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Gene: Apex1 (apurinic/apyrimidinic endodeoxyribonuclease 1) Rattus norvegicus
Symbol: Apex1
Name: apurinic/apyrimidinic endodeoxyribonuclease 1
Description: Exhibits NF-kappaB binding activity and endoribonuclease activity. Involved in several processes, including cellular response to organonitrogen compound; negative regulation of smooth muscle cell migration; and positive regulation of G1/S transition of mitotic cell cycle. Localizes to mitochondrion; nucleus; and transcription regulator complex. Biomarker of brain ischemia; lung disease; status epilepticus; and visual epilepsy. Human ortholog(s) of this gene implicated in breast cancer; female reproductive organ cancer (multiple); spina bifida; and urinary bladder cancer. Orthologous to human APEX1 (apurinic/apyrimidinic endodeoxyribonuclease 1); PARTICIPATES IN base excision repair pathway; hypoxia inducible factor pathway; INTERACTS WITH (+)-pilocarpine; (+)-schisandrin B; 1,2,4-trimethylbenzene.
Type: protein-coding
Also known as: AP endonuclease 1; APE; APEN; Apex; APEX nuclease (multifunctional DNA repair enzyme) 1; APEX nuclease 1; apurinic-apyrimidinic endonuclease 1; apurinic/apyrimidinic endonuclease; Apurinic/apyrimidinic endonuclease 1; DNA-(apurinic or apyrimidinic site) endonuclease; DNA-(apurinic or apyrimidinic site) lyase; redox factor-1; REF-1
Homo sapiens (human) : APEX1 (apurinic/apyrimidinic endodeoxyribonuclease 1)  HGNC  Alliance
Mus musculus (house mouse) : Apex1 (apurinic/apyrimidinic endonuclease 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Apex1 (apurinic/apyrimidinic endodeoxyribonuclease 1)
Pan paniscus (bonobo/pygmy chimpanzee) : APEX1 (apurinic/apyrimidinic endodeoxyribonuclease 1)
Canis lupus familiaris (dog) : APEX1 (apurinic/apyrimidinic endodeoxyribonuclease 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Apex1 (apurinic/apyrimidinic endodeoxyribonuclease 1)
Sus scrofa (pig) : APEX1 (apurinic/apyrimidinic endodeoxyribonuclease 1)
Heterocephalus glaber (naked mole-rat) : Apex1 (apurinic/apyrimidinic endodeoxyribonuclease 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01527,849,943 - 27,852,083 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1527,849,979 - 27,852,082 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01531,682,368 - 31,684,508 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41526,904,124 - 26,906,224 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11526,919,823 - 26,921,924 (+)NCBI
Celera1524,464,809 - 24,466,909 (+)NCBICelera
Cytogenetic Map15p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Apex1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2126
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-06-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.