NKX2-5 (NK2 homeobox 5) - Rat Genome Database

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Gene: NKX2-5 (NK2 homeobox 5) Canis lupus familiaris
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Symbol: NKX2-5
Name: NK2 homeobox 5
RGD ID: 12257048
Description: ENCODES a protein that exhibits DNA-binding transcription factor activity (ortholog); histone deacetylase binding (ortholog); identical protein binding (ortholog); INVOLVED IN adult heart development (ortholog); apoptotic process (ortholog); apoptotic process involved in heart morphogenesis (ortholog); ASSOCIATED WITH aortic valve disease 2 (ortholog); atrial fibrillation (ortholog); atrial heart septal defect (ortholog); FOUND IN nucleus (ortholog)
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: homeobox protein Nkx-2.5; NK2 transcription factor related, locus 5; NKX2.5; transcription factor NKX2.5
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1439,240,755 - 39,254,585 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl439,244,286 - 39,247,592 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha439,189,667 - 39,192,973 (+)NCBI
ROS_Cfam_1.0439,612,560 - 39,618,296 (+)NCBI
ROS_Cfam_1.0 Ensembl439,614,913 - 39,618,296 (+)Ensembl
UMICH_Zoey_3.1439,432,539 - 39,435,856 (+)NCBI
UNSW_CanFamBas_1.0439,621,539 - 39,624,869 (+)NCBI
UU_Cfam_GSD_1.0440,130,495 - 40,133,809 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adult heart development  (IEA,ISO)
apoptotic process  (IEA,ISO)
apoptotic process involved in heart morphogenesis  (IEA,ISO)
atrial cardiac muscle tissue development  (IEA)
atrial septum morphogenesis  (IEA)
atrioventricular node cell development  (IEA,ISO)
atrioventricular node cell fate commitment  (IEA,ISO)
atrioventricular node development  (IEA)
bundle of His development  (IEA,ISO)
cardiac conduction system development  (IEA,ISO)
cardiac muscle cell development  (IEA)
cardiac muscle cell differentiation  (IEA,ISO)
cardiac muscle cell proliferation  (IEA,ISO)
cardiac muscle contraction  (IEA,ISO)
cardiac muscle tissue development  (IEA,ISO)
cardiac muscle tissue morphogenesis  (IEA)
cardiac ventricle formation  (IEA,ISO)
cardiac ventricle morphogenesis  (IEA,ISO)
cell differentiation  (IBA)
cell population proliferation  (IEA,ISO)
cellular response to growth factor stimulus  (ISO)
cellular response to hydrogen peroxide  (ISO)
embryonic heart tube development  (IEA,ISO)
embryonic heart tube left/right pattern formation  (IEA,ISO)
epithelial cell apoptotic process  (IEA,ISO)
epithelial cell differentiation  (IEA,ISO)
epithelial cell proliferation  (IEA,ISO)
heart contraction  (IEA,ISO)
heart development  (IEA,ISO)
heart looping  (IEA,ISO)
heart morphogenesis  (IEA,ISO)
heart trabecula formation  (IEA,ISO)
hemopoiesis  (IEA,ISO)
negative regulation of canonical Wnt signaling pathway  (IEA)
negative regulation of cardiac muscle cell apoptotic process  (IEA)
negative regulation of epithelial cell apoptotic process  (IEA,ISO)
negative regulation of myotube differentiation  (IEA)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
outflow tract morphogenesis  (IEA,ISO)
outflow tract septum morphogenesis  (IEA)
pharyngeal system development  (IEA,ISO)
positive regulation of cardioblast differentiation  (IEA)
positive regulation of cell population proliferation  (IEA)
positive regulation of epithelial cell proliferation  (IEA,ISO)
positive regulation of gene expression  (IEA)
positive regulation of heart contraction  (IEA)
positive regulation of neuron differentiation  (IEA)
positive regulation of sodium ion transport  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of transcription initiation from RNA polymerase II promoter  (IEA)
positive regulation of transcription via serum response element binding  (IEA)
positive regulation of transcription, DNA-templated  (IEA,ISO)
proepicardium development  (IEA,ISO)
pulmonary myocardium development  (IEA,ISO)
Purkinje myocyte differentiation  (IEA,ISO)
regulation of cardiac conduction  (IEA)
regulation of cardiac muscle cell proliferation  (IEA,ISO)
regulation of cardiac muscle contraction  (IEA)
regulation of transcription by RNA polymerase II  (IBA,IEA,ISO)
regulation of transcription, DNA-templated  (IEA)
response to estradiol  (ISO)
right ventricular cardiac muscle tissue morphogenesis  (IEA)
sarcomere organization  (IEA)
septum secundum development  (IEA)
spleen development  (IEA,ISO)
thyroid gland development  (IEA)
transcription by RNA polymerase II  (IEA,ISO)
vasculogenesis  (IEA,ISO)
ventricular cardiac myofibril assembly  (IEA,ISO)
ventricular septum morphogenesis  (IEA)
ventricular trabecula myocardium morphogenesis  (IEA,ISO)

Cellular Component

References
Additional References at PubMed
PMID:16706928  


Genomics

Comparative Map Data
NKX2-5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1439,240,755 - 39,254,585 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl439,244,286 - 39,247,592 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha439,189,667 - 39,192,973 (+)NCBI
ROS_Cfam_1.0439,612,560 - 39,618,296 (+)NCBI
ROS_Cfam_1.0 Ensembl439,614,913 - 39,618,296 (+)Ensembl
UMICH_Zoey_3.1439,432,539 - 39,435,856 (+)NCBI
UNSW_CanFamBas_1.0439,621,539 - 39,624,869 (+)NCBI
UU_Cfam_GSD_1.0440,130,495 - 40,133,809 (+)NCBI
NKX2-5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385173,232,109 - 173,235,206 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl5173,232,109 - 173,235,311 (-)EnsemblGRCh38hg38GRCh38
GRCh375172,659,112 - 172,662,209 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365172,591,744 - 172,594,868 (-)NCBINCBI36hg18NCBI36
Celera5168,692,473 - 168,695,681 (-)NCBI
Cytogenetic Map5q35.1NCBI
HuRef5167,754,405 - 167,757,613 (-)NCBIHuRef
CHM1_15172,091,589 - 172,094,797 (-)NCBICHM1_1
T2T-CHM13v2.05173,772,181 - 173,775,278 (-)NCBI
Nkx2-5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391727,057,638 - 27,063,962 (-)NCBIGRCm39mm39
GRCm39 Ensembl1727,057,638 - 27,063,983 (-)Ensembl
GRCm381726,838,664 - 26,844,988 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1726,838,664 - 26,845,009 (-)EnsemblGRCm38mm10GRCm38
MGSCv371726,975,610 - 26,978,510 (-)NCBIGRCm37mm9NCBIm37
MGSCv361726,566,254 - 26,569,154 (-)NCBImm8
Celera1727,375,289 - 27,378,187 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1713.6NCBI
Nkx2-5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21016,340,428 - 16,347,004 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1016,344,159 - 16,346,934 (+)Ensembl
Rnor_6.01016,635,989 - 16,638,758 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1016,635,989 - 16,638,764 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01016,520,570 - 16,527,836 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41016,606,183 - 16,608,952 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11016,607,231 - 16,610,001 (+)NCBI
Celera1016,004,548 - 16,007,317 (+)NCBICelera
Cytogenetic Map10q12NCBI
Nkx2-5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540825,832,683 - 25,836,840 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540825,833,649 - 25,836,673 (-)NCBIChiLan1.0ChiLan1.0
NKX2-5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.15175,492,288 - 175,495,514 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5175,492,288 - 175,495,514 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v05168,584,197 - 168,589,406 (-)NCBIMhudiblu_PPA_v0panPan3
Nkx2-5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721393,683,325 - 93,686,308 (+)NCBI
SpeTri2.0NW_0049366092,406,004 - 2,408,980 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NKX2-5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1651,086,011 - 51,089,165 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11651,086,014 - 51,089,165 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21655,400,567 - 55,403,626 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NKX2-5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12375,391,833 - 75,399,003 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2375,391,847 - 75,395,205 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660343,212,995 - 3,216,184 (+)NCBIVero_WHO_p1.0
Nkx2-5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473316,881,191 - 16,884,210 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462473316,881,189 - 16,884,245 (+)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5
Low 4 15 1 2 12 10 6
Below cutoff 1 7 6 6 4 6 8

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000048845   ⟹   ENSCAFP00000041395
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl439,244,286 - 39,247,592 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845001038   ⟹   ENSCAFP00845000787
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl439,614,913 - 39,618,296 (+)Ensembl
RefSeq Acc Id: NM_001010959   ⟹   NP_001010959
RefSeq Status: VALIDATED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1439,244,286 - 39,247,592 (+)NCBI
Dog10K_Boxer_Tasha439,189,667 - 39,192,973 (+)NCBI
ROS_Cfam_1.0439,614,963 - 39,618,267 (+)NCBI
UMICH_Zoey_3.1439,432,539 - 39,435,856 (+)NCBI
UNSW_CanFamBas_1.0439,621,539 - 39,624,869 (+)NCBI
UU_Cfam_GSD_1.0440,130,495 - 40,133,809 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038662303   ⟹   XP_038518231
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0439,612,577 - 39,618,296 (+)NCBI
RefSeq Acc Id: XM_038662304   ⟹   XP_038518232
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0439,612,560 - 39,616,806 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001010959 (Get FASTA)   NCBI Sequence Viewer  
  XP_038518231 (Get FASTA)   NCBI Sequence Viewer  
  XP_038518232 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAS99114 (Get FASTA)   NCBI Sequence Viewer  
  ABB00236 (Get FASTA)   NCBI Sequence Viewer  
  ABC71311 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001010959   ⟸   NM_001010959
- UniProtKB: Q5J2F2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000041395   ⟸   ENSCAFT00000048845
RefSeq Acc Id: XP_038518232   ⟸   XM_038662304
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038518231   ⟸   XM_038662303
- Peptide Label: isoform X1
RefSeq Acc Id: ENSCAFP00845000787   ⟸   ENSCAFT00845001038
Protein Domains
Homeobox


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000031960 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030001855 UniProtKB/TrEMBL
  ENSCAFG00040000105 UniProtKB/TrEMBL
  ENSCAFG00845000634 Ensembl, ENTREZGENE
Ensembl Protein ENSCAFP00000041395 UniProtKB/TrEMBL
  ENSCAFP00030002990 UniProtKB/TrEMBL
  ENSCAFP00040000107 UniProtKB/TrEMBL
  ENSCAFP00845000787 ENTREZGENE
Ensembl Transcript ENSCAFT00000048845 UniProtKB/TrEMBL
  ENSCAFT00030003375 UniProtKB/TrEMBL
  ENSCAFT00040000145 UniProtKB/TrEMBL
  ENSCAFT00845001038 ENTREZGENE
InterPro Homeobox-like_sf UniProtKB/TrEMBL
  Homeobox_CS UniProtKB/TrEMBL
  Homeobox_dom UniProtKB/TrEMBL
  Homeobox_metazoa UniProtKB/TrEMBL
  NKX-2.5 UniProtKB/TrEMBL
KEGG Report cfa:489113 UniProtKB/TrEMBL
NCBI Gene NKX2-5 ENTREZGENE
PANTHER PTHR24340:SF28 UniProtKB/TrEMBL
Pfam Homeodomain UniProtKB/TrEMBL
PRINTS HOMEOBOX UniProtKB/TrEMBL
PROSITE HOMEOBOX_1 UniProtKB/TrEMBL
  HOMEOBOX_2 UniProtKB/TrEMBL
SMART HOX UniProtKB/TrEMBL
Superfamily-SCOP SSF46689 UniProtKB/TrEMBL
UniProt A0A8C0LX42_CANLF UniProtKB/TrEMBL
  Q5J2F2 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:43834 ENTREZGENE