NKX2-5 (NK2 homeobox 5) - Rat Genome Database

Name: NKX2-5
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: NKX2-5 (NK2 homeobox 5) Canis lupus familiaris

Analyze

Symbol:

NKX2-5

Name:

NK2 homeobox 5

RGD ID:

12257048

Description:

ENCODES a protein that exhibits DNA-binding transcription factor activity (ortholog); histone deacetylase binding (ortholog); identical protein binding (ortholog); INVOLVED IN adult heart development (ortholog); apoptotic process (ortholog); apoptotic process involved in heart morphogenesis (ortholog); ASSOCIATED WITH aortic valve disease 2 (ortholog); atrial fibrillation (ortholog); atrial heart septal defect (ortholog); FOUND IN nucleus (ortholog)

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

homeobox protein Nkx-2.5; NK2 transcription factor related, locus 5; NKX2.5; transcription factor NKX2.5

RGD Orthologs

Human

Mouse

Rat

Chinchilla

Bonobo

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	NKX2-5 (NK2 homeobox 5)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Mus musculus (house mouse):	Nkx2-5 (NK2 homeobox 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Nkx2-5 (NK2 homeobox 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Nkx2-5 (NK2 homeobox 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	NKX2-5 (NK2 homeobox 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Nkx2-5 (NK2 homeobox 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	NKX2-5 (NK2 homeobox 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	NKX2-5 (NK2 homeobox 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Nkx2-5 (NK2 homeobox 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	4	39,240,755 - 39,254,585 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	4	39,244,286 - 39,247,592 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	4	39,189,667 - 39,192,973 (+)	NCBI
ROS_Cfam_1.0	4	39,612,560 - 39,618,296 (+)	NCBI
ROS_Cfam_1.0 Ensembl	4	39,614,913 - 39,618,296 (+)	Ensembl
UMICH_Zoey_3.1	4	39,432,539 - 39,435,856 (+)	NCBI
UNSW_CanFamBas_1.0	4	39,621,539 - 39,624,869 (+)	NCBI
UU_Cfam_GSD_1.0	4	40,130,495 - 40,133,809 (+)	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

aortic valve disease 2 (ISO)

atrial fibrillation (ISO)

atrial heart septal defect (ISO)

atrial heart septal defect 7 (ISO)

Atrial Septal Defect with Atrioventricular Conduction Defects (ISO)

atrioventricular block (ISO)

atrioventricular septal defect (ISO)

Cardiac Conduction Defect (ISO)

Cardiomegaly (ISO)

Cardiovascular Abnormalities (ISO)

Common Ventricle (ISO)

congenital heart disease (ISO)

congenital nongoitrous hypothyroidism 5 (ISO)

Conotruncal Cardiac Defects (ISO)

dilated cardiomyopathy (ISO)

genetic disease (ISO)

heart septal defect (ISO)

hypertrophic cardiomyopathy (ISO)

hypoplastic left heart syndrome (ISO)

Hypoplastic Left Heart Syndrome 2 (ISO)

lissencephaly 3 (ISO)

myotonic disease (ISO)

pulmonary fibrosis (ISO)

second-degree atrioventricular block (ISO)

Splenic Hypoplasia (ISO)

Stroke (ISO)

tetralogy of Fallot (ISO)

Ventricular Fibrillation (ISO)

ventricular septal defect (ISO)

Ventricular Septal Defect 3 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adult heart development (IEA,ISO)

apoptotic process (IEA,ISO)

apoptotic process involved in heart morphogenesis (IEA,ISO)

atrial cardiac muscle tissue development (IEA)

atrial septum morphogenesis (IEA)

atrioventricular node cell development (IEA,ISO)

atrioventricular node cell fate commitment (IEA,ISO)

atrioventricular node development (IEA)

bundle of His development (IEA,ISO)

cardiac conduction system development (IEA,ISO)

cardiac muscle cell development (IEA)

cardiac muscle cell differentiation (IEA,ISO)

cardiac muscle cell proliferation (IEA,ISO)

cardiac muscle contraction (IEA,ISO)

cardiac muscle tissue development (IEA,ISO)

cardiac muscle tissue morphogenesis (IEA)

cardiac ventricle formation (IEA,ISO)

cardiac ventricle morphogenesis (IEA,ISO)

cell differentiation (IBA)

cell population proliferation (IEA,ISO)

cellular response to growth factor stimulus (ISO)

cellular response to hydrogen peroxide (ISO)

embryonic heart tube development (IEA,ISO)

embryonic heart tube left/right pattern formation (IEA,ISO)

epithelial cell apoptotic process (IEA,ISO)

epithelial cell differentiation (IEA,ISO)

epithelial cell proliferation (IEA,ISO)

heart contraction (IEA,ISO)

heart development (IEA,ISO)

heart looping (IEA,ISO)

heart morphogenesis (IEA,ISO)

heart trabecula formation (IEA,ISO)

hemopoiesis (IEA,ISO)

negative regulation of canonical Wnt signaling pathway (IEA)

negative regulation of cardiac muscle cell apoptotic process (IEA)

negative regulation of epithelial cell apoptotic process (IEA,ISO)

negative regulation of myotube differentiation (IEA)

negative regulation of transcription by RNA polymerase II (IEA,ISO)

outflow tract morphogenesis (IEA,ISO)

outflow tract septum morphogenesis (IEA)

pharyngeal system development (IEA,ISO)

positive regulation of cardioblast differentiation (IEA)

positive regulation of cell population proliferation (IEA)

positive regulation of epithelial cell proliferation (IEA,ISO)

positive regulation of gene expression (IEA)

positive regulation of heart contraction (IEA)

positive regulation of neuron differentiation (IEA)

positive regulation of sodium ion transport (IEA)

positive regulation of transcription by RNA polymerase II (IEA,ISO)

positive regulation of transcription initiation from RNA polymerase II promoter (IEA)

positive regulation of transcription via serum response element binding (IEA)

positive regulation of transcription, DNA-templated (IEA,ISO)

proepicardium development (IEA,ISO)

pulmonary myocardium development (IEA,ISO)

Purkinje myocyte differentiation (IEA,ISO)

regulation of cardiac conduction (IEA)

regulation of cardiac muscle cell proliferation (IEA,ISO)

regulation of cardiac muscle contraction (IEA)

regulation of transcription by RNA polymerase II (IBA,IEA,ISO)

regulation of transcription, DNA-templated (IEA)

response to estradiol (ISO)

right ventricular cardiac muscle tissue morphogenesis (IEA)

sarcomere organization (IEA)

septum secundum development (IEA)

spleen development (IEA,ISO)

thyroid gland development (IEA)

transcription by RNA polymerase II (IEA,ISO)

vasculogenesis (IEA,ISO)

ventricular cardiac myofibril assembly (IEA,ISO)

ventricular septum morphogenesis (IEA)

ventricular trabecula myocardium morphogenesis (IEA,ISO)

Cellular Component

cytoplasm (IEA)

nucleus (IBA,IEA,ISO)

protein-containing complex (IEA)

protein-DNA complex (IEA)

RNA polymerase II transcription regulator complex (IEA)

transcription regulator complex (IEA)

Molecular Function

chromatin binding (IEA)

DNA binding (IEA)

DNA-binding transcription activator activity (IEA)

DNA-binding transcription activator activity, RNA polymerase II-specific (IEA)

DNA-binding transcription factor activity (IEA,ISO)

DNA-binding transcription factor activity, RNA polymerase II-specific (IBA,IEA)

histone deacetylase binding (ISO)

identical protein binding (ISO)

protein binding (ISO)

protein homodimerization activity (IEA)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IBA,IEA)

RNA polymerase II-specific DNA-binding transcription factor binding (IEA)

sequence-specific DNA binding (IEA,ISO)

sequence-specific double-stranded DNA binding (IEA)

transcription cis-regulatory region binding (IEA)

References

Additional References at PubMed

PMID:16706928

Genomics

Comparative Map Data

NKX2-5
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	4	39,240,755 - 39,254,585 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	4	39,244,286 - 39,247,592 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	4	39,189,667 - 39,192,973 (+)	NCBI
ROS_Cfam_1.0	4	39,612,560 - 39,618,296 (+)	NCBI
ROS_Cfam_1.0 Ensembl	4	39,614,913 - 39,618,296 (+)	Ensembl
UMICH_Zoey_3.1	4	39,432,539 - 39,435,856 (+)	NCBI
UNSW_CanFamBas_1.0	4	39,621,539 - 39,624,869 (+)	NCBI
UU_Cfam_GSD_1.0	4	40,130,495 - 40,133,809 (+)	NCBI

NKX2-5
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	173,232,109 - 173,235,206 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	5	173,232,109 - 173,235,311 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	172,659,112 - 172,662,209 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	172,591,744 - 172,594,868 (-)	NCBI	NCBI36		hg18	NCBI36
Celera	5	168,692,473 - 168,695,681 (-)	NCBI
Cytogenetic Map	5	q35.1	NCBI
HuRef	5	167,754,405 - 167,757,613 (-)	NCBI		HuRef
CHM1_1	5	172,091,589 - 172,094,797 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	5	173,772,181 - 173,775,278 (-)	NCBI

Nkx2-5
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	27,057,638 - 27,063,962 (-)	NCBI	GRCm39		mm39
GRCm39 Ensembl	17	27,057,638 - 27,063,983 (-)	Ensembl
GRCm38	17	26,838,664 - 26,844,988 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	26,838,664 - 26,845,009 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	26,975,610 - 26,978,510 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	17	26,566,254 - 26,569,154 (-)	NCBI			mm8
Celera	17	27,375,289 - 27,378,187 (-)	NCBI		Celera
Cytogenetic Map	17	A3.3	NCBI
cM Map	17	13.6	NCBI

Nkx2-5
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	10	16,340,428 - 16,347,004 (+)	NCBI	mRatBN7.2
mRatBN7.2 Ensembl	10	16,344,159 - 16,346,934 (+)	Ensembl
Rnor_6.0	10	16,635,989 - 16,638,758 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	16,635,989 - 16,638,764 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	16,520,570 - 16,527,836 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	16,606,183 - 16,608,952 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	10	16,607,231 - 16,610,001 (+)	NCBI
Celera	10	16,004,548 - 16,007,317 (+)	NCBI		Celera
Cytogenetic Map	10	q12	NCBI

Nkx2-5
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955408	25,832,683 - 25,836,840 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955408	25,833,649 - 25,836,673 (-)	NCBI	ChiLan1.0	ChiLan1.0

NKX2-5
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	5	175,492,288 - 175,495,514 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	175,492,288 - 175,495,514 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	5	168,584,197 - 168,589,406 (-)	NCBI	Mhudiblu_PPA_v0		panPan3

Nkx2-5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	93,683,325 - 93,686,308 (+)	NCBI
SpeTri2.0	NW_004936609	2,406,004 - 2,408,980 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

NKX2-5
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	16	51,086,011 - 51,089,165 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	16	51,086,014 - 51,089,165 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	16	55,400,567 - 55,403,626 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

NKX2-5
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	23	75,391,833 - 75,399,003 (-)	NCBI	ChlSab1.1		chlSab2
ChlSab1.1 Ensembl	23	75,391,847 - 75,395,205 (-)	Ensembl	ChlSab1.1		chlSab2
Vero_WHO_p1.0	NW_023666034	3,212,995 - 3,216,184 (+)	NCBI	Vero_WHO_p1.0

Nkx2-5
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624733	16,881,191 - 16,884,210 (+)	Ensembl	HetGla_female_1.0		hetGla2
HetGla 1.0	NW_004624733	16,881,189 - 16,884,245 (+)	NCBI	HetGla_female_1.0		hetGla2

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	reproductive system	respiratory system	adipose tissue
High
Medium		5			5
Low	4		15		1		2		12		10	6
Below cutoff	1		7	6		6	4	6		8

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001010959	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_014112769	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_022417341	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_022417342	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038662303	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038662304	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY527225	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DQ220791	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DQ350454	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000051	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000088	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000355	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSCAFT00000048845 ⟹ ENSCAFP00000041395

RefSeq Status:

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	4	39,244,286 - 39,247,592 (+)	Ensembl

RefSeq Acc Id:

ENSCAFT00845001038 ⟹ ENSCAFP00845000787

RefSeq Status:

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	4	39,614,913 - 39,618,296 (+)	Ensembl

RefSeq Acc Id:

NM_001010959 ⟹ NP_001010959

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	4	39,244,286 - 39,247,592 (+)	NCBI
Dog10K_Boxer_Tasha	4	39,189,667 - 39,192,973 (+)	NCBI
ROS_Cfam_1.0	4	39,614,963 - 39,618,267 (+)	NCBI
UMICH_Zoey_3.1	4	39,432,539 - 39,435,856 (+)	NCBI
UNSW_CanFamBas_1.0	4	39,621,539 - 39,624,869 (+)	NCBI
UU_Cfam_GSD_1.0	4	40,130,495 - 40,133,809 (+)	NCBI

Sequence:

show sequence

GCCTGGTCCCGCCTCTGCTGCCCCTGGTGCTCCGCACTACCTGCCGCCGGGCCACAACCCGAGC
TGGAAGGCGGGTGCTCGGGCGGGCGGCGGGCACCATGCGGGGAGGCTGCCAAAGGCCGTGGGCA
GCGCTGCTCTCTGCCGCCCACCTGGCGCTGTGAGACGCGCACTGCCACCATGTTCCCCAGCCCT
GCGCTCACGCCCACGCCGTTCTCGGTCAAAGACATCCTGAACCTGGAGCAGCAGCAGCGCAGCC
TGGCTGCCGGGGAGCTCTCGGCGCGCCTGGAGGCCACGCTGGCGCCCGCCTCCTGCATGCTGGC
CGCCTTCAAGCCCGAGGCCTACGCGGGGCCTGAGGCCGCTGCGCCCGCCCTCCCCGAGCTACGC
GCCGAGCTGGGCCCCGCGCCCTCGCCTGCCAAGTGTGCGCCTGCATTTCCAGGCGCCCCTGCCT
TCTATCCGCGGGCCTATGGCGACCCCGACACCGCCAAGGACCCTCGAGCTGATAAGAAAGAGCT
GTGCTCACTGCAGAAGGCGGTGGAGCTGGAGAAGCCGGAGGCCGACGGCGCGGAGCGACCCAGG
GCGCGACGGCGGAGGAAGCCGCGCGTGCTCTTCTCGCAGGCGCAGGTCTACGAGCTGGAGCGGC
GCTTCAAGCAGCAGCGGTATCTGTCGGCCCCTGAGCGCGACCAGCTGGCCAGCGTGCTGAAGCT
CACGTCCACGCAGGTCAAGATCTGGTTCCAGAACCGGCGCTACAAGTGCAAGCGGCAGCGGCAG
GACCAGACTCTGGAGCTGGTGGGACTGCCCCCGCCGCCGCCGCCCGCCCGCAGGATCGCGGTAC
CGGTGCTGGTGCGCGACGGCAAGCCCTGCCTGGGGGACTCGGCGCCCTACGCGCCCGCCTACGG
CGTGGGCCTCAACGCCTACGGCTATAACGCCTACCCCGCCTATCCGGGTTACGGGAGCGCGGCC
TGCAGCCCTGGCTACAGCTGCGCCGCCGCTTACCCAGCCGGTCCGCCCCCGGCGCAGGCGGCTA
CGGCCGCCACCAACAACAACTTCGTGAACTTTGGCGTCGGGGACTTGAACGCGGTGCAGAGCCC
CGGGATTCCGCAGGGCAACTCGGGAGTGTCCACGTTGCACGGTATCCGAGCCTGGTAGGAAAGG
GCCCTAGGACCTGGGGCGCCCCGACCGATCCCAGCTCTAGAGAGGGACACTGAGTCTCGGGGGA
GGGAGGACCCCGACGTGTCTCCACGTCCCTTGGATTTCACATTCACTCCCGCAGGGGCCTCAGA
GCTCTTTTCGCCCCGTGCGCCTTTGTCCCCAAGCGCGGGAGAGTTTGTGGCCGCGTTTACAGAG
CTTGCGGAGAATGATCCCGCAGCCTGGTGCCTTAGCCATCGCCCCCAGAGTGGCCTCCAAACGC
CCACGGGCACCCCCAACCGGCTGAACCTGGGCCAGTTGGGACTGGGAGCCCGGGTGCACCTTTC
CTCGAGCCTGGGCCCGGCGCCCGGGCCCTTGCCGCCTTGCCGCCGCCCACCCAGCCCACCCACC
CGTATTTATGTTTTTACCTGTTGCTGTAAGAAATGGGAA

hide sequence

RefSeq Acc Id:

XM_038662303 ⟹ XP_038518231

RefSeq Status:

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	4	39,612,577 - 39,618,296 (+)	NCBI

RefSeq Acc Id:

XM_038662304 ⟹ XP_038518232

RefSeq Status:

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	4	39,612,560 - 39,616,806 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001010959	(Get FASTA)	NCBI Sequence Viewer
	XP_038518231	(Get FASTA)	NCBI Sequence Viewer
	XP_038518232	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAS99114	(Get FASTA)	NCBI Sequence Viewer
	ABB00236	(Get FASTA)	NCBI Sequence Viewer
	ABC71311	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_001010959 ⟸ NM_001010959

- UniProtKB:

Q5J2F2 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MFPSPALTPTPFSVKDILNLEQQQRSLAAGELSARLEATLAPASCMLAAFKPEAYAGPEAAAPA
LPELRAELGPAPSPAKCAPAFPGAPAFYPRAYGDPDTAKDPRADKKELCSLQKAVELEKPEADG
AERPRARRRRKPRVLFSQAQVYELERRFKQQRYLSAPERDQLASVLKLTSTQVKIWFQNRRYKC
KRQRQDQTLELVGLPPPPPPARRIAVPVLVRDGKPCLGDSAPYAPAYGVGLNAYGYNAYPAYPG
YGSAACSPGYSCAAAYPAGPPPAQAATAATNNNFVNFGVGDLNAVQSPGIPQGNSGVSTLHGIR
AW

hide sequence

RefSeq Acc Id:

ENSCAFP00000041395 ⟸ ENSCAFT00000048845

RefSeq Acc Id:	XP_038518232 ⟸ XM_038662304
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038518231 ⟸ XM_038662303
- Peptide Label:	isoform X1

RefSeq Acc Id:

ENSCAFP00845000787 ⟸ ENSCAFT00845001038

Protein Domains

Homeobox

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000031960	Ensembl, UniProtKB/TrEMBL
	ENSCAFG00030001855	UniProtKB/TrEMBL
	ENSCAFG00040000105	UniProtKB/TrEMBL
	ENSCAFG00845000634	Ensembl, ENTREZGENE
Ensembl Protein	ENSCAFP00000041395	UniProtKB/TrEMBL
	ENSCAFP00030002990	UniProtKB/TrEMBL
	ENSCAFP00040000107	UniProtKB/TrEMBL
	ENSCAFP00845000787	ENTREZGENE
Ensembl Transcript	ENSCAFT00000048845	UniProtKB/TrEMBL
	ENSCAFT00030003375	UniProtKB/TrEMBL
	ENSCAFT00040000145	UniProtKB/TrEMBL
	ENSCAFT00845001038	ENTREZGENE
InterPro	Homeobox-like_sf	UniProtKB/TrEMBL
	Homeobox_CS	UniProtKB/TrEMBL
	Homeobox_dom	UniProtKB/TrEMBL
	Homeobox_metazoa	UniProtKB/TrEMBL
	NKX-2.5	UniProtKB/TrEMBL
KEGG Report	cfa:489113	UniProtKB/TrEMBL
NCBI Gene	NKX2-5	ENTREZGENE
PANTHER	PTHR24340:SF28	UniProtKB/TrEMBL
Pfam	Homeodomain	UniProtKB/TrEMBL
PRINTS	HOMEOBOX	UniProtKB/TrEMBL
PROSITE	HOMEOBOX_1	UniProtKB/TrEMBL
	HOMEOBOX_2	UniProtKB/TrEMBL
SMART	HOX	UniProtKB/TrEMBL
Superfamily-SCOP	SSF46689	UniProtKB/TrEMBL
UniProt	A0A8C0LX42_CANLF	UniProtKB/TrEMBL
	Q5J2F2	ENTREZGENE, UniProtKB/TrEMBL
VGNC ID	VGNC:43834	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM