Nfatc1 (nuclear factor of activated T cells 1) - Rat Genome Database

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Gene: Nfatc1 (nuclear factor of activated T cells 1) Chinchilla lanigera
Analyze
Symbol: Nfatc1
Name: nuclear factor of activated T cells 1
RGD ID: 8898569
Description: ENCODES a protein that exhibits chromatin binding (ortholog); DNA binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); INVOLVED IN aortic valve development (ortholog); aortic valve morphogenesis (ortholog); B-1a B cell differentiation (ortholog); ASSOCIATED WITH Burn-McKeown syndrome (ortholog); chromosome 18q deletion syndrome (ortholog); intestinal volvulus (ortholog); FOUND IN chromatin (ortholog); cytoplasm (ortholog); nuclear body (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: nuclear factor of activated T-cells 1; nuclear factor of activated T-cells, cytoplasmic 1; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540262,558,286 - 62,674,457 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540262,558,392 - 62,674,347 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aortic valve development  (ISO)
aortic valve morphogenesis  (ISO)
B-1a B cell differentiation  (ISO)
branching involved in lymph vessel morphogenesis  (ISO)
calcineurin-NFAT signaling cascade  (ISO)
calcium ion transport  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
cellular response to tumor necrosis factor  (ISO)
endocardial cushion development  (ISO)
epithelial to mesenchymal transition  (ISO)
G1/S transition of mitotic cell cycle  (ISO)
heart development  (ISO)
heart trabecula morphogenesis  (ISO)
heart valve development  (ISO)
heart valve morphogenesis  (ISO)
intracellular signal transduction  (ISO)
keratinocyte proliferation  (ISO)
lymphangiogenesis  (ISO)
mononuclear cell differentiation  (ISO)
negative regulation of keratinocyte proliferation  (ISO)
negative regulation of osteoblast differentiation  (ISO)
negative regulation of stem cell proliferation  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of vascular associated smooth muscle cell differentiation  (ISO)
osteoclast differentiation  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
pulmonary valve development  (ISO)
pulmonary valve morphogenesis  (ISO)
regulation of hair cycle  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
semi-lunar valve development  (ISO)
stem cell proliferation  (ISO)
transcription by RNA polymerase II  (ISO)
transition between fast and slow fiber  (ISO)
ventricular septum morphogenesis  (ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISS annotations to Chinchilla, Squirrel, Bonobo and/or Dog genes from Human gene annotations

Genomics

Comparative Map Data
Nfatc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540262,558,286 - 62,674,457 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540262,558,392 - 62,674,347 (+)NCBIChiLan1.0ChiLan1.0
NFATC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381879,395,930 - 79,529,323 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1879,395,856 - 79,529,325 (+)EnsemblGRCh38hg38GRCh38
GRCh371877,155,930 - 77,289,323 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361875,256,760 - 75,390,311 (+)NCBINCBI36hg18NCBI36
Build 341875,256,759 - 75,329,165NCBI
Celera1873,929,368 - 74,061,687 (+)NCBI
Cytogenetic Map18q23NCBI
HuRef1873,783,058 - 73,914,637 (+)NCBIHuRef
CHM1_11877,150,992 - 77,284,501 (+)NCBICHM1_1
T2T-CHM13v2.01879,649,928 - 79,782,943 (+)NCBI
Nfatc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391880,649,418 - 80,756,286 (-)NCBIGRCm39mm39
GRCm39 Ensembl1880,649,420 - 80,756,286 (-)Ensembl
GRCm381880,606,205 - 80,713,071 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1880,606,205 - 80,713,071 (-)EnsemblGRCm38mm10GRCm38
MGSCv371880,802,944 - 80,909,810 (-)NCBIGRCm37mm9NCBIm37
MGSCv361880,768,264 - 80,875,117 (-)NCBImm8
Celera1881,715,612 - 81,822,471 (-)NCBICelera
Cytogenetic Map18E3NCBI
cM Map1853.66NCBI
Nfatc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21874,046,421 - 74,156,041 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1874,046,904 - 74,156,028 (-)Ensembl
Rnor_6.01877,203,517 - 77,322,690 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1877,203,525 - 77,322,690 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01876,309,900 - 76,426,095 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41877,498,654 - 77,581,231 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1872,704,426 - 72,813,069 (-)NCBICelera
Cytogenetic Map18q12.3NCBI
NFATC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11876,020,443 - 76,133,790 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1876,017,454 - 76,094,453 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01872,948,067 - 73,083,180 (+)NCBIMhudiblu_PPA_v0panPan3
NFATC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.111,027,021 - 1,121,362 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl11,028,695 - 1,121,588 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha12,030,800 - 2,126,866 (-)NCBI
ROS_Cfam_1.01826,991 - 923,076 (-)NCBI
ROS_Cfam_1.0 Ensembl1827,017 - 923,153 (-)Ensembl
UMICH_Zoey_3.11879,585 - 975,578 (-)NCBI
UNSW_CanFamBas_1.01825,423 - 922,065 (-)NCBI
UU_Cfam_GSD_1.01996,485 - 1,092,567 (-)NCBI
Nfatc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494415,162,918 - 15,264,081 (-)NCBI
SpeTri2.0NW_004936616484,062 - 584,950 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NFATC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1145,911,046 - 146,008,139 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11145,940,099 - 146,002,897 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21161,528,147 - 161,632,555 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NFATC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.118690,313 - 815,804 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl18689,671 - 811,100 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606025,265,195 - 25,449,498 (+)NCBIVero_WHO_p1.0
Nfatc1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624806905,174 - 1,022,800 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_004624806905,487 - 1,022,784 (-)NCBIHetGla_female_1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000013979   ⟹   ENSCLAP00000013823
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495540262,558,286 - 62,674,457 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000013980   ⟹   ENSCLAP00000013824
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495540262,558,286 - 62,674,457 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000013981   ⟹   ENSCLAP00000013825
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495540262,562,734 - 62,674,457 (+)Ensembl
RefSeq Acc Id: XM_005373108   ⟹   XP_005373165
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495540262,558,392 - 62,674,347 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005373109   ⟹   XP_005373166
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495540262,558,393 - 62,674,347 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005373110   ⟹   XP_005373167
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495540262,562,657 - 62,674,347 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005373112   ⟹   XP_005373169
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495540262,558,398 - 62,674,347 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005373113   ⟹   XP_005373170
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495540262,558,399 - 62,674,347 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013511612   ⟹   XP_013367066
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495540262,558,392 - 62,658,250 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013511624   ⟹   XP_013367078
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495540262,562,659 - 62,625,134 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_005373165   ⟸   XM_005373108
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_005373166   ⟸   XM_005373109
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_005373169   ⟸   XM_005373112
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_005373170   ⟸   XM_005373113
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_005373167   ⟸   XM_005373110
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_013367066   ⟸   XM_013511612
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_013367078   ⟸   XM_013511624
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: ENSCLAP00000013823   ⟸   ENSCLAT00000013979
RefSeq Acc Id: ENSCLAP00000013824   ⟸   ENSCLAT00000013980
RefSeq Acc Id: ENSCLAP00000013825   ⟸   ENSCLAT00000013981
Protein Domains
RHD


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000009557 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCLAP00000013823 ENTREZGENE
  ENSCLAP00000013823.1 UniProtKB/TrEMBL
  ENSCLAP00000013824.1 UniProtKB/TrEMBL
  ENSCLAP00000013825 ENTREZGENE
  ENSCLAP00000013825.1 UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000013979 ENTREZGENE
  ENSCLAT00000013979.1 UniProtKB/TrEMBL
  ENSCLAT00000013980.1 UniProtKB/TrEMBL
  ENSCLAT00000013981 ENTREZGENE
  ENSCLAT00000013981.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
  2.60.40.340 UniProtKB/TrEMBL
InterPro Ig-like_fold UniProtKB/TrEMBL
  Ig_E-set UniProtKB/TrEMBL
  IPT_dom UniProtKB/TrEMBL
  NFAT UniProtKB/TrEMBL
  NFAT1 UniProtKB/TrEMBL
  p53-like_TF_DNA-bd UniProtKB/TrEMBL
  RHD_dimer UniProtKB/TrEMBL
  RHD_DNA_bind_dom UniProtKB/TrEMBL
  RHD_DNA_bind_dom_sf UniProtKB/TrEMBL
NCBI Gene Nfatc1 ENTREZGENE
PANTHER PTHR12533 UniProtKB/TrEMBL
  PTHR12533:SF5 UniProtKB/TrEMBL
Pfam RHD_dimer UniProtKB/TrEMBL
  RHD_DNA_bind UniProtKB/TrEMBL
PRINTS NUCFACTORATC UniProtKB/TrEMBL
PROSITE REL_2 UniProtKB/TrEMBL
SMART IPT UniProtKB/TrEMBL
Superfamily-SCOP SSF49417 UniProtKB/TrEMBL
  SSF81296 UniProtKB/TrEMBL
UniProt A0A8C2VD36_CHILA UniProtKB/TrEMBL
  A0A8C2VD66_CHILA UniProtKB/TrEMBL
  A0A8C2YPJ1_CHILA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-12-19 Nfatc1  nuclear factor of activated T cells 1    nuclear factor of activated T-cells 1  Symbol and/or name change 5135510 APPROVED
2016-08-03 Nfatc1  nuclear factor of activated T-cells 1    nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1  Symbol and/or name change 5135510 APPROVED