MAPK1 (mitogen-activated protein kinase 1) - Rat Genome Database

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Gene: MAPK1 (mitogen-activated protein kinase 1) Canis lupus familiaris
Analyze
Symbol: MAPK1
Name: mitogen-activated protein kinase 1
RGD ID: 12258672
Description: ENCODES a protein that exhibits ATP binding (ortholog); double-stranded DNA binding (ortholog); kinase activity (ortholog); INVOLVED IN aging (ortholog); animal organ morphogenesis (ortholog); B cell receptor signaling pathway (ortholog); PARTICIPATES IN adenosine signaling pathway; Bone morphogenetic proteins signaling pathway; ceramide signaling pathway; ASSOCIATED WITH Aberrant Crypt Foci (ortholog); Alzheimer's disease (ortholog); Animal Disease Models (ortholog); FOUND IN axon (ortholog); cytoplasm (ortholog); cytosol (ortholog); INTERACTS WITH arsane; arsenic atom; arsenous acid
Type: protein-coding
RefSeq Status: INFERRED
Also known as: ERK2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12631,013,607 - 31,132,998 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2631,013,607 - 31,132,998 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2630,970,465 - 31,089,387 (-)NCBI
ROS_Cfam_1.02632,419,917 - 32,539,219 (-)NCBI
UMICH_Zoey_3.12630,468,306 - 30,587,833 (-)NCBI
UNSW_CanFamBas_1.02630,092,195 - 30,211,589 (-)NCBI
UU_Cfam_GSD_1.02631,182,673 - 31,302,626 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Aberrant Crypt Foci  (ISO)
Alzheimer's disease  (ISO)
Animal Disease Models  (ISO)
brain ischemia  (ISO)
breast cancer  (ISO)
Cardiomegaly  (ISO)
cardiomyopathy  (ISO)
childhood pilocytic astrocytoma  (ISO)
chromosome 22q11.2 deletion syndrome, distal  (ISO)
Cocaine-Related Disorders  (ISO)
colon adenocarcinoma  (ISO)
colorectal adenocarcinoma  (ISO)
Colorectal Neoplasms  (ISO)
congenital heart disease  (ISO)
coronary restenosis  (ISO)
Coronavirus infectious disease  (ISO)
demyelinating disease  (ISO)
Diabetic Cardiomyopathies  (ISO)
Diabetic Nephropathies  (ISO)
DiGeorge syndrome  (ISO)
Dwarfism  (ISO)
endometrial adenocarcinoma  (ISO)
endometrial carcinoma  (ISO)
Endometrioid Carcinomas  (ISO)
Experimental Colitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Liver Neoplasms  (ISO)
extrahepatic cholestasis  (ISO)
Female Infertility  (ISO)
gastric ulcer  (ISO)
genetic disease  (ISO)
Gliosis  (ISO)
glomerulonephritis  (ISO)
Head and Neck Neoplasms  (ISO)
head and neck squamous cell carcinoma  (ISO)
Hemorrhagic Shock  (ISO)
Hodgkin's lymphoma  (ISO)
Hyperalgesia  (ISO)
Hypertrophy  (ISO)
juvenile rheumatoid arthritis  (ISO)
kidney disease  (ISO)
Kidney Neoplasms  (ISO)
Lung Neoplasms  (ISO)
Mammary Neoplasms, Experimental  (ISO)
middle cerebral artery infarction  (ISO)
Multiple Organ Failure  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Nerve Degeneration  (ISO)
neuronal ceroid lipofuscinosis 6  (ISO)
Noonan syndrome 13  (ISO)
obesity  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic adenocarcinoma  (ISO)
Pneumococcal Pneumonia  (ISO)
prostate adenocarcinoma  (ISO)
pulmonary hypertension  (ISO)
Radiation Injuries, Experimental  (ISO)
renal cell carcinoma  (ISO)
renal fibrosis  (ISO)
Sepsis  (ISO)
severe acute respiratory syndrome  (ISO)
Sezary's disease  (ISO)
Shock  (ISO)
squamous cell carcinoma  (ISO)
Stomach Neoplasms  (ISO)
Testis Reperfusion Injury  (ISO)
thyroid gland cancer  (ISO)
transitional cell carcinoma  (ISO)
trigeminal neuralgia  (ISO)
type 2 diabetes mellitus  (ISO)
ureteral obstruction  (ISO)
urethral obstruction  (ISO)
Urinary Incontinence  (ISO)
Uterine Cervical Neoplasms  (ISO)
withdrawal disorder  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (ISO)
animal organ morphogenesis  (ISO)
B cell receptor signaling pathway  (IEA,ISO)
Bergmann glial cell differentiation  (IEA,ISO)
cardiac neural crest cell development involved in heart development  (IEA,ISO)
cell surface receptor signaling pathway  (IBA)
cellular response to amino acid starvation  (IEA)
cellular response to cadmium ion  (IEA)
cellular response to DNA damage stimulus  (IEA,ISO)
cellular response to dopamine  (IEA)
cellular response to granulocyte macrophage colony-stimulating factor stimulus  (IEA,ISO)
cellular response to organic substance  (ISO)
cellular response to reactive oxygen species  (IEA)
cellular response to tumor necrosis factor  (IEA,ISO)
cytosine metabolic process  (IEA,ISO)
decidualization  (ISO)
diadenosine tetraphosphate biosynthetic process  (ISO)
ERBB signaling pathway  (IEA)
ERK1 and ERK2 cascade  (IEA,ISO)
face development  (IEA,ISO)
heart development  (ISO)
intracellular signal transduction  (IBA,ISO)
labyrinthine layer blood vessel development  (IEA,ISO)
lipopolysaccharide-mediated signaling pathway  (IEA,ISO)
long-term synaptic potentiation  (IEA,ISO)
lung morphogenesis  (IEA,ISO)
mammary gland epithelial cell proliferation  (IEA,ISO)
MAPK cascade  (ISO)
negative regulation of cell differentiation  (IEA,ISO)
neural crest cell development  (ISO)
outer ear morphogenesis  (IEA,ISO)
peptidyl-serine phosphorylation  (IEA,ISO)
peptidyl-threonine phosphorylation  (IEA)
positive regulation of cardiac muscle cell proliferation  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of gene expression  (IEA)
positive regulation of macrophage chemotaxis  (IEA,ISO)
positive regulation of macrophage proliferation  (IEA,ISO)
positive regulation of peptidyl-threonine phosphorylation  (IEA)
positive regulation of protein import into nucleus  (ISO)
positive regulation of telomerase activity  (IEA)
positive regulation of telomere capping  (IEA)
positive regulation of telomere maintenance via telomerase  (IEA)
positive regulation of transcription, DNA-templated  (ISO)
positive regulation of translation  (ISO)
protein phosphorylation  (ISO)
regulation of cellular pH  (IEA,ISO)
regulation of ossification  (IEA,ISO)
response to epidermal growth factor  (IEA)
response to estrogen  (ISO)
response to exogenous dsRNA  (IEA,ISO)
response to lipopolysaccharide  (ISO)
response to nicotine  (IEA)
response to toxic substance  (ISO)
sensory perception of pain  (ISO)
signal transduction  (ISO)
stress-activated MAPK cascade  (IEA)
T cell receptor signaling pathway  (IEA,ISO)
thymus development  (IEA,ISO)
thyroid gland development  (IEA,ISO)
trachea formation  (IEA,ISO)

Cellular Component

References
Additional References at PubMed
PMID:17219412   PMID:17363898   PMID:24146543   PMID:24557342   PMID:25770213   PMID:28806729  


Genomics

Comparative Map Data
MAPK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12631,013,607 - 31,132,998 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2631,013,607 - 31,132,998 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2630,970,465 - 31,089,387 (-)NCBI
ROS_Cfam_1.02632,419,917 - 32,539,219 (-)NCBI
UMICH_Zoey_3.12630,468,306 - 30,587,833 (-)NCBI
UNSW_CanFamBas_1.02630,092,195 - 30,211,589 (-)NCBI
UU_Cfam_GSD_1.02631,182,673 - 31,302,626 (-)NCBI
MAPK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2221,759,657 - 21,867,680 (-)EnsemblGRCh38hg38GRCh38
GRCh382221,759,657 - 21,867,680 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372222,113,946 - 22,221,970 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362220,443,946 - 20,551,970 (-)NCBINCBI36hg18NCBI36
Build 342220,447,885 - 20,546,524NCBI
Celera225,931,476 - 6,039,519 (-)NCBI
Cytogenetic Map22q11.22NCBI
HuRef225,071,209 - 5,179,617 (-)NCBIHuRef
CHM1_12222,114,127 - 22,222,150 (-)NCBICHM1_1
Mapk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391616,801,246 - 16,865,317 (+)NCBIGRCm39mm39
GRCm39 Ensembl1616,801,246 - 16,865,317 (+)Ensembl
GRCm381616,983,382 - 17,047,453 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1616,983,382 - 17,047,453 (+)EnsemblGRCm38mm10GRCm38
MGSCv371616,983,475 - 17,047,546 (+)NCBIGRCm37mm9NCBIm37
MGSCv361616,896,945 - 16,961,016 (+)NCBImm8
Celera1617,555,561 - 17,620,101 (+)NCBICelera
Cytogenetic Map16A3NCBI
cM Map1610.53NCBI
Mapk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21183,957,813 - 84,023,629 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1183,957,813 - 84,023,616 (-)Ensembl
Rnor_6.01188,203,863 - 88,273,301 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1188,211,599 - 88,273,254 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01191,260,412 - 91,325,570 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41185,968,732 - 86,030,387 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11186,009,328 - 86,070,984 (-)NCBI
Celera1182,713,470 - 82,779,260 (-)NCBICelera
Cytogenetic Map11q23NCBI
Mapk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544217,284,232 - 17,380,020 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544217,284,232 - 17,380,026 (+)NCBIChiLan1.0ChiLan1.0
MAPK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12220,365,480 - 20,412,561 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2220,365,487 - 20,450,335 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0223,883,119 - 3,990,368 (-)NCBIMhudiblu_PPA_v0panPan3
Mapk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118140,821,508 - 140,866,521 (-)NCBI
SpeTri2.0NW_0049366191,889,841 - 1,932,646 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAPK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1450,082,896 - 50,165,523 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11450,083,079 - 50,165,528 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21453,590,429 - 53,613,224 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MAPK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1194,246,144 - 4,352,648 (+)NCBI
ChlSab1.1 Ensembl194,246,122 - 4,353,325 (+)Ensembl
Vero_WHO_p1.0NW_0236660852,649,654 - 2,756,271 (-)NCBI
Mapk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247471,296,062 - 1,389,674 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 16 6 6 2 12 10 6
Low 6 6 6 4 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000035708   ⟹   ENSCAFP00000030998
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2631,013,607 - 31,132,998 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000086868   ⟹   ENSCAFP00000055022
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2631,013,607 - 31,132,998 (-)Ensembl
RefSeq Acc Id: NM_001110800   ⟹   NP_001104270
RefSeq Status: INFERRED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12631,013,607 - 31,132,998 (-)NCBI
Dog10K_Boxer_Tasha2630,970,465 - 31,089,387 (-)NCBI
ROS_Cfam_1.02632,419,917 - 32,539,219 (-)NCBI
UMICH_Zoey_3.12630,468,306 - 30,587,833 (-)NCBI
UNSW_CanFamBas_1.02630,092,195 - 30,211,589 (-)NCBI
UU_Cfam_GSD_1.02631,182,673 - 31,302,626 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001104270 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001104270   ⟸   NM_001110800
- UniProtKB: E2R2N2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000030998   ⟸   ENSCAFT00000035708
RefSeq Acc Id: ENSCAFP00000055022   ⟸   ENSCAFT00000086868

Promoters
RGD ID:13688054
Promoter ID:EPDNEW_C6123
Type:multiple initiation site
Name:MAPK1_1
Description:mitogen-activated protein kinase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12631,133,016 - 31,133,076EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000015421 Ensembl, ENTREZGENE
Ensembl Protein ENSCAFP00000030998 ENTREZGENE
Ensembl Transcript ENSCAFT00000035708 ENTREZGENE
NCBI Gene MAPK1 ENTREZGENE
UniProt E2R2N2 ENTREZGENE
VGNC ID VGNC:42991 ENTREZGENE