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Gene: Nkx2-5 (NK2 homeobox 5) Rattus norvegicus
Symbol: Nkx2-5
Name: NK2 homeobox 5
RGD ID: 620520
Description: Exhibits several functions, including DNA-binding transcription factor activity; histone deacetylase binding activity; and identical protein binding activity. Involved in several processes, including cellular response to hydrogen peroxide; negative regulation of transcription by RNA polymerase II; and response to estradiol. Localizes to nucleus. Biomarker of pulmonary fibrosis. Human ortholog(s) of this gene implicated in aortic valve disease 2; atrioventricular block; congenital heart disease (multiple); and congenital nongoitrous hypothyroidism 5. Orthologous to human NKX2-5 (NK2 homeobox 5); INTERACTS WITH acrylamide; ammonium chloride; bisphenol A.
Type: protein-coding
Also known as: Csx; homeobox protein NK-2 homolog E; homeobox protein Nkx-2.5; NK2 transcription factor related, locus 5; NK2 transcription factor related, locus 5 (Drosophila); Nkx2.5; rNKx-2.5
Homo sapiens (human) : NKX2-5 (NK2 homeobox 5)  HGNC  Alliance
Mus musculus (house mouse) : Nkx2-5 (NK2 homeobox 5)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nkx2-5 (NK2 homeobox 5)
Pan paniscus (bonobo/pygmy chimpanzee) : NKX2-5 (NK2 homeobox 5)
Canis lupus familiaris (dog) : NKX2-5 (NK2 homeobox 5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nkx2-5 (NK2 homeobox 5)
Sus scrofa (pig) : NKX2-5 (NK2 homeobox 5)
Chlorocebus sabaeus (African green monkey) : NKX2-5 (NK2 homeobox 5)
Heterocephalus glaber (naked mole-rat) : Nkx2-5 (NK2 homeobox 5)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01016,635,989 - 16,638,758 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1016,635,989 - 16,638,764 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01016,520,570 - 16,527,836 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41016,606,183 - 16,608,952 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11016,607,231 - 16,610,001 (+)NCBI
Celera1016,004,548 - 16,007,317 (+)NCBICelera
Cytogenetic Map10q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Nkx2-5
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620520
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-11-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.