Gene: Nkx2-5 (NK2 homeobox 5) Rattus norvegicus
Analyze
Symbol:
Nkx2-5
Name:
NK2 homeobox 5
Description:
ENCODES a protein that exhibits DNA-binding transcription factor activity; histone deacetylase binding; protein homodimerization activity; INVOLVED IN cardiac muscle cell differentiation; cellular response to growth factor stimulus; cellular response to hydrogen peroxide; ASSOCIATED WITH pulmonary fibrosis; aortic valve disease 2 (ortholog); atrial fibrillation (ortholog); FOUND IN nucleus; cytoplasm (ortholog); protein-containing complex (ortholog); INTERACTS WITH acrylamide; ammonium chloride; bisphenol A
AGR Description:
Exhibits several functions, including DNA-binding transcription factor activity, histone deacetylase binding activity, and protein homodimerization activity; involved in several processes, including cardiac muscle cell differentiation, cellular response to growth factor stimulus, and cellular response to hydrogen peroxide; localizes to the nucleus; biomarker of pulmonary fibrosis; orthologous to human NKX2-5 (NK2 homeobox 5).
Merged Description:
Exhibits several functions, including DNA-binding transcription factor activity, histone deacetylase binding activity, and protein homodimerization activity; involved in several processes, including cardiac muscle cell differentiation, cellular response to growth factor stimulus, and cellular response to hydrogen peroxide; localizes to the nucleus; biomarker of pulmonary fibrosis; orthologous to human NKX2-5 (NK2 homeobox 5); INTERACTS WITH acrylamide; ammonium chloride; bisphenol A.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
Csx; homeobox protein NK-2 homolog E; homeobox protein Nkx-2.5; NK2 transcription factor related, locus 5; NK2 transcription factor related, locus 5 (Drosophila); Nkx2.5; rNKx-2.5
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
NKX2-5 (NK2 homeobox 5) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):
Nkx2-5 (NK2 homeobox 5) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Nkx2-5 (NK2 homeobox 5) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
NKX2-5 (NK2 homeobox 5) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
NKX2-5 (NK2 homeobox 5) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Nkx2-5 (NK2 homeobox 5) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
NKX2-5 (NK2 homeobox 5) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Mus musculus (house mouse):
Nkx2-5 (NK2 homeobox 5)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Homo sapiens (human):
NKX2-5 (NK2 homeobox 5)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):
nkx2.5 (NK2 homeobox 5)
Alliance
DIOPT (Ensembl Compara, Hieranoid, OMA, OrthoFinder, PhylomeDB, TreeFam)
Drosophila melanogaster (fruit fly):
tin
Alliance
DIOPT (Ensembl Compara, PhylomeDB, TreeFam)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 10 16,635,989 - 16,638,758 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_5.0 10 16,520,570 - 16,527,836 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 10 16,606,183 - 16,608,952 (+) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 10 16,607,231 - 16,610,001 (+) NCBI Celera 10 16,004,548 - 16,007,317 (+) NCBI Celera Cytogenetic Map 10 q12 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - ClinVar
atrial heart septal defect ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Atrial septal defect ClinVar PMID:18414213 more ... atrial heart septal defect ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Atrial septal defect ClinVar PMID:24033266 atrial heart septal defect 7 ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Atrial septal defect 7 with or without atrioventricular conduction defects ClinVar PMID:28492532 atrial heart septal defect 7 ISO RGD:1606841 8554872 ClinVar Annotator: match by term: ASD WITH OR WITHOUT ATRIOVENTRICULAR CONDUCTION DEFECTS ClinVar PMID:14607454 PMID:28492532 atrial heart septal defect 7 ISO RGD:1606841 8554872 ClinVar Annotator: match by term: ASD WITH OR WITHOUT ATRIOVENTRICULAR CONDUCTION DEFECTS ClinVar PMID:10948187 more ... atrial heart septal defect 7 ISO RGD:1606841 8554872 ClinVar Annotator: match by term: ASD WITH OR WITHOUT ATRIOVENTRICULAR CONDUCTION DEFECTS ClinVar PMID:18414213 more ... atrial heart septal defect 7 ISO RGD:1606841 8554872 ClinVar Annotator: match by term: ASD WITH OR WITHOUT ATRIOVENTRICULAR CONDUCTION DEFECTS ClinVar PMID:19948535 more ... atrial heart septal defect 7 ISO RGD:1606841 8554872 ClinVar Annotator: match by term: ASD WITH OR WITHOUT ATRIOVENTRICULAR CONDUCTION DEFECTS ClinVar PMID:18076106 more ... atrial heart septal defect 7 ISO RGD:1606841 8554872 ClinVar Annotator: match by term: ASD WITH OR WITHOUT ATRIOVENTRICULAR CONDUCTION DEFECTS ClinVar PMID:18414213 more ... atrial heart septal defect 7 ISO RGD:1606841 8554872 ClinVar Annotator: match by term: ASD WITH OR WITHOUT ATRIOVENTRICULAR CONDUCTION DEFECTS ClinVar PMID:15689439 PMID:28492532 atrial heart septal defect 7 ISO RGD:1606841 8554872 ClinVar Annotator: match by term: ASD WITH OR WITHOUT ATRIOVENTRICULAR CONDUCTION DEFECTS ClinVar PMID:18414213 more ... atrial heart septal defect 7 ISO RGD:1606841 8554872 ClinVar Annotator: match by term: ASD WITH OR WITHOUT ATRIOVENTRICULAR CONDUCTION DEFECTS ClinVar PMID:19533775 more ... atrial heart septal defect 7 ISO RGD:1606841 8554872 ClinVar Annotator: match by term: ASD WITH OR WITHOUT ATRIOVENTRICULAR CONDUCTION DEFECTS ClinVar PMID:16418214 more ... atrial heart septal defect 7 ISO RGD:1606841 8554872 ClinVar Annotator: match by term: ASD WITH OR WITHOUT ATRIOVENTRICULAR CONDUCTION DEFECTS ClinVar PMID:23661673 more ... atrial heart septal defect 7 ISO RGD:1606841 8554872 ClinVar Annotator: match by term: ASD WITH OR WITHOUT ATRIOVENTRICULAR CONDUCTION DEFECTS ClinVar PMID:24880466 PMID:25319568 atrial heart septal defect 7 ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Atrial septal defect 7 with or without atrioventricular conduction defects ClinVar PMID:11714651 more ... atrial heart septal defect 7 ISO RGD:1606841 8554872 ClinVar Annotator: match by term: ASD WITH OR WITHOUT ATRIOVENTRICULAR CONDUCTION DEFECTS ClinVar PMID:10587520 more ... atrial heart septal defect 7 ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Atrial septal defect 7 with or without atrioventricular conduction defects ClinVar PMID:25741868 PMID:28492532 atrial heart septal defect 7 ISO RGD:1606841 8554872 ClinVar Annotator: match by term: ASD WITH OR WITHOUT ATRIOVENTRICULAR CONDUCTION DEFECTS ClinVar PMID:10021345 PMID:28492532 atrial heart septal defect 7 ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Atrial septal defect 7 with or without atrioventricular conduction defects ClinVar PMID:18414213 PMID:28492532 atrial heart septal defect 7 ISO RGD:1606841 8554872 ClinVar Annotator: match by OMIM:108900 ClinVar PMID:25741868 atrial heart septal defect 7 ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Atrial septal defect 7 with or without atrioventricular conduction defects ClinVar PMID:21110066 PMID:28492532 atrial heart septal defect 7 ISO RGD:1606841 8554872 ClinVar Annotator: match by OMIM:108900 ClinVar PMID:14607454 atrial heart septal defect 7 ISO RGD:1606841 8554872 ClinVar Annotator: match by OMIM:108900 ClinVar PMID:15810002 atrial heart septal defect 7 ISO RGD:1606841 8554872 ClinVar Annotator: match by OMIM:108900 ClinVar atrial heart septal defect 7 ISO RGD:1606841 8554872 ClinVar Annotator: match by OMIM:108900 ClinVar PMID:16896344 atrial heart septal defect 7 ISO RGD:1606841 8554872 ClinVar Annotator: match by OMIM:108900 ClinVar PMID:12414819 atrial heart septal defect 7 ISO RGD:1606841 8554872 ClinVar Annotator: match by OMIM:108900 ClinVar PMID:15342699 atrial heart septal defect 7 ISO RGD:1606841 8554872 ClinVar Annotator: match by OMIM:108900 ClinVar PMID:10021345 more ... atrial heart septal defect 7 ISO RGD:1606841 8554872 ClinVar Annotator: match by OMIM:108900 ClinVar PMID:10021345 PMID:10943630 atrial heart septal defect 7 ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Atrial septal defect 7 with or without atrioventricular conduction defects ClinVar PMID:11714651 more ... Atrial Septal Defect with Atrioventricular Conduction Defects ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Atrial septal defect with atrioventricular conduction defects ClinVar PMID:15810002 Atrial Septal Defect with Atrioventricular Conduction Defects ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Atrial septal defect with atrioventricular conduction defects ClinVar PMID:14607454 PMID:28492532 Atrial Septal Defect with Atrioventricular Conduction Defects ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Atrial septal defect with atrioventricular conduction defects ClinVar PMID:10948187 more ... Atrial Septal Defect with Atrioventricular Conduction Defects ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Atrial septal defect with atrioventricular conduction defects ClinVar PMID:18414213 more ... Atrial Septal Defect with Atrioventricular Conduction Defects ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Atrial septal defect with atrioventricular conduction defects ClinVar PMID:19948535 more ... Atrial Septal Defect with Atrioventricular Conduction Defects ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Atrial septal defect with atrioventricular conduction defects ClinVar PMID:18076106 more ... Atrial Septal Defect with Atrioventricular Conduction Defects ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Atrial septal defect with atrioventricular conduction defects ClinVar PMID:18414213 more ... Atrial Septal Defect with Atrioventricular Conduction Defects ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Atrial septal defect with atrioventricular conduction defects ClinVar PMID:15689439 PMID:28492532 Atrial Septal Defect with Atrioventricular Conduction Defects ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Atrial septal defect with atrioventricular conduction defects ClinVar PMID:18414213 more ... Atrial Septal Defect with Atrioventricular Conduction Defects ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Atrial septal defect with atrioventricular conduction defects ClinVar PMID:19533775 more ... Atrial Septal Defect with Atrioventricular Conduction Defects ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Atrial septal defect with atrioventricular conduction defects ClinVar PMID:25741868 Atrial Septal Defect with Atrioventricular Conduction Defects ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Atrial septal defect with atrioventricular conduction defects ClinVar PMID:11714651 more ... Atrial Septal Defect with Atrioventricular Conduction Defects ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Atrial septal defect with atrioventricular conduction defects ClinVar PMID:14607454 Atrial Septal Defect with Atrioventricular Conduction Defects ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Atrial septal defect with atrioventricular conduction defects ClinVar PMID:21110066 PMID:28492532 Atrial Septal Defect with Atrioventricular Conduction Defects ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Atrial septal defect with atrioventricular conduction defects ClinVar PMID:16418214 more ... Atrial Septal Defect with Atrioventricular Conduction Defects ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Atrial septal defect with atrioventricular conduction defects ClinVar PMID:12414819 Atrial Septal Defect with Atrioventricular Conduction Defects ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Atrial septal defect with atrioventricular conduction defects ClinVar PMID:23661673 more ... Atrial Septal Defect with Atrioventricular Conduction Defects ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Atrial septal defect with atrioventricular conduction defects ClinVar PMID:10021345 PMID:10943630 Atrial Septal Defect with Atrioventricular Conduction Defects ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Atrial septal defect with atrioventricular conduction defects ClinVar PMID:11714651 more ... Atrial Septal Defect with Atrioventricular Conduction Defects ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Atrial septal defect with atrioventricular conduction defects ClinVar PMID:24880466 PMID:25319568 Atrial Septal Defect with Atrioventricular Conduction Defects ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Atrial septal defect with atrioventricular conduction defects ClinVar PMID:25741868 PMID:28492532 Atrial Septal Defect with Atrioventricular Conduction Defects ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Atrial septal defect with atrioventricular conduction defects ClinVar PMID:10587520 more ... Atrial Septal Defect with Atrioventricular Conduction Defects ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Atrial septal defect with atrioventricular conduction defects ClinVar PMID:16896344 Atrial Septal Defect with Atrioventricular Conduction Defects ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Atrial septal defect with atrioventricular conduction defects ClinVar Atrial Septal Defect with Atrioventricular Conduction Defects ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Atrial septal defect with atrioventricular conduction defects ClinVar PMID:10021345 PMID:28492532 Atrial Septal Defect with Atrioventricular Conduction Defects ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Atrial septal defect with atrioventricular conduction defects ClinVar PMID:15342699 Atrial Septal Defect with Atrioventricular Conduction Defects ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Atrial septal defect with atrioventricular conduction defects ClinVar PMID:28492532 Atrial Septal Defect with Atrioventricular Conduction Defects ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Atrial septal defect with atrioventricular conduction defects ClinVar PMID:18414213 PMID:28492532 Atrial Septal Defect with Atrioventricular Conduction Defects ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Atrial septal defect with atrioventricular conduction defects ClinVar PMID:10021345 more ... atrioventricular septal defect ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Atrioventricular septal defect, somatic ClinVar PMID:15342699 atrioventricular septal defect ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Atrioventricular septal defect, somatic ClinVar PMID:15917268 Cardiovascular Abnormalities ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Abnormality of cardiovascular system morphology ClinVar PMID:18414213 Cardiovascular Abnormalities ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Abnormality of cardiovascular system morphology ClinVar PMID:18414213 more ... Common Ventricle ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Single ventricle ClinVar PMID:19948535 more ... Congenital Disorder of Glycosylation Type 1I ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Congenital disorders of glycosylation type II ClinVar congenital heart disease ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Malformation of the heart and great vessels ClinVar PMID:18414213 more ... congenital heart disease ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Malformation of the heart and great vessels ClinVar PMID:18414213 more ... congenital heart disease ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Malformation of the heart and great vessels ClinVar PMID:10587520 more ... congenital heart disease ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Congenital heart disease ClinVar PMID:11714651 more ... congenital heart disease ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Malformation of the heart and great vessels ClinVar PMID:18414213 congenital heart disease ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Malformation of the heart and great vessels ClinVar congenital nongoitrous hypothyroidism 5 ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Hypothyroidism, congenital, nongoitrous, 5 ClinVar PMID:10587520 more ... congenital nongoitrous hypothyroidism 5 ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Hypothyroidism, congenital, nongoitrous, 5 ClinVar PMID:16418214 more ... congenital nongoitrous hypothyroidism 5 ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Hypothyroidism, congenital, nongoitrous, 5 ClinVar PMID:16418214 Conotruncal Cardiac Defects ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Truncus arteriosus communis ClinVar PMID:10587520 more ... dilated cardiomyopathy ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Primary dilated cardiomyopathy ClinVar PMID:25741868 double outlet right ventricle ISO RGD:1606841 8554872 ClinVar Annotator: match by null ClinVar PMID:14607454 double outlet right ventricle ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Double outlet right ventricle ClinVar PMID:14607454 PMID:28492532 genetic disease ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Inborn genetic diseases ClinVar PMID:11714651 more ... Hypoplastic Left Heart Syndrome 2 ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Hypoplastic left heart syndrome 2 ClinVar PMID:10587520 more ... Splenic Hypoplasia ISO RGD:1606841 8554872 ClinVar Annotator: match by null ClinVar PMID:20846672 more ... tetralogy of Fallot ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Tetralogy of Fallot ClinVar PMID:11714651 more ... tetralogy of Fallot ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Tetralogy of Fallot ClinVar PMID:10587520 more ... tetralogy of Fallot ISO RGD:1606841 8554872 ClinVar Annotator: match by OMIM:187500 ClinVar PMID:11714651 tetralogy of Fallot ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Tetralogy of Fallot ClinVar PMID:11714651 more ... Ventricular Septal Defect 3 ISO RGD:1606841 8554872 ClinVar Annotator: match by OMIM:614432 ClinVar PMID:20659440 Ventricular Septal Defect 3 ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Ventricular septal defect 3 ClinVar PMID:25741868 PMID:28492532 Ventricular Septal Defect 3 ISO RGD:1606841 8554872 ClinVar Annotator: match by term: Ventricular septal defect 3 ClinVar PMID:21110066 PMID:28492532 Ventricular Septal Defect 3 ISO RGD:1606841 8554872 ClinVar Annotator: match by OMIM:614432 ClinVar PMID:21165553
Imported Annotations - CTD
atrial fibrillation ISO RGD:1606841 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:20062060 more ... Cardiomegaly ISO RGD:1606841 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:28973413 dilated cardiomyopathy ISO RGD:1606841 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:28973413 hypoplastic left heart syndrome ISO RGD:1606841 11554173 CTD Direct Evidence: marker/mechanism CTD myotonic dystrophy type 1 ISO RGD:1606841 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:18084293 Stroke ISO RGD:1606841 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:29531354 ventricular septal defect ISO RGD:1606841 11554173 CTD Direct Evidence: marker/mechanism CTD Imported Annotations - MGI
double outlet right ventricle ISS RGD:1606841 13592920 OMIM:217095 MouseDO Imported Annotations - OMIM
atrial heart septal defect 7 ISO RGD:1606841 7240710 OMIM congenital nongoitrous hypothyroidism 5 ISO RGD:1606841 7240710 OMIM Conotruncal Cardiac Defects ISO RGD:1606841 7240710 OMIM Hypoplastic Left Heart Syndrome 2 ISO RGD:1606841 7240710 OMIM tetralogy of Fallot ISO RGD:1606841 7240710 OMIM Ventricular Septal Defect 3 ISO RGD:1606841 7240710 OMIM
2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:731878 6480464 Tetrachlorodibenzodioxin results in increased expression of NKX2-5 mRNA CTD PMID:24058054 2,3,7,8-tetrachlorodibenzodioxine decreases localization ISO RGD:731878 6480464 Tetrachlorodibenzodioxin results in decreased localization of NKX2-5 protein CTD PMID:26139165 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:731878 6480464 Tetrachlorodibenzodioxin affects the expression of NKX2-5 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:731878 6480464 Tetrachlorodibenzodioxin results in decreased expression of NKX2-5 mRNA; more ... CTD PMID:20130022 5-azacytidine increases expression ISO RGD:1606841 6480464 Azacitidine results in increased expression of NKX2-5 mRNA CTD PMID:18557828 acrylamide decreases expression EXP 6480464 Acrylamide results in decreased expression of NKX2-5 mRNA CTD PMID:28959563 all-trans-retinoic acid multiple interactions ISO RGD:1606841 6480464 [Tretinoin co-treated with Phenylbutyrates co-treated with 1-hydroxy-2-oxo-3,3-bis(2-aminoethyl)-1-triazene] results in increased expression of NKX2-5 protein CTD PMID:23284745 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of NKX2-5 mRNA CTD PMID:16483693 arsenite(3-) increases methylation ISO RGD:1606841 6480464 arsenite results in increased methylation of NKX2-5 promoter CTD PMID:23974009 benzo[a]pyrene decreases expression ISO RGD:731878 6480464 Benzo(a)pyrene results in decreased expression of NKX2-5 mRNA CTD PMID:22228805 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of NKX2-5 mRNA CTD PMID:25181051 bisphenol A affects methylation ISO RGD:731878 6480464 bisphenol A affects the methylation of NKX2-5 promoter CTD PMID:27334623 cadmium dichloride decreases expression ISO RGD:1606841 6480464 Cadmium Chloride results in decreased expression of NKX2-5 mRNA CTD PMID:26472689 cisplatin increases expression ISO RGD:1606841 6480464 Cisplatin results in increased expression of NKX2-5 mRNA CTD PMID:19561079 PMID:27392435 cisplatin multiple interactions ISO RGD:1606841 6480464 [Cisplatin co-treated with jinfukang] results in increased expression of NKX2-5 mRNA CTD PMID:27392435 curcumin decreases expression ISO RGD:731878 6480464 Curcumin results in decreased expression of NKX2-5 mRNA CTD PMID:27237783 doxorubicin decreases expression EXP 6480464 Doxorubicin results in decreased expression of NKX2-5 mRNA CTD PMID:11073966 doxorubicin decreases expression ISO RGD:1606841 6480464 Doxorubicin results in decreased expression of NKX2-5 mRNA CTD PMID:29803840 homocysteine multiple interactions EXP 6480464 Particulate Matter promotes the reaction [Homocysteine results in decreased expression of NKX2-5 protein] CTD PMID:27203204 homocysteine decreases expression EXP 6480464 Homocysteine results in decreased expression of NKX2-5 mRNA; more ... CTD PMID:27203204 hydrogen peroxide increases expression ISO RGD:731878 6480464 Hydrogen Peroxide results in increased expression of NKX2-5 mRNA CTD PMID:23562911 icariin increases expression ISO RGD:731878 6480464 icariin results in increased expression of NKX2-5 mRNA CTD PMID:16490167 isoprenaline multiple interactions ISO RGD:731878 6480464 [Phenylephrine co-treated with Isoproterenol] results in increased expression of NKX2-5 mRNA CTD PMID:10710348 L-ascorbic acid increases expression ISO RGD:731878 6480464 Ascorbic Acid results in increased expression of NKX2-5 mRNA CTD PMID:12668514 leflunomide increases expression ISO RGD:1606841 6480464 leflunomide results in increased expression of NKX2-5 mRNA CTD PMID:28988120 metacetamol decreases expression ISO RGD:731878 6480464 3-hydroxyacetanilide results in decreased expression of NKX2-5 mRNA CTD PMID:18544908 paracetamol decreases expression ISO RGD:731878 6480464 Acetaminophen results in decreased expression of NKX2-5 mRNA CTD PMID:18544908 perfluorooctane-1-sulfonic acid increases expression ISO RGD:731878 6480464 perfluorooctane sulfonic acid results in increased expression of NKX2-5 mRNA CTD PMID:23562911 perfluorooctane-1-sulfonic acid decreases expression ISO RGD:731878 6480464 perfluorooctane sulfonic acid results in decreased expression of NKX2-5 mRNA CTD PMID:23562911 phenylephrine multiple interactions ISO RGD:731878 6480464 [Phenylephrine co-treated with Isoproterenol] results in increased expression of NKX2-5 mRNA CTD PMID:10710348 pirinixic acid increases expression ISO RGD:731878 6480464 pirinixic acid results in increased expression of NKX2-5 mRNA CTD PMID:17951219 trichloroethene increases expression ISO RGD:1606841 6480464 Trichloroethylene results in increased expression of NKX2-5 mRNA CTD PMID:25847060 valproic acid increases expression ISO RGD:731878 6480464 Valproic Acid results in increased expression of NKX2-5 mRNA CTD PMID:21427059 PMID:27237783
Biological Process adult heart development ISO RGD:1606841 1624291 RGD PMID:9651244 adult heart development IEA UniProtKB:P52952|ensembl:ENSP00000327758 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 adult heart development IEA UniProtKB:P42582|ensembl:ENSMUSP00000015723 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 adult heart development ISO RGD:731878 1624291 MGI:MGI:1927227 RGD MGI:MGI:74918 PMID:7628699 apoptotic process involved in heart morphogenesis ISO RGD:731878 1624291 RGD MGI:MGI:3773736 PMID:16510504 apoptotic process involved in heart morphogenesis IEA UniProtKB:P42582|ensembl:ENSMUSP00000015723 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 atrial septum morphogenesis ISO RGD:1606841 1624291 RGD PMID:10587520 PMID:9651244 atrial septum morphogenesis IEA UniProtKB:P52952|ensembl:ENSP00000327758 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 atrioventricular node cell development ISO RGD:731878 1624291 MGI:MGI:3042511 RGD MGI:MGI:4355491 PMID:19546853 atrioventricular node cell development IEA UniProtKB:P42582|ensembl:ENSMUSP00000015723 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 atrioventricular node cell fate commitment ISO RGD:731878 1624291 MGI:MGI:3042511 RGD MGI:MGI:3040116 PMID:15109497 atrioventricular node cell fate commitment IEA UniProtKB:P42582|ensembl:ENSMUSP00000015723 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 atrioventricular node development ISO RGD:731878 1624291 RGD MGI:MGI:3829107 PMID:18689573 BMP signaling pathway ISO RGD:731878 1624291 RGD MGI:MGI:3703823 PMID:17360443 BMP signaling pathway IEA UniProtKB:P42582|ensembl:ENSMUSP00000015723 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 bundle of His development ISO RGD:731878 1624291 MGI:MGI:102541 RGD MGI:MGI:3716040 PMID:17604724 bundle of His development IEA UniProtKB:P42582|ensembl:ENSMUSP00000015723 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 canonical Wnt signaling pathway ISO RGD:731878 1624291 RGD MGI:MGI:3703823 PMID:17360443 canonical Wnt signaling pathway IEA UniProtKB:P42582|ensembl:ENSMUSP00000015723 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 cardiac conduction system development ISO RGD:731878 1624291 MGI:MGI:106211 RGD MGI:MGI:5052204 PMID:21690310 cardiac conduction system development ISO RGD:1606841 1624291 RGD PMID:15109497 PMID:27207958 cardiac muscle cell differentiation IEP 5131636 RGD cardiac muscle cell differentiation ISO RGD:731878 1624291 MGI:MGI:1857618|MGI:MGI:3655239|MGI:MGI:99458 RGD MGI:MGI:1329801 more ... cardiac muscle cell proliferation ISO RGD:731878 1624291 MGI:MGI:109452 RGD MGI:MGI:5429684 PMID:17350578 cardiac muscle cell proliferation IEA UniProtKB:P42582|ensembl:ENSMUSP00000015723 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 cardiac muscle contraction ISO RGD:731878 1624291 MGI:MGI:3042511 RGD MGI:MGI:4355491 PMID:19546853 cardiac muscle contraction IEA InterPro:IPR033629 1600115 GO_REF:0000002 InterPro GO_REF:0000002 cardiac muscle contraction IEA UniProtKB:P42582|ensembl:ENSMUSP00000015723 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 cardiac muscle tissue development ISO RGD:731878 1624291 MGI:MGI:1927227 RGD MGI:MGI:74918 PMID:7628699 cardiac muscle tissue morphogenesis ISO RGD:1606841 1624291 RGD PMID:11889119 cardiac ventricle formation ISO RGD:731878 1624291 MGI:MGI:99458 RGD MGI:MGI:3820390 PMID:19035347 cardiac ventricle formation IEA UniProtKB:P42582|ensembl:ENSMUSP00000015723 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 cardiac ventricle morphogenesis ISO RGD:731878 1624291 RGD MGI:MGI:3773736 PMID:16510504 cardiovascular system development ISO RGD:731878 1624291 MGI:MGI:1914004 RGD MGI:MGI:4829405 PMID:20713518 cell differentiation ISO RGD:731878 1624291 MGI:MGI:97351 RGD MGI:MGI:2135851 PMID:11390666 cell differentiation IBA FB:FBgn0000576|FB:FBgn0002941|FB:FBgn0004110|FB:FBgn0028993|FB:FBgn0040318|FB:FBgn0261930|MGI:MGI:108015|MGI:MGI:108067|MGI:MGI:1206039|MGI:MGI:1270158|MGI:MGI:1352738|MGI:MGI:1921811|MGI:MGI:97347|MGI:MGI:97348|MGI:MGI:97350|MGI:MGI:97351|PANTHER:PTN000678271|RGD:620520|RGD:69318|UniProtKB:P52952|WB:WBGene00000445|WB:WBGene00000584|ZFIN:ZDB-GENE-030328-42|ZFIN:ZDB-GENE-040718-178|ZFIN:ZDB-GENE-050217-3|ZFIN:ZDB-GENE-070626-1|ZFIN:ZDB-GENE-980526-321|ZFIN:ZDB-GENE-980526-403|ZFIN:ZDB-GENE-990415-179 13792537 PMID:21873635 GO_Central cellular response to growth factor stimulus IEP 5131637 RGD cellular response to hydrogen peroxide IEP 12911227 RGD embryonic heart tube development ISO RGD:731878 1624291 MGI:MGI:1888496 RGD MGI:MGI:3578574 PMID:15843414 embryonic heart tube left/right pattern formation ISO RGD:731878 1624291 MGI:MGI:1927227 RGD MGI:MGI:892786 PMID:9192865 embryonic heart tube left/right pattern formation IEA UniProtKB:P42582|ensembl:ENSMUSP00000015723 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 heart contraction ISO RGD:731878 1624291 MGI:MGI:106211 RGD MGI:MGI:5052204 PMID:21690310 heart development ISO RGD:731878 1624291 MGI:MGI:1857618|MGI:MGI:97351 RGD MGI:MGI:1329801 more ... heart looping ISO RGD:731878 1624291 MGI:MGI:1927227 RGD MGI:MGI:3773736 more ... heart looping IEA UniProtKB:P42582|ensembl:ENSMUSP00000015723 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 heart morphogenesis ISO RGD:731878 1624291 MGI:MGI:1927227 RGD MGI:MGI:2153294 PMID:11784028 heart trabecula formation ISO RGD:731878 1624291 RGD MGI:MGI:3773736 PMID:16510504 heart trabecula formation IEA UniProtKB:P42582|ensembl:ENSMUSP00000015723 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 hemopoiesis ISO RGD:731878 1624291 MGI:MGI:1857618 RGD MGI:MGI:1329801 PMID:10021345 hemopoiesis IEA UniProtKB:P42582|ensembl:ENSMUSP00000015723 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of apoptotic process ISO RGD:731878 1624291 MGI:MGI:97351 RGD MGI:MGI:2135851 PMID:11390666 negative regulation of canonical Wnt signaling pathway ISO RGD:731878 1624291 RGD MGI:MGI:3848291 PMID:19479054 negative regulation of canonical Wnt signaling pathway IEA UniProtKB:P42582|ensembl:ENSMUSP00000015723 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of cardiac muscle cell apoptotic process ISO RGD:1606841 1624291 RGD PMID:11889119 negative regulation of cardiac muscle cell apoptotic process IEA UniProtKB:P52952|ensembl:ENSP00000327758 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of cardiac muscle cell apoptotic process IEA UniProtKB:P42582|ensembl:ENSMUSP00000015723 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of cardiac muscle cell apoptotic process ISO RGD:731878 1624291 RGD MGI:MGI:3784761 PMID:11889119 negative regulation of myotube differentiation ISO RGD:1606841 1624291 RGD PMID:15653675 negative regulation of myotube differentiation IEA UniProtKB:P52952|ensembl:ENSP00000327758 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of transcription by RNA polymerase II IDA 5131637 RGD negative regulation of transcription by RNA polymerase II IEA UniProtKB:P52952|ensembl:ENSP00000327758 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of transcription by RNA polymerase II IEA UniProtKB:P42582|ensembl:ENSMUSP00000015723 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of transcription by RNA polymerase II ISO RGD:731878 1624291 MGI:MGI:1276574 RGD MGI:MGI:2179901 more ... negative regulation of transcription by RNA polymerase II ISO RGD:1606841 1624291 RGD PMID:19479054 outflow tract morphogenesis ISO RGD:731878 1624291 MGI:MGI:99458 RGD MGI:MGI:3773736 more ... outflow tract septum morphogenesis ISO RGD:1606841 1624291 RGD PMID:20807224 outflow tract septum morphogenesis IEA UniProtKB:P52952|ensembl:ENSP00000327758 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 pharyngeal system development ISO RGD:731878 1624291 MGI:MGI:97351 RGD MGI:MGI:2135851 PMID:11390666 pharyngeal system development IEA UniProtKB:P42582|ensembl:ENSMUSP00000015723 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of cardioblast differentiation ISO RGD:731878 1624291 RGD MGI:MGI:3784761 PMID:11889119 positive regulation of cardioblast differentiation IEA UniProtKB:P42582|ensembl:ENSMUSP00000015723 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of cell population proliferation ISO RGD:731878 1624291 MGI:MGI:97351 RGD MGI:MGI:2135851 PMID:11390666 positive regulation of cell population proliferation IEA UniProtKB:P42582|ensembl:ENSMUSP00000015723 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of gene expression ISO RGD:731878 1624291 RGD MGI:MGI:5142394 PMID:9857019 positive regulation of heart contraction ISO RGD:731878 1624291 RGD MGI:MGI:3829107 PMID:18689573 positive regulation of heart contraction IEA UniProtKB:P42582|ensembl:ENSMUSP00000015723 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of neuron differentiation ISO RGD:1606841 1624291 RGD PMID:15653675 positive regulation of neuron differentiation IEA UniProtKB:P52952|ensembl:ENSP00000327758 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of sodium ion transport ISO RGD:731878 1624291 RGD MGI:MGI:3829107 PMID:18689573 positive regulation of sodium ion transport IEA UniProtKB:P42582|ensembl:ENSMUSP00000015723 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of transcription by RNA polymerase II ISO RGD:1606841 1624291 UniProtKB:O70218|UniProtKB:O94983 RGD PMID:10206974 more ... positive regulation of transcription by RNA polymerase II IBA FB:FBgn0004110|FB:FBgn0004862|FB:FBgn0040318|FB:FBgn0261930|MGI:MGI:108067|MGI:MGI:97347|MGI:MGI:97348|MGI:MGI:97350|PANTHER:PTN000678271|RGD:3866|UniProtKB:A6NCS4|UniProtKB:A6NJ46|UniProtKB:O15522|UniProtKB:P43699|UniProtKB:P52952|UniProtKB:Q99801|WB:WBGene00000445|WB:WBGene00000450 13792537 PMID:21873635 GO_Central positive regulation of transcription by RNA polymerase II ISO RGD:731878 1624291 MGI:MGI:102541|MGI:MGI:103580|MGI:MGI:1197010|MGI:MGI:1347465|MGI:MGI:98493 RGD MGI:MGI:3055632 more ... positive regulation of transcription initiation from RNA polymerase II promoter ISO RGD:731878 1624291 RGD MGI:MGI:83559 PMID:8887666 positive regulation of transcription initiation from RNA polymerase II promoter IEA UniProtKB:P42582|ensembl:ENSMUSP00000015723 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of transcription via serum response element binding ISO RGD:731878 1624291 RGD MGI:MGI:83559 PMID:8887666 positive regulation of transcription via serum response element binding IEA UniProtKB:P42582|ensembl:ENSMUSP00000015723 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of transcription, DNA-templated ISO RGD:731878 1624291 RGD MGI:MGI:2150876 more ... positive regulation of transcription, DNA-templated ISO RGD:1606841 1624291 RGD PMID:11431700 proepicardium development ISO RGD:731878 1624291 MGI:MGI:2654594 RGD MGI:MGI:3815254 PMID:18722343 proepicardium development IEA UniProtKB:P42582|ensembl:ENSMUSP00000015723 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 pulmonary myocardium development ISO RGD:731878 1624291 MGI:MGI:2448972 RGD MGI:MGI:3818134 PMID:17823370 pulmonary myocardium development IEA UniProtKB:P42582|ensembl:ENSMUSP00000015723 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 Purkinje myocyte differentiation ISO RGD:731878 1624291 MGI:MGI:1857618 RGD MGI:MGI:3785685 PMID:17250822 Purkinje myocyte differentiation IEA UniProtKB:P42582|ensembl:ENSMUSP00000015723 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of cardiac conduction ISO RGD:731878 1624291 RGD MGI:MGI:3829107 PMID:18689573 regulation of cardiac conduction IEA InterPro:IPR033629 1600115 GO_REF:0000002 InterPro GO_REF:0000002 regulation of cardiac conduction IEA UniProtKB:P42582|ensembl:ENSMUSP00000015723 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of cardiac muscle cell proliferation ISO RGD:731878 1624291 RGD MGI:MGI:4829405 PMID:20713518 regulation of cardiac muscle cell proliferation IEA UniProtKB:P42582|ensembl:ENSMUSP00000015723 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of cardiac muscle contraction ISO RGD:731878 1624291 RGD MGI:MGI:3829107 PMID:18689573 regulation of cardiac muscle contraction IEA UniProtKB:P42582|ensembl:ENSMUSP00000015723 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of transcription by RNA polymerase II ISO RGD:731878 1624291 RGD MGI:MGI:2682181 PMID:14645532 response to estradiol IEP 2306247 RGD right ventricular cardiac muscle tissue morphogenesis ISO RGD:1606841 1624291 RGD PMID:20807224 right ventricular cardiac muscle tissue morphogenesis IEA UniProtKB:P52952|ensembl:ENSP00000327758 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 sarcomere organization IEA UniProtKB:P42582|ensembl:ENSMUSP00000015723 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 sarcomere organization ISO RGD:731878 1624291 MGI:MGI:1914004 RGD MGI:MGI:4829405 PMID:20713518 septum secundum development ISO RGD:1606841 1624291 RGD PMID:10587520 septum secundum development IEA UniProtKB:P52952|ensembl:ENSP00000327758 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 spleen development ISO RGD:1606841 1624291 RGD PMID:22560297 spleen development ISS UniProtKB:P52952 1600115 GO_REF:0000024 UniProt GO_REF:0000024 spleen development IEA UniProtKB:P52952|ensembl:ENSP00000327758 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 spleen development IEA UniProtKB:P42582|ensembl:ENSMUSP00000015723 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 spleen development ISO RGD:731878 1624291 MGI:MGI:104737|MGI:MGI:97495 RGD MGI:MGI:5424277 PMID:22560297 thyroid gland development ISO RGD:1606841 1624291 RGD PMID:16418214 thyroid gland development IEA UniProtKB:P52952|ensembl:ENSP00000327758 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 thyroid gland development IEA UniProtKB:P42582|ensembl:ENSMUSP00000015723 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 thyroid gland development ISO RGD:731878 1624291 RGD MGI:MGI:3828401 PMID:16418214 vasculogenesis ISO RGD:731878 1624291 MGI:MGI:1857618 RGD MGI:MGI:1329801 PMID:10021345 vasculogenesis IEA UniProtKB:P42582|ensembl:ENSMUSP00000015723 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 ventricular cardiac myofibril assembly ISO RGD:731878 1624291 MGI:MGI:3042511 RGD MGI:MGI:4355491 PMID:19546853 ventricular cardiac myofibril assembly IEA UniProtKB:P42582|ensembl:ENSMUSP00000015723 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 ventricular septum morphogenesis ISO RGD:1606841 1624291 RGD PMID:10587520 PMID:20807224 ventricular septum morphogenesis IEA UniProtKB:P52952|ensembl:ENSP00000327758 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 ventricular trabecula myocardium morphogenesis ISO RGD:731878 1624291 MGI:MGI:3042511 RGD MGI:MGI:3040116 PMID:15109497 ventricular trabecula myocardium morphogenesis IEA UniProtKB:P42582|ensembl:ENSMUSP00000015723 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 Cellular Component cytoplasm ISO RGD:731878 1624291 RGD MGI:MGI:3828406 PMID:15653675 cytoplasm IEA UniProtKB:P42582|ensembl:ENSMUSP00000015723 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 nucleus IDA 2289909 RGD nucleus IBA FB:FBgn0000576|FB:FBgn0002941|FB:FBgn0004110|FB:FBgn0004862|FB:FBgn0040318|FB:FBgn0261930|MGI:MGI:108067|MGI:MGI:1206039|MGI:MGI:1352738|MGI:MGI:97347|MGI:MGI:97350|MGI:MGI:97352|PANTHER:PTN000678271|RGD:1308443|RGD:1310629|RGD:3866|RGD:620520|RGD:69318|UniProtKB:F1NC42|UniProtKB:P43699|UniProtKB:P52952|UniProtKB:Q90788|UniProtKB:Q99801|WB:WBGene00000445 13792537 PMID:21873635 GO_Central nucleus ISO RGD:731878 1624291 RGD MGI:MGI:3828406 more ... nucleus ISO RGD:1606841 1624291 RGD PMID:10948187 PMID:9858576 protein-containing complex ISO RGD:1606841 1624291 RGD PMID:26926761 protein-containing complex ISS UniProtKB:P52952 1600115 GO_REF:0000024 UniProt GO_REF:0000024 protein-DNA complex ISO RGD:1606841 1624291 RGD PMID:22849347 protein-DNA complex ISS UniProtKB:P52952 1600115 GO_REF:0000024 UniProt GO_REF:0000024 protein-DNA complex IEA UniProtKB:P52952|ensembl:ENSP00000327758 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 RNA polymerase II transcription factor complex ISO RGD:1606841 1624291 RGD PMID:9312027 RNA polymerase II transcription factor complex IEA UniProtKB:P52952|ensembl:ENSP00000327758 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 transcription factor complex ISO RGD:731878 1624291 UniProtKB:Q5SSP7 RGD MGI:MGI:2179901 more ... Molecular Function chromatin binding ISO RGD:1606841 1624291 RGD PMID:16678093 chromatin binding IEA UniProtKB:P52952|ensembl:ENSP00000327758 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 chromatin binding IEA UniProtKB:P42582|ensembl:ENSMUSP00000015723 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 chromatin binding ISO RGD:731878 1624291 RGD MGI:MGI:3850584 more ... DNA binding ISO RGD:1606841 1624291 RGD PMID:9858576 DNA binding ISO RGD:731878 1624291 RGD MGI:MGI:2387286 more ... DNA-binding transcription activator activity, RNA polymerase II-specific ISO RGD:1606841 1624291 RGD PMID:15649947 PMID:19578358 DNA-binding transcription activator activity, RNA polymerase II-specific ISO RGD:731878 1624291 RGD MGI:MGI:3055632 more ... DNA-binding transcription activator activity, RNA polymerase II-specific IEA UniProtKB:P52952|ensembl:ENSP00000327758 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 DNA-binding transcription activator activity, RNA polymerase II-specific IEA UniProtKB:P42582|ensembl:ENSMUSP00000015723 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 DNA-binding transcription factor activity IDA 727751 RGD DNA-binding transcription factor activity IBA FB:FBgn0261930|MGI:MGI:108067|MGI:MGI:1352738|MGI:MGI:97347|MGI:MGI:97350|MGI:MGI:97352|PANTHER:PTN000678271|RGD:3866|RGD:69318|UniProtKB:A6NCS4|UniProtKB:O15522|UniProtKB:P43699|UniProtKB:P52952|UniProtKB:Q99801 13792537 PMID:21873635 GO_Central DNA-binding transcription factor activity ISO RGD:731878 1624291 RGD MGI:MGI:2150876 more ... DNA-binding transcription factor activity contributes_to ISO RGD:1606841 1624291 RGD PMID:9312027 DNA-binding transcription factor activity ISO RGD:1606841 1624291 RGD PMID:10948187 more ... DNA-binding transcription factor activity IDA 1580258 RGD DNA-binding transcription factor activity, RNA polymerase II-specific ISO RGD:731878 1624291 RGD MGI:MGI:4950833 PMID:21379568 histone deacetylase binding IPI RGD:619980 9590153 RGD protein binding IPI RGD:620036 2289909 RGD protein binding ISO RGD:1606841 1624291 UniProtKB:O75925|UniProtKB:P43694|UniProtKB:Q8IZQ8|UniProtKB:Q99593|UniProtKB:Q99593-1 RGD PMID:11431700 more ... protein binding ISO RGD:731878 1624291 UniProtKB:O88621|UniProtKB:O94983|UniProtKB:P11831|UniProtKB:P70326|UniProtKB:P79457|UniProtKB:Q08369|UniProtKB:Q60707|UniProtKB:Q62315|UniProtKB:Q8BVE8-2|UniProtKB:Q99593|UniProtKB:Q9EPZ6|UniProtKB:Q9ES03|UniProtKB:Q9QZR5 RGD MGI:MGI:1303245 more ... protein heterodimerization activity ISO RGD:731878 1624291 UniProtKB:Q61039 RGD MGI:MGI:3607868 PMID:12392994 protein heterodimerization activity IEA UniProtKB:P42582|ensembl:ENSMUSP00000015723 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein homodimerization activity IDA 2306248 RGD protein homodimerization activity ISO RGD:731878 1624291 RGD MGI:MGI:3843444 PMID:11042197 protein homodimerization activity IEA UniProtKB:P42582|ensembl:ENSMUSP00000015723 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 RNA polymerase II proximal promoter sequence-specific DNA binding ISO RGD:1606841 1624291 RGD PMID:15649947 more ... RNA polymerase II proximal promoter sequence-specific DNA binding IBA MGI:MGI:108015|MGI:MGI:108067|MGI:MGI:1352738|MGI:MGI:97350|PANTHER:PTN000678271|RGD:69318|UniProtKB:O15522|UniProtKB:P52952|UniProtKB:Q99801 13792537 PMID:21873635 GO_Central RNA polymerase II proximal promoter sequence-specific DNA binding ISS UniProtKB:P52952 1600115 GO_REF:0000024 UniProt GO_REF:0000024 sequence-specific DNA binding IDA 2306248 RGD sequence-specific DNA binding IBA FB:FBgn0000576|FB:FBgn0004110|FB:FBgn0004862|MGI:MGI:108015|MGI:MGI:108067|MGI:MGI:1352738|MGI:MGI:97347|MGI:MGI:97350|MGI:MGI:97352|PANTHER:PTN000678271|RGD:1310629|RGD:3866|RGD:620520|RGD:69318|UniProtKB:A6NCS4|UniProtKB:A6NJ46|UniProtKB:O15522|UniProtKB:P43699|UniProtKB:P52952|UniProtKB:Q99801|WB:WBGene00000445 13792537 PMID:21873635 GO_Central sequence-specific DNA binding ISO RGD:1606841 1624291 RGD PMID:10948187 serum response element binding ISO RGD:731878 1624291 RGD MGI:MGI:83559 PMID:8887666 serum response element binding IEA UniProtKB:P42582|ensembl:ENSMUSP00000015723 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 transcription factor binding ISO RGD:1606841 1624291 UniProtKB:P43694|UniProtKB:Q99593 RGD PMID:11431700 PMID:9858576 transcription factor binding IEA UniProtKB:P52952|ensembl:ENSP00000327758 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 transcription regulatory region DNA binding ISO RGD:1606841 1624291 RGD PMID:19479054
Gene-Chemical Interaction Annotations
