Nkx2-5 (NK2 homeobox 5) - Rat Genome Database

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Gene: Nkx2-5 (NK2 homeobox 5) Ictidomys tridecemlineatus
Analyze
Symbol: Nkx2-5
Name: NK2 homeobox 5
RGD ID: 12534617
Description: ENCODES a protein that exhibits chromatin binding (ortholog); DNA binding (ortholog); DNA-binding transcription activator activity (ortholog); INVOLVED IN adult heart development (ortholog); apoptotic process involved in heart morphogenesis (ortholog); atrial cardiac muscle tissue development (ortholog); ASSOCIATED WITH aortic valve disease 2 (ortholog); atrial fibrillation (ortholog); atrial heart septal defect (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog); protein-containing complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: homeobox protein Nkx-2.5
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721393,683,325 - 93,686,308 (+)NCBI
SpeTri2.0NW_0049366092,406,004 - 2,408,980 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adult heart development  (ISO)
apoptotic process involved in heart morphogenesis  (ISO)
atrial cardiac muscle tissue development  (ISO)
atrial septum morphogenesis  (ISO)
atrioventricular node cell development  (ISO)
atrioventricular node cell fate commitment  (ISO)
atrioventricular node development  (ISO)
bundle of His development  (ISO)
cardiac conduction system development  (ISO)
cardiac muscle cell development  (ISO)
cardiac muscle cell differentiation  (ISO)
cardiac muscle cell proliferation  (ISO)
cardiac muscle contraction  (ISO)
cardiac muscle tissue development  (ISO)
cardiac muscle tissue morphogenesis  (ISO)
cardiac ventricle formation  (ISO)
cardiac ventricle morphogenesis  (ISO)
cell differentiation  (ISO)
cellular response to growth factor stimulus  (ISO)
cellular response to hydrogen peroxide  (ISO)
circulatory system development  (ISO)
embryonic heart tube development  (ISO)
embryonic heart tube left/right pattern formation  (ISO)
heart contraction  (ISO)
heart development  (ISO)
heart looping  (ISO)
heart morphogenesis  (ISO)
heart trabecula formation  (ISO)
hemopoiesis  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of canonical Wnt signaling pathway  (ISO)
negative regulation of cardiac muscle cell apoptotic process  (ISO)
negative regulation of myotube differentiation  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
outflow tract morphogenesis  (ISO)
outflow tract septum morphogenesis  (ISO)
pharyngeal system development  (ISO)
positive regulation of cardioblast differentiation  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of heart contraction  (ISO)
positive regulation of neuron differentiation  (ISO)
positive regulation of sodium ion transport  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription initiation from RNA polymerase II promoter  (ISO)
positive regulation of transcription via serum response element binding  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
proepicardium development  (ISO)
pulmonary myocardium development  (ISO)
Purkinje myocyte differentiation  (ISO)
regulation of cardiac conduction  (ISO)
regulation of cardiac muscle cell proliferation  (ISO)
regulation of cardiac muscle contraction  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
response to estradiol  (ISO)
right ventricular cardiac muscle tissue morphogenesis  (ISO)
sarcomere organization  (ISO)
septum secundum development  (ISO)
spleen development  (ISO)
thyroid gland development  (ISO)
vasculogenesis  (ISO)
ventricular cardiac myofibril assembly  (ISO)
ventricular septum morphogenesis  (ISO)
ventricular trabecula myocardium morphogenesis  (ISO)

Cellular Component

References
Additional References at PubMed
PMID:25679215  


Genomics

Comparative Map Data
Nkx2-5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721393,683,325 - 93,686,308 (+)NCBI
SpeTri2.0NW_0049366092,406,004 - 2,408,980 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NKX2-5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl5173,232,109 - 173,235,311 (-)EnsemblGRCh38hg38GRCh38
GRCh385173,232,109 - 173,235,321 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh375172,659,112 - 172,662,209 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365172,591,744 - 172,594,868 (-)NCBINCBI36hg18NCBI36
Celera5168,692,473 - 168,695,681 (-)NCBI
Cytogenetic Map5q35.1NCBI
HuRef5167,754,405 - 167,757,613 (-)NCBIHuRef
CHM1_15172,091,589 - 172,094,797 (-)NCBICHM1_1
Nkx2-5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391727,057,638 - 27,063,962 (-)NCBIGRCm39mm39
GRCm39 Ensembl1727,057,638 - 27,063,983 (-)Ensembl
GRCm381726,838,664 - 26,844,988 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1726,838,664 - 26,845,009 (-)EnsemblGRCm38mm10GRCm38
MGSCv371726,975,610 - 26,978,510 (-)NCBIGRCm37mm9NCBIm37
MGSCv361726,566,254 - 26,569,154 (-)NCBImm8
Celera1727,375,289 - 27,378,187 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1713.6NCBI
Nkx2-5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21016,340,428 - 16,347,004 (+)NCBImRatBN7.2
Rnor_6.0 Ensembl1016,635,989 - 16,638,764 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01016,635,989 - 16,638,758 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01016,520,570 - 16,527,836 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41016,606,183 - 16,608,952 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11016,607,231 - 16,610,001 (+)NCBI
Celera1016,004,548 - 16,007,317 (+)NCBICelera
Cytogenetic Map10q12NCBI
Nkx2-5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540825,832,683 - 25,836,840 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540825,833,649 - 25,836,673 (-)NCBIChiLan1.0ChiLan1.0
NKX2-5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.15175,492,288 - 175,495,514 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5175,492,288 - 175,495,514 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v05168,584,197 - 168,589,406 (-)NCBIMhudiblu_PPA_v0panPan3
NKX2-5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1439,240,755 - 39,254,585 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl439,244,286 - 39,247,592 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha439,189,667 - 39,192,973 (+)NCBI
ROS_Cfam_1.0439,612,560 - 39,618,296 (+)NCBI
UMICH_Zoey_3.1439,432,539 - 39,435,856 (+)NCBI
UNSW_CanFamBas_1.0439,621,539 - 39,624,869 (+)NCBI
UU_Cfam_GSD_1.0440,130,495 - 40,133,809 (+)NCBI
NKX2-5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1651,086,011 - 51,089,165 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11651,086,014 - 51,089,165 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21655,400,567 - 55,403,626 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NKX2-5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12375,391,833 - 75,399,003 (-)NCBI
ChlSab1.1 Ensembl2375,391,847 - 75,395,205 (-)Ensembl
Vero_WHO_p1.0NW_0236660343,212,995 - 3,216,184 (+)NCBI
Nkx2-5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473316,881,189 - 16,884,245 (+)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_005334114   ⟹   XP_005334171
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440721393,683,325 - 93,686,308 (+)NCBI
SpeTri2.0NW_0049366092,406,004 - 2,408,980 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005334171 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AGC95105 (Get FASTA)   NCBI Sequence Viewer  
  KAG3265246 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005334171   ⟸   XM_005334114
- UniProtKB: I3M459 (UniProtKB/TrEMBL)
- Sequence:
Protein Domains
Homeobox


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000004407 ENTREZGENE
Ensembl Protein ENSSTOP00000003943 ENTREZGENE
NCBI Gene Nkx2-5 ENTREZGENE
UniProt I3M459 ENTREZGENE