Nkx2-5 (NK2 homeobox 5) - Rat Genome Database

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Gene: Nkx2-5 (NK2 homeobox 5) Rattus norvegicus
Symbol: Nkx2-5
Name: NK2 homeobox 5
RGD ID: 620520
Description: Enables several functions, including DNA-binding transcription factor activity; histone deacetylase binding activity; and identical protein binding activity. Involved in several processes, including cellular response to hydrogen peroxide; negative regulation of transcription by RNA polymerase II; and response to estradiol. Predicted to be located in cytoplasm. Predicted to be part of Nkx-2.5 complex and protein-DNA complex. Predicted to be active in nucleus. Biomarker of pulmonary fibrosis. Human ortholog(s) of this gene implicated in aortic valve disease 2; atrioventricular block; congenital heart disease (multiple); and congenital nongoitrous hypothyroidism 5. Orthologous to human NKX2-5 (NK2 homeobox 5); INTERACTS WITH acrylamide; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Csx; homeobox protein NK-2 homolog E; homeobox protein Nkx-2.5; NK2 transcription factor related, locus 5; NK2 transcription factor related, locus 5 (Drosophila); Nkx2.5; rNKx-2.5
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81016,844,888 - 16,851,458 (+)NCBIGRCr8
mRatBN7.21016,340,428 - 16,347,004 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1016,344,159 - 16,346,934 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1021,093,028 - 21,095,888 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01020,581,977 - 20,584,837 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01016,071,642 - 16,074,502 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01016,635,989 - 16,638,758 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1016,635,989 - 16,638,764 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01016,520,570 - 16,527,836 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41016,606,183 - 16,608,952 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11016,607,231 - 16,610,001 (+)NCBI
Celera1016,004,548 - 16,007,317 (+)NCBICelera
Cytogenetic Map10q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adult heart development  (IEA,ISO)
apoptotic process  (ISO)
apoptotic process involved in heart morphogenesis  (IEA,ISO)
atrial cardiac muscle tissue development  (IEA,ISO)
atrial septum morphogenesis  (IEA,ISO)
atrioventricular node cell development  (IEA,ISO)
atrioventricular node cell fate commitment  (IEA,ISO)
atrioventricular node development  (ISO)
bundle of His development  (IEA,ISO)
cardiac conduction system development  (ISO)
cardiac muscle cell development  (ISO)
cardiac muscle cell differentiation  (IEP,ISO)
cardiac muscle cell proliferation  (IEA,ISO)
cardiac muscle contraction  (IEA,ISO)
cardiac muscle tissue development  (ISO)
cardiac muscle tissue morphogenesis  (ISO)
cardiac septum morphogenesis  (ISO)
cardiac ventricle formation  (IEA,ISO)
cardiac ventricle morphogenesis  (ISO)
cell differentiation  (IBA)
cell population proliferation  (ISO)
cellular response to growth factor stimulus  (IEP)
cellular response to hydrogen peroxide  (IEP)
embryonic heart tube development  (ISO)
embryonic heart tube left/right pattern formation  (IEA,ISO)
epithelial cell apoptotic process  (IEA,ISO)
epithelial cell differentiation  (IEA,ISO)
epithelial cell proliferation  (IEA,ISO)
heart contraction  (ISO)
heart development  (ISO)
heart looping  (IEA,ISO)
heart morphogenesis  (ISO)
heart trabecula formation  (IEA,ISO)
hemopoiesis  (IEA,ISO)
negative regulation of canonical Wnt signaling pathway  (IEA,ISO)
negative regulation of cardiac muscle cell apoptotic process  (IEA,ISO)
negative regulation of epithelial cell apoptotic process  (IEA,ISO)
negative regulation of myotube differentiation  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IDA,IEA,ISO)
outflow tract morphogenesis  (ISO)
outflow tract septum morphogenesis  (IEA,ISO)
pharyngeal system development  (IEA,ISO)
positive regulation of cardioblast differentiation  (IEA,ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of epithelial cell proliferation  (IEA,ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of heart contraction  (IEA,ISO)
positive regulation of neuron differentiation  (IEA,ISO)
positive regulation of sodium ion transport  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (ISO,ISS)
positive regulation of transcription initiation by RNA polymerase II  (IEA,ISO)
proepicardium development  (IEA,ISO)
pulmonary myocardium development  (IEA,ISO)
Purkinje myocyte differentiation  (IEA,ISO)
regulation of cardiac conduction  (IEA,ISO)
regulation of cardiac muscle cell proliferation  (IEA,ISO)
regulation of cardiac muscle contraction  (IEA,ISO)
regulation of DNA-templated transcription  (ISO)
regulation of transcription by RNA polymerase II  (IBA,ISO)
response to estradiol  (IEP)
right ventricular cardiac muscle tissue morphogenesis  (IEA,ISO)
septum secundum development  (IEA,ISO)
spleen development  (IEA,ISO,ISS)
thyroid gland development  (IEA,ISO)
transcription by RNA polymerase II  (IEA,ISO)
vasculogenesis  (IEA,ISO)
ventricular cardiac myofibril assembly  (IEA,ISO)
ventricular septum morphogenesis  (IEA,ISO)
ventricular trabecula myocardium morphogenesis  (IEA,ISO)

Cellular Component


References - curated
# Reference Title Reference Citation
1. NKX2-5 mutations in an inbred consanguineous population: genetic and phenotypic diversity. Abou Hassan OK, etal., Sci Rep. 2015 Mar 6;5:8848. doi: 10.1038/srep08848.
2. A mouse model of human congenital heart disease: high incidence of diverse cardiac anomalies and ventricular noncompaction produced by heterozygous Nkx2-5 homeodomain missense mutation. Ashraf H, etal., Circ Cardiovasc Genet. 2014 Aug;7(4):423-33. doi: 10.1161/CIRCGENETICS.113.000281. Epub 2014 Jul 15.
3. Cardiac septal and valvular dysmorphogenesis in mice heterozygous for mutations in the homeobox gene Nkx2-5. Biben C, etal., Circ Res. 2000 Nov 10;87(10):888-95.
4. Histone deacetylases facilitate sodium/calcium exchanger up-regulation in adult cardiomyocytes. Chandrasekaran S, etal., FASEB J. 2009 Nov;23(11):3851-64. doi: 10.1096/fj.09-132415. Epub 2009 Jul 28.
5. The different cardiac expression of the type 2 iodothyronine deiodinase gene between human and rat is related to the differential response of the Dio2 genes to Nkx-2.5 and GATA-4 transcription factors. Dentice M, etal., Mol Endocrinol. 2003 Aug;17(8):1508-21. Epub 2003 May 29.
6. Familial Atrial Septal Defect and Sudden Cardiac Death: Identification of a Novel NKX2-5 Mutation and a Review of the Literature. Elles√łe SG, etal., Congenit Heart Dis. 2016 May;11(3):283-90. doi: 10.1111/chd.12317. Epub 2015 Dec 18.
7. Endothelin-converting enzyme-1 (ECE-1) is a downstream target of the homeobox transcription factor Nkx2-5. Funke-Kaiser H, etal., FASEB J 2003 Aug;17(11):1487-9.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. NKX2.5 mutations in patients with tetralogy of fallot. Goldmuntz E, etal., Circulation. 2001 Nov 20;104(21):2565-8.
10. A novel CSX/NKX2-5 mutation causes autosomal-dominant AV block: are atrial fibrillation and syncopes part of the phenotype? Gutierrez-Roelens I, etal., Eur J Hum Genet. 2006 Dec;14(12):1313-6. Epub 2006 Aug 9.
11. Progressive AV-block and anomalous venous return among cardiac anomalies associated with two novel missense mutations in the CSX/NKX2-5 gene. Gutierrez-Roelens I, etal., Hum Mutat. 2002 Jul;20(1):75-6.
12. Nkx2.5/Csx represses myofibroblast differentiation. Hu B, etal., Am J Respir Cell Mol Biol. 2010 Feb;42(2):218-26. Epub 2009 Apr 24.
13. Functional dissection of sequence-specific NKX2-5 DNA binding domain mutations associated with human heart septation defects using a yeast-based system. Inga A, etal., Hum Mol Genet. 2005 Jul 15;14(14):1965-75. Epub 2005 May 25.
14. Characterization of homo- and heterodimerization of cardiac Csx/Nkx2.5 homeoprotein. Kasahara H, etal., J Biol Chem. 2001 Feb 16;276(7):4570-80. Epub 2000 Oct 20.
15. Progressive atrioventricular conduction defects and heart failure in mice expressing a mutant Csx/Nkx2.5 homeoprotein. Kasahara H, etal., J Clin Invest. 2001 Jul;108(2):189-201.
16. Carboxyl terminus of Nkx2.5 impairs its interaction with p300. Li T, etal., J Mol Biol. 2007 Jul 27;370(5):976-92. Epub 2007 May 18.
17. Novel NKX2-5 mutations in patients with familial atrial septal defects. Liu XY, etal., Pediatr Cardiol. 2011 Feb;32(2):193-201. doi: 10.1007/s00246-010-9859-6. Epub 2010 Dec 25.
18. Cardiomyocyte differentiation of rat bone marrow multipotent progenitor cells is associated with downregulation of Oct-4 expression. Lu T, etal., Tissue Eng Part A. 2010 Oct;16(10):3111-7.
19. 17 beta-estradiol modulates expression of low-voltage-activated Ca(V)3.2 T-type calcium channel via extracellularly regulated kinase pathway in cardiomyocytes. Marni F, etal., Endocrinology. 2009 Feb;150(2):879-88. Epub 2008 Oct 1.
20. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
21. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
22. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
23. A novel stop mutation truncating critical regions of the cardiac transcription factor NKX2-5 in a large family with autosomal-dominant inherited congenital heart disease. Pabst S, etal., Clin Res Cardiol. 2008 Jan;97(1):39-42. Epub 2007 Sep 25.
24. Ventricular noncompaction and distal chromosome 5q deletion. Pauli RM, etal., Am J Med Genet 1999 Aug 6;85(4):419-23.
25. Novel and highly lethal NKX2.5 missense mutation in a family with sudden death and ventricular arrhythmia. Perera JL, etal., Pediatr Cardiol. 2014 Oct;35(7):1206-12. doi: 10.1007/s00246-014-0917-3. Epub 2014 Jun 1.
26. A novel NKX2.5 loss-of-function mutation associated with congenital bicuspid aortic valve. Qu XK, etal., Am J Cardiol. 2014 Dec 15;114(12):1891-5. doi: 10.1016/j.amjcard.2014.09.028. Epub 2014 Sep 28.
27. Somatic NKX2-5 mutations as a novel mechanism of disease in complex congenital heart disease. Reamon-Buettner SM and Borlak J, J Med Genet. 2004 Sep;41(9):684-90.
28. GOA pipeline RGD automated data pipeline
29. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
30. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
31. Epistatic rescue of Nkx2.5 adult cardiac conduction disease phenotypes by prospero-related homeobox protein 1 and HDAC3. Risebro CA, etal., Circ Res. 2012 Jul 6;111(2):e19-31. doi: 10.1161/CIRCRESAHA.111.260695. Epub 2012 May 29.
32. Congenital heart disease caused by mutations in the transcription factor NKX2-5. Schott JJ, etal., Science. 1998 Jul 3;281(5373):108-11.
33. The ambiguous role of NKX2-5 mutations in thyroid dysgenesis. van Engelen K, etal., PLoS One. 2012;7(12):e52685. doi: 10.1371/journal.pone.0052685. Epub 2012 Dec 28.
34. Novel NKX2-5 mutations responsible for congenital heart disease. Wang J, etal., Genet Mol Res. 2011 Nov 29;10(4):2905-15. doi: 10.4238/2011.November.29.1.
35. A novel NKX2-5 mutation in familial ventricular septal defect. Wang J, etal., Int J Mol Med. 2011 Mar;27(3):369-75. doi: 10.3892/ijmm.2010.585. Epub 2010 Dec 16.
36. SIRT1 mediates the protective function of Nkx2.5 during stress in cardiomyocytes. Zheng W, etal., Basic Res Cardiol. 2013 Jul;108(4):364. doi: 10.1007/s00395-013-0364-y. Epub 2013 Jun 7.
37. Functional analyses of three Csx/Nkx-2.5 mutations that cause human congenital heart disease. Zhu W, etal., J Biol Chem. 2000 Nov 10;275(45):35291-6.
Additional References at PubMed
PMID:7628699   PMID:8887666   PMID:8900044   PMID:9192865   PMID:9312027   PMID:9857019   PMID:9858576   PMID:10021345   PMID:10206974   PMID:10587520   PMID:11390666   PMID:11431700  
PMID:11572777   PMID:11784028   PMID:11889119   PMID:12023302   PMID:12297045   PMID:12392994   PMID:12754203   PMID:14550786   PMID:14645532   PMID:14978031   PMID:15085192   PMID:15109497  
PMID:15363409   PMID:15649947   PMID:15653675   PMID:15843414   PMID:16380715   PMID:16418214   PMID:16510504   PMID:16556915   PMID:16678093   PMID:17234970   PMID:17250822   PMID:17350578  
PMID:17360443   PMID:17498735   PMID:17604724   PMID:17823370   PMID:18079734   PMID:18285513   PMID:18689573   PMID:18722343   PMID:19035347   PMID:19253817   PMID:19479054   PMID:19483677  
PMID:19546853   PMID:19578358   PMID:20457810   PMID:20713518   PMID:20807224   PMID:21379568   PMID:21690310   PMID:21931855   PMID:22527936   PMID:22560297   PMID:22849347   PMID:23892084  
PMID:24866243   PMID:26926761   PMID:27207958   PMID:27747432   PMID:31104268   PMID:32780729   PMID:33035436  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81016,844,888 - 16,851,458 (+)NCBIGRCr8
mRatBN7.21016,340,428 - 16,347,004 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1016,344,159 - 16,346,934 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1021,093,028 - 21,095,888 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01020,581,977 - 20,584,837 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01016,071,642 - 16,074,502 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01016,635,989 - 16,638,758 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1016,635,989 - 16,638,764 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01016,520,570 - 16,527,836 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41016,606,183 - 16,608,952 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11016,607,231 - 16,610,001 (+)NCBI
Celera1016,004,548 - 16,007,317 (+)NCBICelera
Cytogenetic Map10q12NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh385173,232,109 - 173,235,206 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5173,232,109 - 173,235,311 (-)EnsemblGRCh38hg38GRCh38
GRCh375172,659,112 - 172,662,209 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365172,591,744 - 172,594,868 (-)NCBINCBI36Build 36hg18NCBI36
Celera5168,692,473 - 168,695,681 (-)NCBICelera
Cytogenetic Map5q35.1NCBI
HuRef5167,754,405 - 167,757,613 (-)NCBIHuRef
CHM1_15172,091,589 - 172,094,797 (-)NCBICHM1_1
T2T-CHM13v2.05173,772,181 - 173,775,278 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391727,057,638 - 27,063,962 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1727,057,638 - 27,063,983 (-)EnsemblGRCm39 Ensembl
GRCm381726,838,664 - 26,844,988 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1726,838,664 - 26,845,009 (-)EnsemblGRCm38mm10GRCm38
MGSCv371726,975,610 - 26,978,510 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361726,566,254 - 26,569,154 (-)NCBIMGSCv36mm8
Celera1727,375,289 - 27,378,187 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1713.6NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495540825,832,683 - 25,836,840 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540825,833,649 - 25,836,673 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v24168,367,607 - 168,372,490 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15166,507,149 - 166,512,032 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05168,584,197 - 168,589,406 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15175,492,288 - 175,495,514 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5175,492,288 - 175,495,514 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1439,240,755 - 39,254,585 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl439,244,286 - 39,247,592 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha439,189,667 - 39,192,973 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0439,612,560 - 39,618,296 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl439,614,913 - 39,618,296 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1439,432,539 - 39,435,856 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0439,621,539 - 39,624,869 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0440,130,495 - 40,133,809 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440721393,683,325 - 93,686,308 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366092,406,004 - 2,409,046 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366092,406,004 - 2,408,980 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1651,086,011 - 51,089,162 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11651,086,014 - 51,089,165 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21655,400,567 - 55,403,626 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.12375,391,833 - 75,399,003 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2375,391,847 - 75,395,205 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660343,212,995 - 3,216,184 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462473316,881,191 - 16,884,210 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473316,881,189 - 16,884,245 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Nkx2-5
9 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:60
Count of miRNA genes:56
Interacting mature miRNAs:59
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10124158324Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135225947Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138328221Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
1576304Schws7Schwannoma susceptibility QTL 70.0115nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)10476552719816042Rat
631828Alc5Alcohol consumption QTL 52.4consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10514402717245662Rat
737820Alc9Alcohol consumption QTL 92.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10514402719233348Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21016,346,390 - 16,347,001 (+)MAPPERmRatBN7.2
Rnor_6.01016,638,221 - 16,638,831NCBIRnor6.0
Rnor_5.01016,527,223 - 16,527,833UniSTSRnor5.0
RGSC_v3.41016,608,415 - 16,609,025UniSTSRGSC3.4
Celera1016,006,780 - 16,007,390UniSTS
Cytogenetic Map10q12UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21016,346,853 - 16,347,004 (+)MAPPERmRatBN7.2
Rnor_6.01016,638,684 - 16,638,834NCBIRnor6.0
Rnor_5.01016,527,686 - 16,527,836UniSTSRnor5.0
RGSC_v3.41016,608,878 - 16,609,028UniSTSRGSC3.4
Celera1016,007,243 - 16,007,393UniSTS
RH 3.4 Map10149.46UniSTS
Cytogenetic Map10q12UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21016,344,531 - 16,346,227 (+)MAPPERmRatBN7.2
Rnor_6.01016,636,362 - 16,638,057NCBIRnor6.0
Rnor_5.01016,525,364 - 16,527,059UniSTSRnor5.0
RGSC_v3.41016,606,556 - 16,608,251UniSTSRGSC3.4
Celera1016,004,921 - 16,006,616UniSTS
Cytogenetic Map10q12UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21016,346,121 - 16,346,297 (+)MAPPERmRatBN7.2
Rnor_6.01016,637,952 - 16,638,127NCBIRnor6.0
Rnor_5.01016,526,954 - 16,527,129UniSTSRnor5.0
RGSC_v3.41016,608,146 - 16,608,321UniSTSRGSC3.4
Celera1016,006,511 - 16,006,686UniSTS
Cytogenetic Map10q12UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21016,346,035 - 16,346,252 (+)MAPPERmRatBN7.2
Rnor_6.01016,637,866 - 16,638,082NCBIRnor6.0
Rnor_5.01016,526,868 - 16,527,084UniSTSRnor5.0
RGSC_v3.41016,608,060 - 16,608,276UniSTSRGSC3.4
Celera1016,006,425 - 16,006,641UniSTS
Cytogenetic Map10q12UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21016,344,042 - 16,344,577 (+)MAPPERmRatBN7.2
Rnor_6.01016,635,873 - 16,636,407NCBIRnor6.0
Rnor_5.01016,524,875 - 16,525,409UniSTSRnor5.0
RGSC_v3.41016,606,067 - 16,606,601UniSTSRGSC3.4
Celera1016,004,432 - 16,004,966UniSTS
Cytogenetic Map10q12UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 43 2 3
Low 4 4 9 4 4 6
Below cutoff 12 7 4 7 1 1 4 5 13 3 1


RefSeq Acc Id: ENSRNOT00000028155   ⟹   ENSRNOP00000028155
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1016,344,159 - 16,346,934 (+)Ensembl
Rnor_6.0 Ensembl1016,635,989 - 16,638,764 (+)Ensembl
RefSeq Acc Id: NM_053651   ⟹   NP_446103
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
GRCr81016,848,600 - 16,851,458 (+)NCBI
mRatBN7.21016,344,146 - 16,347,004 (+)NCBI
Rnor_6.01016,635,989 - 16,638,758 (+)NCBI
Rnor_5.01016,520,570 - 16,527,836 (+)NCBI
RGSC_v3.41016,606,183 - 16,608,952 (+)RGD
Celera1016,004,548 - 16,007,317 (+)RGD
RefSeq Acc Id: XM_039085022   ⟹   XP_038940950
Rat AssemblyChrPosition (strand)Source
GRCr81016,844,888 - 16,851,454 (+)NCBI
mRatBN7.21016,340,428 - 16,347,004 (+)NCBI
Protein Sequences
Protein RefSeqs NP_446103 (Get FASTA)   NCBI Sequence Viewer  
  XP_038940950 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB62696 (Get FASTA)   NCBI Sequence Viewer  
  EDM04040 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000028155
GenBank Protein O35767 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_446103   ⟸   NM_053651
- UniProtKB: O35767 (UniProtKB/Swiss-Prot),   G3V8T2 (UniProtKB/TrEMBL),   A6HDD5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000028155   ⟸   ENSRNOT00000028155
RefSeq Acc Id: XP_038940950   ⟸   XM_039085022
- Peptide Label: isoform X1
- UniProtKB: O35767 (UniProtKB/Swiss-Prot),   G3V8T2 (UniProtKB/TrEMBL),   A6HDD5 (UniProtKB/TrEMBL)
Protein Domains

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35767-F1-model_v2 AlphaFold O35767 1-318 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620520 AgrOrtholog
BioCyc Gene G2FUF-25651 BioCyc
Ensembl Genes ENSRNOG00000020747 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000028155 ENTREZGENE
  ENSRNOT00000028155.6 UniProtKB/TrEMBL
Gene3D-CATH Homeodomain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Homeobox-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_metazoa UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:114109 UniProtKB/Swiss-Prot
  PTHR24340:SF28 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Homeodomain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nkx2-5 PhenoGen
  HOMEOBOX_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020747 RatGTEx
SMART HOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF46689 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NKX25_RAT UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-02 Nkx2-5  NK2 homeobox 5  Nkx2-5  NK2 transcription factor related, locus 5 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Nkx2-5  NK2 transcription factor related, locus 5 (Drosophila)  Csx    Symbol updated 1299863 APPROVED
2002-08-07 Csx  NK2 transcription factor related, locus 5 (Drosophila)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_function binds within the ECE-1c promoter to activate expression of Endothelin-converting enzyme-1 727751