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Gene: NFATC1 (nuclear factor of activated T cells 1) Homo sapiens
Symbol: NFATC1
Name: nuclear factor of activated T cells 1
Description: Predicted to have several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II regulatory region sequence-specific DNA binding activity; and RNA polymerase II transcription factor binding activity. Involved in calcineurin-NFAT signaling cascade; negative regulation of vascular smooth muscle cell differentiation; and positive regulation of transcription by RNA polymerase II. Localizes to the nuclear body and nuclear chromatin.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: MGC138448; NF-ATC; NF-ATc1; NF-ATc1.2; NFAT transcription complex cytosolic component; NFAT2; NFATc; nuclear factor of activated T-cells 'c'; nuclear factor of activated T-cells 1; nuclear factor of activated T-cells, cytoplasmic 1; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
Mus musculus (house mouse) : Nfatc1 (nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Nfatc1 (nuclear factor of activated T-cells 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nfatc1 (nuclear factor of activated T cells 1)
Pan paniscus (bonobo/pygmy chimpanzee) : NFATC1 (nuclear factor of activated T cells 1)
Canis lupus familiaris (dog) : NFATC1 (nuclear factor of activated T cells 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nfatc1 (nuclear factor of activated T cells 1)
Sus scrofa (pig) : NFATC1 (nuclear factor of activated T cells 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381879,395,930 - 79,529,323 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371877,155,772 - 77,289,323 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361875,256,760 - 75,390,311 (+)NCBINCBI36hg18NCBI36
Build 341875,256,759 - 75,329,165NCBI
Celera1873,929,368 - 74,061,687 (+)NCBI
Cytogenetic Map18q23NCBI
HuRef1873,783,058 - 73,914,637 (+)NCBIHuRef
CHM1_11877,150,992 - 77,284,501 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on NFATC1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1346235
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.