MAPK1 (mitogen-activated protein kinase 1)

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Gene: MAPK1 (mitogen-activated protein kinase 1) Canis lupus familiaris

Analyze

Symbol:

MAPK1

Name:

mitogen-activated protein kinase 1

RGD ID:

12258672

Description:

ENCODES a protein that exhibits ATP binding (ortholog); double-stranded DNA binding (ortholog); MAP kinase activity (ortholog); INVOLVED IN aging (ortholog); animal organ morphogenesis (ortholog); B cell receptor signaling pathway (ortholog); PARTICIPATES IN adenosine signaling pathway; Bone morphogenetic proteins signaling pathway; ceramide signaling pathway; ASSOCIATED WITH Aberrant Crypt Foci (ortholog); Alzheimer's disease (ortholog); Animal Disease Models (ortholog); FOUND IN axon (ortholog); cytosol (ortholog); dendrite cytoplasm (ortholog); INTERACTS WITH arsane; arsenic atom; arsenous acid

Type:

protein-coding

RefSeq Status:

INFERRED

Previously known as:

ERK2

RGD Orthologs

Human

Mouse

Rat

Chinchilla

Bonobo

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	26	31,013,607 - 31,132,998 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	26	31,013,607 - 31,132,998 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	26	30,970,465 - 31,089,387 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	26	32,419,917 - 32,539,219 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	26	32,418,294 - 32,539,230 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	26	30,468,306 - 30,587,833 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	26	30,092,195 - 30,211,589 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	26	31,182,673 - 31,302,626 (-)	NCBI		UU_Cfam_GSD_1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Aberrant Crypt Foci (ISO)

Alzheimer's disease (ISO)

Animal Disease Models (ISO)

autism spectrum disorder (ISO)

brain ischemia (ISO)

breast cancer (ISO)

Cardiomegaly (ISO)

cardiomyopathy (ISO)

childhood pilocytic astrocytoma (ISO)

chromosome 22q11.2 deletion syndrome, distal (ISO)

Cocaine-Related Disorders (ISO)

colon adenocarcinoma (ISO)

colorectal adenocarcinoma (ISO)

Colorectal Neoplasms (ISO)

congenital heart disease (ISO)

coronary restenosis (ISO)

Coronavirus infectious disease (ISO)

demyelinating disease (ISO)

Diabetic Cardiomyopathies (ISO)

Diabetic Nephropathies (ISO)

DiGeorge syndrome (ISO)

Dwarfism (ISO)

endometrial adenocarcinoma (ISO)

endometrial carcinoma (ISO)

Endometrioid Carcinomas (ISO)

Experimental Colitis (ISO)

Experimental Diabetes Mellitus (ISO)

Experimental Liver Cirrhosis (ISO)

Experimental Liver Neoplasms (ISO)

Experimental Mammary Neoplasms (ISO)

Experimental Radiation Injuries (ISO)

extrahepatic cholestasis (ISO)

Female Infertility (ISO)

gastric ulcer (ISO)

genetic disease (ISO)

Gliosis (ISO)

glomerulonephritis (ISO)

Head and Neck Neoplasms (ISO)

head and neck squamous cell carcinoma (ISO)

Hemorrhagic Shock (ISO)

hepatocellular carcinoma (ISO)

Hodgkin's lymphoma (ISO)

Hyperalgesia (ISO)

Hypertrophy (ISO)

juvenile rheumatoid arthritis (ISO)

kidney disease (ISO)

Kidney Neoplasms (ISO)

Lung Neoplasms (ISO)

middle cerebral artery infarction (ISO)

Multiple Organ Failure (ISO)

myocardial infarction (ISO)

Myocardial Reperfusion Injury (ISO)

Neoplasm Invasiveness (ISO)

Neoplasm Metastasis (ISO)

Nerve Degeneration (ISO)

neuronal ceroid lipofuscinosis 6A (ISO)

Noonan syndrome 13 (ISO)

obesity (ISO)

Ovarian Neoplasms (ISO)

pancreatic adenocarcinoma (ISO)

Pneumococcal Pneumonia (ISO)

prostate adenocarcinoma (ISO)

pulmonary hypertension (ISO)

renal cell carcinoma (ISO)

renal fibrosis (ISO)

Sepsis (ISO)

severe acute respiratory syndrome (ISO)

Sezary's disease (ISO)

Shock (ISO)

squamous cell carcinoma (ISO)

Stomach Neoplasms (ISO)

Testis Reperfusion Injury (ISO)

thyroid gland cancer (ISO)

Thyroid Neoplasms (ISO)

transitional cell carcinoma (ISO)

trigeminal neuralgia (ISO)

type 2 diabetes mellitus (ISO)

ureteral obstruction (ISO)

urethral obstruction (ISO)

Urinary Incontinence (ISO)

Uterine Cervical Neoplasms (ISO)

velocardiofacial syndrome (ISO)

Weissenbacher-Zweymuller syndrome (ISO)

withdrawal disorder (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

arsane (EXP)

arsenic atom (EXP)

arsenous acid (EXP)

colforsin daropate hydrochloride (EXP)

D-glucitol (EXP)

diarsenic trioxide (EXP)

glutathione (EXP)

hydrogen peroxide (EXP)

N-acetyl-L-cysteine (EXP)

phorbol 13-acetate 12-myristate (EXP)

sodium chloride (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

aging (ISO)

animal organ morphogenesis (IEA,ISO)

B cell receptor signaling pathway (IEA,ISO)

Bergmann glial cell differentiation (IEA,ISO)

cardiac neural crest cell development involved in heart development (IEA,ISO)

caveolin-mediated endocytosis (IEA)

cell surface receptor signaling pathway (IBA)

cellular response to amino acid starvation (IEA)

cellular response to cadmium ion (IEA)

cellular response to DNA damage stimulus (IEA,ISO)

cellular response to dopamine (IEA)

cellular response to granulocyte macrophage colony-stimulating factor stimulus (IEA)

cellular response to organic substance (ISO)

cellular response to reactive oxygen species (IEA)

cellular response to tumor necrosis factor (IEA,ISO)

cytosine metabolic process (IEA,ISO)

decidualization (ISO)

diadenosine tetraphosphate biosynthetic process (ISO)

ERBB signaling pathway (IEA)

ERK1 and ERK2 cascade (IEA,ISO)

face development (IEA,ISO)

heart development (IEA,ISO)

insulin receptor signaling pathway (IEA)

insulin-like growth factor receptor signaling pathway (IEA)

intracellular signal transduction (IBA,ISO)

labyrinthine layer blood vessel development (IEA,ISO)

lipopolysaccharide-mediated signaling pathway (IEA,ISO)

long-term synaptic potentiation (IEA,ISO)

lung morphogenesis (IEA,ISO)

mammary gland epithelial cell proliferation (IEA,ISO)

MAPK cascade (IEA,ISO)

negative regulation of cell differentiation (IEA,ISO)

neural crest cell development (IEA,ISO)

outer ear morphogenesis (IEA,ISO)

peptidyl-serine phosphorylation (IEA,ISO)

peptidyl-threonine phosphorylation (IEA)

phosphorylation (IEA)

positive regulation of cardiac muscle cell proliferation (ISO)

positive regulation of cell migration (ISO)

positive regulation of cell population proliferation (ISO)

positive regulation of DNA-templated transcription (ISO)

positive regulation of gene expression (IEA)

positive regulation of macrophage chemotaxis (IEA,ISO)

positive regulation of macrophage proliferation (IEA,ISO)

positive regulation of peptidyl-threonine phosphorylation (IEA)

positive regulation of protein import into nucleus (ISO)

positive regulation of protein metabolic process (IEA)

positive regulation of telomerase activity (IEA)

positive regulation of telomere capping (IEA)

positive regulation of telomere maintenance via telomerase (IEA)

positive regulation of translation (ISO)

protein phosphorylation (IEA,ISO)

regulation of cellular pH (IEA,ISO)

regulation of cytoskeleton organization (IEA)

regulation of early endosome to late endosome transport (IEA)

regulation of Golgi inheritance (IEA)

regulation of ossification (IEA,ISO)

regulation of stress-activated MAPK cascade (IEA)

response to epidermal growth factor (IEA)

response to estrogen (ISO)

response to exogenous dsRNA (IEA,ISO)

response to lipopolysaccharide (IEA,ISO)

response to nicotine (IEA)

response to toxic substance (ISO)

sensory perception of pain (ISO)

signal transduction (ISO)

stress-activated MAPK cascade (IEA)

T cell receptor signaling pathway (IEA,ISO)

thymus development (IEA,ISO)

thyroid gland development (IEA,ISO)

trachea formation (IEA,ISO)

Cellular Component

axon (ISO)

caveola (IEA)

cytoplasm (IBA,IEA)

cytoskeleton (IEA)

cytosol (IEA,ISO)

dendrite cytoplasm (ISO)

early endosome (IEA)

focal adhesion (IEA)

Golgi apparatus (IEA)

late endosome (IEA)

mitochondrion (IEA)

nucleoplasm (ISO)

nucleus (IBA,IEA,ISO)

perikaryon (ISO)

plasma membrane (ISO)

postsynaptic density (ISO)

protein-containing complex (ISO)

pseudopodium (IEA)

Molecular Function

ATP binding (IEA,ISO)

double-stranded DNA binding (ISO)

identical protein binding (IEA)

kinase activity (IEA)

MAP kinase activity (IBA,IEA,ISO)

MAP kinase kinase activity (IEA)

mitogen-activated protein kinase kinase kinase binding (ISO)

nucleotide binding (IEA)

phosphatase binding (IEA)

phosphotyrosine residue binding (IEA)

protein binding (ISO)

protein kinase activity (IEA)

protein kinase binding (ISO)

protein serine kinase activity (IEA)

protein serine/threonine kinase activity (IBA,IEA)

protein serine/threonine/tyrosine kinase activity (IEA)

RNA polymerase II CTD heptapeptide repeat kinase activity (IEA)

transcription factor binding (ISO)

transferase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

adenosine signaling pathway (ISO)

Bone morphogenetic proteins signaling pathway (ISO)

ceramide signaling pathway (ISO)

endothelin signaling pathway (ISO)

ephrin - ephrin receptor bidirectional signaling axis (ISO)

epidermal growth factor/neuregulin signaling pathway (ISO)

Fc epsilon receptor mediated signaling pathway (ISO)

fibroblast growth factor signaling pathway (ISO)

granulocyte-macrophage colony-stimulating factor signaling pathway (ISO)

insulin signaling pathway (ISO)

interleukin-2 signaling pathway (ISO)

mTOR signaling pathway (ISO)

platelet-derived growth factor signaling pathway (ISO)

sphingosine 1-phosphate signaling pathway (ISO)

syndecan signaling pathway (ISO)

the extracellular signal-regulated Raf/Mek/Erk signaling pathway (ISO)

Trail mediated signaling pathway (ISO)

type II interferon signaling pathway (ISO)

vascular endothelial growth factor signaling pathway (ISO)

References

Additional References at PubMed

PMID:17219412	PMID:17363898	PMID:24146543	PMID:24557342	PMID:25770213	PMID:28806729

Genomics

Comparative Map Data

MAPK1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	26	31,013,607 - 31,132,998 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	26	31,013,607 - 31,132,998 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	26	30,970,465 - 31,089,387 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	26	32,419,917 - 32,539,219 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	26	32,418,294 - 32,539,230 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	26	30,468,306 - 30,587,833 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	26	30,092,195 - 30,211,589 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	26	31,182,673 - 31,302,626 (-)	NCBI		UU_Cfam_GSD_1.0

MAPK1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	22	21,759,657 - 21,867,680 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	22	21,759,657 - 21,867,680 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	22	22,113,946 - 22,221,970 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	22	20,443,946 - 20,551,970 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	22	20,447,885 - 20,546,524	NCBI
Celera	22	5,931,476 - 6,039,519 (-)	NCBI		Celera
Cytogenetic Map	22	q11.22	NCBI
HuRef	22	5,071,209 - 5,179,617 (-)	NCBI		HuRef
CHM1_1	22	22,114,127 - 22,222,150 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	22	22,173,148 - 22,281,196 (-)	NCBI		T2T-CHM13v2.0

Mapk1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	16	16,801,246 - 16,865,317 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	16	16,801,246 - 16,865,317 (+)	Ensembl		GRCm39 Ensembl
GRCm38	16	16,983,382 - 17,047,453 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	16	16,983,382 - 17,047,453 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	16	16,983,475 - 17,047,546 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	16	16,896,945 - 16,961,016 (+)	NCBI		MGSCv36	mm8
Celera	16	17,555,561 - 17,620,101 (+)	NCBI		Celera
Cytogenetic Map	16	A3	NCBI
cM Map	16	10.53	NCBI

Mapk1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	11	83,957,813 - 84,023,629 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	83,957,813 - 84,023,616 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	11	92,681,387 - 92,746,630 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	11	85,342,529 - 85,407,764 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	11	84,396,110 - 84,461,350 (-)	NCBI	Rnor_WKY
Rnor_6.0	11	88,203,863 - 88,273,301 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	88,211,599 - 88,273,254 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	11	91,260,412 - 91,325,570 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	11	85,968,732 - 86,030,387 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	11	86,009,328 - 86,070,984 (-)	NCBI
Celera	11	82,713,470 - 82,779,260 (-)	NCBI		Celera
Cytogenetic Map	11	q23	NCBI

Mapk1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955442	17,284,232 - 17,380,020 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955442	17,284,232 - 17,380,026 (+)	NCBI	ChiLan1.0	ChiLan1.0

MAPK1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	22	20,365,480 - 20,412,561 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	22	20,365,487 - 20,450,335 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	22	3,883,119 - 3,990,368 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

Mapk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	140,821,508 - 140,866,521 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936619	1,889,708 - 1,932,646 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936619	1,889,841 - 1,932,646 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MAPK1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	50,082,896 - 50,165,513 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	50,083,079 - 50,165,528 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	53,590,429 - 53,613,224 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MAPK1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	19	4,246,144 - 4,352,648 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	19	4,246,122 - 4,353,325 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666085	2,649,654 - 2,756,271 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Mapk1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624747	1,296,221 - 1,389,757 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624747	1,296,062 - 1,389,674 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in MAPK1
1266 total Variants

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	reproductive system	respiratory system	adipose tissue
High
Medium	5	5	16		6		6	2	12		10	6
Low			6	6		6		4		8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001110800	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000026	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000286	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000065	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000375	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000026	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSCAFT00000035708 ⟹ ENSCAFP00000030998

RefSeq Status:

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	26	31,013,607 - 31,132,998 (-)	Ensembl

RefSeq Acc Id:

ENSCAFT00000086868 ⟹ ENSCAFP00000055022

RefSeq Status:

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	26	31,013,607 - 31,132,998 (-)	Ensembl

RefSeq Acc Id:

ENSCAFT00845046534 ⟹ ENSCAFP00845036530

RefSeq Status:

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	26	32,418,294 - 32,539,230 (-)	Ensembl

RefSeq Acc Id:

ENSCAFT00845046604 ⟹ ENSCAFP00845036590

RefSeq Status:

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	26	32,418,294 - 32,539,230 (-)	Ensembl

RefSeq Acc Id:

NM_001110800 ⟹ NP_001104270

RefSeq Status:

INFERRED

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	26	31,013,607 - 31,132,998 (-)	NCBI
Dog10K_Boxer_Tasha	26	30,970,465 - 31,089,387 (-)	NCBI
ROS_Cfam_1.0	26	32,419,917 - 32,539,219 (-)	NCBI
UMICH_Zoey_3.1	26	30,468,306 - 30,587,833 (-)	NCBI
UNSW_CanFamBas_1.0	26	30,092,195 - 30,211,589 (-)	NCBI
UU_Cfam_GSD_1.0	26	31,182,673 - 31,302,626 (-)	NCBI

Sequence:

show sequence

TCGGTCCGAGCGGCCGTAGTCTCTCCCGCGGTCCTGAGCGCTGCCCTCCTTGCTCCTTTCCGAT
CAGCGTCGGCAGCTGCACCCGCAGCGGCGCAGTCCCCCCGGGAGGCGCGGCGTGGGCCGAGCGG
CGGCCGCGGAGCGTCGAGCCTTTCGCGGCGGCGGCGGCGGCGGCCCGGCAGCCAACATGGCGGC
GGCGGCGGCGGCGGGCGCGGGCCCGGAGATGGTCCGCGGGCAGGTGTTCGACGTGGGGCCGCGC
TACACCAACCTCTCCTACATCGGCGAGGGCGCCTACGGCATGGTGTGCTCTGCTTATGATAATG
TCAACAAAGTTCGAGTAGCCATCAAGAAAATCAGTCCTTTTGAGCACCAGACCTACTGCCAGAG
AACCCTGAGGGAGATAAAAATCTTACTGCGCTTCAGACATGAGAACATCATTGGAATCAATGAT
ATTATTCGAGCACCAACCATCGAGCAAATGAAAGATGTATATATAGTACAAGACCTCATGGAAA
CAGATCTTTACAAGCTCTTGAAGACGCAACACCTCAGCAACGACCATATCTGCTATTTTCTTTA
CCAGATCCTCAGAGGGTTAAAATATATCCATTCAGCTAATGTACTGCACCGTGACCTCAAACCT
TCCAACCTGCTGCTCAATACCACCTGCGATCTCAAGATCTGTGACTTTGGCTTGGCCCGTGTTG
CAGATCCGGATCATGATCACACAGGGTTCCTGACGGAGTATGTAGCCACACGTTGGTACAGGGC
TCCAGAAATTATGTTGAATTCCAAGGGCTATACCAAGTCCATTGATATTTGGTCTGTAGGCTGC
ATTCTGGCAGAGATGCTGTCCAACAGGCCCATCTTCCCGGGGAAGCATTATCTCGACCAGCTGA
ACCACATTTTGGGTATTCTTGGATCCCCATCACAGGAAGACCTGAACTGTATAATAAATTTAAA
AGCTAGAAACTACTTGCTTTCTCTTCCACACAAAAATAAGGTGCCATGGAACAGGCTGTTCCCA
AATGCTGACTCGAAAGCTCTGGATTTACTGGACAAAATGTTGACATTCAACCCTCACAAGAGGA
TTGAAGTAGAACAGGCTCTGGCCCATCCGTATCTGGAGCAGTATTATGACCCAAGTGATGAGCC
CATCGCTGAGGCGCCATTCAAGTTTGACATGGAGCTAGATGACCTGCCCAAGGAAAAGCTCAAG
GAGCTCATCTTCGAAGAGACAGCTAGATTCCAGCCGGGATACAGATCTTAAATTTATCAGGACA
AGGGCTCAGAGGACTGGACGTGCTCAGACATCGGTGTTGTTCTTCCCAGTTCTTGACCCCGGTC
CTGTCTCCAGCCCGTCTCGGCTTAATCCACCTTGACTCCTTTGAGCCGTTCGGAGGGGCGGTTT
CTGGTAGTTGTGGCTTTTATGCTTTCAAAGAATTCCTTCAGTCCAGAGAACTGTTCCTGGCATC
CCTGTGTGTGTCACCCACCGGTGACCTGTGGCAGTATGTACTTTCAGTGCACCTACTGCTTACC
GTTGCTTTAGTCACTAATCGCTTTCTGGTTTGAAAGATGCAGTGGTTCCTCCCTCTCCTGAATC
CTCCCTATGTACCGCCCTGCTGACCCATGCAGTCACATCAGAGATAGTTCTTTCCAGATTGGCT
CTCGTCACTGGCCTCTCACTTTATGATAGGGAAGGCTACTACCTAGGGCACTTTAAGTCAGTGA
CAGCCCCTTATTTGCACATCACCTTTTCACCATCAGCGTTTCCCCGGAGCAGGAGTGTTTGGAA
ACAACTGGGATGTCGTTGCAGCCTGCGGCAAGTGCTCCCATCTCGGGAACCTTTAGGGGCACTT
GCCCGTGTCTTTTCTCATATCATGTTAGTCACTAACATATTTAAGGTTTGTGCTGTTTGCCCAG
CTTTTAGAATACTCAACCATTTTTCTAAATAAAAGAAGTACTGCATCCAGCAACTTCACTCTGT
AGATTTATGTGGTTTCTTACACCATTTATTGAGGTATAACACTTGCCCCAGATGTGTCATCTGC
AGTACTGTTTGCAAGGCTTACACAAAAAGATTTAAAGTGACAGCTGCACTCAGGATTTAGTGAG
AGATGTACACAGGTCACAACAGGGTGCTAAAGAAAGTGTCTGGAGAAGCAGCCAGCAGGCCACC
CAGCTGTCATGGGGCAGAGCTGCACACACAGGTGGTGTACGTATATCCCCGAGCTACTTCACAT
GGTGTGCCACGTTCAGTGTAACCACATTCAATGCCTCAGGATTTAGCAGAGAGGAGCCCTGCGT
CTTTAAATGAGAAAGTGTACAATTCTTTTTCCTCCTACAGCATGTCAGCATCTCAAGTTCATTT
TTCAACCTACGATATAACAATTTGTAATAAAGCCTTCATGAGCTCATGGCGTGAAGCACTGTTC
TGTCGTCAAGTACTCTCAAATGTTTCTGATACTGCTGAGCTAAGACCATGAGAAAAAGCTAGCA
CTAAGTCATGTTTGGAGCTCTATCCCATATTCTCCTGATCTCTTTAAGTATTTGTTCCTGCCAC
TGTACACTGTGGCGTTGACTTGGTGTTCTGTCCCAGTGCGGTGCCTCCTCTTGACTCCCCCACT
GCTCTCTGTGGTGAGAAATTTGCCTTGTTCAATAATTACTGTACCCTCGCATGACTGTTACAGC
TTTCTGTGCAGAGATGACTGTCCAAGTGCCACATGCCTATGATTGAAACGAAAAATTTATTGTT
ACCTCTGAGTTTGTGTTCCACGGAAATGCTATCCAGCAGATCACTTAGGAAAAATAATTCTATT
TTTAGCTTTTCATTTCTCAGCTGTCCTTTTTTTCTTGTTTGATTTTTGACAGCAATGGAGAATG
GGTTATATAAAGACTGCCTGCTAATATGAACAGAAATGCACTTGTAATTCATGAAAATAAATGT
ACATCTTCGATCTTCATATTCATGTTAAGATTCAGTGTCAATTTCCTCTGGATCAGCGTGTCCA
AATGGACAGTCAGCTTCAGTTGTGCTTGGAGCAGAAATGCTTACGGGCCTCCCCTTCCCGCCCG
GACACTGCCCCAACACTGGTTTACACAGGATGATTTAGAAGGCATTTCTGTAGGGTCCTAGTTT
CCTAGGATCAACTCTGACATGTTCCTTTACTCAAACCATAGGTCTAAAATACTATATCAAACTC
TGATGAAGAGCCCAAACGTCTCAGGTTGGATTCTCTGGTTCTTTCTAAAGAGGGCCTGCCTATG
TGCCCTAGAACTGCTCCTGGGCATGGCGGGGTGCTGGGAAGGGCTGCCCAGTGTCACTTGGCCC
ATACCACCTGGGTCAGGGTGTGGATGCTCACACCTCATGGGCTAACGATGGACGGCTAACTCAG
CCTCAGAGATCGGAACCACATCTAGATTCTTGCCCTAAAATACGTGATTCATCTCCATGCTCAG
AGCTGCCAGGCCAAGGTCAATGCATCCGGCATTGACAGAATAGAAGTTTGATTGTTACTTAATA
ACATTGGTGAGTCAGTTTTCATTTTCGAAGAAGCAGTGACAGTTTTCTTACTCTTCTTTTGTTC
TTTTTTTAATGGAATGTTAGTATTATTATGAGGTTAATTTGCAGTCCTCTAAATAGAAAGCCAT
AGCCTTGGTTACTAATACCTGAGGACTGTGGG

hide sequence

Protein Sequences


Protein RefSeqs	NP_001104270	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_001104270 ⟸ NM_001110800

- UniProtKB:

E2R2N2 (UniProtKB/TrEMBL), A0A8C0TIJ2 (UniProtKB/TrEMBL), A0A8I3PZP0 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTY
CQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICY
FLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRW
YRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII
NLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPS
DEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS

hide sequence

RefSeq Acc Id:

ENSCAFP00000030998 ⟸ ENSCAFT00000035708

RefSeq Acc Id:

ENSCAFP00000055022 ⟸ ENSCAFT00000086868

RefSeq Acc Id:

ENSCAFP00845036590 ⟸ ENSCAFT00845046604

RefSeq Acc Id:

ENSCAFP00845036530 ⟸ ENSCAFT00845046534

Protein Domains

Protein kinase

Promoters

RGD ID:

13688054

Promoter ID:

EPDNEW_C6123

Type:

multiple initiation site

Name:

MAPK1_1

Description:

mitogen-activated protein kinase 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	26	31,133,016 - 31,133,076	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000015421	Ensembl, UniProtKB/TrEMBL
	ENSCAFG00030025445	UniProtKB/TrEMBL
	ENSCAFG00040022369	UniProtKB/TrEMBL
	ENSCAFG00845026389	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSCAFP00000030998.3	UniProtKB/TrEMBL
	ENSCAFP00000055022.1	UniProtKB/TrEMBL
	ENSCAFP00030041079.1	UniProtKB/TrEMBL
	ENSCAFP00030041088.1	UniProtKB/TrEMBL
	ENSCAFP00030041103.1	UniProtKB/TrEMBL
	ENSCAFP00040036261	UniProtKB/TrEMBL
	ENSCAFP00040036291	UniProtKB/TrEMBL
	ENSCAFP00845036530	ENTREZGENE
	ENSCAFP00845036530.1	UniProtKB/TrEMBL
	ENSCAFP00845036590.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00000035708.4	UniProtKB/TrEMBL
	ENSCAFT00000086868.2	UniProtKB/TrEMBL
	ENSCAFT00030046991.1	UniProtKB/TrEMBL
	ENSCAFT00030047001.1	UniProtKB/TrEMBL
	ENSCAFT00030047015.1	UniProtKB/TrEMBL
	ENSCAFT00040041571	UniProtKB/TrEMBL
	ENSCAFT00040041605	UniProtKB/TrEMBL
	ENSCAFT00845046534	ENTREZGENE
	ENSCAFT00845046534.1	UniProtKB/TrEMBL
	ENSCAFT00845046604.1	UniProtKB/TrEMBL
InterPro	Kinase-like_dom_sf	UniProtKB/TrEMBL
	MAP_kinase_CS	UniProtKB/TrEMBL
	MAPK_ERK1/2	UniProtKB/TrEMBL
	Prot_kinase_dom	UniProtKB/TrEMBL
	Protein_kinase_ATP_BS	UniProtKB/TrEMBL
	Ser/Thr_kinase_AS	UniProtKB/TrEMBL
NCBI Gene	MAPK1	ENTREZGENE
Pfam	Pkinase	UniProtKB/TrEMBL
PRINTS	ERK1ERK2MAPK	UniProtKB/TrEMBL
PROSITE	MAPK	UniProtKB/TrEMBL
	PROTEIN_KINASE_ATP	UniProtKB/TrEMBL
	PROTEIN_KINASE_DOM	UniProtKB/TrEMBL
	PROTEIN_KINASE_ST	UniProtKB/TrEMBL
SMART	S_TKc	UniProtKB/TrEMBL
Superfamily-SCOP	SSF56112	UniProtKB/TrEMBL
UniProt	A0A8C0PFT9_CANLF	UniProtKB/TrEMBL
	A0A8C0RTM8_CANLF	UniProtKB/TrEMBL
	A0A8C0TIJ2	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I3PZP0	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I3PZT6_CANLF	UniProtKB/TrEMBL
	E2R2N2	ENTREZGENE
VGNC ID	VGNC:42991	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - PID (archival)