GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ep300 | decreases expression | EXP | | 6480464 | CTD | resveratrol results in decreased expression of EP300 mRNA; resveratrol results in decreased expression of EP300 protein | PMID:23297412 PMID:25905778 | Ep300 | multiple interactions | EXP | | 6480464 | CTD | resveratrol inhibits the reaction [Phenylephrine promotes the reaction [EP300 protein binds to NPPA promoter]]; resveratrol inhibits the reaction [Phenylephrine results in increased expression of EP300 protein] | PMID:23297412 | Ep300 | affects expression | ISO | Ep300 (Mus musculus) | 6480464 | CTD | resveratrol affects the expression of EP300 protein | PMID:24254769 | Ep300 | decreases expression | ISO | EP300 (Homo sapiens) | 6480464 | CTD | resveratrol results in decreased expression of EP300 mRNA; resveratrol results in decreased expression of EP300 protein | PMID:25707573 | Ep300 | decreases expression | ISO | Ep300 (Mus musculus) | 6480464 | CTD | resveratrol results in decreased expression of EP300 protein | PMID:23297412 | Ep300 | increases expression | ISO | EP300 (Homo sapiens) | 6480464 | CTD | resveratrol results in increased expression of EP300 mRNA | PMID:12002526 PMID:12569576 | Ep300 | multiple interactions | ISO | EP300 (Homo sapiens) | 6480464 | CTD | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol promotes the reaction [PTGS2 protein binds to EP300 protein]]; [[Resveratrol results in increased activity of SIRT1 protein] promotes the reaction [SIRT1 protein binds to and results in decreased activity of EP300 protein]] which results in decreased acetylation of and results in decreased activity of CTNNB1 protein; [[Resveratrol results in increased activity of SIRT1 protein] promotes the reaction [SIRT1 protein binds to and results in decreased activity of EP300 protein]] which results in decreased acetylation of and results in decreased activity of RELA protein; [Resveratrol results in increased activity of SIRT1 protein] promotes the reaction [SIRT1 protein binds to and results in decreased activity of EP300 protein]; EP300 protein inhibits the reaction [Resveratrol results in decreased expression of ZBTB7A mRNA]; Resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in decreased susceptibility to Doxorubicin]; Resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in decreased susceptibility to Etoposide]; Resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of ABCB1 mRNA]; Resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of ABCB1 protein]; Resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of BCL2L1 mRNA]; Resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of BCL2L1 protein]; Resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in decreased susceptibility to Doxorubicin]; Resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in decreased susceptibility to Etoposide]; Resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of ABCB1 mRNA]; Resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of ABCB1 protein]; Resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of BCL2L1 mRNA]; Resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of BCL2L1 protein]; Resveratrol inhibits the reaction [EP300 protein binds to ZBTB7A promoter]; Resveratrol inhibits the reaction [TGFB2 protein promotes the reaction [EP300 protein binds to COL1A2 promoter]]; Resveratrol inhibits the reaction [TGFB2 protein results in increased expression of EP300 protein]; Resveratrol inhibits the reaction [TNF protein promotes the reaction [EP300 protein binds to IL6 promoter]]; Resveratrol inhibits the reaction [TNF protein results in increased expression of EP300 mRNA]; Resveratrol inhibits the reaction [TNF protein results in increased expression of EP300 protein]; Resveratrol promotes the reaction [PTGS2 protein binds to EP300 protein]; Resveratrol promotes the reaction [SIRT1 protein binds to and results in decreased activity of EP300 protein] | PMID:16928824 PMID:19047049 PMID:24771768 PMID:25707573 PMID:25875864 PMID:33515544 | Ep300 | multiple interactions | ISO | Ep300 (Mus musculus) | 6480464 | CTD | 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in increased expression of EP300 protein]]; resveratrol inhibits the reaction [DMD gene mutant form results in increased expression of EP300 protein]; resveratrol inhibits the reaction [Doxorubicin results in increased expression of EP300 protein]; SIRT1 mutant form inhibits the reaction [resveratrol results in decreased expression of EP300 protein]; sirtinol inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in increased expression of EP300 protein]] | PMID:23297412 PMID:25665036 | | ||||||||||||||||||||||
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