Kat2b (lysine acetyltransferase 2B) - Rat Genome Database

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Gene: Kat2b (lysine acetyltransferase 2B) Rattus norvegicus
Analyze
Symbol: Kat2b
Name: lysine acetyltransferase 2B
RGD ID: 1305902
Description: Enables chromatin binding activity; histone acetyltransferase binding activity; and histone deacetylase binding activity. Involved in several processes, including cellular response to parathyroid hormone stimulus; memory; and positive regulation of transcription by RNA polymerase II. Located in chromatin. Orthologous to human KAT2B (lysine acetyltransferase 2B); PARTICIPATES IN cortisol signaling pathway; histone modification pathway; p53 signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,4-dinitrotoluene; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AABR07066180.1; histone acetyltransferase KAT2B; K(lysine) acetyltransferase 2B; LOC301164; p300/CBP-associated factor; Pcaf
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr896,799,101 - 6,903,616 (+)NCBIGRCr8
mRatBN7.296,562,525 - 6,667,064 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl96,562,288 - 6,667,064 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.094,440,982 - 4,492,949 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl94,440,982 - 4,447,715 (-)NCBIRnor6.0rn6Rnor6.0
Rnor_5.093,479,552 - 3,531,771 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.49882,928 - 889,661NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.19882,927 - 889,661NCBI
Cytogenetic Map9q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
(S)-naringenin  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dinitrotoluene  (EXP)
2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid  (ISO)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
acetyl-CoA  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aflatoxin M1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
buta-1,3-diene  (ISO)
butanal  (ISO)
butyryl-CoA  (ISO)
cadmium atom  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
coenzyme A  (ISO)
coumestrol  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
enzalutamide  (ISO)
ethyl methanesulfonate  (ISO)
fluvastatin  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
hydroxyurea  (ISO)
irinotecan  (ISO)
isobutyryl-CoA  (ISO)
linalool  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methapyrilene  (EXP,ISO)
methidathion  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
N-nitrosodiethylamine  (EXP)
nickel dichloride  (EXP)
okadaic acid  (ISO)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
potassium bromate  (ISO)
potassium chromate  (ISO)
propiconazole  (ISO)
prostaglandin E2  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sulforaphane  (ISO)
superoxide  (ISO)
temozolomide  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
triadimefon  (ISO)
trichostatin A  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vincristine  (ISO)
zearalenone  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
A band  (IEA,ISO)
actomyosin  (IEA,ISO)
ATAC complex  (IBA,IEA,ISO)
centrosome  (IEA,ISO)
chromatin  (IDA)
cytoplasm  (IEA,ISO)
cytoskeleton  (IEA)
cytosol  (IEA,ISO)
histone acetyltransferase complex  (IEA,ISO)
I band  (IEA,ISO)
kinetochore  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IEA,ISO)
protein-containing complex  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transcriptional regulation by p53. Beckerman R and Prives C, Cold Spring Harb Perspect Biol. 2010 Aug;2(8):a000935. doi: 10.1101/cshperspect.a000935. Epub 2010 Apr 28.
2. Spatial memory consolidation is associated with induction of several lysine-acetyltransferase (histone acetyltransferase) expression levels and H2B/H4 acetylation-dependent transcriptional events in the rat hippocampus. Bousiges O, etal., Neuropsychopharmacology. 2010 Dec;35(13):2521-37. doi: 10.1038/npp.2010.117. Epub 2010 Sep 1.
3. P300/CBP associated factor regulates nitroglycerin-dependent arterial relaxation by N(epsilon)-lysine acetylation of contractile proteins. Colussi C, etal., Arterioscler Thromb Vasc Biol. 2012 Oct;32(10):2435-43. doi: 10.1161/ATVBAHA.112.254011. Epub 2012 Aug 2.
4. Regulation of acetylation of histone deacetylase 2 by p300/CBP-associated factor/histone deacetylase 5 in the development of cardiac hypertrophy. Eom GH, etal., Circ Res. 2014 Mar 28;114(7):1133-43. doi: 10.1161/CIRCRESAHA.114.303429. Epub 2014 Feb 13.
5. HDAC inhibition promotes neuronal outgrowth and counteracts growth cone collapse through CBP/p300 and P/CAF-dependent p53 acetylation. Gaub P, etal., Cell Death Differ. 2010 Sep;17(9):1392-408. doi: 10.1038/cdd.2009.216. Epub 2010 Jan 22.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Upregulation of KAT2B and ESCO2 gene expression level in patients with rheumatoid arthritis. Ghasemi A, etal., Clin Rheumatol. 2022 Sep 15. doi: 10.1007/s10067-022-06351-4.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Parathyroid hormone activation of matrix metalloproteinase-13 transcription requires the histone acetyltransferase activity of p300 and PCAF and p300-dependent acetylation of PCAF. Lee M and Partridge NC, J Biol Chem. 2010 Dec 3;285(49):38014-22. doi: 10.1074/jbc.M110.142141. Epub 2010 Sep 24.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Histone-modifier gene expression profiles are associated with pathological and clinical outcomes in human breast cancer. Patani N, etal., Anticancer Res. 2011 Dec;31(12):4115-25.
12. Physical and functional HAT/HDAC interplay regulates protein acetylation balance. Peserico A and Simone C, J Biomed Biotechnol. 2011;2011:371832. doi: 10.1155/2011/371832. Epub 2010 Dec 5.
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. Genetic variation in PCAF, a key mediator in epigenetics, is associated with reduced vascular morbidity and mortality: evidence for a new concept from three independent prospective studies. Pons D, etal., Heart. 2011 Jan;97(2):143-50. doi: 10.1136/hrt.2010.199927. Epub 2010 Nov 8.
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. GSK-3-mediated phosphorylation enhances Maf-transforming activity. Rocques N, etal., Mol Cell. 2007 Nov 30;28(4):584-97.
17. Proteomics profiling of nuclear proteins for kidney fibroblasts suggests hypoxia, meiosis, and cancer may meet in the nucleus. Shakib K, etal., Proteomics. 2005 Jul;5(11):2819-38.
18. Loss of androgen receptor in aging and oxidative stress through Myb protooncoprotein-regulated reciprocal chromatin dynamics of p53 and poly(ADP-ribose) polymerase PARP-1. Shi L, etal., J Biol Chem. 2008 Dec 26;283(52):36474-85. Epub 2008 Oct 21.
19. ATAC-king the complexity of SAGA during evolution. Spedale G, etal., Genes Dev. 2012 Mar 15;26(6):527-41. doi: 10.1101/gad.184705.111.
20. [Expression of PCAF in hepatocellular carcinoma and its clinical significance]. Tuo H, etal., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2013 Mar;29(3):297-300.
21. Nerve growth factor receptor signaling induces histone acetyltransferase domain-dependent nuclear translocation of p300/CREB-binding protein-associated factor and hGCN5 acetyltransferases. Wong K, etal., J Biol Chem. 2004 Dec 31;279(53):55667-74. Epub 2004 Oct 20.
22. Characterization of tumor suppressive function of P300/CBP-associated factor at frequently deleted region 3p24 in esophageal squamous cell carcinoma. Zhu C, etal., Oncogene. 2009 Aug 6;28(31):2821-8. doi: 10.1038/onc.2009.137. Epub 2009 Jun 15.
Additional References at PubMed
PMID:8684459   PMID:9742083   PMID:11250901   PMID:12435739   PMID:12477932   PMID:12887892   PMID:14519686   PMID:14645221   PMID:15273251   PMID:15509593   PMID:15601857   PMID:15607978  
PMID:15647252   PMID:15992539   PMID:16055439   PMID:16245309   PMID:16829519   PMID:17301242   PMID:17505058   PMID:17707232   PMID:18250163   PMID:18834332   PMID:18838386   PMID:19303849  
PMID:19470756   PMID:19710011   PMID:19773423   PMID:20508642   PMID:21402781   PMID:23555303   PMID:23932781   PMID:24051374   PMID:26867678   PMID:27796307   PMID:29174768   PMID:30935684  
PMID:32506381   PMID:32770803   PMID:39138001  


Genomics

Comparative Map Data
Kat2b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr896,799,101 - 6,903,616 (+)NCBIGRCr8
mRatBN7.296,562,525 - 6,667,064 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl96,562,288 - 6,667,064 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.094,440,982 - 4,492,949 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl94,440,982 - 4,447,715 (-)NCBIRnor6.0rn6Rnor6.0
Rnor_5.093,479,552 - 3,531,771 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.49882,928 - 889,661NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.19882,927 - 889,661NCBI
Cytogenetic Map9q11NCBI
KAT2B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38320,040,446 - 20,154,404 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl320,040,446 - 20,154,404 (+)EnsemblGRCh38hg38GRCh38
GRCh37320,081,938 - 20,195,896 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36320,056,528 - 20,170,900 (+)NCBINCBI36Build 36hg18NCBI36
Build 34320,056,527 - 20,170,898NCBI
Celera320,022,291 - 20,136,515 (+)NCBICelera
Cytogenetic Map3p24.3NCBI
HuRef320,021,882 - 20,135,958 (+)NCBIHuRef
CHM1_1320,033,609 - 20,147,728 (+)NCBICHM1_1
T2T-CHM13v2.0320,044,513 - 20,158,472 (+)NCBIT2T-CHM13v2.0
Kat2b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391753,873,802 - 53,979,749 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1753,873,889 - 53,979,748 (+)EnsemblGRCm39 Ensembl
GRCm381753,566,774 - 53,672,721 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1753,566,861 - 53,672,720 (+)EnsemblGRCm38mm10GRCm38
MGSCv371753,706,640 - 53,812,045 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361753,032,244 - 53,137,649 (+)NCBIMGSCv36mm8
Celera1757,012,579 - 57,114,621 (+)NCBICelera
Cytogenetic Map17CNCBI
cM Map1727.86NCBI
Kat2b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543012,128,069 - 12,198,117 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543012,109,493 - 12,196,102 (+)NCBIChiLan1.0ChiLan1.0
KAT2B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2220,004,090 - 20,118,205 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1320,008,861 - 20,122,967 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0319,956,067 - 20,070,637 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1320,286,080 - 20,399,970 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl320,286,865 - 20,400,770 (+)Ensemblpanpan1.1panPan2
KAT2B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12323,166,722 - 23,242,447 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2323,168,600 - 23,233,478 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2323,190,019 - 23,289,543 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02323,651,391 - 23,751,080 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2323,651,410 - 23,751,080 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12323,363,816 - 23,463,316 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02323,429,027 - 23,528,696 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02323,675,265 - 23,774,811 (-)NCBIUU_Cfam_GSD_1.0
Kat2b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118179,183,147 - 179,277,064 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647312,344,343 - 12,417,875 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647312,341,545 - 12,415,637 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KAT2B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl136,985,235 - 7,100,345 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1136,985,151 - 7,099,771 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2137,975,063 - 8,051,510 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KAT2B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11564,769,590 - 64,885,536 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1564,770,185 - 64,886,219 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604137,788,721 - 37,904,736 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kat2b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248215,387,212 - 5,489,013 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kat2b
1023 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9510982650109826Rat
10054141Gmadr4Adrenal mass QTL 42.450.0074adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)9114209783Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9125408446254084Rat
1578675Bss17Bone structure and strength QTL 173.8femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)9336865213533896Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)9137999212Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9143718459Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9125408446254084Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9140594091Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9510982642921101Rat
70226Eae4Experimental allergic encephalomyelitis QTL 4nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)9125661317Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)9137999212Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9137999212Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9143718459Rat

Markers in Region
Kat2b  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2535,427,123 - 35,427,190 (+)MAPPERmRatBN7.2
Rnor_6.0536,022,224 - 36,022,290NCBIRnor6.0
Rnor_5.0540,677,186 - 40,677,252UniSTSRnor5.0
RGSC_v3.4536,629,653 - 36,629,719UniSTSRGSC3.4
Celera534,441,108 - 34,441,174UniSTS
Cytogenetic Map9q11UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSRNOT00000061882   ⟹   ENSRNOP00000058599
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl96,562,288 - 6,667,064 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000104333   ⟹   ENSRNOP00000078189
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl96,562,288 - 6,667,064 (+)Ensembl
RefSeq Acc Id: NM_001024252   ⟹   NP_001019423
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr896,799,145 - 6,903,616 (+)NCBI
RefSeq Acc Id: XM_039084397   ⟹   XP_038940325
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr896,799,101 - 6,903,616 (+)NCBI
mRatBN7.296,562,525 - 6,667,064 (+)NCBI
RefSeq Acc Id: XM_039084398   ⟹   XP_038940326
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr896,824,037 - 6,903,616 (+)NCBI
mRatBN7.296,587,498 - 6,667,064 (+)NCBI
RefSeq Acc Id: XM_039084399   ⟹   XP_038940327
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr896,832,598 - 6,903,616 (+)NCBI
mRatBN7.296,596,544 - 6,667,064 (+)NCBI
RefSeq Acc Id: XM_039084400   ⟹   XP_038940328
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr896,871,129 - 6,903,616 (+)NCBI
mRatBN7.296,634,725 - 6,667,064 (+)NCBI
RefSeq Acc Id: XM_063266833   ⟹   XP_063122903
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr896,799,102 - 6,903,616 (+)NCBI
RefSeq Acc Id: XM_063266834   ⟹   XP_063122904
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr896,799,103 - 6,897,405 (+)NCBI
RefSeq Acc Id: XM_063266835   ⟹   XP_063122905
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr896,799,103 - 6,897,405 (+)NCBI
RefSeq Acc Id: XM_063266836   ⟹   XP_063122906
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr896,799,101 - 6,891,140 (+)NCBI
RefSeq Acc Id: XP_038940325   ⟸   XM_039084397
- Peptide Label: isoform X2
- UniProtKB: A0A8J8YC15 (UniProtKB/TrEMBL),   A6KUI5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038940326   ⟸   XM_039084398
- Peptide Label: isoform X3
- UniProtKB: A6KUI5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038940327   ⟸   XM_039084399
- Peptide Label: isoform X6
- UniProtKB: A6KUI5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038940328   ⟸   XM_039084400
- Peptide Label: isoform X8
Ensembl Acc Id: ENSRNOP00000078189   ⟸   ENSRNOT00000104333
Ensembl Acc Id: ENSRNOP00000058599   ⟸   ENSRNOT00000061882
RefSeq Acc Id: XP_063122906   ⟸   XM_063266836
- Peptide Label: isoform X7
RefSeq Acc Id: XP_063122903   ⟸   XM_063266833
- Peptide Label: isoform X1
- UniProtKB: A6KUI5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122905   ⟸   XM_063266835
- Peptide Label: isoform X5
- UniProtKB: A6KUI5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122904   ⟸   XM_063266834
- Peptide Label: isoform X4
- UniProtKB: A6KUI5 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001019423   ⟸   NM_001024252
- UniProtKB: A0A8I5Y222 (UniProtKB/TrEMBL),   A6KUI5 (UniProtKB/TrEMBL)
Protein Domains
Bromo   N-acetyltransferase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q568Z2-F1-model_v2 AlphaFold Q568Z2 1-84 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305902 AgrOrtholog
BioCyc Gene G2FUF-28395 BioCyc
Ensembl Genes ENSRNOG00000011871 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000061882 ENTREZGENE
  ENSRNOT00000061882.5 UniProtKB/TrEMBL
  ENSRNOT00000104333 ENTREZGENE
  ENSRNOT00000104333.1 UniProtKB/TrEMBL
  ENSRNOT00000128479 ENTREZGENE
Gene3D-CATH 1.20.920.10 UniProtKB/TrEMBL
  3.40.630.30 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7316752 IMAGE-MGC_LOAD
InterPro Acyl_CoA_acyltransferase UniProtKB/TrEMBL
  Bromodomain UniProtKB/TrEMBL
  Bromodomain-like_sf UniProtKB/TrEMBL
  Bromodomain_CS UniProtKB/TrEMBL
  GCN5 UniProtKB/TrEMBL
  GCN5/PCAF UniProtKB/TrEMBL
  GNAT_dom UniProtKB/TrEMBL
  PCAF_N UniProtKB/TrEMBL
MGC_CLONE MGC:109373 IMAGE-MGC_LOAD
NCBI Gene 301164 ENTREZGENE
PANTHER HISTONE ACETYLTRANSFERASE KAT2B UniProtKB/TrEMBL
  PTHR45750 UniProtKB/TrEMBL
Pfam Acetyltransf_1 UniProtKB/TrEMBL
  Bromodomain UniProtKB/TrEMBL
  PCAF_N UniProtKB/TrEMBL
PhenoGen Kat2b PhenoGen
PIRSF Histone_acetylase_PCAF UniProtKB/TrEMBL
PRINTS BROMODOMAIN UniProtKB/TrEMBL
PROSITE BROMODOMAIN_1 UniProtKB/TrEMBL
  BROMODOMAIN_2 UniProtKB/TrEMBL
  GNAT UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011871 RatGTEx
SMART BROMO UniProtKB/TrEMBL
Superfamily-SCOP SSF47370 UniProtKB/TrEMBL
  SSF55729 UniProtKB/TrEMBL
UniProt A0A8I5Y222 ENTREZGENE, UniProtKB/TrEMBL
  A0A8J8YC15 ENTREZGENE, UniProtKB/TrEMBL
  A6KUI5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Kat2b  lysine acetyltransferase 2B  AABR07066180.1    Data merged from RGD:15003381 737654 PROVISIONAL
2021-09-02 AABR07066180.1    Kat2b  lysine acetyltransferase 2B  Symbol and/or name change 19259462 PROVISIONAL
2021-08-09 Kat2b  lysine acetyltransferase 2B  AABR07066180.1    Symbol and/or name change 19259462 PROVISIONAL
2019-11-08 AABR07066180.1        Symbol and Name status set to provisional 45752 PROVISIONAL
2016-02-17 Kat2b  lysine acetyltransferase 2B  Kat2b  K(lysine) acetyltransferase 2B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-06-25 Kat2b  K(lysine) acetyltransferase 2B  Pcaf  p300/CBP-associated factor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Pcaf  p300/CBP-associated factor  Pcaf_predicted  p300/CBP-associated factor (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Pcaf_predicted  p300/CBP-associated factor (predicted)      Symbol and Name status set to approved 70820 APPROVED