(+)-pilocarpine increases expression EXP 6480464 Pilocarpine results in increased expression of APEX1 mRNA CTD PMID:17971868 (+)-pilocarpine affects localization EXP 6480464 Pilocarpine affects the localization of APEX1 mRNA CTD PMID:20206232 (+)-pilocarpine decreases expression EXP 6480464 Pilocarpine results in decreased expression of APEX1 protein CTD PMID:20446108 (+)-schisandrin B multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of APEX1 mRNA] CTD PMID:31150632 (S)-nicotine multiple interactions ISO RGD:735443 6480464 [Nicotine co-treated with 1-Methyl-4-phenyl-1 more ... CTD PMID:20230807 1,2,4-trimethylbenzene decreases expression EXP 6480464 pseudocumene results in decreased expression of APEX1 protein CTD PMID:17337753 1,4-dithiothreitol multiple interactions ISO RGD:1606343 6480464 Dithiothreitol promotes the reaction [MAPK1 protein binds to APEX1 protein] CTD PMID:23370007 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine multiple interactions ISO RGD:735443 6480464 [Caffeine co-treated with 1-Methyl-4-phenyl-1 more ... CTD PMID:20230807 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine increases expression ISO RGD:735443 6480464 1-Methyl-4-phenyl-1 more ... CTD PMID:20230807 1-naphthyl isothiocyanate increases expression EXP 6480464 1-Naphthylisothiocyanate results in increased expression of APEX1 mRNA CTD PMID:17522070 17alpha-ethynylestradiol affects expression ISO RGD:735443 6480464 Ethinyl Estradiol affects the expression of APEX1 mRNA CTD PMID:17555576 17alpha-ethynylestradiol increases expression ISO RGD:735443 6480464 Ethinyl Estradiol results in increased expression of APEX1 mRNA CTD PMID:17942748 17alpha-ethynylestradiol multiple interactions ISO RGD:735443 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of APEX1 mRNA CTD PMID:17942748 17beta-estradiol increases expression EXP 6480464 Estradiol results in increased expression of APEX1 mRNA CTD PMID:17522070 1H-pyrazole increases expression ISO RGD:735443 6480464 pyrazole results in increased expression of APEX1 mRNA CTD PMID:17945193 2,2',4,4'-Tetrabromodiphenyl ether affects expression ISO RGD:735443 6480464 2 more ... CTD PMID:30294300 2,3',4,4',5-Pentachlorobiphenyl increases expression ISO RGD:735443 6480464 2 more ... CTD PMID:31388691 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:735443 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of APEX1 mRNA, Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to APEX1 promoter] CTD PMID:17942748 , PMID:19654925 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:735443 6480464 Tetrachlorodibenzodioxin affects the expression of APEX1 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:735443 6480464 Tetrachlorodibenzodioxin results in increased expression of APEX1 mRNA CTD PMID:17942748 2,4,6-trinitrotoluene affects expression EXP 6480464 Trinitrotoluene affects the expression of APEX1 mRNA CTD PMID:21346803 2,4-dinitrotoluene affects expression EXP 6480464 2, 4-dinitrotoluene affects the expression of APEX1 mRNA CTD PMID:21346803 2-hydroxypropanoic acid increases expression ISO RGD:1606343 6480464 Lactic Acid results in increased expression of APEX1 mRNA CTD PMID:30851411 2-nitrofluorene increases expression EXP 6480464 2-nitrofluorene results in increased expression of APEX1 mRNA CTD PMID:15890375 2-nitropropane multiple interactions ISO RGD:735443 6480464 APEX1 protein inhibits the reaction [2-nitropropane results in increased activity of CASP3 protein] more ... CTD PMID:19268524 2-nitropropane increases expression ISO RGD:735443 6480464 2-nitropropane results in increased expression of APEX1 mRNA, 2-nitropropane results in increased expression of APEX1 protein CTD PMID:19268524 2-nitropropane affects response to substance ISO RGD:735443 6480464 APEX1 protein affects the susceptibility to 2-nitropropane CTD PMID:19268524 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine multiple interactions ISO RGD:735443 6480464 1, 3-dimethylthiourea inhibits the reaction [Puromycin Aminonucleoside results in increased expression of APEX1 protein] CTD PMID:17035936 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine increases expression ISO RGD:735443 6480464 Puromycin Aminonucleoside results in increased expression of APEX1 protein CTD PMID:17035936 3H-1,2-dithiole-3-thione decreases expression EXP 6480464 1, 2-dithiol-3-thione results in decreased expression of APEX1 mRNA CTD PMID:19162173 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one increases expression EXP 6480464 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of APEX1 mRNA CTD PMID:15890375 4-hydroperoxycyclophosphamide decreases expression EXP 6480464 perfosfamide results in decreased expression of APEX1 mRNA CTD PMID:11754170 4-hydroxynon-2-enal increases expression ISO RGD:735443 6480464 4-hydroxy-2-nonenal results in increased expression of APEX1 mRNA CTD PMID:19191707 5-fluorouracil increases response to substance ISO RGD:1606343 6480464 APEX1 protein mutant form results in increased susceptibility to Fluorouracil CTD PMID:19470598 7,12-dimethyltetraphene multiple interactions ISO RGD:1606343 6480464 Metformin inhibits the reaction [9 more ... CTD PMID:25697376 7,12-dimethyltetraphene increases expression ISO RGD:1606343 6480464 9 more ... CTD PMID:25697376 8-hydroxy-2'-deoxyguanosine affects abundance ISO RGD:1606343 6480464 APEX1 gene SNP affects the abundance of 8-Hydroxy-2'-Deoxyguanosine CTD PMID:19896490 acrylamide increases expression ISO RGD:735443 6480464 Acrylamide results in increased expression of APEX1 mRNA CTD PMID:30807115 aflatoxin B1 decreases expression EXP 6480464 Aflatoxin B1 results in decreased expression of APEX1 mRNA CTD PMID:15890375 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of APEX1 mRNA CTD PMID:16483693 amphibole asbestos affects expression ISO RGD:1606343 6480464 Asbestos, Amphibole affects the expression of APEX1 protein CTD PMID:24598051 aniline increases expression EXP 6480464 aniline results in increased expression of APEX1 mRNA CTD PMID:23352893 aniline multiple interactions EXP 6480464 aniline results in increased expression of and results in increased activity of APEX1 protein CTD PMID:23352893 arecoline decreases expression ISO RGD:1606343 6480464 Arecoline results in decreased expression of APEX1 mRNA CTD PMID:17682004 Aroclor 1254 decreases expression ISO RGD:735443 6480464 Chlorodiphenyl (54% Chlorine) results in decreased expression of APEX1 mRNA CTD PMID:25113976 arsane affects response to substance ISO RGD:1606343 6480464 APEX1 gene polymorphism affects the susceptibility to Arsenic, APEX1 protein affects the susceptibility to Arsenic CTD PMID:17374727 , PMID:18053222 arsenic atom affects response to substance ISO RGD:1606343 6480464 APEX1 gene polymorphism affects the susceptibility to Arsenic, APEX1 protein affects the susceptibility to Arsenic CTD PMID:17374727 , PMID:18053222 arsenite(3-) affects expression ISO RGD:1606343 6480464 arsenite affects the expression of APEX1 mRNA CTD PMID:18252256 arsenite(3-) increases expression ISO RGD:1606343 6480464 arsenite results in increased expression of APEX1 mRNA, arsenite results in increased expression of APEX1 protein CTD PMID:15996700 , PMID:18252256 atrazine increases expression ISO RGD:735443 6480464 Atrazine results in increased expression of APEX1 protein CTD PMID:27957240 benzene affects response to substance ISO RGD:1606343 6480464 APEX1 gene polymorphism affects the susceptibility to Benzene CTD PMID:22245109 benzene affects expression ISO RGD:1606343 6480464 Benzene affects the expression of APEX1 mRNA CTD PMID:16188086 benzo[a]pyrene decreases expression ISO RGD:735443 6480464 Benzo(a)pyrene results in decreased expression of APEX1 mRNA CTD PMID:19770486 benzo[a]pyrene increases expression ISO RGD:735443 6480464 Benzo(a)pyrene results in increased expression of APEX1 mRNA CTD PMID:22228805 benzo[a]pyrene multiple interactions ISO RGD:735443 6480464 AHR protein affects the reaction [Benzo(a)pyrene affects the expression of APEX1 mRNA] CTD PMID:22228805 benzoquinones multiple interactions ISO RGD:1606343 6480464 APEX1 protein results in increased reduction of and results in increased susceptibility to Benzoquinones CTD PMID:10190555 beryllium dichloride affects expression ISO RGD:735443 6480464 beryllium chloride affects the expression of APEX1 mRNA CTD PMID:23793613 bezafibrate increases expression ISO RGD:735443 6480464 Bezafibrate results in increased expression of APEX1 mRNA CTD PMID:15447978 bisphenol A increases expression ISO RGD:735443 6480464 bisphenol A results in increased expression of APEX1 mRNA CTD PMID:21932408 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of APEX1 mRNA CTD PMID:25181051 busulfan increases response to substance ISO RGD:1606343 6480464 APEX1 protein mutant form results in increased susceptibility to Busulfan CTD PMID:19470598 cadmium atom affects activity ISO RGD:1606343 6480464 Cadmium affects the activity of APEX1 protein CTD PMID:21605570 cadmium atom affects expression ISO RGD:1606343 6480464 Cadmium affects the expression of APEX1 mRNA CTD PMID:21605570 cadmium atom multiple interactions ISO RGD:1606343 6480464 TP53 protein affects the reaction [Cadmium affects the activity of APEX1 protein], TP53 protein affects the reaction [Cadmium affects the expression of APEX1 mRNA] CTD PMID:21605570 caffeine multiple interactions ISO RGD:735443 6480464 [Caffeine co-treated with 1-Methyl-4-phenyl-1 more ... CTD PMID:20230807 carbon atom increases expression ISO RGD:735443 6480464 Carbon analog results in increased expression of APEX1 mRNA CTD PMID:24792328 carbon nanotube increases expression ISO RGD:735443 6480464 Nanotubes, Carbon analog results in increased expression of APEX1 mRNA, Nanotubes, Carbon results in increased expression of APEX1 mRNA CTD PMID:25554681 carmustine increases response to substance ISO RGD:1606343 6480464 APEX1 protein mutant form results in increased susceptibility to Carmustine CTD PMID:17259346 , PMID:19470598 carmustine decreases response to substance ISO RGD:1606343 6480464 APEX1 protein results in decreased susceptibility to Carmustine CTD PMID:12231548 , PMID:16243814 chloroform increases expression EXP 6480464 Chloroform results in increased expression of APEX1 mRNA CTD PMID:17522070 chlorpyrifos increases expression ISO RGD:1606343 6480464 Chlorpyrifos results in increased expression of APEX1 mRNA CTD PMID:28887667 chlorpyrifos multiple interactions ISO RGD:1606343 6480464 Chlorpyrifos results in increased expression of and affects the localization of APEX1 protein CTD PMID:28887667 choline multiple interactions ISO RGD:735443 6480464 [Methionine deficiency co-treated with Choline deficiency] results in increased expression of APEX1 mRNA, [Methionine deficiency co-treated with Choline deficiency] results in increased expression of APEX1 protein CTD PMID:25690533 cisplatin decreases expression ISO RGD:1606343 6480464 Cisplatin results in decreased expression of APEX1 mRNA CTD PMID:27594783 cisplatin multiple interactions ISO RGD:735443 6480464 [methoxyamine results in decreased activity of APEX1 protein] which results in decreased susceptibility to Cisplatin CTD PMID:21357694 cisplatin decreases expression ISO RGD:735443 6480464 Cisplatin results in decreased expression of APEX1 mRNA CTD PMID:21151649 cisplatin increases acetylation ISO RGD:1606343 6480464 Cisplatin results in increased acetylation of APEX1 protein CTD PMID:20856196 cisplatin multiple interactions ISO RGD:1606343 6480464 [Cisplatin results in increased acetylation of APEX1 protein] promotes the reaction [[APEX1 protein modified form binds to ABCB1 promoter] which results in increased expression of ABCB1 mRNA] more ... CTD PMID:20856196 cisplatin decreases response to substance ISO RGD:1606343 6480464 APEX1 protein results in decreased susceptibility to Cisplatin CTD PMID:16373707 , PMID:20856196 clofibrate decreases expression EXP 6480464 Clofibrate results in decreased expression of APEX1 mRNA CTD PMID:17522070 clofibric acid multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of APEX1 mRNA CTD PMID:17602206 cobalt dichloride decreases expression ISO RGD:1606343 6480464 cobaltous chloride results in decreased expression of APEX1 mRNA CTD PMID:19320972 cobalt dichloride multiple interactions ISO RGD:1606343 6480464 [cobaltous chloride results in increased activity of SRC protein] promotes the reaction [[[HIF1A protein binds to STAT3 protein modified form] which binds to VEGFA promoter] binds to [APEX1 protein binds to CREBBP promoter]] CTD PMID:15735682 copper(II) sulfate decreases expression ISO RGD:1606343 6480464 Copper Sulfate results in decreased expression of APEX1 mRNA CTD PMID:19549813 crocidolite asbestos affects localization ISO RGD:735443 6480464 Asbestos, Crocidolite affects the localization of APEX1 protein CTD PMID:12023366 crocidolite asbestos multiple interactions ISO RGD:735443 6480464 diphenyleneiodonium inhibits the reaction [Asbestos, Crocidolite affects the localization of APEX1 protein] CTD PMID:12023366 crocidolite asbestos affects localization ISO RGD:1606343 6480464 Asbestos, Crocidolite affects the localization of APEX1 protein CTD PMID:12023366 cyclophosphamide increases expression EXP 6480464 Cyclophosphamide results in increased expression of APEX1 mRNA CTD PMID:11599041 cyproconazole increases expression EXP 6480464 cyproconazole results in increased expression of APEX1 mRNA CTD PMID:29038839 cyproconazole multiple interactions EXP 6480464 [cyproconazole co-treated with epoxiconazole co-treated with prochloraz] results in increased expression of APEX1 mRNA, [cyproconazole co-treated with epoxiconazole] results in increased expression of APEX1 mRNA CTD PMID:29038839 dacarbazine increases response to substance ISO RGD:1606343 6480464 APEX1 protein mutant form results in increased susceptibility to Dacarbazine CTD PMID:19470598 dacarbazine decreases response to substance ISO RGD:1606343 6480464 APEX1 protein results in decreased susceptibility to Dacarbazine CTD PMID:16373707 daunorubicin multiple interactions ISO RGD:1606343 6480464 APEX1 protein results in increased reduction of and results in increased susceptibility to Daunorubicin CTD PMID:10190555 diamminedichloroplatinum multiple interactions ISO RGD:735443 6480464 [methoxyamine results in decreased activity of APEX1 protein] which results in increased susceptibility to transplatin CTD PMID:21357694 dibenziodolium multiple interactions ISO RGD:735443 6480464 diphenyleneiodonium inhibits the reaction [Asbestos, Crocidolite affects the localization of APEX1 protein] CTD PMID:12023366 dibutyl phthalate decreases expression ISO RGD:735443 6480464 Dibutyl Phthalate results in decreased expression of APEX1 mRNA CTD PMID:17361019 , PMID:21266533 dichlorine multiple interactions EXP 6480464 [Ozone co-treated with Chlorine] results in decreased expression of APEX1 mRNA CTD PMID:18636392 diethylstilbestrol increases expression EXP 6480464 Diethylstilbestrol results in increased expression of APEX1 mRNA CTD PMID:15890375 dioxygen decreases expression ISO RGD:1606343 6480464 Oxygen deficiency results in decreased expression of APEX1 protein CTD PMID:25030372 dioxygen multiple interactions ISO RGD:735443 6480464 [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of APEX1 mRNA CTD PMID:30529165 dioxygen multiple interactions ISO RGD:1606343 6480464 APEX1 protein inhibits the reaction [RAC1 protein inhibits the reaction [Oxygen deficiency results in increased expression of SERPINE1 mRNA]], APEX1 protein promotes the reaction [Oxygen deficiency results in increased expression of SERPINE1 mRNA] CTD PMID:12719791 disodium selenite increases expression ISO RGD:1606343 6480464 Sodium Selenite results in increased expression of APEX1 mRNA CTD PMID:18175754 disodium selenite multiple interactions ISO RGD:1606343 6480464 [Sodium Selenite co-treated with (1 more ... CTD PMID:28757135 doxorubicin decreases expression ISO RGD:1606343 6480464 Doxorubicin results in decreased expression of APEX1 mRNA CTD PMID:29803840 elemental carbon increases expression ISO RGD:735443 6480464 Carbon analog results in increased expression of APEX1 mRNA CTD PMID:24792328 enzyme inhibitor multiple interactions ISO RGD:1606343 6480464 [Enzyme Inhibitors results in decreased activity of APEX1 protein] which results in decreased expression of BIRC5 mRNA more ... CTD PMID:23301498 , PMID:29541389 enzyme inhibitor decreases activity ISO RGD:1606343 6480464 Enzyme Inhibitors results in decreased activity of APEX1 protein CTD PMID:29541389 epoxiconazole multiple interactions EXP 6480464 [cyproconazole co-treated with epoxiconazole co-treated with prochloraz] results in increased expression of APEX1 mRNA, [cyproconazole co-treated with epoxiconazole] results in increased expression of APEX1 mRNA CTD PMID:29038839 erythromycin estolate decreases expression EXP 6480464 Erythromycin Estolate results in decreased expression of APEX1 mRNA CTD PMID:17522070 ethene increases expression EXP 6480464 ethylene results in increased expression of APEX1 protein CTD PMID:16051529 etoposide decreases response to substance ISO RGD:1606343 6480464 APEX1 protein results in decreased susceptibility to Etoposide CTD PMID:20856196 fenofibrate multiple interactions EXP 6480464 [Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of APEX1 mRNA CTD PMID:18253720 , PMID:18775883 fenofibrate increases expression EXP 6480464 Fenofibrate results in increased expression of APEX1 mRNA CTD PMID:17264098 , PMID:18775883 floxuridine increases response to substance ISO RGD:1606343 6480464 APEX1 protein mutant form results in increased susceptibility to Floxuridine CTD PMID:19470598 floxuridine decreases response to substance ISO RGD:1606343 6480464 APEX1 protein results in decreased susceptibility to Floxuridine CTD PMID:22194930 flutamide increases expression EXP 6480464 Flutamide results in increased expression of APEX1 mRNA CTD PMID:24136188 furan increases expression EXP 6480464 furan results in increased expression of APEX1 mRNA CTD PMID:22079235 , PMID:25539665 gentamycin increases expression EXP 6480464 Gentamicins results in increased expression of APEX1 mRNA CTD PMID:22061828 glafenine increases expression EXP 6480464 Glafenine results in increased expression of APEX1 mRNA CTD PMID:24136188 glycine betaine decreases expression EXP 6480464 Betaine results in decreased expression of APEX1 mRNA CTD PMID:26391144 hydrogen peroxide increases response to substance ISO RGD:1606343 6480464 APEX1 protein mutant form results in increased susceptibility to Hydrogen Peroxide CTD PMID:17259346 hydrogen peroxide affects localization EXP 6480464 Hydrogen Peroxide affects the localization of APEX1 protein CTD PMID:12884291 hydrogen peroxide multiple interactions EXP 6480464 APEX1 protein promotes the reaction [Hydrogen Peroxide results in increased expression of IL4 mRNA], APEX1 protein promotes the reaction [Hydrogen Peroxide results in increased expression of IL6 mRNA] CTD PMID:12884291 hydrogen peroxide multiple interactions ISO RGD:1606343 6480464 APEX1 protein inhibits the reaction [Hydrogen Peroxide results in decreased activity of MAPK1 protein] more ... CTD PMID:23370007 hydrogen peroxide increases expression ISO RGD:1606343 6480464 Hydrogen Peroxide results in increased expression of APEX1 mRNA CTD PMID:22539617 hypochlorous acid multiple interactions ISO RGD:1606343 6480464 Acetylcysteine inhibits the reaction [Hypochlorous Acid results in increased expression of APEX1 protein] CTD PMID:12231548 hypochlorous acid increases expression ISO RGD:1606343 6480464 Hypochlorous Acid results in increased expression of APEX1 protein CTD PMID:12231548 hypochlorous acid increases activity ISO RGD:1606343 6480464 Hypochlorous Acid results in increased activity of APEX1 protein CTD PMID:12231548 imiquimod decreases expression ISO RGD:735443 6480464 imiquimod results in decreased expression of APEX1 mRNA CTD PMID:21878529 iron trichloride affects localization ISO RGD:735443 6480464 ferric chloride affects the localization of APEX1 protein CTD PMID:12023366 iron trichloride multiple interactions ISO RGD:735443 6480464 [ferric chloride co-treated with Tetradecanoylphorbol Acetate] affects the localization of APEX1 protein CTD PMID:12023366 isoprenaline increases expression ISO RGD:735443 6480464 Isoproterenol results in increased expression of APEX1 mRNA CTD PMID:21335049 kainic acid multiple interactions EXP 6480464 [Raloxifene Hydrochloride co-treated with Kainic Acid] results in increased expression of APEX1 mRNA CTD PMID:16120186 L-1,4-dithiothreitol multiple interactions ISO RGD:1606343 6480464 Dithiothreitol promotes the reaction [MAPK1 protein binds to APEX1 protein] CTD PMID:23370007 L-methionine multiple interactions ISO RGD:735443 6480464 [Methionine deficiency co-treated with Choline deficiency] results in increased expression of APEX1 mRNA, [Methionine deficiency co-treated with Choline deficiency] results in increased expression of APEX1 protein CTD PMID:25690533 lead diacetate multiple interactions ISO RGD:1606343 6480464 [lead acetate results in increased expression of APEX1 protein] which results in increased abundance of Reactive Oxygen Species more ... CTD PMID:23370007 lead diacetate increases expression ISO RGD:1606343 6480464 lead acetate results in increased expression of APEX1 protein CTD PMID:23370007 lead diacetate decreases response to substance ISO RGD:1606343 6480464 APEX1 protein results in decreased susceptibility to lead acetate CTD PMID:23370007 lead(0) multiple interactions ISO RGD:1606343 6480464 APEX1 protein inhibits the reaction [Lead results in decreased activity of APEX1 protein] CTD PMID:17013835 lead(0) affects expression ISO RGD:1606343 6480464 Lead affects the expression of APEX1 mRNA CTD PMID:28903495 lead(0) affects response to substance ISO RGD:1606343 6480464 APEX1 gene polymorphism affects the susceptibility to Lead CTD PMID:22466227 lead(2+) affects response to substance ISO RGD:1606343 6480464 APEX1 gene polymorphism affects the susceptibility to Lead CTD PMID:22466227 lead(2+) affects expression ISO RGD:1606343 6480464 Lead affects the expression of APEX1 mRNA CTD PMID:28903495 lead(2+) multiple interactions ISO RGD:1606343 6480464 APEX1 protein inhibits the reaction [Lead results in decreased activity of APEX1 protein] CTD PMID:17013835 menadione increases response to substance ISO RGD:735443 6480464 APEX1 gene mutant form results in increased susceptibility to Vitamin K 3 CTD PMID:11454706 metformin multiple interactions ISO RGD:1606343 6480464 Metformin inhibits the reaction [9 more ... CTD PMID:25697376 methapyrilene increases expression EXP 6480464 Methapyrilene results in increased expression of APEX1 mRNA CTD PMID:15890375 , PMID:28935588 methyl methanesulfonate decreases response to substance ISO RGD:1606343 6480464 APEX1 protein results in decreased susceptibility to Methyl Methanesulfonate CTD PMID:12231548 methyl methanesulfonate decreases expression ISO RGD:1606343 6480464 Methyl Methanesulfonate results in decreased expression of APEX1 mRNA CTD PMID:23649840 methyl methanesulfonate increases response to substance ISO RGD:1606343 6480464 APEX1 protein mutant form results in increased susceptibility to Methyl Methanesulfonate CTD PMID:17259346 miconazole decreases expression EXP 6480464 Miconazole results in decreased expression of APEX1 mRNA CTD PMID:22262564 microcystin-LR increases expression ISO RGD:735443 6480464 cyanoginosin LR results in increased expression of APEX1 mRNA CTD PMID:17654400 mitomycin C multiple interactions ISO RGD:1606343 6480464 APEX1 protein results in increased reduction of and results in increased susceptibility to Mitomycin CTD PMID:10190555 mitomycin C multiple interactions ISO RGD:735443 6480464 [methoxyamine results in decreased activity of APEX1 protein] which results in increased susceptibility to Mitomycin CTD PMID:21357694 monocrotophos multiple interactions ISO RGD:1606343 6480464 Monocrotophos results in increased expression of and affects the localization of APEX1 protein CTD PMID:28887667 monocrotophos increases expression ISO RGD:1606343 6480464 Monocrotophos results in increased expression of APEX1 mRNA CTD PMID:28887667 N-acetyl-L-cysteine multiple interactions ISO RGD:1606343 6480464 Acetylcysteine inhibits the reaction [Hypochlorous Acid results in increased expression of APEX1 protein] CTD PMID:12231548 N-acetyl-L-cysteine multiple interactions ISO RGD:735443 6480464 Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of APEX1 mRNA] CTD PMID:17938202 N-ethylmaleimide multiple interactions ISO RGD:1606343 6480464 Ethylmaleimide inhibits the reaction [APEX1 protein inhibits the reaction [Hydrogen Peroxide results in decreased activity of MAPK1 protein]] CTD PMID:23370007 N-nitrosodiethylamine multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of APEX1 mRNA, [Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of APEX1 mRNA CTD PMID:17602206 more ... N-nitrosodiethylamine decreases expression EXP 6480464 Diethylnitrosamine results in decreased expression of APEX1 mRNA CTD PMID:11323195 N-nitrosodimethylamine increases expression EXP 6480464 Dimethylnitrosamine results in increased expression of APEX1 mRNA CTD PMID:15890375 naloxone decreases expression EXP 6480464 Naloxone results in decreased expression of APEX1 mRNA CTD PMID:17522070 nefazodone increases expression EXP 6480464 nefazodone results in increased expression of APEX1 mRNA CTD PMID:24136188 nicotine multiple interactions ISO RGD:735443 6480464 [Nicotine co-treated with 1-Methyl-4-phenyl-1 more ... CTD PMID:20230807 nimesulide increases expression EXP 6480464 nimesulide results in increased expression of APEX1 mRNA CTD PMID:24136188 nitroglycerin increases expression EXP 6480464 Nitroglycerin results in increased expression of APEX1 mRNA CTD PMID:12102619 O-acetyl-L-carnitine increases expression EXP 6480464 Acetylcarnitine results in increased expression of APEX1 mRNA CTD PMID:14654561 ochratoxin A decreases expression EXP 6480464 ochratoxin A results in decreased expression of APEX1 mRNA CTD PMID:23358140 oxirane increases expression EXP 6480464 Ethylene Oxide results in increased expression of APEX1 protein CTD PMID:16051529 ozone multiple interactions EXP 6480464 [Ozone co-treated with Chlorine] results in decreased expression of APEX1 mRNA CTD PMID:18636392 ozone increases expression EXP 6480464 Ozone results in increased expression of APEX1 mRNA CTD PMID:16330353 paracetamol increases expression EXP 6480464 Acetaminophen results in increased expression of APEX1 mRNA CTD PMID:16751229 paraquat increases response to substance ISO RGD:735443 6480464 APEX1 gene mutant form results in increased susceptibility to Paraquat CTD PMID:11454706 paraquat affects response to substance ISO RGD:1606343 6480464 APEX1 gene SNP affects the susceptibility to Paraquat CTD PMID:28460087 perfluorooctanoic acid increases expression EXP 6480464 perfluorooctanoic acid results in increased expression of APEX1 mRNA CTD PMID:19162173 phenobarbital increases expression EXP 6480464 Phenobarbital results in increased expression of APEX1 mRNA CTD PMID:19162173 phenobarbital decreases expression EXP 6480464 Phenobarbital results in decreased expression of APEX1 mRNA CTD PMID:24090815 phorbol 13-acetate 12-myristate multiple interactions ISO RGD:735443 6480464 [ferric chloride co-treated with Tetradecanoylphorbol Acetate] affects the localization of APEX1 protein CTD PMID:12023366 piperonyl butoxide increases expression EXP 6480464 Piperonyl Butoxide results in increased expression of APEX1 mRNA CTD PMID:15890375 pirinixic acid increases expression EXP 6480464 pirinixic acid results in increased expression of APEX1 mRNA CTD PMID:15890375 more ... pirinixic acid increases expression ISO RGD:735443 6480464 pirinixic acid results in increased expression of APEX1 mRNA CTD PMID:18301758 , PMID:23811191 potassium bromate increases expression ISO RGD:1606343 6480464 potassium bromate results in increased expression of APEX1 mRNA CTD PMID:22539617 pregnenolone 16alpha-carbonitrile decreases expression EXP 6480464 Pregnenolone Carbonitrile results in decreased expression of APEX1 mRNA CTD PMID:19162173 pregnenolone 16alpha-carbonitrile increases expression ISO RGD:735443 6480464 Pregnenolone Carbonitrile results in increased expression of APEX1 mRNA CTD PMID:28903501 prochloraz multiple interactions EXP 6480464 [cyproconazole co-treated with epoxiconazole co-treated with prochloraz] results in increased expression of APEX1 mRNA CTD PMID:29038839 prochloraz increases expression EXP 6480464 prochloraz results in increased expression of APEX1 mRNA CTD PMID:29038839 procymidone increases expression EXP 6480464 procymidone results in increased expression of APEX1 mRNA CTD PMID:15686871 progesterone decreases expression ISO RGD:1606343 6480464 Progesterone results in decreased expression of APEX1 mRNA CTD PMID:18037150 propiconazole increases expression ISO RGD:735443 6480464 propiconazole results in increased expression of APEX1 mRNA CTD PMID:21278054 rac-lactic acid increases expression ISO RGD:1606343 6480464 Lactic Acid results in increased expression of APEX1 mRNA CTD PMID:30851411 raloxifene multiple interactions EXP 6480464 [Raloxifene Hydrochloride co-treated with Kainic Acid] results in increased expression of APEX1 mRNA CTD PMID:16120186 raloxifene increases expression EXP 6480464 Raloxifene Hydrochloride results in increased expression of APEX1 mRNA CTD PMID:16120186 reactive oxygen species multiple interactions ISO RGD:1606343 6480464 [lead acetate results in increased expression of APEX1 protein] which results in increased abundance of Reactive Oxygen Species CTD PMID:23370007 resveratrol decreases activity ISO RGD:1606343 6480464 resveratrol results in decreased activity of APEX1 protein CTD PMID:16373707 S-butyl-DL-homocysteine (S,R)-sulfoximine increases expression EXP 6480464 Buthionine Sulfoximine results in increased expression of APEX1 protein CTD PMID:23736079 silicon dioxide decreases expression ISO RGD:1606343 6480464 Silicon Dioxide results in decreased expression of APEX1 mRNA CTD PMID:25351596 sodium arsenite increases expression ISO RGD:1606343 6480464 sodium arsenite results in increased expression of APEX1 mRNA, sodium arsenite results in increased expression of APEX1 protein CTD PMID:12076508 , PMID:17938202 sodium arsenite decreases expression ISO RGD:735443 6480464 sodium arsenite results in decreased expression of APEX1 mRNA CTD PMID:25787150 sodium arsenite decreases expression ISO RGD:1606343 6480464 sodium arsenite results in decreased expression of APEX1 mRNA, sodium arsenite results in decreased expression of APEX1 protein CTD PMID:12076508 more ... sodium arsenite affects response to substance ISO RGD:1606343 6480464 APEX1 affects the susceptibility to sodium arsenite CTD PMID:17938202 sodium arsenite multiple interactions ISO RGD:1606343 6480464 APEX1 inhibits the reaction [[ATF4 mutant form results in increased susceptibility to sodium arsenite] which results in increased mutagenesis of HPRT1 gene] more ... CTD PMID:17938202 sodium arsenite increases expression ISO RGD:735443 6480464 sodium arsenite results in increased expression of APEX1 mRNA CTD PMID:17451858 more ... sodium arsenite multiple interactions ISO RGD:735443 6480464 [[sodium arsenite promotes the reaction [JUN protein binds to ATF4 protein]] which binds to APEX1 promoter] which results in increased expression of APEX1 mRNA more ... CTD PMID:17938202 sodium arsenite affects response to substance ISO RGD:735443 6480464 APEX1 affects the susceptibility to sodium arsenite CTD PMID:17938202 sodium dichromate increases expression ISO RGD:735443 6480464 sodium bichromate results in increased expression of APEX1 mRNA CTD PMID:22155349 sodium dichromate increases expression EXP 6480464 sodium bichromate results in increased expression of APEX1 mRNA CTD PMID:12325037 more ... streptozocin increases response to substance ISO RGD:1606343 6480464 APEX1 protein mutant form results in increased susceptibility to Streptozocin CTD PMID:19470598 tamoxifen increases expression EXP 6480464 Tamoxifen results in increased expression of APEX1 mRNA CTD PMID:12841865 tamoxifen affects expression ISO RGD:735443 6480464 Tamoxifen affects the expression of APEX1 mRNA CTD PMID:17555576 temozolomide decreases response to substance ISO RGD:1606343 6480464 APEX1 protein results in decreased susceptibility to temozolomide CTD PMID:12231548 , PMID:16243814 temozolomide increases response to substance ISO RGD:1606343 6480464 APEX1 protein mutant form results in increased susceptibility to temozolomide CTD PMID:19470598 tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of APEX1 mRNA CTD PMID:17522070 , PMID:31150632 tetrachloromethane multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of APEX1 mRNA] CTD PMID:31150632 tetrachloromethane increases expression ISO RGD:735443 6480464 Carbon Tetrachloride results in increased expression of APEX1 mRNA CTD PMID:27339419 tetracycline increases expression EXP 6480464 Tetracycline results in increased expression of APEX1 mRNA CTD PMID:17522070 theophylline decreases expression EXP 6480464 Theophylline results in decreased expression of APEX1 mRNA CTD PMID:17522070 thioacetamide increases expression EXP 6480464 Thioacetamide results in increased expression of APEX1 mRNA CTD PMID:23411599 Thiotepa increases response to substance ISO RGD:1606343 6480464 APEX1 protein mutant form results in increased susceptibility to Thiotepa CTD PMID:19470598 transplatin multiple interactions ISO RGD:735443 6480464 [methoxyamine results in decreased activity of APEX1 protein] which results in increased susceptibility to transplatin CTD PMID:21357694 Tributyltin oxide increases expression EXP 6480464 bis(tri-n-butyltin)oxide results in increased expression of APEX1 mRNA CTD PMID:17553608 trichostatin A multiple interactions ISO RGD:1606343 6480464 trichostatin A promotes the reaction [EP300 protein binds to APEX1 protein] CTD PMID:20856196 trichostatin A increases acetylation ISO RGD:1606343 6480464 trichostatin A results in increased acetylation of APEX1 protein CTD PMID:20856196 triclosan affects expression ISO RGD:1606343 6480464 Triclosan affects the expression of APEX1 mRNA CTD PMID:31714634 trimellitic anhydride increases expression ISO RGD:735443 6480464 trimellitic anhydride results in increased expression of APEX1 mRNA CTD PMID:19042947 trovafloxacin multiple interactions ISO RGD:735443 6480464 [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of APEX1 mRNA CTD PMID:18930950 troxacitabine increases response to substance ISO RGD:1606343 6480464 APEX1 protein mutant form results in increased susceptibility to troxacitabine CTD PMID:19470598 valproic acid decreases expression ISO RGD:735443 6480464 Valproic Acid results in decreased expression of APEX1 mRNA CTD PMID:20546886 valproic acid affects expression ISO RGD:1606343 6480464 Valproic Acid affects the expression of APEX1 mRNA CTD PMID:25979313 valproic acid decreases expression ISO RGD:1606343 6480464 Valproic Acid results in decreased expression of APEX1 mRNA CTD PMID:23179753 , PMID:29154799 vancomycin decreases expression ISO RGD:735443 6480464 Vancomycin results in decreased expression of APEX1 mRNA CTD PMID:18930951 vitamin E increases expression ISO RGD:1606343 6480464 Vitamin E results in increased expression of APEX1 mRNA CTD PMID:19244175 zalcitabine increases response to substance ISO RGD:1606343 6480464 APEX1 protein mutant form results in increased susceptibility to Zalcitabine CTD PMID:17259346 zinc atom decreases expression EXP 6480464 Zinc deficiency results in decreased expression of APEX1 mRNA CTD PMID:12672911 zinc(0) decreases expression EXP 6480464 Zinc deficiency results in decreased expression of APEX1 mRNA CTD PMID:12672911
Gene-Chemical Interaction Annotations
