MAPK1 (mitogen-activated protein kinase 1) - Rat Genome Database

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Gene: MAPK1 (mitogen-activated protein kinase 1) Canis lupus familiaris
Analyze
Symbol: MAPK1
Name: mitogen-activated protein kinase 1
RGD ID: 12258672
Description: ENCODES a protein that exhibits ATP binding (ortholog); double-stranded DNA binding (ortholog); MAP kinase activity (ortholog); INVOLVED IN aging (ortholog); animal organ morphogenesis (ortholog); B cell receptor signaling pathway (ortholog); PARTICIPATES IN adenosine signaling pathway; Bone morphogenetic proteins signaling pathway; ceramide signaling pathway; ASSOCIATED WITH Aberrant Crypt Foci (ortholog); Alzheimer's disease (ortholog); Animal Disease Models (ortholog); FOUND IN axon (ortholog); cytosol (ortholog); dendrite cytoplasm (ortholog); INTERACTS WITH arsane; arsenic atom; arsenous acid
Type: protein-coding
RefSeq Status: INFERRED
Previously known as: ERK2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12631,013,607 - 31,132,998 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2631,013,607 - 31,132,998 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2630,970,465 - 31,089,387 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02632,419,917 - 32,539,219 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2632,418,294 - 32,539,230 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12630,468,306 - 30,587,833 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02630,092,195 - 30,211,589 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02631,182,673 - 31,302,626 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Aberrant Crypt Foci  (ISO)
Alzheimer's disease  (ISO)
Animal Disease Models  (ISO)
autism spectrum disorder  (ISO)
brain ischemia  (ISO)
breast cancer  (ISO)
Cardiomegaly  (ISO)
cardiomyopathy  (ISO)
childhood pilocytic astrocytoma  (ISO)
chromosome 22q11.2 deletion syndrome, distal  (ISO)
Cocaine-Related Disorders  (ISO)
colon adenocarcinoma  (ISO)
colorectal adenocarcinoma  (ISO)
Colorectal Neoplasms  (ISO)
congenital heart disease  (ISO)
coronary restenosis  (ISO)
Coronavirus infectious disease  (ISO)
demyelinating disease  (ISO)
Diabetic Cardiomyopathies  (ISO)
Diabetic Nephropathies  (ISO)
DiGeorge syndrome  (ISO)
Dwarfism  (ISO)
endometrial adenocarcinoma  (ISO)
endometrial carcinoma  (ISO)
Endometrioid Carcinomas  (ISO)
Experimental Colitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Liver Neoplasms  (ISO)
Experimental Mammary Neoplasms  (ISO)
Experimental Radiation Injuries  (ISO)
extrahepatic cholestasis  (ISO)
Female Infertility  (ISO)
gastric ulcer  (ISO)
genetic disease  (ISO)
Gliosis  (ISO)
glomerulonephritis  (ISO)
Head and Neck Neoplasms  (ISO)
head and neck squamous cell carcinoma  (ISO)
Hemorrhagic Shock  (ISO)
hepatocellular carcinoma  (ISO)
Hodgkin's lymphoma  (ISO)
Hyperalgesia  (ISO)
Hypertrophy  (ISO)
juvenile rheumatoid arthritis  (ISO)
kidney disease  (ISO)
Kidney Neoplasms  (ISO)
Lung Neoplasms  (ISO)
middle cerebral artery infarction  (ISO)
Multiple Organ Failure  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Nerve Degeneration  (ISO)
neuronal ceroid lipofuscinosis 6A  (ISO)
Noonan syndrome 13  (ISO)
obesity  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic adenocarcinoma  (ISO)
Pneumococcal Pneumonia  (ISO)
prostate adenocarcinoma  (ISO)
pulmonary hypertension  (ISO)
renal cell carcinoma  (ISO)
renal fibrosis  (ISO)
Sepsis  (ISO)
severe acute respiratory syndrome  (ISO)
Sezary's disease  (ISO)
Shock  (ISO)
squamous cell carcinoma  (ISO)
Stomach Neoplasms  (ISO)
Testis Reperfusion Injury  (ISO)
thyroid gland cancer  (ISO)
Thyroid Neoplasms  (ISO)
transitional cell carcinoma  (ISO)
trigeminal neuralgia  (ISO)
type 2 diabetes mellitus  (ISO)
ureteral obstruction  (ISO)
urethral obstruction  (ISO)
Urinary Incontinence  (ISO)
Uterine Cervical Neoplasms  (ISO)
velocardiofacial syndrome  (ISO)
Weissenbacher-Zweymuller syndrome  (ISO)
withdrawal disorder  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (ISO)
animal organ morphogenesis  (IEA,ISO)
B cell receptor signaling pathway  (IEA,ISO)
Bergmann glial cell differentiation  (IEA,ISO)
cardiac neural crest cell development involved in heart development  (IEA,ISO)
caveolin-mediated endocytosis  (IEA)
cell surface receptor signaling pathway  (IBA)
cellular response to amino acid starvation  (IEA)
cellular response to cadmium ion  (IEA)
cellular response to DNA damage stimulus  (IEA,ISO)
cellular response to dopamine  (IEA)
cellular response to granulocyte macrophage colony-stimulating factor stimulus  (IEA)
cellular response to organic substance  (ISO)
cellular response to reactive oxygen species  (IEA)
cellular response to tumor necrosis factor  (IEA,ISO)
cytosine metabolic process  (IEA,ISO)
decidualization  (ISO)
diadenosine tetraphosphate biosynthetic process  (ISO)
ERBB signaling pathway  (IEA)
ERK1 and ERK2 cascade  (IEA,ISO)
face development  (IEA,ISO)
heart development  (IEA,ISO)
insulin receptor signaling pathway  (IEA)
insulin-like growth factor receptor signaling pathway  (IEA)
intracellular signal transduction  (IBA,ISO)
labyrinthine layer blood vessel development  (IEA,ISO)
lipopolysaccharide-mediated signaling pathway  (IEA,ISO)
long-term synaptic potentiation  (IEA,ISO)
lung morphogenesis  (IEA,ISO)
mammary gland epithelial cell proliferation  (IEA,ISO)
MAPK cascade  (IEA,ISO)
negative regulation of cell differentiation  (IEA,ISO)
neural crest cell development  (IEA,ISO)
outer ear morphogenesis  (IEA,ISO)
peptidyl-serine phosphorylation  (IEA,ISO)
peptidyl-threonine phosphorylation  (IEA)
phosphorylation  (IEA)
positive regulation of cardiac muscle cell proliferation  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of gene expression  (IEA)
positive regulation of macrophage chemotaxis  (IEA,ISO)
positive regulation of macrophage proliferation  (IEA,ISO)
positive regulation of peptidyl-threonine phosphorylation  (IEA)
positive regulation of protein import into nucleus  (ISO)
positive regulation of protein metabolic process  (IEA)
positive regulation of telomerase activity  (IEA)
positive regulation of telomere capping  (IEA)
positive regulation of telomere maintenance via telomerase  (IEA)
positive regulation of translation  (ISO)
protein phosphorylation  (IEA,ISO)
regulation of cellular pH  (IEA,ISO)
regulation of cytoskeleton organization  (IEA)
regulation of early endosome to late endosome transport  (IEA)
regulation of Golgi inheritance  (IEA)
regulation of ossification  (IEA,ISO)
regulation of stress-activated MAPK cascade  (IEA)
response to epidermal growth factor  (IEA)
response to estrogen  (ISO)
response to exogenous dsRNA  (IEA,ISO)
response to lipopolysaccharide  (IEA,ISO)
response to nicotine  (IEA)
response to toxic substance  (ISO)
sensory perception of pain  (ISO)
signal transduction  (ISO)
stress-activated MAPK cascade  (IEA)
T cell receptor signaling pathway  (IEA,ISO)
thymus development  (IEA,ISO)
thyroid gland development  (IEA,ISO)
trachea formation  (IEA,ISO)

Cellular Component

References
Additional References at PubMed
PMID:17219412   PMID:17363898   PMID:24146543   PMID:24557342   PMID:25770213   PMID:28806729  


Genomics

Comparative Map Data
MAPK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12631,013,607 - 31,132,998 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2631,013,607 - 31,132,998 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2630,970,465 - 31,089,387 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02632,419,917 - 32,539,219 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2632,418,294 - 32,539,230 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12630,468,306 - 30,587,833 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02630,092,195 - 30,211,589 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02631,182,673 - 31,302,626 (-)NCBIUU_Cfam_GSD_1.0
MAPK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382221,759,657 - 21,867,680 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2221,759,657 - 21,867,680 (-)EnsemblGRCh38hg38GRCh38
GRCh372222,113,946 - 22,221,970 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362220,443,946 - 20,551,970 (-)NCBINCBI36Build 36hg18NCBI36
Build 342220,447,885 - 20,546,524NCBI
Celera225,931,476 - 6,039,519 (-)NCBICelera
Cytogenetic Map22q11.22NCBI
HuRef225,071,209 - 5,179,617 (-)NCBIHuRef
CHM1_12222,114,127 - 22,222,150 (-)NCBICHM1_1
T2T-CHM13v2.02222,173,148 - 22,281,196 (-)NCBIT2T-CHM13v2.0
Mapk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391616,801,246 - 16,865,317 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1616,801,246 - 16,865,317 (+)EnsemblGRCm39 Ensembl
GRCm381616,983,382 - 17,047,453 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1616,983,382 - 17,047,453 (+)EnsemblGRCm38mm10GRCm38
MGSCv371616,983,475 - 17,047,546 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361616,896,945 - 16,961,016 (+)NCBIMGSCv36mm8
Celera1617,555,561 - 17,620,101 (+)NCBICelera
Cytogenetic Map16A3NCBI
cM Map1610.53NCBI
Mapk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21183,957,813 - 84,023,629 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1183,957,813 - 84,023,616 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1192,681,387 - 92,746,630 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01185,342,529 - 85,407,764 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01184,396,110 - 84,461,350 (-)NCBIRnor_WKY
Rnor_6.01188,203,863 - 88,273,301 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1188,211,599 - 88,273,254 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01191,260,412 - 91,325,570 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41185,968,732 - 86,030,387 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11186,009,328 - 86,070,984 (-)NCBI
Celera1182,713,470 - 82,779,260 (-)NCBICelera
Cytogenetic Map11q23NCBI
Mapk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544217,284,232 - 17,380,020 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544217,284,232 - 17,380,026 (+)NCBIChiLan1.0ChiLan1.0
MAPK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12220,365,480 - 20,412,561 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2220,365,487 - 20,450,335 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0223,883,119 - 3,990,368 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
Mapk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118140,821,508 - 140,866,521 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366191,889,708 - 1,932,646 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049366191,889,841 - 1,932,646 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAPK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1450,082,896 - 50,165,513 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11450,083,079 - 50,165,528 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21453,590,429 - 53,613,224 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MAPK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1194,246,144 - 4,352,648 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl194,246,122 - 4,353,325 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660852,649,654 - 2,756,271 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mapk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247471,296,221 - 1,389,757 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247471,296,062 - 1,389,674 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MAPK1
1266 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 16 6 6 2 12 10 6
Low 6 6 6 4 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000035708   ⟹   ENSCAFP00000030998
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2631,013,607 - 31,132,998 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000086868   ⟹   ENSCAFP00000055022
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2631,013,607 - 31,132,998 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845046534   ⟹   ENSCAFP00845036530
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2632,418,294 - 32,539,230 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845046604   ⟹   ENSCAFP00845036590
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2632,418,294 - 32,539,230 (-)Ensembl
RefSeq Acc Id: NM_001110800   ⟹   NP_001104270
RefSeq Status: INFERRED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12631,013,607 - 31,132,998 (-)NCBI
Dog10K_Boxer_Tasha2630,970,465 - 31,089,387 (-)NCBI
ROS_Cfam_1.02632,419,917 - 32,539,219 (-)NCBI
UMICH_Zoey_3.12630,468,306 - 30,587,833 (-)NCBI
UNSW_CanFamBas_1.02630,092,195 - 30,211,589 (-)NCBI
UU_Cfam_GSD_1.02631,182,673 - 31,302,626 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001104270 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001104270   ⟸   NM_001110800
- UniProtKB: E2R2N2 (UniProtKB/TrEMBL),   A0A8C0TIJ2 (UniProtKB/TrEMBL),   A0A8I3PZP0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000030998   ⟸   ENSCAFT00000035708
RefSeq Acc Id: ENSCAFP00000055022   ⟸   ENSCAFT00000086868
RefSeq Acc Id: ENSCAFP00845036590   ⟸   ENSCAFT00845046604
RefSeq Acc Id: ENSCAFP00845036530   ⟸   ENSCAFT00845046534
Protein Domains
Protein kinase

Promoters
RGD ID:13688054
Promoter ID:EPDNEW_C6123
Type:multiple initiation site
Name:MAPK1_1
Description:mitogen-activated protein kinase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12631,133,016 - 31,133,076EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000015421 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030025445 UniProtKB/TrEMBL
  ENSCAFG00040022369 UniProtKB/TrEMBL
  ENSCAFG00845026389 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00000030998.3 UniProtKB/TrEMBL
  ENSCAFP00000055022.1 UniProtKB/TrEMBL
  ENSCAFP00030041079.1 UniProtKB/TrEMBL
  ENSCAFP00030041088.1 UniProtKB/TrEMBL
  ENSCAFP00030041103.1 UniProtKB/TrEMBL
  ENSCAFP00040036261 UniProtKB/TrEMBL
  ENSCAFP00040036291 UniProtKB/TrEMBL
  ENSCAFP00845036530 ENTREZGENE
  ENSCAFP00845036530.1 UniProtKB/TrEMBL
  ENSCAFP00845036590.1 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000035708.4 UniProtKB/TrEMBL
  ENSCAFT00000086868.2 UniProtKB/TrEMBL
  ENSCAFT00030046991.1 UniProtKB/TrEMBL
  ENSCAFT00030047001.1 UniProtKB/TrEMBL
  ENSCAFT00030047015.1 UniProtKB/TrEMBL
  ENSCAFT00040041571 UniProtKB/TrEMBL
  ENSCAFT00040041605 UniProtKB/TrEMBL
  ENSCAFT00845046534 ENTREZGENE
  ENSCAFT00845046534.1 UniProtKB/TrEMBL
  ENSCAFT00845046604.1 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  MAP_kinase_CS UniProtKB/TrEMBL
  MAPK_ERK1/2 UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
NCBI Gene MAPK1 ENTREZGENE
Pfam Pkinase UniProtKB/TrEMBL
PRINTS ERK1ERK2MAPK UniProtKB/TrEMBL
PROSITE MAPK UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A8C0PFT9_CANLF UniProtKB/TrEMBL
  A0A8C0RTM8_CANLF UniProtKB/TrEMBL
  A0A8C0TIJ2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PZP0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PZT6_CANLF UniProtKB/TrEMBL
  E2R2N2 ENTREZGENE
VGNC ID VGNC:42991 ENTREZGENE