Cndp1 (carnosine dipeptidase 1) - Rat Genome Database

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Gene: Cndp1 (carnosine dipeptidase 1) Rattus norvegicus
Analyze
Symbol: Cndp1
Name: carnosine dipeptidase 1
RGD ID: 1359493
Description: Predicted to enable dipeptidase activity. Predicted to be involved in proteolysis. Predicted to act upstream of or within regulation of protein metabolic process. Predicted to be located in extracellular region. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in glomerulonephritis. Orthologous to human CNDP1 (carnosine dipeptidase 1); PARTICIPATES IN beta-alanine metabolic pathway; carnosinemia pathway; GABA aminotransferase deficiency pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: beta-Ala-His dipeptidase; carnosine dipeptidase 1 (metallopeptidase M20 family); CNDP dipeptidase 1; MGC93742; similar to carnosinase 1
RGD Orthologs
Human
Mouse
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21877,984,886 - 78,030,837 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1877,984,907 - 78,007,765 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1880,086,454 - 80,110,173 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01880,758,521 - 80,782,238 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01878,594,182 - 78,617,904 (-)NCBIRnor_WKY
Rnor_6.01881,466,717 - 81,512,841 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1881,466,716 - 81,499,051 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01880,511,683 - 80,543,876 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41881,160,681 - 81,183,558 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11881,234,131 - 81,257,008 (-)NCBI
Celera1876,601,918 - 76,624,795 (-)NCBICelera
Cytogenetic Map18q12.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IBA,ISO)
extracellular region  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Association of variants in the carnosine peptidase 1 gene (CNDP1) with diabetic nephropathy in American Indians. Chakkera HA, etal., Mol Genet Metab. 2011 Jun;103(2):185-90. doi: 10.1016/j.ymgme.2011.02.010. Epub 2011 Feb 19.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Is carnosinase 1 gene (CNDP1) polymorphism associated with chronic kidney disease progression in children and young adults? results of a family-based study. Kilis-Pstrusinska K, etal., Arch Med Res. 2010 Jul;41(5):356-62. doi: 10.1016/j.arcmed.2010.07.006.
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
9. Sequence identification and characterization of human carnosinase and a closely related non-specific dipeptidase. Teufel M, etal., J Biol Chem 2003 Feb 21;278(8):6521-31. Epub 2002 Dec 6.
Additional References at PubMed
PMID:15489334   PMID:24891507  


Genomics

Comparative Map Data
Cndp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21877,984,886 - 78,030,837 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1877,984,907 - 78,007,765 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1880,086,454 - 80,110,173 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01880,758,521 - 80,782,238 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01878,594,182 - 78,617,904 (-)NCBIRnor_WKY
Rnor_6.01881,466,717 - 81,512,841 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1881,466,716 - 81,499,051 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01880,511,683 - 80,543,876 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41881,160,681 - 81,183,558 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11881,234,131 - 81,257,008 (-)NCBI
Celera1876,601,918 - 76,624,795 (-)NCBICelera
Cytogenetic Map18q12.3NCBI
CNDP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381874,534,500 - 74,587,212 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1874,534,500 - 74,587,212 (+)EnsemblGRCh38hg38GRCh38
GRCh371872,201,735 - 72,254,448 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361870,352,672 - 70,403,241 (+)NCBINCBI36Build 36hg18NCBI36
Build 341870,352,841 - 70,403,239NCBI
Celera1869,068,799 - 69,119,423 (+)NCBICelera
Cytogenetic Map18q22.3NCBI
HuRef1868,933,787 - 68,984,414 (+)NCBIHuRef
CHM1_11872,197,014 - 72,247,620 (+)NCBICHM1_1
T2T-CHM13v2.01874,761,868 - 74,814,586 (+)NCBIT2T-CHM13v2.0
Cndp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391884,628,509 - 84,668,359 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1884,628,634 - 84,668,220 (-)EnsemblGRCm39 Ensembl
GRCm381884,610,384 - 84,650,234 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1884,610,509 - 84,650,095 (-)EnsemblGRCm38mm10GRCm38
MGSCv371884,779,901 - 84,819,487 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361884,744,708 - 84,784,277 (-)NCBIMGSCv36mm8
Celera1885,677,210 - 85,716,349 (-)NCBICelera
Cytogenetic Map18E4NCBI
Cndp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540257,970,161 - 58,019,479 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540257,970,205 - 58,019,980 (+)NCBIChiLan1.0ChiLan1.0
CNDP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.114,875,790 - 4,912,148 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl14,876,794 - 4,911,976 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha15,883,238 - 5,919,596 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.014,686,276 - 4,722,647 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl14,686,288 - 4,722,599 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.114,725,208 - 4,761,560 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.014,678,690 - 4,715,036 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.014,849,563 - 4,885,988 (-)NCBIUU_Cfam_GSD_1.0
Cndp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494418,634,365 - 18,662,891 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049366163,955,847 - 3,984,021 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CNDP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1149,521,510 - 149,562,623 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11149,523,983 - 149,564,728 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21165,549,109 - 165,588,550 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CNDP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1185,317,101 - 5,364,323 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl185,317,542 - 5,364,277 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606020,519,189 - 20,567,010 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cndp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248066,113,227 - 6,169,745 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248066,113,052 - 6,169,943 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cndp1
254 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:406
Count of miRNA genes:215
Interacting mature miRNAs:243
Transcripts:ENSRNOT00000034970
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181179151883218561Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181179151883218561Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181927890183218561Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182137289383213037Rat
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182479697779788953Rat
2303120Mamtr8Mammary tumor resistance QTL 80.001mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)183135940883218561Rat
631518Bw11Body weight QTL 112.8body mass (VT:0001259)body weight (CMO:0000012)183587072380870723Rat
61367Iddm4Insulin dependent diabetes mellitus QTL 42.330.0074blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)183819245583192455Rat
1598826Anxrr20Anxiety related response QTL 203.04body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)184143297183828827Rat
6893683Bw110Body weight QTL 1102.70.002body mass (VT:0001259)body weight (CMO:0000012)184334502283828827Rat
8694366Abfw8Abdominal fat weight QTL 86.380.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)184664067583828827Rat
8694432Bw165Body weight QTL 1653.810.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)184664067583828827Rat
9589041Epfw12Epididymal fat weight QTL 1217.080.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)184664067583828827Rat
2303571Bw92Body weight QTL 923body mass (VT:0001259)body weight (CMO:0000012)184852004483828827Rat
2303584Gluco55Glucose level QTL 552blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)184852004483828827Rat
738008Hcar14Hepatocarcinoma resistance QTL 144.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion number (CMO:0001462)185146473383218561Rat
1298072Cia26Collagen induced arthritis QTL 263.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)185470976983828827Rat
724542Kidm2Kidney mass QTL 22.6kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)185917211583828827Rat
6903353Bp353Blood pressure QTL 3532.8arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)185979647883828827Rat
6903356Bp354Blood pressure QTL 3544.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185979647883828827Rat
634333Pia19Pristane induced arthritis QTL 193.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)187399714079532029Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 27 11 8
Low 2 33 57 41 11 41 8 11 74 8 26 3 8
Below cutoff 10 8 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000034970   ⟹   ENSRNOP00000034652
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1877,984,907 - 78,007,765 (-)Ensembl
Rnor_6.0 Ensembl1881,466,716 - 81,499,051 (-)Ensembl
RefSeq Acc Id: NM_001007687   ⟹   NP_001007688
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21877,984,886 - 78,007,765 (-)NCBI
Rnor_6.01881,466,717 - 81,489,769 (-)NCBI
Rnor_5.01880,511,683 - 80,543,876 (-)NCBI
RGSC_v3.41881,160,681 - 81,183,558 (-)RGD
Celera1876,601,918 - 76,624,795 (-)RGD
Sequence:
RefSeq Acc Id: XM_006255009   ⟹   XP_006255071
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21877,984,886 - 78,018,478 (-)NCBI
Rnor_6.01881,466,717 - 81,500,484 (-)NCBI
Rnor_5.01880,511,683 - 80,543,876 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008772135   ⟹   XP_008770357
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21877,984,886 - 78,030,837 (-)NCBI
Rnor_6.01881,466,717 - 81,512,841 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039096770   ⟹   XP_038952698
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21877,984,886 - 78,030,837 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_001007688   ⟸   NM_001007687
- UniProtKB: Q66HG3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006255071   ⟸   XM_006255009
- Peptide Label: isoform X1
- UniProtKB: Q66HG3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008770357   ⟸   XM_008772135
- Peptide Label: isoform X1
- UniProtKB: Q66HG3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000034652   ⟸   ENSRNOT00000034970
RefSeq Acc Id: XP_038952698   ⟸   XM_039096770
- Peptide Label: isoform X2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q66HG3-F1-model_v2 AlphaFold Q66HG3 1-492 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359493 AgrOrtholog
BioCyc Gene G2FUF-6750 BioCyc
Ensembl Genes ENSRNOG00000027739 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000034652 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000034970 ENTREZGENE, UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7107931 IMAGE-MGC_LOAD
InterPro ArgE/DapE_CS UniProtKB/Swiss-Prot
  CNDP/DUG1 UniProtKB/Swiss-Prot
  Peptidase_M20 UniProtKB/Swiss-Prot
  Peptidase_M20_dimer UniProtKB/Swiss-Prot
KEGG Report rno:307212 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93742 IMAGE-MGC_LOAD
NCBI Gene 307212 ENTREZGENE
Pfam M20_dimer UniProtKB/Swiss-Prot
  Peptidase_M20 UniProtKB/Swiss-Prot
PhenoGen Cndp1 PhenoGen
PIRSF CNDP_dipeptidase UniProtKB/Swiss-Prot
PROSITE ARGE_DAPE_CPG2_2 UniProtKB/Swiss-Prot
UniProt CNDP1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-01 Cndp1  carnosine dipeptidase 1  Cndp1  carnosine dipeptidase 1 (metallopeptidase M20 family)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Cndp1  carnosine dipeptidase 1 (metallopeptidase M20 family)  MGC93742  similar to carnosinase 1  Symbol and Name updated 1299863 APPROVED
2005-07-29 MGC93742  similar to carnosinase 1      Symbol and Name status set to provisional 70820 PROVISIONAL