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Gene: Ep300 (E1A binding protein p300) Mus musculus
Symbol: Ep300
Name: E1A binding protein p300
Description: Exhibits several functions, including N-acetyltransferase activity; nucleic acid binding activity; and transcription factor binding activity. Predicted to contribute to DNA-binding transcription factor activity. Involved in several processes, including animal organ development; protein acylation; and regulation of transcription, DNA-templated. Localizes to the histone acetyltransferase complex and transcription factor complex. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in Rubinstein-Taybi syndrome and congestive heart failure. Is expressed in several structures, including epidermis; heart; intestine epithelium; liver; and lung. Orthologous to human EP300 (E1A binding protein p300); PARTICIPATES IN androgen signaling pathway; cortisol signaling pathway; estrogen signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 5-(2-chloroethyl)-4-methylthiazole; 5-aza-2'-deoxycytidine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: A430090G16; A730011L11; E1A-associated protein p300; histone acetyltransferase p300; histone butyryltransferase p300; histone crotonyltransferase p300; KAT3B; p300; p300 HAT
Homo sapiens (human) : EP300 (E1A binding protein p300)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Ep300 (E1A binding protein p300)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ep300 (E1A binding protein p300)
Pan paniscus (bonobo/pygmy chimpanzee) : EP300 (E1A binding protein p300)
Canis lupus familiaris (dog) : ZC3H7B (zinc finger CCCH-type containing 7B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ep300 (E1A binding protein p300)
Sus scrofa (pig) : EP300 (E1A binding protein p300)
Chlorocebus sabaeus (African green monkey) : EP300 (E1A binding protein p300)
more info ...
Related Pseudogenes: Gm18256  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1581,585,351 - 81,652,077 (+)Ensembl
GRCm381581,586,209 - 81,652,077 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371581,416,644 - 81,482,507 (+)NCBIGRCm37mm9NCBIm37
MGSCv361581,413,469 - 81,479,332 (+)NCBImm8
Celera1583,704,343 - 83,770,860 (+)NCBICelera
Cytogenetic Map15 E1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Ep300
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1552027
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2020-01-14
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.