RGD Reference Report - Genetic and molecular basis of quantitative trait loci of arthritis in rat: genes and polymorphisms. - Rat Genome Database

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Genetic and molecular basis of quantitative trait loci of arthritis in rat: genes and polymorphisms.

Authors: Xiong, Q  Jiao, Y  Hasty, KA  Stuart, JM  Postlethwaite, A  Kang, AH  Gu, W 
Citation: Xiong Q, etal., J Immunol. 2008 Jul 15;181(2):859-64.
RGD ID: 2300074
Pubmed: (View Article at PubMed) PMID:18606636

Rheumatoid arthritis (RA) is an autoimmune disease, the pathogenesis of which is affected by multiple genetic and environmental factors. To understand the genetic and molecular basis of RA, a large number of quantitative trait loci (QTL) that regulate experimental autoimmune arthritis have been identified using various rat models for RA. However, identifying the particular responsible genes within these QTL remains a major challenge. Using currently available genome data and gene annotation information, we systematically examined RA-associated genes and polymorphisms within and outside QTL over the whole rat genome. By the whole genome analysis of genes and polymorphisms, we found that there are significantly more RA-associated genes in QTL regions as contrasted with non-QTL regions. Further experimental studies are necessary to determine whether these known RA-associated genes or polymorphisms are genetic components causing the QTL effect.

Annotation

Objects referenced in this article
QTL Aia1 Adjuvant induced arthritis QTL 1 Rattus norvegicus
QTL Aia2 Adjuvant induced arthritis QTL 2 Rattus norvegicus
QTL Aia3 Adjuvant induced arthritis QTL 3 Rattus norvegicus
QTL Aia4 Adjuvant induced arthritis QTL 4 Rattus norvegicus
QTL Apr1 Acute phase response QTL 1 Rattus norvegicus
QTL Apr2 Acute phase response QTL 2 Rattus norvegicus
QTL Cia1 Collagen induced arthritis QTL 1 Rattus norvegicus
QTL Cia10 Collagen induced arthritis QTL 10 Rattus norvegicus
QTL Cia11 Collagen induced arthritis QTL 11 Rattus norvegicus
QTL Cia12 Collagen induced arthritis QTL 12 Rattus norvegicus
QTL Cia13 Collagen induced arthritis QTL 13 Rattus norvegicus
QTL Cia14 Collagen induced arthritis QTL 14 Rattus norvegicus
QTL Cia15 Collagen induced arthritis QTL 15 Rattus norvegicus
QTL Cia16 Collagen induced arthritis QTL 16 Rattus norvegicus
QTL Cia17 Collagen induced arthritis QTL 17 Rattus norvegicus
QTL Cia18 Collagen induced arthritis QTL 18 Rattus norvegicus
QTL Cia19 Collagen induced arthritis QTL 19 Rattus norvegicus
QTL Cia2 Collagen induced arthritis QTL 2 Rattus norvegicus
QTL Cia24 Collagen induced arthritis QTL 24 Rattus norvegicus
QTL Cia25 Collagen induced arthritis QTL 25 Rattus norvegicus
QTL Cia26 Collagen induced arthritis QTL 26 Rattus norvegicus
QTL Cia3 Collagen induced arthritis QTL 3 Rattus norvegicus
QTL Cia4 Collagen induced arthritis QTL 4 Rattus norvegicus
QTL Cia5 Collagen induced arthritis QTL 5 Rattus norvegicus
QTL Cia6 Collagen induced arthritis QTL 6 Rattus norvegicus
QTL Cia7 Collagen induced arthritis QTL 7 Rattus norvegicus
QTL Ciaa1 CIA Autoantibody QTL 1 Rattus norvegicus
QTL Ciaa2 CIA Autoantibody QTL 2 Rattus norvegicus
QTL Ciaa3 CIA Autoantibody QTL 3 Rattus norvegicus
QTL Ciaa4 CIA Autoantibody QTL 4 Rattus norvegicus
QTL Ciaa5 CIA Autoantibody QTL 5 Rattus norvegicus
QTL Oia2 Oil induced arthritis QTL 2 Rattus norvegicus
QTL Oia3 Oil induced arthritis QTL 3 Rattus norvegicus
QTL Pia1 Pristane induced arthritis QTL 1 Rattus norvegicus
QTL Pia11 Pristane induced arthritis QTL 11 Rattus norvegicus
QTL Pia12 Pristane induced arthritis QTL 12 Rattus norvegicus
QTL Pia13 Pristane induced arthritis QTL 13 Rattus norvegicus
QTL Pia14 Pristane induced arthritis QTL 14 Rattus norvegicus
QTL Pia15 Pristane induced arthritis QTL 15 Rattus norvegicus
QTL Pia16 Pristane induced arthritis QTL 16 Rattus norvegicus
QTL Pia17 Pristane induced arthritis QTL 17 Rattus norvegicus
QTL Pia18 Pristane induced arthritis QTL 18 Rattus norvegicus
QTL Pia19 Pristane induced arthritis QTL 19 Rattus norvegicus
QTL Pia2 Pristane induced arthritis QTL 2 Rattus norvegicus
QTL Pia21 Pristane induced arthritis QTL 21 Rattus norvegicus
QTL Pia22 Pristane induced arthritis QTL 22 Rattus norvegicus
QTL Pia23 Pristane induced arthritis QTL 23 Rattus norvegicus
QTL Pia3 Pristane induced arthritis QTL 3 Rattus norvegicus
QTL Pia4 Pristane induced arthritis QTL 4 Rattus norvegicus
QTL Pia5 Pristane induced arthritis QTL 5 Rattus norvegicus
QTL Pia6 Pristane induced arthritis QTL 6 Rattus norvegicus
QTL Pia7 Pristane induced arthritis QTL 7 Rattus norvegicus
QTL Pia8 Pristane induced arthritis QTL 8 Rattus norvegicus

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