RGD Reference Report - Huntington's disease of the endocrine pancreas: insulin deficiency and diabetes mellitus due to impaired insulin gene expression. - Rat Genome Database

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Huntington's disease of the endocrine pancreas: insulin deficiency and diabetes mellitus due to impaired insulin gene expression.

Authors: Andreassen, Ole A  Dedeoglu, Alpaslan  Stanojevic, Violeta  Hughes, Duncan B  Browne, Susan E  Leech, Colin A  Ferrante, Robert J  Habener, Joel F  Beal, M Flint  Thomas, Melissa K 
Citation: Andreassen OA, etal., Neurobiol Dis. 2002 Dec;11(3):410-24.
RGD ID: 13432192
Pubmed: PMID:12586550   (View Abstract at PubMed)

In a transgenic mouse model of the neurodegenerative disorder Huntington's disease (HD), age-dependent neurologic defects are accompanied by progressive alterations in glucose tolerance that culminate in the development of diabetes mellitus and insulin deficiency. Pancreatic islets from HD transgenic mice express reduced levels of the pancreatic islet hormones insulin, somatostatin, and glucagon and exhibit intrinsic defects in insulin production. Intranuclear inclusions accumulate with aging in transgenic pancreatic islets, concomitant with the decline in glucose tolerance. HD transgenic mice develop an age-dependent reduction of insulin mRNA expression and diminished expression of key regulators of insulin gene transcription, including the pancreatic homeoprotein PDX-1, E2A proteins, and the coactivators CBP and p300. Disrupted expression of a subset of transcription factors in pancreatic beta cells by a polyglutamine expansion tract in the huntingtin protein selectively impairs insulin gene expression to result in insulin deficiency and diabetes. Selective dysregulation of gene expression in triplet repeat disorders provides a mechanism for pleiotropic cellular dysfunction that restricts the toxicity of ubiquitously expressed proteins to highly specialized subpopulations of cells.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Huntington's disease  ISOEp300 (Mus musculus)13432192; 13432192 RGD 
Huntington's disease  IEP 13432192 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ep300  (E1A binding protein p300)

Genes (Mus musculus)
Ep300  (E1A binding protein p300)

Genes (Homo sapiens)
EP300  (E1A binding protein p300)


Additional Information