Timm21 (translocase of inner mitochondrial membrane 21) - Rat Genome Database

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Gene: Timm21 (translocase of inner mitochondrial membrane 21) Rattus norvegicus
Analyze
Symbol: Timm21
Name: translocase of inner mitochondrial membrane 21
RGD ID: 1307279
Description: Predicted to be involved in mitochondrial cytochrome c oxidase assembly; mitochondrial respiratory chain complex I assembly; and protein import into mitochondrial matrix. Predicted to be part of TIM23 mitochondrial import inner membrane translocase complex. Orthologous to human TIMM21 (translocase of inner mitochondrial membrane 21); PARTICIPATES IN presequence pathway of mitochondrial protein import; INTERACTS WITH 17alpha-ethynylestradiol; 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC307210; MGC94128; mitochondrial import inner membrane translocase subunit Tim21; RGD1307279; similar to RIKEN cDNA 2700002I20; TIM21-like protein, mitochondrial; translocase of inner mitochondrial membrane 21 homolog; translocase of inner mitochondrial membrane 21 homolog (yeast)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81880,589,775 - 80,594,237 (-)NCBIGRCr8
mRatBN7.21878,314,900 - 78,319,362 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1878,314,909 - 78,319,454 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1880,425,523 - 80,429,995 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01881,097,587 - 81,102,059 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01878,933,271 - 78,937,743 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01881,803,165 - 81,807,627 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1881,803,173 - 81,807,627 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01880,841,873 - 80,846,335 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41881,524,258 - 81,528,720 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11881,597,712 - 81,602,170 (-)NCBI
Celera1876,929,506 - 76,933,968 (-)NCBICelera
Cytogenetic Map18q12.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Comprehensive gene review and curation RGD comprehensive gene curation
5. Unlocking the presequence import pathway. Schulz C, etal., Trends Cell Biol. 2015 May;25(5):265-75. doi: 10.1016/j.tcb.2014.12.001. Epub 2014 Dec 23.
6. Cooperation of protein machineries in mitochondrial protein sorting. Wenz LS, etal., Biochim Biophys Acta. 2015 May;1853(5):1119-29. doi: 10.1016/j.bbamcr.2015.01.012. Epub 2015 Jan 26.
Additional References at PubMed
PMID:12477932   PMID:15489334   PMID:18614015   PMID:23260140  


Genomics

Comparative Map Data
Timm21
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81880,589,775 - 80,594,237 (-)NCBIGRCr8
mRatBN7.21878,314,900 - 78,319,362 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1878,314,909 - 78,319,454 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1880,425,523 - 80,429,995 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01881,097,587 - 81,102,059 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01878,933,271 - 78,937,743 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01881,803,165 - 81,807,627 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1881,803,173 - 81,807,627 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01880,841,873 - 80,846,335 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41881,524,258 - 81,528,720 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11881,597,712 - 81,602,170 (-)NCBI
Celera1876,929,506 - 76,933,968 (-)NCBICelera
Cytogenetic Map18q12.3NCBI
TIMM21
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381874,148,523 - 74,160,531 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1874,148,523 - 74,160,531 (+)EnsemblGRCh38hg38GRCh38
GRCh371871,815,758 - 71,827,766 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361869,966,726 - 69,977,184 (+)NCBINCBI36Build 36hg18NCBI36
Build 341869,966,824 - 69,977,067NCBI
Celera1868,680,277 - 68,690,735 (+)NCBICelera
Cytogenetic Map18q22.3NCBI
HuRef1868,548,250 - 68,558,708 (+)NCBIHuRef
CHM1_11871,810,946 - 71,821,404 (+)NCBICHM1_1
T2T-CHM13v2.01874,369,489 - 74,381,497 (+)NCBIT2T-CHM13v2.0
Timm21
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391884,964,316 - 84,970,168 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1884,964,316 - 84,969,649 (-)EnsemblGRCm39 Ensembl
GRCm381884,946,191 - 84,951,530 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1884,946,191 - 84,951,524 (-)EnsemblGRCm38mm10GRCm38
MGSCv371885,116,686 - 85,120,916 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361885,081,487 - 85,085,717 (-)NCBIMGSCv36mm8
Celera1886,012,402 - 86,016,632 (-)NCBICelera
Cytogenetic Map18E4NCBI
cM Map1857.53NCBI
Timm21
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540257,586,998 - 57,599,869 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540257,586,651 - 57,598,817 (+)NCBIChiLan1.0ChiLan1.0
TIMM21
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21791,677,594 - 91,688,618 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11877,370,217 - 77,381,166 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01867,530,610 - 67,540,966 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11870,815,069 - 70,825,425 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1870,815,069 - 70,825,436 (+)Ensemblpanpan1.1panPan2
TIMM21
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.115,175,702 - 5,182,096 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl15,175,714 - 5,181,883 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha16,182,962 - 6,189,339 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.014,986,113 - 4,992,490 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl14,986,115 - 4,992,294 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.115,024,903 - 5,031,280 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.014,978,599 - 4,984,976 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.015,149,814 - 5,156,191 (-)NCBIUU_Cfam_GSD_1.0
Timm21
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494418,942,780 - 18,950,805 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366164,263,464 - 4,272,039 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366164,263,912 - 4,271,927 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TIMM21
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1149,845,199 - 149,855,908 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11149,845,189 - 149,855,903 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21166,037,961 - 166,048,650 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TIMM21
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1185,735,562 - 5,745,258 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl185,734,091 - 5,745,267 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606020,137,690 - 20,147,393 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Timm21
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248066,510,998 - 6,520,496 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248066,509,711 - 6,520,687 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Timm21
25 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:40
Count of miRNA genes:36
Interacting mature miRNAs:37
Transcripts:ENSRNOT00000020376
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181179151883218561Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181179151883218561Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181927890183218561Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182137289383213037Rat
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182479697779788953Rat
2303120Mamtr8Mammary tumor resistance QTL 80.001mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)183135940883218561Rat
631518Bw11Body weight QTL 112.8body mass (VT:0001259)body weight (CMO:0000012)183587072380870723Rat
61367Iddm4Insulin dependent diabetes mellitus QTL 42.330.0074blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)183819245583192455Rat
1598826Anxrr20Anxiety related response QTL 203.04body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)184143297183828827Rat
6893683Bw110Body weight QTL 1102.70.002body mass (VT:0001259)body weight (CMO:0000012)184334502283828827Rat
8694366Abfw8Abdominal fat weight QTL 86.380.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)184664067583828827Rat
8694432Bw165Body weight QTL 1653.810.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)184664067583828827Rat
9589041Epfw12Epididymal fat weight QTL 1217.080.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)184664067583828827Rat
2303571Bw92Body weight QTL 923body mass (VT:0001259)body weight (CMO:0000012)184852004483828827Rat
2303584Gluco55Glucose level QTL 552blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)184852004483828827Rat
738008Hcar14Hepatocarcinoma resistance QTL 144.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion number (CMO:0001462)185146473383218561Rat
1298072Cia26Collagen induced arthritis QTL 263.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)185470976983828827Rat
724542Kidm2Kidney mass QTL 22.6kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)185917211583828827Rat
6903353Bp353Blood pressure QTL 3532.8arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)185979647883828827Rat
6903356Bp354Blood pressure QTL 3544.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185979647883828827Rat
634333Pia19Pristane induced arthritis QTL 193.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)187399714079532029Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 54 38 18 38 8 11 74 35 37 11 8
Low 3 3 1 3 4
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000020376   ⟹   ENSRNOP00000020376
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1878,314,917 - 78,319,454 (-)Ensembl
Rnor_6.0 Ensembl1881,803,173 - 81,807,627 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000120215   ⟹   ENSRNOP00000088057
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1878,314,909 - 78,319,382 (-)Ensembl
RefSeq Acc Id: NM_001008343   ⟹   NP_001008344
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81880,589,775 - 80,594,237 (-)NCBI
mRatBN7.21878,314,900 - 78,319,362 (-)NCBI
Rnor_6.01881,803,165 - 81,807,627 (-)NCBI
Rnor_5.01880,841,873 - 80,846,335 (-)NCBI
RGSC_v3.41881,524,258 - 81,528,720 (-)RGD
Celera1876,929,506 - 76,933,968 (-)RGD
Sequence:
RefSeq Acc Id: XM_063277289   ⟹   XP_063133359
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81880,589,775 - 80,594,024 (-)NCBI
RefSeq Acc Id: NP_001008344   ⟸   NM_001008343
- Peptide Label: precursor
- UniProtKB: Q5U2X7 (UniProtKB/Swiss-Prot),   A6K5M3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000020376   ⟸   ENSRNOT00000020376
RefSeq Acc Id: ENSRNOP00000088057   ⟸   ENSRNOT00000120215
RefSeq Acc Id: XP_063133359   ⟸   XM_063277289
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A8J0 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5U2X7-F1-model_v2 AlphaFold Q5U2X7 1-245 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700896
Promoter ID:EPDNEW_R11420
Type:multiple initiation site
Name:Timm21_1
Description:translocase of inner mitochondrial membrane 21
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01881,807,649 - 81,807,709EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307279 AgrOrtholog
BioCyc Gene G2FUF-6739 BioCyc
Ensembl Genes ENSRNOG00000015142 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055013698 UniProtKB/Swiss-Prot
  ENSRNOG00060015064 UniProtKB/Swiss-Prot
  ENSRNOG00065002921 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000020376 ENTREZGENE
  ENSRNOT00000020376.5 UniProtKB/Swiss-Prot
  ENSRNOT00000120215.1 UniProtKB/TrEMBL
  ENSRNOT00055023530 UniProtKB/Swiss-Prot
  ENSRNOT00060025823 UniProtKB/Swiss-Prot
  ENSRNOT00065004069 UniProtKB/Swiss-Prot
Gene3D-CATH 3.10.450.320 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7126835 IMAGE-MGC_LOAD
InterPro Tim21 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tim21_IMS_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:307210 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:94128 IMAGE-MGC_LOAD
NCBI Gene 307210 ENTREZGENE
PANTHER MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR13032 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam TIM21 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Timm21 PhenoGen
RatGTEx ENSRNOG00000015142 RatGTEx
  ENSRNOG00055013698 RatGTEx
  ENSRNOG00060015064 RatGTEx
  ENSRNOG00065002921 RatGTEx
UniProt A0A8I6A8J0 ENTREZGENE, UniProtKB/TrEMBL
  A6K5M3 ENTREZGENE, UniProtKB/TrEMBL
  Q5U2X7 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-15 Timm21  translocase of inner mitochondrial membrane 21  Timm21  translocase of inner mitochondrial membrane 21 homolog (yeast)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-12-06 Timm21  translocase of inner mitochondrial membrane 21 homolog (yeast)  RGD1307279  similar to RIKEN cDNA 2700002I20  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 RGD1307279  similar to RIKEN cDNA 2700002I20  RGD1307279_predicted  similar to RIKEN cDNA 2700002I20 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1307279_predicted  similar to RIKEN cDNA 2700002I20 (predicted)  LOC307210_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC307210_predicted  similar to RIKEN cDNA 2700002I20 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL