Nkx2-5 (NK2 homeobox 5) - Rat Genome Database

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Gene: Nkx2-5 (NK2 homeobox 5) Mus musculus
Analyze
Symbol: Nkx2-5
Name: NK2 homeobox 5
RGD ID: 731878
MGI Page MGI
Description: Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein homodimerization activity. Involved in several processes, including cardiac muscle tissue development; positive regulation of transcription by RNA polymerase II; and regulation of heart contraction. Acts upstream of or within several processes, including circulatory system development; hematopoietic or lymphoid organ development; and regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; brain; branchial arch; heart; and hemolymphoid system. Used to study atrial heart septal defect 7; congenital heart disease; hypoplastic left heart syndrome; and tetralogy of Fallot. Human ortholog(s) of this gene implicated in aortic valve disease 2; atrioventricular block; congenital heart disease (multiple); and congenital nongoitrous hypothyroidism 5. Orthologous to human NKX2-5 (NK2 homeobox 5); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; benzo[a]pyrene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: cardiac-specific homeobox; Cs; Csx; Drosophila NK2 transcription factor related, locus 5; homeobox protein CSX; homeobox protein NK-2 homolog E; homeobox protein Nkx-2.5; NK2 transcription factor related, locus 5; Nkx-2.; Nkx-2.5; Nkx2.; Nkx2.5; ti; tinman
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391727,057,638 - 27,063,962 (-)NCBIGRCm39mm39
GRCm39 Ensembl1727,057,638 - 27,063,983 (-)Ensembl
GRCm381726,838,664 - 26,844,988 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1726,838,664 - 26,845,009 (-)EnsemblGRCm38mm10GRCm38
MGSCv371726,975,610 - 26,978,510 (-)NCBIGRCm37mm9NCBIm37
MGSCv361726,566,254 - 26,569,154 (-)NCBImm8
Celera1727,375,289 - 27,378,187 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1713.6NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adult heart development  (IMP,ISO)
apoptotic process involved in heart morphogenesis  (IMP)
atrial cardiac muscle cell development  (TAS)
atrial cardiac muscle tissue development  (IMP)
atrial septum morphogenesis  (ISO)
atrioventricular node cell development  (IMP)
atrioventricular node cell fate commitment  (IMP)
atrioventricular node development  (IMP)
bundle of His development  (IGI)
cardiac conduction system development  (IGI,ISO)
cardiac muscle cell development  (IMP)
cardiac muscle cell differentiation  (IDA,IGI,IMP,ISO,TAS)
cardiac muscle cell proliferation  (IGI)
cardiac muscle contraction  (IMP)
cardiac muscle tissue development  (IMP)
cardiac muscle tissue morphogenesis  (IMP,ISO)
cardiac ventricle formation  (IGI)
cardiac ventricle morphogenesis  (IMP)
cell differentiation  (IBA,IGI)
cellular response to growth factor stimulus  (ISO)
cellular response to hydrogen peroxide  (ISO)
circulatory system development  (IGI)
embryonic heart tube development  (IGI)
embryonic heart tube left/right pattern formation  (IMP)
endoderm development  (TAS)
heart contraction  (IGI)
heart development  (IGI,IMP)
heart looping  (IMP)
heart morphogenesis  (IMP)
heart trabecula formation  (IMP)
hemopoiesis  (IMP)
negative regulation of apoptotic process  (IGI)
negative regulation of canonical Wnt signaling pathway  (IDA)
negative regulation of cardiac muscle cell apoptotic process  (IMP,ISO)
negative regulation of myotube differentiation  (ISO)
negative regulation of transcription by RNA polymerase II  (IDA,IGI,ISO)
outflow tract morphogenesis  (IGI,IMP)
outflow tract septum morphogenesis  (ISO)
pharyngeal system development  (IGI)
positive regulation of cardioblast differentiation  (IMP)
positive regulation of cell population proliferation  (IGI)
positive regulation of gene expression  (IDA)
positive regulation of heart contraction  (IMP)
positive regulation of neuron differentiation  (ISO)
positive regulation of sodium ion transport  (IMP)
positive regulation of transcription by RNA polymerase II  (IDA,IGI,IMP,ISO)
positive regulation of transcription initiation from RNA polymerase II promoter  (IDA)
positive regulation of transcription via serum response element binding  (IDA)
positive regulation of transcription, DNA-templated  (IDA,ISO)
proepicardium development  (IMP)
pulmonary myocardium development  (IMP)
Purkinje myocyte differentiation  (IMP)
regulation of cardiac conduction  (IMP)
regulation of cardiac muscle cell proliferation  (IDA)
regulation of cardiac muscle contraction  (IMP)
regulation of transcription by RNA polymerase II  (IBA,IDA)
regulation of transcription, DNA-templated  (IEA)
response to estradiol  (ISO)
right ventricular cardiac muscle tissue morphogenesis  (ISO)
sarcomere organization  (IGI)
septum secundum development  (ISO)
spleen development  (IGI,ISO,TAS)
thyroid gland development  (IMP,ISO)
tongue development  (TAS)
vasculogenesis  (IMP)
ventricular cardiac muscle cell development  (TAS)
ventricular cardiac myofibril assembly  (IMP)
ventricular septum morphogenesis  (ISO)
ventricular trabecula myocardium morphogenesis  (IMP)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal A band morphology  (IAGP)
abnormal aortic arch and aortic arch branch attachment  (IAGP)
abnormal aortic valve commissure morphology  (IAGP)
abnormal artery morphology  (IAGP)
abnormal atrial thrombosis  (IAGP)
abnormal atrioventricular bundle morphology  (IAGP)
abnormal atrioventricular cushion morphology  (IAGP)
abnormal atrioventricular node conduction  (IAGP)
abnormal atrioventricular node morphology  (IAGP)
abnormal blood vessel morphology  (IAGP)
abnormal cardiac epithelial to mesenchymal transition  (IAGP)
abnormal cardiac jelly morphology  (IAGP)
abnormal cardiac muscle tissue morphology  (IAGP)
abnormal cardiac outflow tract development  (IAGP)
abnormal cardiac thrombosis  (IAGP)
abnormal cardiovascular system physiology  (IAGP)
abnormal cell cycle checkpoint function  (IAGP)
abnormal conotruncal ridge morphology  (IAGP)
abnormal coronary vessel morphology  (IAGP)
abnormal diastolic filling velocity  (IAGP)
abnormal dorsal aorta morphology  (IAGP)
abnormal embryonic hematopoiesis  (IAGP)
abnormal embryonic tissue morphology  (IAGP)
abnormal extraembryonic tissue morphology  (IAGP)
abnormal fetal atrioventricular canal morphology  (IAGP)
abnormal fetal cardiomyocyte morphology  (IAGP)
abnormal fetal cardiomyocyte physiology  (IAGP)
abnormal fetal cardiomyocyte proliferation  (IAGP)
abnormal H zone morphology  (IAGP)
abnormal heart apex morphology  (IAGP)
abnormal heart atrium morphology  (IAGP)
abnormal heart development  (IAGP)
abnormal heart electrocardiography waveform feature  (IAGP)
abnormal heart left ventricle morphology  (IAGP)
abnormal heart left ventricle pressure  (IAGP)
abnormal heart looping  (IAGP)
abnormal heart morphology  (IAGP)
abnormal heart right ventricle morphology  (IAGP)
abnormal heart septum morphology  (IAGP)
abnormal heart shape  (IAGP)
abnormal heart tube morphology  (IAGP)
abnormal heart ventricle morphology  (IAGP)
abnormal I band morphology  (IAGP)
abnormal impulse conducting system conduction  (IAGP)
abnormal impulse conducting system morphology  (IAGP)
abnormal interatrial septum morphology  (IAGP)
abnormal intercalated disk morphology  (IAGP)
abnormal intersomitic artery morphology  (IAGP)
abnormal interventricular septum morphology  (IAGP)
abnormal interventricular septum muscular part morphology  (IAGP)
abnormal left posterior bundle morphology  (IAGP)
abnormal mitral valve cusp morphology  (IAGP)
abnormal myocardial fiber morphology  (IAGP)
abnormal myocardial fiber physiology  (IAGP)
abnormal myocardial trabeculae morphology  (IAGP)
abnormal myocardium compact layer morphology  (IAGP)
abnormal myocardium layer morphology  (IAGP)
abnormal myogenesis  (IAGP)
abnormal neural crest cell apoptosis  (IAGP)
abnormal neural crest cell migration  (IAGP)
abnormal neural crest cell morphology  (IAGP)
abnormal pharyngeal arch artery morphology  (IAGP)
abnormal pharyngeal arch mesenchyme morphology  (IAGP)
abnormal pharyngeal arch morphology  (IAGP)
abnormal pharyngeal pouch morphology  (IAGP)
abnormal pharynx morphology  (IAGP)
abnormal PR interval  (IAGP)
abnormal pulmonary artery morphology  (IAGP)
abnormal pulmonary pressure  (IAGP)
abnormal Purkinje fiber morphology  (IAGP)
abnormal pyloric sphincter morphology  (IAGP)
abnormal QRS complex  (IAGP)
abnormal respiratory electron transport chain  (IAGP)
abnormal response of heart to induced stress  (IAGP)
abnormal sarcomere morphology  (IAGP)
abnormal semilunar valve morphology  (IAGP)
abnormal sinoatrial node conduction  (IAGP)
abnormal sinus venosus morphology  (IAGP)
abnormal somite development  (IAGP)
abnormal splanchnic mesoderm morphology  (IAGP)
abnormal spleen mesenchyme morphology  (IAGP)
abnormal spleen morphology  (IAGP)
abnormal ST segment  (IAGP)
abnormal stomach smooth muscle circular layer morphology  (IAGP)
abnormal stomach smooth muscle outer longitudinal layer morphology  (IAGP)
abnormal trabecula carnea morphology  (IAGP)
abnormal tricuspid valve cusp morphology  (IAGP)
abnormal tricuspid valve morphology  (IAGP)
abnormal ventricular thrombosis  (IAGP)
abnormal visceral yolk sac morphology  (IAGP)
abnormal vitelline vasculature morphology  (IAGP)
absent atrioventricular cushions  (IAGP)
absent cardiac outflow tract  (IAGP)
absent fourth pharyngeal arch artery  (IAGP)
absent heart  (IAGP)
absent heart right ventricle  (IAGP)
absent M line  (IAGP)
absent myocardial trabeculae  (IAGP)
absent trabeculae carneae  (IAGP)
absent tricuspid valve cusps  (IAGP)
absent vitelline blood vessels  (IAGP)
absent Z line  (IAGP)
anemia  (IAGP)
aortic valve stenosis  (IAGP)
aortopulmonary window  (IAGP)
atrial septal aneurysm  (IAGP)
atrial septal defect  (IAGP)
atrioventricular block  (IAGP)
atrioventricular cushion hypoplasia  (IAGP)
atrioventricular node hypoplasia  (IAGP)
atrioventricular septal defect  (IAGP)
bicuspid aortic valve  (IAGP)
bundle branch block  (IAGP)
cardiac edema  (IAGP)
cardiac fibrosis  (IAGP)
cardiac hypertrophy  (IAGP)
cardiac interstitial fibrosis  (IAGP)
cardiomyopathy  (IAGP)
common ventricle  (IAGP)
congestive heart failure  (IAGP)
conotruncal ridge hypoplasia  (IAGP)
cyanosis  (IAGP)
decreased acetylcholinesterase activity  (IAGP)
decreased atrioventricular cushion size  (IAGP)
decreased body size  (IAGP)
decreased cardiac muscle contractility  (IAGP)
decreased cardiac muscle glycogen level  (IAGP)
decreased cardiac output  (IAGP)
decreased cardiac stroke volume  (IAGP)
decreased cardiomyocyte apoptosis  (IAGP)
decreased cell proliferation  (IAGP)
decreased embryo size  (IAGP)
decreased fetal cardiomyocyte proliferation  (IAGP)
decreased heart left ventricle weight  (IAGP)
decreased heart rate  (IAGP)
decreased heart right ventricle size  (IAGP)
decreased left ventricle systolic pressure  (IAGP)
decreased mitotic index  (IAGP)
decreased physiological sensitivity to xenobiotic  (IAGP)
decreased right ventricle systolic pressure  (IAGP)
decreased ventricle muscle contractility  (IAGP)
delayed heart development  (IAGP)
diffuse Z line  (IAGP)
dilated cardiomyopathy  (IAGP)
dilated heart  (IAGP)
dilated heart atrium  (IAGP)
dilated heart left ventricle  (IAGP)
dilated heart right atrium  (IAGP)
dilated heart right ventricle  (IAGP)
dilated pulmonary artery  (IAGP)
disorganized myocardium  (IAGP)
distended pericardium  (IAGP)
double chambered heart right ventricle  (IAGP)
double outlet right ventricle  (IAGP)
Ebstein's malformation of tricuspid valve  (IAGP)
edema  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality during organogenesis  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
enlarged heart  (IAGP)
enlarged heart right atrium  (IAGP)
excessive folding of visceral yolk sac  (IAGP)
failure of heart looping  (IAGP)
fourth pharyngeal arch artery hypoplasia  (IAGP)
heart block  (IAGP)
heart hypoplasia  (IAGP)
heart right ventricle hypoplasia  (IAGP)
hemorrhage  (IAGP)
hydrops fetalis  (IAGP)
impaired muscle relaxation  (IAGP)
incomplete somite formation  (IAGP)
increased apoptosis  (IAGP)
increased cardiac muscle contractility  (IAGP)
increased cardiomyocyte apoptosis  (IAGP)
increased fetal cardiomyocyte proliferation  (IAGP)
increased heart weight  (IAGP)
increased physiological sensitivity to xenobiotic  (IAGP)
increased response of heart to induced stress  (IAGP)
interrupted aortic arch  (IAGP)
interventricular septum membranous part aneurysm  (IAGP)
irregular heartbeat  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
muscular ventricular septal defect  (IAGP)
myocardial fiber disarray  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
neonatal lethality, incomplete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
ostium secundum atrial septal defect  (IAGP)
overriding aortic valve  (IAGP)
pale yolk sac  (IAGP)
patent cardiac foramen ovale  (IAGP)
pericardial edema  (IAGP)
pericardial effusion  (IAGP)
perimembraneous ventricular septal defect  (IAGP)
perinatal lethality  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
persistent truncus arteriosis  (IAGP)
pharyngeal arch artery hypoplasia  (IAGP)
pharyngeal arch hypoplasia  (IAGP)
pharynx hypoplasia  (IAGP)
poor circulation  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
preweaning lethality, incomplete penetrance  (IAGP)
prolonged P wave  (IAGP)
prolonged PQ interval  (IAGP)
prolonged PR interval  (IAGP)
prolonged QRS complex duration  (IAGP)
prolonged QT interval  (IAGP)
right atrial isomerism  (IAGP)
shortened ST segment  (IAGP)
sinoatrial block  (IAGP)
skin edema  (IAGP)
small heart  (IAGP)
small myocardial fiber  (IAGP)
small thymus  (IAGP)
spleen hypoplasia  (IAGP)
thick aortic valve cusps  (IAGP)
thick interventricular septum  (IAGP)
thick myocardium compact layer  (IAGP)
thick tricuspid valve cusps  (IAGP)
thick ventricular wall  (IAGP)
thin myocardium  (IAGP)
thin myocardium compact layer  (IAGP)
thin ventricle myocardium compact layer  (IAGP)
thin ventricular wall  (IAGP)
trabecula carnea hypoplasia  (IAGP)
tricuspid valve atresia  (IAGP)
ventricular hypoplasia  (IAGP)
ventricular septal defect  (IAGP)
References

References - curated
1. Abou Hassan OK, etal., Sci Rep. 2015 Mar 6;5:8848. doi: 10.1038/srep08848.
2. Ashraf H, etal., Circ Cardiovasc Genet. 2014 Aug;7(4):423-33. doi: 10.1161/CIRCGENETICS.113.000281. Epub 2014 Jul 15.
3. Biben C, etal., Circ Res. 2000 Nov 10;87(10):888-95.
4. Elles√łe SG, etal., Congenit Heart Dis. 2016 May;11(3):283-90. doi: 10.1111/chd.12317. Epub 2015 Dec 18.
5. Goldmuntz E, etal., Circulation. 2001 Nov 20;104(21):2565-8.
6. Gutierrez-Roelens I, etal., Eur J Hum Genet. 2006 Dec;14(12):1313-6. Epub 2006 Aug 9.
7. Gutierrez-Roelens I, etal., Hum Mutat. 2002 Jul;20(1):75-6.
8. Hu B, etal., Am J Respir Cell Mol Biol. 2010 Feb;42(2):218-26. Epub 2009 Apr 24.
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11. Liu XY, etal., Pediatr Cardiol. 2011 Feb;32(2):193-201. doi: 10.1007/s00246-010-9859-6. Epub 2010 Dec 25.
12. MGD data from the GO Consortium
13. MGD IEA
14. OMIM Disease Annotation Pipeline
15. Pabst S, etal., Clin Res Cardiol. 2008 Jan;97(1):39-42. Epub 2007 Sep 25.
16. Pauli RM, etal., Am J Med Genet 1999 Aug 6;85(4):419-23.
17. Perera JL, etal., Pediatr Cardiol. 2014 Oct;35(7):1206-12. doi: 10.1007/s00246-014-0917-3. Epub 2014 Jun 1.
18. Qu XK, etal., Am J Cardiol. 2014 Dec 15;114(12):1891-5. doi: 10.1016/j.amjcard.2014.09.028. Epub 2014 Sep 28.
19. Reamon-Buettner SM and Borlak J, J Med Genet. 2004 Sep;41(9):684-90.
20. RGD automated import pipeline
21. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. RGD automated import pipeline for gene-chemical interactions
23. Risebro CA, etal., Circ Res. 2012 Jul 6;111(2):e19-31. doi: 10.1161/CIRCRESAHA.111.260695. Epub 2012 May 29.
24. Schott JJ, etal., Science. 1998 Jul 3;281(5373):108-11.
25. van Engelen K, etal., PLoS One. 2012;7(12):e52685. doi: 10.1371/journal.pone.0052685. Epub 2012 Dec 28.
26. Wang J, etal., Genet Mol Res. 2011 Nov 29;10(4):2905-15. doi: 10.4238/2011.November.29.1.
27. Wang J, etal., Int J Mol Med. 2011 Mar;27(3):369-75. doi: 10.3892/ijmm.2010.585. Epub 2010 Dec 16.
28. Zhu W, etal., J Biol Chem. 2000 Nov 10;275(45):35291-6.
Additional References at PubMed
PMID:7628699   PMID:7690144   PMID:7797561   PMID:7894168   PMID:7904557   PMID:7910553   PMID:8628271   PMID:8674419   PMID:8887666   PMID:8888684   PMID:8898212   PMID:8900044  
PMID:8900537   PMID:9043061   PMID:9096116   PMID:9136932   PMID:9136933   PMID:9162005   PMID:9171826   PMID:9192865   PMID:9344671   PMID:9389458   PMID:9500551   PMID:9501024  
PMID:9584153   PMID:9598591   PMID:9621431   PMID:9676193   PMID:9748262   PMID:9778505   PMID:9811571   PMID:9834187   PMID:9857019   PMID:9895330   PMID:10021345   PMID:10068637  
PMID:10079226   PMID:10331975   PMID:10331979   PMID:10349636   PMID:10364163   PMID:10477287   PMID:10529425   PMID:10588864   PMID:10603087   PMID:10625552   PMID:10733590   PMID:10772952  
PMID:10864469   PMID:10882515   PMID:10888889   PMID:10892744   PMID:10926765   PMID:11042159   PMID:11042197   PMID:11076677   PMID:11076861   PMID:11180810   PMID:11180966   PMID:11217851  
PMID:11245568   PMID:11336496   PMID:11390666   PMID:11440720   PMID:11517919   PMID:11572777   PMID:11668679   PMID:11783008   PMID:11784028   PMID:11854453   PMID:11889119   PMID:11891982  
PMID:11892011   PMID:11923206   PMID:11923873   PMID:11944934   PMID:11944935   PMID:12023302   PMID:12117810   PMID:12122109   PMID:12128222   PMID:12141427   PMID:12141429   PMID:12149478  
PMID:12163410   PMID:12194849   PMID:12223416   PMID:12297045   PMID:12392994   PMID:12464436   PMID:12466851   PMID:12477932   PMID:12490556   PMID:12606287   PMID:12692125   PMID:12702154  
PMID:12717733   PMID:12738802   PMID:12754203   PMID:12781968   PMID:12845333   PMID:12858529   PMID:12858530   PMID:12858532   PMID:12858555   PMID:14502571   PMID:14516662   PMID:14550786  
PMID:14573518   PMID:14597408   PMID:14645532   PMID:14662776   PMID:14681479   PMID:14741210   PMID:14757752   PMID:14766969   PMID:14975726   PMID:14976138   PMID:14978031   PMID:15070745  
PMID:15073151   PMID:15085192   PMID:15109497   PMID:15143159   PMID:15162503   PMID:15169892   PMID:15172687   PMID:15175244   PMID:15226419   PMID:15226643   PMID:15329346   PMID:15363409  
PMID:15464586   PMID:15525990   PMID:15542826   PMID:15618518   PMID:15621532   PMID:15653675   PMID:15673394   PMID:15680351   PMID:15721864   PMID:15743826   PMID:15767668   PMID:15843407  
PMID:15843409   PMID:15843414   PMID:15850572   PMID:15901664   PMID:15902305   PMID:15929941   PMID:15944191   PMID:15958514   PMID:16137232   PMID:16141072   PMID:16141073   PMID:16223478  
PMID:16267821   PMID:16284121   PMID:16291790   PMID:16314491   PMID:16380715   PMID:16418214   PMID:16510504   PMID:16514068   PMID:16554359   PMID:16555308   PMID:16556595   PMID:16556596  
PMID:16556915   PMID:16567502   PMID:16618415   PMID:16678093   PMID:16709898   PMID:16720880   PMID:16730346   PMID:16831833   PMID:16847256   PMID:17003108   PMID:17008600   PMID:17050624  
PMID:17069789   PMID:17108969   PMID:17131407   PMID:17133411   PMID:17208226   PMID:17234970   PMID:17250822   PMID:17258700   PMID:17261658   PMID:17286298   PMID:17289022   PMID:17332425  
PMID:17341133   PMID:17344228   PMID:17350578   PMID:17360443   PMID:17372176   PMID:17397913   PMID:17441204   PMID:17473172   PMID:17519332   PMID:17526730   PMID:17559079   PMID:17573777  
PMID:17584735   PMID:17585069   PMID:17604724   PMID:17626279   PMID:17635645   PMID:17668378   PMID:17823370   PMID:17855428   PMID:17868091   PMID:17923686   PMID:17947796   PMID:17964124  
PMID:18000065   PMID:18084293   PMID:18178574   PMID:18178777   PMID:18202317   PMID:18265012   PMID:18267097   PMID:18285513   PMID:18287057   PMID:18287559   PMID:18316483   PMID:18328475  
PMID:18400219   PMID:18448675   PMID:18452913   PMID:18462699   PMID:18467625   PMID:18470945   PMID:18480752   PMID:18568026   PMID:18591257   PMID:18624775   PMID:18689573   PMID:18701545  
PMID:18718461   PMID:18722343   PMID:18723448   PMID:18724007   PMID:18775691   PMID:18781631   PMID:18784615   PMID:18794329   PMID:18832393   PMID:18849322   PMID:18851995   PMID:18854137  
PMID:18981480   PMID:19035347   PMID:19084512   PMID:19091769   PMID:19096026   PMID:19097191   PMID:19116164   PMID:19129488   PMID:19166829   PMID:19208343   PMID:19217425   PMID:19359597  
PMID:19366374   PMID:19369973   PMID:19372463   PMID:19403656   PMID:19411759   PMID:19479054   PMID:19483677   PMID:19531353   PMID:19546853   PMID:19564151   PMID:19578358   PMID:19622544  
PMID:19631635   PMID:19660448   PMID:19706423   PMID:19727199   PMID:19877281   PMID:19910576   PMID:20007915   PMID:20018673   PMID:20037164   PMID:20059953   PMID:20065166   PMID:20071776  
PMID:20110338   PMID:20130022   PMID:20139090   PMID:20159597   PMID:20167925   PMID:20185795   PMID:20207226   PMID:20211142   PMID:20212279   PMID:20221402   PMID:20230754   PMID:20305823  
PMID:20347762   PMID:20417598   PMID:20457810   PMID:20522556   PMID:20549724   PMID:20558824   PMID:20562861   PMID:20596014   PMID:20651287   PMID:20658695   PMID:20705924   PMID:20713518  
PMID:20737509   PMID:20816796   PMID:20824138   PMID:20847311   PMID:20890042   PMID:20929948   PMID:20941780   PMID:20974940   PMID:21122108   PMID:21127295   PMID:21145505   PMID:21149574  
PMID:21177343   PMID:21224256   PMID:21267068   PMID:21285290   PMID:21304516   PMID:21311046   PMID:21364285   PMID:21379568   PMID:21382375   PMID:21399557   PMID:21429986   PMID:21447557  
PMID:21454626   PMID:21464046   PMID:21466802   PMID:21511879   PMID:21512031   PMID:21600894   PMID:21640717   PMID:21664901   PMID:21677750   PMID:21677783   PMID:21690310   PMID:21691712  
PMID:21693517   PMID:21708977   PMID:21731673   PMID:21757658   PMID:21768366   PMID:21779394   PMID:21822279   PMID:21828931   PMID:21839733   PMID:21871065   PMID:21873635   PMID:21896782  
PMID:21898690   PMID:21930795   PMID:21931855   PMID:21983003   PMID:21989917   PMID:22012595   PMID:22028467   PMID:22046433   PMID:22052916   PMID:22075149   PMID:22087235   PMID:22116619  
PMID:22130515   PMID:22146296   PMID:22155005   PMID:22158708   PMID:22192413   PMID:22207710   PMID:22215809   PMID:22226977   PMID:22307400   PMID:22312437   PMID:22343712   PMID:22364862  
PMID:22403241   PMID:22412967   PMID:22421361   PMID:22431517   PMID:22504313   PMID:22534315   PMID:22553207   PMID:22560297   PMID:22569553   PMID:22573622   PMID:22589735   PMID:22693350  
PMID:22711842   PMID:22719862   PMID:22826212   PMID:22863011   PMID:22865640   PMID:22898775   PMID:22912798   PMID:22921202   PMID:22932696   PMID:22996691   PMID:23028370   PMID:23056209  
PMID:23088431   PMID:23093675   PMID:23139287   PMID:23144723   PMID:23165293   PMID:23168335   PMID:23184148   PMID:23303524   PMID:23307821   PMID:23314057   PMID:23351706   PMID:23369715  
PMID:23475960   PMID:23477547   PMID:23565059   PMID:23571217   PMID:23575307   PMID:23601687   PMID:23620086   PMID:23637775   PMID:23743334   PMID:23744058   PMID:23785004   PMID:23797856  
PMID:23836893   PMID:23873040   PMID:23892084   PMID:23974038   PMID:24091702   PMID:24120474   PMID:24123312   PMID:24123507   PMID:24133047   PMID:24142516   PMID:24143284   PMID:24186978  
PMID:24255096   PMID:24293546   PMID:24335256   PMID:24335282   PMID:24380800   PMID:24563458   PMID:24565863   PMID:24613616   PMID:24650916   PMID:24657234   PMID:24704900   PMID:24748541  
PMID:24812305   PMID:24843018   PMID:24860998   PMID:24927531   PMID:24938781   PMID:24963028   PMID:24970776   PMID:25014164   PMID:25035421   PMID:25053429   PMID:25139745   PMID:25168381  
PMID:25190705   PMID:25199831   PMID:25250575   PMID:25299188   PMID:25313962   PMID:25336743   PMID:25344074   PMID:25344367   PMID:25362681   PMID:25411333   PMID:25428115   PMID:25436607  
PMID:25505152   PMID:25514037   PMID:25521757   PMID:25524439   PMID:25560321   PMID:25626636   PMID:25661081   PMID:25670795   PMID:25703143   PMID:25725482   PMID:25787764   PMID:25803368  
PMID:25813538   PMID:25830876   PMID:25848000   PMID:25912687   PMID:25953344   PMID:25992544   PMID:25995316   PMID:26017770   PMID:26017771   PMID:26028220   PMID:26113728   PMID:26138475  
PMID:26139165   PMID:26168347   PMID:26173459   PMID:26193633   PMID:26226998   PMID:26295701   PMID:26305214   PMID:26321200   PMID:26334248   PMID:26369831   PMID:26411676   PMID:26489465  
PMID:26493106   PMID:26496195   PMID:26515110   PMID:26526197   PMID:26534985   PMID:26619120   PMID:26642209   PMID:26786475   PMID:26787680   PMID:26811383   PMID:26821812   PMID:26822476  
PMID:26875865   PMID:26876450   PMID:26897459   PMID:26906632   PMID:26957275   PMID:27019112   PMID:27026076   PMID:27052172   PMID:27056911   PMID:27056912   PMID:27106802   PMID:27166947  
PMID:27217161   PMID:27256596   PMID:27266388   PMID:27287812   PMID:27331609   PMID:27333774   PMID:27348588   PMID:27396331   PMID:27470638   PMID:27518902   PMID:27580238   PMID:27584790  
PMID:27606604   PMID:27612405   PMID:27687577   PMID:27713415   PMID:27725084   PMID:27775552   PMID:27783597   PMID:27794491   PMID:27840107   PMID:27997827   PMID:28098558   PMID:28109039  
PMID:28195173   PMID:28271994   PMID:28283550   PMID:28287088   PMID:28302382   PMID:28352650   PMID:28357999   PMID:28436940   PMID:28446132   PMID:28580685   PMID:28669819   PMID:28698371  
PMID:28846746   PMID:28945738   PMID:28973413   PMID:28974782   PMID:29021295   PMID:29033129   PMID:29061339   PMID:29078393   PMID:29117561   PMID:29183906   PMID:29202929   PMID:29203676  
PMID:29217753   PMID:29282804   PMID:29367466   PMID:29374072   PMID:29417167   PMID:29422515   PMID:29467410   PMID:29579159   PMID:29654745   PMID:29665845   PMID:29791855   PMID:29842877  
PMID:29891551   PMID:29891665   PMID:29979676   PMID:30061196   PMID:30087351   PMID:30151366   PMID:30242109   PMID:30318151   PMID:30347193   PMID:30428088   PMID:30451828   PMID:30521808  
PMID:30578278   PMID:30596653   PMID:30642836   PMID:30742009   PMID:30787001   PMID:30840660   PMID:30909860   PMID:30936115   PMID:30939177   PMID:30940539   PMID:30959515   PMID:31112136  
PMID:31147515   PMID:31175693   PMID:31201155   PMID:31206334   PMID:31286141   PMID:31300538   PMID:31320323   PMID:31371508   PMID:31420575   PMID:31422919   PMID:31541101   PMID:31566563  
PMID:31641210   PMID:31649032   PMID:31688894   PMID:32123336   PMID:32130910   PMID:32179481   PMID:32251422   PMID:32413023   PMID:32450132   PMID:32469866   PMID:32492036   PMID:32515350  
PMID:32546759   PMID:32687896   PMID:32692983   PMID:32857951   PMID:32866472   PMID:32883967   PMID:32901292   PMID:33030203   PMID:33082351   PMID:33230114   PMID:33414188   PMID:33443158  
PMID:33665549   PMID:33758249   PMID:33913477  


Genomics

Comparative Map Data
Nkx2-5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391727,057,638 - 27,063,962 (-)NCBIGRCm39mm39
GRCm39 Ensembl1727,057,638 - 27,063,983 (-)Ensembl
GRCm381726,838,664 - 26,844,988 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1726,838,664 - 26,845,009 (-)EnsemblGRCm38mm10GRCm38
MGSCv371726,975,610 - 26,978,510 (-)NCBIGRCm37mm9NCBIm37
MGSCv361726,566,254 - 26,569,154 (-)NCBImm8
Celera1727,375,289 - 27,378,187 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1713.6NCBI
NKX2-5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl5173,232,109 - 173,235,311 (-)EnsemblGRCh38hg38GRCh38
GRCh385173,232,109 - 173,235,321 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh375172,659,112 - 172,662,209 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365172,591,744 - 172,594,868 (-)NCBINCBI36hg18NCBI36
Celera5168,692,473 - 168,695,681 (-)NCBI
Cytogenetic Map5q35.1NCBI
HuRef5167,754,405 - 167,757,613 (-)NCBIHuRef
CHM1_15172,091,589 - 172,094,797 (-)NCBICHM1_1
Nkx2-5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21016,340,428 - 16,347,004 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1016,344,159 - 16,346,934 (+)Ensembl
Rnor_6.01016,635,989 - 16,638,758 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1016,635,989 - 16,638,764 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01016,520,570 - 16,527,836 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41016,606,183 - 16,608,952 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11016,607,231 - 16,610,001 (+)NCBI
Celera1016,004,548 - 16,007,317 (+)NCBICelera
Cytogenetic Map10q12NCBI
Nkx2-5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540825,832,683 - 25,836,840 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540825,833,649 - 25,836,673 (-)NCBIChiLan1.0ChiLan1.0
NKX2-5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.15175,492,288 - 175,495,514 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5175,492,288 - 175,495,514 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v05168,584,197 - 168,589,406 (-)NCBIMhudiblu_PPA_v0panPan3
NKX2-5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1439,240,755 - 39,254,585 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl439,244,286 - 39,247,592 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha439,189,667 - 39,192,973 (+)NCBI
ROS_Cfam_1.0439,612,560 - 39,618,296 (+)NCBI
UMICH_Zoey_3.1439,432,539 - 39,435,856 (+)NCBI
UNSW_CanFamBas_1.0439,621,539 - 39,624,869 (+)NCBI
UU_Cfam_GSD_1.0440,130,495 - 40,133,809 (+)NCBI
Nkx2-5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721393,683,325 - 93,686,308 (+)NCBI
SpeTri2.0NW_0049366092,406,004 - 2,408,980 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NKX2-5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1651,086,011 - 51,089,165 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11651,086,014 - 51,089,165 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21655,400,567 - 55,403,626 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NKX2-5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12375,391,833 - 75,399,003 (-)NCBI
ChlSab1.1 Ensembl2375,391,847 - 75,395,205 (-)Ensembl
Vero_WHO_p1.0NW_0236660343,212,995 - 3,216,184 (+)NCBI
Nkx2-5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473316,881,189 - 16,884,245 (+)NCBI

Position Markers
Nkx2-5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381726,838,854 - 26,839,113UniSTSGRCm38
MGSCv371726,975,799 - 26,976,058UniSTSGRCm37
Celera1727,375,478 - 27,375,737UniSTS
Cytogenetic Map17A3.3UniSTS
cM Map1713.0UniSTS
Nkx2-5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381726,838,667 - 26,839,271UniSTSGRCm38
MGSCv371726,975,612 - 26,976,216UniSTSGRCm37
Celera1727,375,291 - 27,375,895UniSTS
Cytogenetic Map17A3.3UniSTS
Nkx2-5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381726,839,617 - 26,841,086UniSTSGRCm38
Celera1727,376,241 - 27,377,708UniSTS
Cytogenetic Map17A3.3UniSTS
Nkx2-5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381726,839,435 - 26,841,075UniSTSGRCm38
MGSCv371726,976,380 - 26,978,020UniSTSGRCm37
Celera1727,376,059 - 27,377,697UniSTS
Cytogenetic Map17A3.3UniSTS
Nkx2-5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381726,839,365 - 26,839,540UniSTSGRCm38
MGSCv371726,976,310 - 26,976,485UniSTSGRCm37
Celera1727,375,989 - 27,376,164UniSTS
Cytogenetic Map17A3.3UniSTS
Nkx2-5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381726,839,410 - 26,839,626UniSTSGRCm38
MGSCv371726,976,355 - 26,976,571UniSTSGRCm37
Celera1727,376,034 - 27,376,250UniSTS
Cytogenetic Map17A3.3UniSTS
cM Map1713.0UniSTS
Nkx2-5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map17A3.3UniSTS
cM Map1713.0UniSTS
Nkx2-5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map17A3.3UniSTS
cM Map1713.0UniSTS
Nkx2-5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381726,841,030 - 26,841,564UniSTSGRCm38
MGSCv371726,977,975 - 26,978,509UniSTSGRCm37
Celera1727,377,652 - 27,378,186UniSTS
Cytogenetic Map17A3.3UniSTS
cM Map1713.0UniSTS
Nkx2-5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map17A3.3UniSTS
Nkx2-5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381726,838,664 - 26,838,886UniSTSGRCm38
MGSCv371726,975,609 - 26,975,831UniSTSGRCm37
Celera1727,375,288 - 27,375,510UniSTS
Cytogenetic Map17A3.3UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300613Pcyts4_mplasmacytoma susceptibility 4 (mouse)Not determined17126862710Mouse
1301615Cfld3_mcystic fibrosis lung disease 3 (mouse)Not determined17126862710Mouse
1302100Circp2_mcircadian photosensitivity 2 (mouse)Not determined17128979566Mouse
12910527Nrq1a_mnoise-induced hearing loss resistant QTL 1a (mouse)17128979566Mouse
12910528Nrq1_mnoise-induced hearing loss resistant QTL 1 (mouse)17128979566Mouse
13524851Asrq8_macoustic startle response 8 (mouse)17130809908Mouse
10412276Leci2_mleukocyte endothelial cell interactions 2 (mouse)Not determined17312791337128037Mouse
1300890Bhr3_mbronchial hyperresponsiveness 3 (mouse)Not determined17392461548559063Mouse
1301327Lmr7_mleishmaniasis resistance 7 (mouse)Not determined17480447727496965Mouse
4141215Mnic1_mmacronutrient intake, carbohydrate 1 (mouse)Not determined480447745359340Mouse
1300706Alan1_malloantigen response 1 (mouse)Not determined17480447746158776Mouse
1357789Kdnw3_mkidney weight 3 (mouse)Not determined17480447747574740Mouse
4141272Tfv1_mtotal food volume 1 (mouse)Not determined480447765330362Mouse
10043949Pbft7_mpercent body fat 7 (mouse)Not determined17667496240674962Mouse
4141608Phl1_mprogressive hearing loss 1 (mouse)Not determined17765701129268449Mouse
1301935Skull24_mskull morphology 24 (mouse)Not determined17836594042366175Mouse
1300787Cd8mts5_mCD8 memory T cell subset 5 (mouse)Not determined17836594042366175Mouse
1301338Lmr1_mleishmaniasis resistance 1 (mouse)Not determined17986241186688972Mouse
1302028Asbb3_mautoimmune susceptibility in C57BL/6J and BALB/c 3 (mouse)Not determined171065914544659245Mouse
4142342Lfnq4_mlung function QTL 4 (mouse)Not determined1098759739053168Mouse
4141067Hbnr2_mHeligmosomoides bakeri nematode resistance 2 (mouse)Not determined1166699745667145Mouse
14747010Mancz14_mmandible centroid size 14 (mouse)171177921045779210Mouse
4142150Stheal11_msoft tissue heal 11 (mouse)Not determined171206732483054339Mouse
12904946Tammq8_mtibialis anterior muscle mass QTL 8 (mouse)171223281346232813Mouse
13524847Asrq8a_macoustic startle response 8a (mouse)171242798746427987Mouse
11081168Tir7_mtrypanosome infection response 7 (mouse)171390439847904522Mouse
1300914Pcir4_mperiosteal circumference 4 (mouse)Not determined171484267848842786Mouse
1558886Lgth9_mbody length 9 (mouse)Not determined171484267848842786Mouse
1302070Tbbmd7_mtotal body bone mineral density 7 (mouse)Not determined171484267848842786Mouse
1300995Fembrs4_mfemur breaking strength 4 (mouse)Not determined171484267848842786Mouse
1302140Wta4_mweight adult 4 (mouse)Not determined171660074750600869Mouse
1302152Skull25_mskull morphology 25 (mouse)Not determined171660074750600869Mouse
1301505Tir1_mtrypanosome infection response 1 (mouse)Not determined171660074750600869Mouse
1302038Radpf1_mradiation pulmonary fibrosis 1 (mouse)Not determined171661519333600869Mouse
10412083Sm2_msusceptibility to Schistosoma mansoni infection 2 (mouse)Not determined171681096950811104Mouse
1302042Acsns3_mAngiostrongylus costaricensis nematode susceptibility 3 (mouse)Not determined171724323451243371Mouse
1300535Char3_mP. chabaudi malaria resistance QTL 3 (mouse)Not determined171724323451243371Mouse
10412214Sxbq3_mSGC/Knj cross B6 QTL 3 (mouse)Not determined171724323451243371Mouse
13452396Leusq3_mleucocytosis susceptibility QTL 3 (mouse)171724323451243371Mouse
13452399Leusq6_mleucocytosis susceptibility QTL 6 (mouse)171724323451243371Mouse
1301840Ssial4_msusceptibility to sialadenitiss 4 (mouse)Not determined171795643651959238Mouse
1301331Lbw1_mlupus NZB x NZW 1 (mouse)Not determined171819938152202007Mouse
1301056Pas2_mpulmonary adenoma susceptibility 2 (mouse)Not determined171820316552205351Mouse
15039354Nmrs36_mNAFLD-associated magnetic resonance shift 36 (mouse)171883413352834133Mouse
1301454Eae5_msusceptibility to experimental allergic encephalomyelitis 5 (mouse)Not determined172430185958301973Mouse
10412198Sst5_msusceptibility to tuberculosis 5 (mouse)Not determined172485760955405969Mouse
10412196Bbaa28_mB.burgdorferi-associated arthritis 28 (mouse)Not determined172536594043665344Mouse
12903990Opfaq5_mopen field activity QTL 5 (mouse)172573195128773124Mouse
10412204Bbaa29_mB.burgdorferi-associated arthritis 29 (mouse)Not determined172574029459740461Mouse
1558758Kcal2_mkilocalorie 2 (mouse)Not determined172618203852604676Mouse
1300602Eye2_meye weight 2 (mouse)Not determined172628636340794146Mouse
1302005Loco2_mlocomotor activity 2 (mouse)Not determined172657408160574223Mouse
12904013Cfq12_mconditioned fear QTL 12 (mouse)172660980730445981Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:238
Count of miRNA genes:178
Interacting mature miRNAs:200
Transcripts:ENSMUST00000015723
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000015723   ⟹   ENSMUSP00000015723
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1727,057,638 - 27,060,539 (-)Ensembl
GRCm38.p6 Ensembl1726,838,664 - 26,841,565 (-)Ensembl
RefSeq Acc Id: ENSMUST00000235454   ⟹   ENSMUSP00000157537
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1727,058,000 - 27,063,983 (-)Ensembl
GRCm38.p6 Ensembl1726,839,026 - 26,845,009 (-)Ensembl
RefSeq Acc Id: NM_008700   ⟹   NP_032726
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391727,057,639 - 27,060,539 (-)NCBI
GRCm381726,838,665 - 26,841,565 (-)NCBI
MGSCv371726,975,610 - 26,978,510 (-)RGD
Celera1727,375,289 - 27,378,187 (-)RGD
cM Map17 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006523797   ⟹   XP_006523860
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391727,057,638 - 27,063,962 (-)NCBI
GRCm381726,838,664 - 26,844,988 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_032726   ⟸   NM_008700
- UniProtKB: P42582 (UniProtKB/Swiss-Prot),   Q3UQU2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006523860   ⟸   XM_006523797
- Peptide Label: isoform X1
- UniProtKB: P42582 (UniProtKB/Swiss-Prot),   Q3UQU2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000015723   ⟸   ENSMUST00000015723
RefSeq Acc Id: ENSMUSP00000157537   ⟸   ENSMUST00000235454
Protein Domains
Homeobox

Promoters
RGD ID:13675258
Promoter ID:EPDNEW_M21778
Type:initiation region
Name:Nkx2-5_1
Description:Mus musculus NK2 homeobox 5 (Nkx2-5), mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381726,841,468 - 26,841,528EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97350 AgrOrtholog
Ensembl Genes ENSMUSG00000015579 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000015723 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000157537 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000015723 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000235454 ENTREZGENE, UniProtKB/TrEMBL
InterPro Homeobox-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_metazoa UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NKX-2.5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:18091 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:97350 ENTREZGENE
NCBI Gene 18091 ENTREZGENE
PANTHER PTHR24340:SF28 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Homeodomain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nkx2-5 PhenoGen
PRINTS HOMEOBOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE HOMEOBOX_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HOMEOBOX_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF46689 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A494B983_MOUSE UniProtKB/TrEMBL
  NKX25_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3UQU2 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary P97335 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-06 Nkx2-5  NK2 homeobox 5    NK2 transcription factor related, locus 5 (Drosophila)  Symbol and/or name change 5135510 APPROVED