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Gene: NFATC1 (nuclear factor of activated T cells 1) Homo sapiens
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Symbol: NFATC1
Name: nuclear factor of activated T cells 1
Description: Predicted to have several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II regulatory region sequence-specific DNA binding activity; and RNA polymerase II transcription factor binding activity. Involved in calcineurin-NFAT signaling cascade; negative regulation of vascular smooth muscle cell differentiation; and positive regulation of transcription by RNA polymerase II. Localizes to the nuclear body and nuclear chromatin.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: MGC138448; NF-ATC; NF-ATc1; NF-ATc1.2; NFAT transcription complex cytosolic component; NFAT2; NFATc; nuclear factor of activated T-cells 'c'; nuclear factor of activated T-cells 1; nuclear factor of activated T-cells, cytoplasmic 1; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
Orthologs:
Mus musculus (house mouse) : Nfatc1 (nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Nfatc1 (nuclear factor of activated T-cells 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nfatc1 (nuclear factor of activated T cells 1)
Pan paniscus (bonobo/pygmy chimpanzee) : NFATC1 (nuclear factor of activated T cells 1)
Canis lupus familiaris (dog) : NFATC1 (nuclear factor of activated T cells 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nfatc1 (nuclear factor of activated T cells 1)
Sus scrofa (pig) : NFATC1 (nuclear factor of activated T cells 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381879,395,930 - 79,529,323 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371877,155,772 - 77,289,323 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361875,256,760 - 75,390,311 (+)NCBINCBI36hg18NCBI36
Build 341875,256,759 - 75,329,165NCBI
Celera1873,929,368 - 74,061,687 (+)NCBI
Cytogenetic Map18q23NCBI
HuRef1873,783,058 - 73,914,637 (+)NCBIHuRef
CHM1_11877,150,992 - 77,284,501 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on NFATC1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1346235
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.