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Gene: Tcf3 (transcription factor 3) Rattus norvegicus
Symbol: Tcf3
Name: transcription factor 3
RGD ID: 620914
Description: Exhibits PDZ domain binding activity and bHLH transcription factor binding activity. Contributes to E-box binding activity. Involved in positive regulation of transcription, DNA-templated. Localizes to transcription regulator complex. Human ortholog(s) of this gene implicated in agammaglobulinemia and colorectal cancer. Orthologous to human TCF3 (transcription factor 3); PARTICIPATES IN acute myeloid leukemia pathway; arrhythmogenic right ventricular cardiomyopathy pathway; basal cell carcinoma pathway; INTERACTS WITH 2,4-dinitrotoluene; 6-propyl-2-thiouracil; amphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: immunoglobulin enhancer-binding factor E12/E47; LOC100364490; LOC688265; Pan2; pancreas specific transcription factor 1c; similar to Transcription factor E2-alpha (Immunoglobulin enhancer-binding factor E12/E47) (Transcription factor 3) (TCF-3) (Transcription regulator Pan); TCF-3; Tcfe2a; transcription factor E2-alpha; transcription factor E2a; transcription factor E2a-like; transcription regulator Pan
Homo sapiens (human) : TCF3 (transcription factor 3)  HGNC  Alliance
Mus musculus (house mouse) : Tcf3 (transcription factor 3)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tcf3 (transcription factor 3)
Pan paniscus (bonobo/pygmy chimpanzee) : TCF3 (transcription factor 3)
Canis lupus familiaris (dog) : TCF3 (transcription factor 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tcf3 (transcription factor 3)
Sus scrofa (pig) : TCF3 (transcription factor 3)
Chlorocebus sabaeus (African green monkey) : TCF3 (transcription factor 3)
Heterocephalus glaber (naked mole-rat) : Tcf3 (transcription factor 3)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0712,146,642 - 12,168,400 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,144,162 - 12,168,410 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0712,316,323 - 12,338,455 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4710,791,311 - 10,813,613 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1710,791,310 - 10,813,165 (+)NCBI
Celera77,461,200 - 7,481,028 (+)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Tcf3
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620914
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.