxj2forkhead box J24156047043156073540Rat
1589986Vom2r49vomeronasal 2 receptor, 494156733978156781086Rat
1585454Vom2r48vomeronasal 2 receptor, 484156661971156702951Rat
7546468LOC102550396LRRGT001884156121822156134151Rat
11516150LOC108350823eukaryotic translation initiation factor 4E pseudogene4156653571156657665Rat
41401725LOC120102735small nucleolar RNA SNORA174156772988156773105Rat
40989992LOC12010218160S ribosomal protein L7-like4156171212156172467Rat
41227954LOC120102684small nucleolar RNA SNORA174157084756157084883Rat
41066520LOC120102683small nucleolar RNA SNORA174156849122156849249Rat

Markers in Region
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolExpected SizeChrStartStopSpeciesMatch
37922D4Rat902014156653369156653578Ratregion
60422D4Got1361424157232171157232313Ratregion
60413D4Got1262644156050654156050920Ratregion
60415D4Got1281464156085418156085563Ratregion
1630250D4Got2941634156226387156226550Ratregion
1630250D4Got2941634156226387156226550Ratregion
5028464C862532184156606828156607046Ratregion
5059464BI2910131184156075544156075662Ratregion
5044320RH1305352134156224520156224733Ratregion
5048542RH1329632154156188901156189116Ratregion
5075210RH1384621294156077849156077978Ratregion
7240487D4Kiru901874156124880156125067Ratregion
7240489D4Kiru1512404156191879156192119Ratregion
7240491D4Kiru122054156207922156208127Ratregion
7240493D4Kiru961934156260547156260744Ratregion
7240495D4Kiru551644156684359156684523Ratregion
7240497D4Kiru592494156704822156705071Ratregion
7240499D4Kiru772474156879824156880073Ratregion
7240501D4Kiru802524156955988156956242Ratregion
5079820RH1412221914156118668156118859Ratregion
5080140RH1414072164157059101157059317Ratregion
5078326RH1402761554157117692157117847Ratregion
5071188RH1349381814156073235156073416Ratregion
5066202AA9980171444156113085156113229Ratregion
5087670D4Won522184156684151156684369Ratregion
5504324D16S2601E1324156135401156135533Ratregion
Position Markers

Flank 1: (D4Got126)
Rat AssemblyChrPosition (strand)Source
mRatBN7.24156,050,654 - 156,050,920 (+)MAPPER
Rnor_6.04155,657,051 - 155,657,314NCBI
Rnor_5.04222,677,930 - 222,678,193UniSTS
RGSC_v3.44159,298,584 - 159,298,848RGD
RGSC_v3.44159,298,585 - 159,298,848UniSTS
RGSC_v3.14159,543,521 - 159,543,784RGD
Celera4144,871,081 - 144,871,344UniSTS
RH 3.4 Map4997.3RGD
RH 3.4 Map4997.3UniSTS
Cytogenetic Map4q42UniSTS
Flank 2: (D4Got136)
Rat AssemblyChrPosition (strand)Source
mRatBN7.24157,232,171 - 157,232,313 (+)MAPPER
Rnor_6.04156,945,430 - 156,945,571NCBI
Rnor_5.04223,964,554 - 223,964,695UniSTS
RGSC_v3.44160,528,306 - 160,528,447UniSTS
RGSC_v3.44160,528,306 - 160,528,447RGD
RGSC_v3.14160,773,242 - 160,773,383RGD
Celera4145,973,618 - 145,973,765UniSTS
RH 3.4 Map41003.8UniSTS
RH 3.4 Map41003.8RGD
Cytogenetic Map4q42UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61446Coreg2Compensatory renal growth QTL 23.5kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)4148423102157580971Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4126395976167139601Rat
724535Cm18Cardiac mass QTL 182.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)4118856416163856416Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
631683Bp116Blood pressure QTL 1160.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4124303370169303370Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4119428175157578333Rat
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4148090542168069246Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
731178Oia7Oil induced arthritis QTL 70.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4156050654157232313Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
1581574Eae20Experimental allergic encephalomyelitis QTL 207.8nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)4153031106158841762Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4146565735175236377Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4123143783168143783Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)cortical volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4132396220177396220Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4132642577167139601Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4124778595169778595Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4125590636170590636Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4155561574182687754Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4114627026159627026Rat
12798525Anxrr57Anxiety related response QTL 573.210.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4147278504167139601Rat


Additional Information

Database Acc Id Source(s)
NCBI Gene Oia7

RGD Curation Notes
Note Type Note Reference
qtl_cross_type backcross  
qtl_gene 823 known and 278 novel genes were found in an analysis based on PubMed and OMIM data 2307198
qtl_general congenic DA rats that carried the PVG allele for Clec4a3 gene were resistant to Oia 1642519
qtl_general DA allele assoicated with increased arthritis incidence, severity and day of onset, in both males and females 730281
qtl_map located within 0.8 cM on the cytogenetic band 4q42 730281