Gene: Nkx2-5 (NK2 homeobox 5) Rattus norvegicus
Analyze
Symbol:
Nkx2-5
Name:
NK2 homeobox 5
RGD ID:
620520
Description:
Exhibits several functions, including DNA-binding transcription factor activity; histone deacetylase binding activity; and identical protein binding activity. Involved in several processes, including cellular response to hydrogen peroxide; negative regulation of transcription by RNA polymerase II; and response to estradiol. Localizes to nucleus. Biomarker of pulmonary fibrosis. Human ortholog(s) of this gene implicated in aortic valve disease 2; atrioventricular block; congenital heart disease (multiple); and congenital nongoitrous hypothyroidism 5. Orthologous to human NKX2-5 (NK2 homeobox 5); INTERACTS WITH acrylamide; ammonium chloride; bisphenol A.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
Csx; homeobox protein NK-2 homolog E; homeobox protein Nkx-2.5; NK2 transcription factor related, locus 5; NK2 transcription factor related, locus 5 (Drosophila); Nkx2.5; rNKx-2.5
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
NKX2-5 (NK2 homeobox 5) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):
Nkx2-5 (NK2 homeobox 5) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Nkx2-5 (NK2 homeobox 5) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
NKX2-5 (NK2 homeobox 5) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
NKX2-5 (NK2 homeobox 5) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Nkx2-5 (NK2 homeobox 5) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
NKX2-5 (NK2 homeobox 5) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
NKX2-5 (NK2 homeobox 5) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Nkx2-5 (NK2 homeobox 5) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Mus musculus (house mouse):
Nkx2-5 (NK2 homeobox 5)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|TreeFam)
Homo sapiens (human):
NKX2-5 (NK2 homeobox 5)
Alliance
DIOPT (Ensembl Compara|HGNC|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|TreeFam)
Danio rerio (zebrafish):
nkx2.5 (NK2 homeobox 5)
Alliance
DIOPT (PhylomeDB|TreeFam)
Drosophila melanogaster (fruit fly):
tin
Alliance
DIOPT (Ensembl Compara|OrthoFinder|PANTHER|PhylomeDB|TreeFam)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 10 16,635,989 - 16,638,758 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 10 16,635,989 - 16,638,764 (+) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 10 16,520,570 - 16,527,836 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 10 16,606,183 - 16,608,952 (+) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 10 16,607,231 - 16,610,001 (+) NCBI Celera 10 16,004,548 - 16,007,317 (+) NCBI Celera Cytogenetic Map 10 q12 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - ClinVar
atrial heart septal defect ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Atrial septal defect ClinVar PMID:18414213 more ... atrial heart septal defect 7 ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Atrial septal defect 7 with or without atrioventricular conduction defects ClinVar PMID:28492532 atrial heart septal defect 7 ISO RGD:1606841 8554872 ClinVar Annotator: match by term: ASD WITH OR WITHOUT ATRIOVENTRICULAR CONDUCTION DEFECTS ClinVar PMID:18414213 more ... atrial heart septal defect 7 ISO RGD:1606841 8554872 ClinVar Annotator: match by term: ASD WITH OR WITHOUT ATRIOVENTRICULAR CONDUCTION DEFECTS ClinVar PMID:20022124 , PMID:28492532 atrial heart septal defect 7 ISO RGD:1606841 8554872 ClinVar Annotator: match by term: ASD WITH OR WITHOUT ATRIOVENTRICULAR CONDUCTION DEFECTS ClinVar PMID:19678963 more ... atrial heart septal defect 7 ISO RGD:1606841 8554872 ClinVar Annotator: match by term: ASD WITH OR WITHOUT ATRIOVENTRICULAR CONDUCTION DEFECTS ClinVar PMID:19933292 , PMID:28492532 atrial heart septal defect 7 ISO RGD:1606841 8554872 ClinVar Annotator: match by term: ASD WITH OR WITHOUT ATRIOVENTRICULAR CONDUCTION DEFECTS ClinVar PMID:10948187 more ... atrial heart septal defect 7 ISO RGD:1606841 8554872 ClinVar Annotator: match by term: ASD WITH OR WITHOUT ATRIOVENTRICULAR CONDUCTION DEFECTS ClinVar PMID:18414213 more ... atrial heart septal defect 7 ISO RGD:1606841 8554872 ClinVar Annotator: match by term: ASD WITH OR WITHOUT ATRIOVENTRICULAR CONDUCTION DEFECTS ClinVar PMID:15689439 , PMID:28492532 atrial heart septal defect 7 ISO RGD:1606841 8554872 ClinVar Annotator: match by term: ASD WITH OR WITHOUT ATRIOVENTRICULAR CONDUCTION DEFECTS ClinVar PMID:18414213 more ... atrial heart septal defect 7 ISO RGD:1606841 8554872 ClinVar Annotator: match by term: ASD WITH OR WITHOUT ATRIOVENTRICULAR CONDUCTION DEFECTS ClinVar PMID:19533775 more ... atrial heart septal defect 7 ISO RGD:1606841 8554872 ClinVar Annotator: match by term: ASD WITH OR WITHOUT ATRIOVENTRICULAR CONDUCTION DEFECTS ClinVar PMID:24880466 , PMID:25319568 atrial heart septal defect 7 ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Atrial septal defect 7 with or without atrioventricular conduction defects ClinVar PMID:10587520 , PMID:28492532 atrial heart septal defect 7 ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Atrial septal defect 7 with or without atrioventricular conduction defects ClinVar PMID:25205790 more ... atrial heart septal defect 7 ISO RGD:1606841 8554872 ClinVar Annotator: match by term: ASD WITH OR WITHOUT ATRIOVENTRICULAR CONDUCTION DEFECTS ClinVar PMID:18414213 , PMID:28492532 atrial heart septal defect 7 ISO RGD:1606841 8554872 ClinVar Annotator: match by term: ASD WITH OR WITHOUT ATRIOVENTRICULAR CONDUCTION DEFECTS ClinVar PMID:10587520 more ... atrial heart septal defect 7 ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Atrial septal defect 7 with or without atrioventricular conduction defects ClinVar PMID:15689439 more ... atrial heart septal defect 7 ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Atrial septal defect 7 with or without atrioventricular conduction defects ClinVar PMID:11714651 more ... atrial heart septal defect 7 ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Atrial septal defect 7 with or without atrioventricular conduction defects ClinVar PMID:14607454 , PMID:28492532 atrial heart septal defect 7 ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Atrial septal defect 7 with or without atrioventricular conduction defects ClinVar PMID:10948187 more ... atrial heart septal defect 7 ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Atrial septal defect 7 with or without atrioventricular conduction defects ClinVar PMID:21091212 more ... atrial heart septal defect 7 ISO RGD:1606841 8554872 ClinVar Annotator: match by term: ASD WITH OR WITHOUT ATRIOVENTRICULAR CONDUCTION DEFECTS ClinVar PMID:16418214 more ... atrial heart septal defect 7 ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Atrial septal defect 7 with or without atrioventricular conduction defects ClinVar PMID:10021345 more ... atrial heart septal defect 7 ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Atrial septal defect 7 with or without atrioventricular conduction defects ClinVar PMID:10587520 more ... atrial heart septal defect 7 ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Atrial septal defect 7 with or without atrioventricular conduction defects ClinVar PMID:25741868 , PMID:28492532 atrial heart septal defect 7 ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Atrial septal defect 7 with or without atrioventricular conduction defects ClinVar PMID:26014430 , PMID:28492532 atrial heart septal defect 7 ISO RGD:1606841 8554872 ClinVar Annotator: match by term: ASD WITH OR WITHOUT ATRIOVENTRICULAR CONDUCTION DEFECTS ClinVar PMID:10021345 , PMID:28492532 atrial heart septal defect 7 ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Atrial septal defect 7 with or without atrioventricular conduction defects ClinVar PMID:11714651 more ... atrial heart septal defect 7 ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Atrial septal defect 7 with or without atrioventricular conduction defects ClinVar PMID:10948187 more ... atrial heart septal defect 7 ISO RGD:1606841 8554872 ClinVar Annotator: match by OMIM:108900 ClinVar PMID:25741868 atrial heart septal defect 7 ISO RGD:1606841 8554872 ClinVar Annotator: match by term: ASD WITH OR WITHOUT ATRIOVENTRICULAR CONDUCTION DEFECTS ClinVar PMID:19948535 more ... atrial heart septal defect 7 ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Atrial septal defect 7 with or without atrioventricular conduction defects ClinVar PMID:21110066 , PMID:28492532 atrial heart septal defect 7 ISO RGD:1606841 8554872 ClinVar Annotator: match by OMIM:108900 ClinVar PMID:14607454 atrial heart septal defect 7 ISO RGD:1606841 8554872 ClinVar Annotator: match by OMIM:108900 ClinVar PMID:15810002 atrial heart septal defect 7 ISO RGD:1606841 8554872 ClinVar Annotator: match by OMIM:108900 ClinVar atrial heart septal defect 7 ISO RGD:1606841 8554872 ClinVar Annotator: match by OMIM:108900 ClinVar PMID:16896344 atrial heart septal defect 7 ISO RGD:1606841 8554872 ClinVar Annotator: match by OMIM:108900 ClinVar PMID:12414819 atrial heart septal defect 7 ISO RGD:1606841 8554872 ClinVar Annotator: match by OMIM:108900 ClinVar PMID:15342699 atrial heart septal defect 7 ISO RGD:1606841 8554872 ClinVar Annotator: match by OMIM:108900 ClinVar PMID:10021345 , PMID:10943630 atrial heart septal defect 7 ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Atrial septal defect 7 with or without atrioventricular conduction defects ClinVar PMID:11714651 more ... Atrial Septal Defect with Atrioventricular Conduction Defects ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Atrial septal defect with atrioventricular conduction defects ClinVar PMID:19948535 more ... Atrial Septal Defect with Atrioventricular Conduction Defects ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Atrial septal defect with atrioventricular conduction defects ClinVar PMID:18414213 more ... Atrial Septal Defect with Atrioventricular Conduction Defects ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Atrial septal defect with atrioventricular conduction defects ClinVar PMID:20022124 , PMID:28492532 Atrial Septal Defect with Atrioventricular Conduction Defects ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Atrial septal defect with atrioventricular conduction defects ClinVar PMID:10587520 more ... Atrial Septal Defect with Atrioventricular Conduction Defects ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Atrial septal defect with atrioventricular conduction defects ClinVar PMID:11714651 more ... Atrial Septal Defect with Atrioventricular Conduction Defects ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Atrial septal defect with atrioventricular conduction defects ClinVar PMID:19678963 more ... Atrial Septal Defect with Atrioventricular Conduction Defects ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Atrial septal defect with atrioventricular conduction defects ClinVar PMID:19933292 , PMID:28492532 Atrial Septal Defect with Atrioventricular Conduction Defects ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Atrial septal defect with atrioventricular conduction defects ClinVar PMID:18414213 more ... Atrial Septal Defect with Atrioventricular Conduction Defects ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Atrial septal defect with atrioventricular conduction defects ClinVar PMID:19533775 more ... Atrial Septal Defect with Atrioventricular Conduction Defects ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Atrial septal defect with atrioventricular conduction defects ClinVar PMID:18414213 , PMID:28492532 Atrial Septal Defect with Atrioventricular Conduction Defects ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Atrial septal defect with atrioventricular conduction defects ClinVar PMID:25741868 , PMID:28492532 Atrial Septal Defect with Atrioventricular Conduction Defects ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Atrial septal defect with atrioventricular conduction defects ClinVar PMID:16418214 more ... Atrial Septal Defect with Atrioventricular Conduction Defects ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Atrial septal defect with atrioventricular conduction defects ClinVar PMID:28492532 atrioventricular septal defect ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Atrioventricular septal defect, somatic ClinVar PMID:15342699 atrioventricular septal defect ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Atrioventricular septal defect, somatic ClinVar PMID:15917268 Cardiovascular Abnormalities ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Abnormality of cardiovascular system morphology ClinVar PMID:18414213 Cardiovascular Abnormalities ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Abnormality of cardiovascular system morphology ClinVar PMID:18414213 more ... Common Ventricle ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Single ventricle ClinVar PMID:19948535 more ... congenital heart disease ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Heart, malformation of ClinVar PMID:24033266 congenital heart disease ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Malformation of the heart and great vessels ClinVar PMID:18414213 more ... congenital heart disease ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Malformation of the heart and great vessels ClinVar PMID:18414213 more ... congenital heart disease ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Malformation of the heart and great vessels ClinVar PMID:10587520 more ... congenital heart disease ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Congenital heart disease ClinVar PMID:11714651 more ... congenital heart disease ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Malformation of the heart and great vessels ClinVar PMID:18414213 congenital heart disease ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Malformation of the heart and great vessels ClinVar congenital nongoitrous hypothyroidism 5 ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Hypothyroidism, congenital, nongoitrous, 5 ClinVar PMID:16418214 more ... congenital nongoitrous hypothyroidism 5 ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Hypothyroidism, congenital, nongoitrous, 5 ClinVar PMID:10587520 more ... congenital nongoitrous hypothyroidism 5 ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Hypothyroidism, congenital, nongoitrous, 5 ClinVar PMID:16418214 Conotruncal Cardiac Defects ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Truncus arteriosus communis ClinVar PMID:10587520 more ... dilated cardiomyopathy ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Dilated Cardiomyopathy, Dominant ClinVar PMID:10587520 more ... genetic disease ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Inborn genetic diseases ClinVar PMID:11714651 more ... hypertrophic cardiomyopathy ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Hypertrophic cardiomyopathy ClinVar PMID:25741868 Hypoplastic Left Heart Syndrome 2 ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Hypoplastic left heart syndrome 2 ClinVar PMID:10587520 more ... Lissencephaly 3 ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Lissencephaly 3 ClinVar PMID:18414213 more ... second-degree atrioventricular block ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Atrioventricular block, idiopathic second-degree ClinVar PMID:10587520 Splenic Hypoplasia ISO RGD:1606841 8554872 ClinVar Annotator: match by null ClinVar PMID:20846672 more ... tetralogy of Fallot ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Tetralogy of Fallot ClinVar PMID:25741868 tetralogy of Fallot ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Tetralogy of Fallot ClinVar PMID:10587520 more ... tetralogy of Fallot ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Tetralogy of Fallot ClinVar PMID:11714651 more ... tetralogy of Fallot ISO RGD:1606841 8554872 ClinVar Annotator: match by OMIM:187500 ClinVar PMID:11714651 tetralogy of Fallot ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Tetralogy of Fallot ClinVar PMID:11714651 more ... Ventricular Septal Defect 3 ISO RGD:1606841 8554872 ClinVar Annotator: match by OMIM:614432 ClinVar PMID:20659440 Ventricular Septal Defect 3 ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Ventricular septal defect 3 ClinVar PMID:21110066 , PMID:28492532 Ventricular Septal Defect 3 ISO RGD:1606841 8554872 ClinVar Annotator: match by OMIM:614432 ClinVar PMID:21165553
Gene-Chemical Interaction Annotations
