Kat2b (lysine acetyltransferase 2B)

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Gene: Kat2b (lysine acetyltransferase 2B) Rattus norvegicus

Analyze

Symbol:

Kat2b

Name:

lysine acetyltransferase 2B

RGD ID:

1305902

Description:

Enables chromatin binding activity; histone acetyltransferase binding activity; and histone deacetylase binding activity. Involved in several processes, including cellular response to parathyroid hormone stimulus; memory; and vasodilation. Part of chromatin. Orthologous to human KAT2B (lysine acetyltransferase 2B); PARTICIPATES IN cortisol signaling pathway; histone modification pathway; p53 signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,4-dinitrotoluene; acrylamide.

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

AABR07066180.1; histone acetyltransferase KAT2B; K(lysine) acetyltransferase 2B; LOC301164; p300/CBP-associated factor; Pcaf

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	9	6,562,525 - 6,667,064 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	6,562,288 - 6,667,064 (+)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	9	4,440,982 - 4,492,949 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	4,440,982 - 4,447,715 (-)	NCBI	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	3,479,552 - 3,531,771 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	9	882,928 - 889,661	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	9	882,927 - 889,661	NCBI
Cytogenetic Map	9	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

3p deletion syndrome (ISO)

breast cancer (ISO)

Coronary Disease (ISO)

esophagus squamous cell carcinoma (ISO)

genetic disease (ISO)

hepatocellular carcinoma (ISO)

rheumatoid arthritis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

(1->4)-beta-D-glucan (ISO)

(S)-naringenin (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (EXP,ISO)

17beta-estradiol (ISO)

17beta-hydroxy-17-methylestra-4,9,11-trien-3-one (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4-dinitrotoluene (EXP)

2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid (ISO)

3,5-diethoxycarbonyl-1,4-dihydrocollidine (ISO)

4-hydroxyphenyl retinamide (ISO)

5-aza-2'-deoxycytidine (ISO)

acetyl-CoA (ISO)

acrylamide (EXP)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

aflatoxin M1 (ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

arsenite(3-) (ISO)

arsenous acid (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

Benzo[k]fluoranthene (ISO)

bis(2-chloroethyl) sulfide (ISO)

bisphenol A (EXP,ISO)

bortezomib (ISO)

buta-1,3-diene (ISO)

butanal (ISO)

butyryl-CoA (ISO)

cadmium atom (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chromium(6+) (ISO)

cisplatin (ISO)

coenzyme A (ISO)

coumestrol (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

deoxynivalenol (ISO)

dexamethasone (ISO)

diarsenic trioxide (ISO)

dibutyl phthalate (ISO)

disodium selenite (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

entinostat (ISO)

enzalutamide (ISO)

ethyl methanesulfonate (ISO)

fluvastatin (ISO)

formaldehyde (ISO)

genistein (ISO)

gentamycin (EXP)

glafenine (EXP)

hydroxyurea (ISO)

irinotecan (ISO)

isobutyryl-CoA (ISO)

linalool (ISO)

methapyrilene (EXP,ISO)

methidathion (ISO)

methotrexate (ISO)

methyl methanesulfonate (ISO)

methylmercury chloride (ISO)

methylparaben (ISO)

N-nitrosodiethylamine (EXP)

nickel dichloride (EXP)

ozone (ISO)

panobinostat (ISO)

paracetamol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (ISO)

phenylmercury acetate (ISO)

potassium bromate (ISO)

potassium chromate (ISO)

propiconazole (ISO)

prostaglandin E2 (ISO)

quercetin (ISO)

resveratrol (ISO)

SB 431542 (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sodium fluoride (ISO)

sulforaphane (ISO)

superoxide (ISO)

temozolomide (ISO)

thimerosal (ISO)

thioacetamide (EXP)

triadimefon (ISO)

trichostatin A (ISO)

triptonide (ISO)

tris(2-butoxyethyl) phosphate (ISO)

tunicamycin (ISO)

urethane (ISO)

valproic acid (ISO)

vincristine (ISO)

zearalenone (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to insulin stimulus (ISO)

cellular response to oxidative stress (IEP)

cellular response to parathyroid hormone stimulus (IEP)

chromatin remodeling (ISO)

gluconeogenesis (ISO)

memory (IEP)

negative regulation of cell population proliferation (ISO)

negative regulation of centriole replication (ISO)

negative regulation of rRNA processing (ISO)

negative regulation of transcription by RNA polymerase II (IEA,ISO)

positive regulation of attachment of mitotic spindle microtubules to kinetochore (ISO)

positive regulation of chromatin binding (IMP)

positive regulation of DNA-templated transcription (ISO)

positive regulation of fatty acid biosynthetic process (ISO)

positive regulation of gluconeogenesis (ISO)

positive regulation of glycolytic process (ISO)

positive regulation of lipid biosynthetic process (ISO)

positive regulation of neuron projection development (IMP)

positive regulation of transcription by RNA polymerase II (IMP,ISO)

positive regulation of transcription from RNA polymerase II promoter by glucose (ISO)

protein acetylation (IMP)

vasodilation (IDA)

Cellular Component

A band (ISO)

actomyosin (ISO)

ATAC complex (ISO)

centrosome (ISO)

chromatin (IDA)

cytosol (IEA,ISO)

histone acetyltransferase complex (ISO)

I band (ISO)

kinetochore (ISO)

nucleoplasm (IEA,ISO)

nucleus (ISO)

protein-containing complex (ISO)

Molecular Function

acetyltransferase activity (ISO)

chromatin binding (IDA,ISO)

cyclin-dependent protein serine/threonine kinase inhibitor activity (ISO)

DNA-binding transcription factor binding (ISO)

histone acetyltransferase activity (ISO)

histone acetyltransferase binding (IPI)

histone deacetylase binding (IPI,ISO)

histone H3K9 acetyltransferase activity (ISO)

lysine N-acetyltransferase activity, acting on acetyl phosphate as donor (ISO)

peptide-lysine-N-acetyltransferase activity (ISO)

protein binding (IPI,ISO)

protein kinase binding (ISO)

RNA polymerase II transcription regulatory region sequence-specific DNA binding (ISO)

transcription coactivator activity (ISO)

transcription coregulator activity (ISO)

transcription factor binding (IPI)

Molecular Pathway Annotations Click to see Annotation Detail View

cortisol signaling pathway (ISO)

histone modification pathway (ISO)

Notch signaling pathway (IEA)

p53 signaling pathway (ISO)

RNA polymerase II transcription initiation pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transcriptional regulation by p53.	Beckerman R and Prives C, Cold Spring Harb Perspect Biol. 2010 Aug;2(8):a000935. doi: 10.1101/cshperspect.a000935. Epub 2010 Apr 28.
2.	Spatial memory consolidation is associated with induction of several lysine-acetyltransferase (histone acetyltransferase) expression levels and H2B/H4 acetylation-dependent transcriptional events in the rat hippocampus.	Bousiges O, etal., Neuropsychopharmacology. 2010 Dec;35(13):2521-37. doi: 10.1038/npp.2010.117. Epub 2010 Sep 1.
3.	P300/CBP associated factor regulates nitroglycerin-dependent arterial relaxation by N(epsilon)-lysine acetylation of contractile proteins.	Colussi C, etal., Arterioscler Thromb Vasc Biol. 2012 Oct;32(10):2435-43. doi: 10.1161/ATVBAHA.112.254011. Epub 2012 Aug 2.
4.	Regulation of acetylation of histone deacetylase 2 by p300/CBP-associated factor/histone deacetylase 5 in the development of cardiac hypertrophy.	Eom GH, etal., Circ Res. 2014 Mar 28;114(7):1133-43. doi: 10.1161/CIRCRESAHA.114.303429. Epub 2014 Feb 13.
5.	HDAC inhibition promotes neuronal outgrowth and counteracts growth cone collapse through CBP/p300 and P/CAF-dependent p53 acetylation.	Gaub P, etal., Cell Death Differ. 2010 Sep;17(9):1392-408. doi: 10.1038/cdd.2009.216. Epub 2010 Jan 22.
6.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7.	Upregulation of KAT2B and ESCO2 gene expression level in patients with rheumatoid arthritis.	Ghasemi A, etal., Clin Rheumatol. 2022 Sep 15. doi: 10.1007/s10067-022-06351-4.
8.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
9.	Parathyroid hormone activation of matrix metalloproteinase-13 transcription requires the histone acetyltransferase activity of p300 and PCAF and p300-dependent acetylation of PCAF.	Lee M and Partridge NC, J Biol Chem. 2010 Dec 3;285(49):38014-22. doi: 10.1074/jbc.M110.142141. Epub 2010 Sep 24.
10.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
11.	Histone-modifier gene expression profiles are associated with pathological and clinical outcomes in human breast cancer.	Patani N, etal., Anticancer Res. 2011 Dec;31(12):4115-25.
12.	Physical and functional HAT/HDAC interplay regulates protein acetylation balance.	Peserico A and Simone C, J Biomed Biotechnol. 2011;2011:371832. doi: 10.1155/2011/371832. Epub 2010 Dec 5.
13.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
14.	Genetic variation in PCAF, a key mediator in epigenetics, is associated with reduced vascular morbidity and mortality: evidence for a new concept from three independent prospective studies.	Pons D, etal., Heart. 2011 Jan;97(2):143-50. doi: 10.1136/hrt.2010.199927. Epub 2010 Nov 8.
15.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
16.	GSK-3-mediated phosphorylation enhances Maf-transforming activity.	Rocques N, etal., Mol Cell. 2007 Nov 30;28(4):584-97.
17.	Proteomics profiling of nuclear proteins for kidney fibroblasts suggests hypoxia, meiosis, and cancer may meet in the nucleus.	Shakib K, etal., Proteomics. 2005 Jul;5(11):2819-38.
18.	Loss of androgen receptor in aging and oxidative stress through Myb protooncoprotein-regulated reciprocal chromatin dynamics of p53 and poly(ADP-ribose) polymerase PARP-1.	Shi L, etal., J Biol Chem. 2008 Dec 26;283(52):36474-85. Epub 2008 Oct 21.
19.	ATAC-king the complexity of SAGA during evolution.	Spedale G, etal., Genes Dev. 2012 Mar 15;26(6):527-41. doi: 10.1101/gad.184705.111.
20.	[Expression of PCAF in hepatocellular carcinoma and its clinical significance].	Tuo H, etal., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2013 Mar;29(3):297-300.
21.	Nerve growth factor receptor signaling induces histone acetyltransferase domain-dependent nuclear translocation of p300/CREB-binding protein-associated factor and hGCN5 acetyltransferases.	Wong K, etal., J Biol Chem. 2004 Dec 31;279(53):55667-74. Epub 2004 Oct 20.
22.	Characterization of tumor suppressive function of P300/CBP-associated factor at frequently deleted region 3p24 in esophageal squamous cell carcinoma.	Zhu C, etal., Oncogene. 2009 Aug 6;28(31):2821-8. doi: 10.1038/onc.2009.137. Epub 2009 Jun 15.

Additional References at PubMed

PMID:8684459	PMID:9742083	PMID:11250901	PMID:12435739	PMID:12477932	PMID:12887892	PMID:14519686	PMID:14645221	PMID:15273251	PMID:15509593	PMID:15601857	PMID:15607978
PMID:15647252	PMID:15992539	PMID:16055439	PMID:16245309	PMID:16829519	PMID:17301242	PMID:17505058	PMID:17707232	PMID:18250163	PMID:18834332	PMID:18838386	PMID:19303849
PMID:19470756	PMID:19710011	PMID:19773423	PMID:20508642	PMID:21402781	PMID:23555303	PMID:23932781	PMID:24051374	PMID:26867678	PMID:27796307	PMID:29174768	PMID:30935684
PMID:32506381	PMID:32770803

Genomics

Comparative Map Data

Kat2b
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	9	6,562,525 - 6,667,064 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	6,562,288 - 6,667,064 (+)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	9	4,440,982 - 4,492,949 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	4,440,982 - 4,447,715 (-)	NCBI	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	3,479,552 - 3,531,771 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	9	882,928 - 889,661	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	9	882,927 - 889,661	NCBI
Cytogenetic Map	9	q11	NCBI

KAT2B
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	20,040,446 - 20,154,404 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	20,040,446 - 20,154,404 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	20,081,938 - 20,195,896 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	20,056,528 - 20,170,900 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	3	20,056,527 - 20,170,898	NCBI
Celera	3	20,022,291 - 20,136,515 (+)	NCBI		Celera
Cytogenetic Map	3	p24.3	NCBI
HuRef	3	20,021,882 - 20,135,958 (+)	NCBI		HuRef
CHM1_1	3	20,033,609 - 20,147,728 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	3	20,044,513 - 20,158,472 (+)	NCBI		T2T-CHM13v2.0

Kat2b
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	53,873,802 - 53,979,749 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	53,873,889 - 53,979,748 (+)	Ensembl		GRCm39 Ensembl
GRCm38	17	53,566,774 - 53,672,721 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	53,566,861 - 53,672,720 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	53,706,640 - 53,812,045 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	53,032,244 - 53,137,649 (+)	NCBI		MGSCv36	mm8
Celera	17	57,012,579 - 57,114,621 (+)	NCBI		Celera
Cytogenetic Map	17	C	NCBI
cM Map	17	27.86	NCBI

Kat2b
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955430	12,128,069 - 12,198,117 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955430	12,109,493 - 12,196,102 (+)	NCBI	ChiLan1.0	ChiLan1.0

KAT2B
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	3	20,008,861 - 20,122,967 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	19,956,067 - 20,070,637 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	20,286,080 - 20,399,970 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	20,286,865 - 20,400,770 (+)	Ensembl	panpan1.1		panPan2

KAT2B
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	23	23,166,722 - 23,242,447 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	23	23,168,600 - 23,233,478 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	23	23,190,019 - 23,289,543 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	23	23,651,391 - 23,751,080 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	23	23,651,410 - 23,751,080 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	23	23,363,816 - 23,463,316 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	23	23,429,027 - 23,528,696 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	23	23,675,265 - 23,774,811 (-)	NCBI		UU_Cfam_GSD_1.0

Kat2b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	179,183,147 - 179,277,064 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936473	12,344,343 - 12,417,875 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936473	12,341,545 - 12,415,637 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

KAT2B
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	6,985,235 - 7,100,345 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	6,985,151 - 7,099,771 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	7,975,063 - 8,051,510 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

KAT2B
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	15	64,769,590 - 64,885,536 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	15	64,770,185 - 64,886,219 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666041	37,788,721 - 37,904,736 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Kat2b
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624821	5,387,212 - 5,489,013 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Kat2b
901 total Variants

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
10054141	Gmadr4	Adrenal mass QTL 4	2.45	0.0074	adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	9	1	14209783	Rat
70226	Eae4	Experimental allergic encephalomyelitis QTL 4			nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	9	1	25661317	Rat
9589055	Scfw5	Subcutaneous fat weight QTL 5	5.55	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	9	1	37999212	Rat
7411592	Foco8	Food consumption QTL 8	7.4	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	9	1	37999212	Rat
9589158	Gluco65	Glucose level QTL 65	6.82	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	9	1	37999212	Rat
1300124	Cm4	Cardiac mass QTL 4	3.55		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	9	1	40594091	Rat
1298088	Edpm11	Estrogen-dependent pituitary mass QTL 11	2.5		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	9	1	43718459	Rat
1641911	Alcrsp13	Alcohol response QTL 13			response to alcohol trait (VT:0010489)	brain neurotensin receptor 1 density (CMO:0002068)	9	1	43718459	Rat
10054125	Srcrt7	Stress Responsive Cort QTL 7	3.33	0.0011	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	9	1	87073594	Rat
1331757	Cdexp1	CD45RC expression in CD8 T cells QTL 1	4.3		CD8-positive T cell quantity (VT:0008077)	blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)	9	1024537	67509080	Rat
1354650	Despr5	Despair related QTL 5	4.01	0.0017	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	9	1254084	46254084	Rat
2303559	Gluco54	Glucose level QTL 54	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	9	1254084	46254084	Rat
1578675	Bss17	Bone structure and strength QTL 17	3.8		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	9	3368652	13533896	Rat
61425	Cia15	Collagen induced arthritis QTL 15	4.6		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	9	5109826	42921101	Rat
631211	Bw4	Body weight QTL4	5.31		retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	9	5109826	50109826	Rat

Markers in Region

Kat2b

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	35,427,123 - 35,427,190 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	36,022,224 - 36,022,290	NCBI	Rnor6.0
Rnor_5.0	5	40,677,186 - 40,677,252	UniSTS	Rnor5.0
RGSC_v3.4	5	36,629,653 - 36,629,719	UniSTS	RGSC3.4
Celera	5	34,441,108 - 34,441,174	UniSTS
Cytogenetic Map	9	q11	UniSTS

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003750617	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039084396	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039084397	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039084398	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039084399	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039084400	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC092639	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474184	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000207	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000061882 ⟹ ENSRNOP00000058599

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	9	6,562,288 - 6,667,064 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000104333 ⟹ ENSRNOP00000078189

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	9	6,562,288 - 6,667,064 (+)	Ensembl

RefSeq Acc Id:

XM_039084396 ⟹ XP_038940324

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	9	6,562,527 - 6,667,064 (+)	NCBI

RefSeq Acc Id:

XM_039084397 ⟹ XP_038940325

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	9	6,562,525 - 6,667,064 (+)	NCBI

RefSeq Acc Id:

XM_039084398 ⟹ XP_038940326

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	9	6,587,498 - 6,667,064 (+)	NCBI

RefSeq Acc Id:

XM_039084399 ⟹ XP_038940327

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	9	6,596,544 - 6,667,064 (+)	NCBI

RefSeq Acc Id:

XM_039084400 ⟹ XP_038940328

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	9	6,634,725 - 6,667,064 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_038940324	(Get FASTA)	NCBI Sequence Viewer
	XP_038940325	(Get FASTA)	NCBI Sequence Viewer
	XP_038940326	(Get FASTA)	NCBI Sequence Viewer
	XP_038940327	(Get FASTA)	NCBI Sequence Viewer
	XP_038940328	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH92639	(Get FASTA)	NCBI Sequence Viewer
	EDL82852	(Get FASTA)	NCBI Sequence Viewer
	EDL82853	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_038940325 ⟸ XM_039084397
- Peptide Label:	isoform X2
- UniProtKB:	A0A8J8YC15 (UniProtKB/TrEMBL), A6KUI5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038940324 ⟸ XM_039084396
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I5Y222 (UniProtKB/TrEMBL), A6KUI5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038940326 ⟸ XM_039084398
- Peptide Label:	isoform X3
- UniProtKB:	A6KUI5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038940327 ⟸ XM_039084399
- Peptide Label:	isoform X4
- UniProtKB:	A6KUI5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038940328 ⟸ XM_039084400
- Peptide Label:	isoform X5

RefSeq Acc Id:

ENSRNOP00000078189 ⟸ ENSRNOT00000104333

RefSeq Acc Id:

ENSRNOP00000058599 ⟸ ENSRNOT00000061882

Protein Domains

Bromo N-acetyltransferase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q568Z2-F1-model_v2	AlphaFold	Q568Z2	1-84	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1305902	AgrOrtholog
BioCyc Gene	G2FUF-28395	BioCyc
Ensembl Genes	ENSRNOG00000011871	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000058599	ENTREZGENE
	ENSRNOP00000058599.5	UniProtKB/TrEMBL
	ENSRNOP00000078189	ENTREZGENE
	ENSRNOP00000078189.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000061882	ENTREZGENE
	ENSRNOT00000061882.5	UniProtKB/TrEMBL
	ENSRNOT00000104333	ENTREZGENE
	ENSRNOT00000104333.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.920.10	UniProtKB/TrEMBL
	3.40.630.30	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7316752	IMAGE-MGC_LOAD
InterPro	Acyl_CoA_acyltransferase	UniProtKB/TrEMBL
	Bromodomain	UniProtKB/TrEMBL
	Bromodomain-like_sf	UniProtKB/TrEMBL
	Bromodomain_CS	UniProtKB/TrEMBL
	GCN5	UniProtKB/TrEMBL
	GCN5/PCAF	UniProtKB/TrEMBL
	GNAT_dom	UniProtKB/TrEMBL
	PCAF_N	UniProtKB/TrEMBL
MGC_CLONE	MGC:109373	IMAGE-MGC_LOAD
NCBI Gene	301164	ENTREZGENE
PANTHER	HISTONE ACETYLTRANSFERASE KAT2B	UniProtKB/TrEMBL
	PTHR45750	UniProtKB/TrEMBL
Pfam	Acetyltransf_1	UniProtKB/TrEMBL
	Bromodomain	UniProtKB/TrEMBL
	PCAF_N	UniProtKB/TrEMBL
PhenoGen	Kat2b	PhenoGen
PIRSF	Histone_acetylase_PCAF	UniProtKB/TrEMBL
PRINTS	BROMODOMAIN	UniProtKB/TrEMBL
PROSITE	BROMODOMAIN_1	UniProtKB/TrEMBL
	BROMODOMAIN_2	UniProtKB/TrEMBL
	GNAT	UniProtKB/TrEMBL
SMART	BROMO	UniProtKB/TrEMBL
Superfamily-SCOP	SSF47370	UniProtKB/TrEMBL
	SSF55729	UniProtKB/TrEMBL
UniProt	A0A8I5Y222	ENTREZGENE, UniProtKB/TrEMBL
	A0A8J8YC15	ENTREZGENE, UniProtKB/TrEMBL
	A6KUI5	ENTREZGENE, UniProtKB/TrEMBL
	Q568Z2_RAT	UniProtKB/TrEMBL
UniProt Secondary	F1LQ54	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2022-06-02	Kat2b	lysine acetyltransferase 2B	AABR07066180.1		Data Merged	737654	PROVISIONAL
2021-09-02	AABR07066180.1		Kat2b	lysine acetyltransferase 2B	Symbol and/or name change	19259462	PROVISIONAL
2021-08-09	Kat2b	lysine acetyltransferase 2B	AABR07066180.1		Symbol and/or name change	19259462	PROVISIONAL
2019-11-08	AABR07066180.1				Symbol and Name status set to provisional	45752	PROVISIONAL
2016-02-17	Kat2b	lysine acetyltransferase 2B	Kat2b	K(lysine) acetyltransferase 2B	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2014-06-25	Kat2b	K(lysine) acetyltransferase 2B	Pcaf	p300/CBP-associated factor	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	Pcaf	p300/CBP-associated factor	Pcaf_predicted	p300/CBP-associated factor (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Pcaf_predicted	p300/CBP-associated factor (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - KEGG (archival)