Mapk1 (mitogen-activated protein kinase 1) - Rat Genome Database

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Gene: Mapk1 (mitogen-activated protein kinase 1) Ictidomys tridecemlineatus
Analyze
Symbol: Mapk1
Name: mitogen-activated protein kinase 1
RGD ID: 12485316
Description: ENCODES a protein that exhibits ATP binding (ortholog); double-stranded DNA binding (ortholog); MAP kinase activity (ortholog); INVOLVED IN animal organ morphogenesis (ortholog); B cell receptor signaling pathway (ortholog); Bergmann glial cell differentiation (ortholog); PARTICIPATES IN adenosine signaling pathway; Bone morphogenetic proteins signaling pathway; ceramide signaling pathway; ASSOCIATED WITH Aberrant Crypt Foci (ortholog); alcohol dependence (ortholog); alcohol use disorder (ortholog); FOUND IN axon (ortholog); cytosol (ortholog); dendrite cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118140,821,508 - 140,866,521 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366191,889,708 - 1,932,646 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366191,889,841 - 1,932,646 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Aberrant Crypt Foci  (ISO)
alcohol dependence  (ISO)
alcohol use disorder  (ISO)
Alzheimer's disease  (ISO)
Animal Disease Models  (ISO)
autism spectrum disorder  (ISO)
brain ischemia  (ISO)
breast cancer  (ISO)
Cardiomegaly  (ISO)
cardiomyopathy  (ISO)
childhood pilocytic astrocytoma  (ISO)
chromosome 22q11.2 deletion syndrome, distal  (ISO)
cocaine abuse  (ISO)
cocaine dependence  (ISO)
Cocaine-Related Disorders  (ISO)
colon adenocarcinoma  (ISO)
colon cancer  (ISO)
colorectal adenocarcinoma  (ISO)
Colorectal Neoplasms  (ISO)
congenital heart disease  (ISO)
coronary restenosis  (ISO)
Coronavirus infectious disease  (ISO)
demyelinating disease  (ISO)
depressive disorder  (ISO)
Diabetic Cardiomyopathies  (ISO)
Diabetic Nephropathies  (ISO)
DiGeorge syndrome  (ISO)
Dwarfism  (ISO)
endometrial adenocarcinoma  (ISO)
endometrial carcinoma  (ISO)
Endometrioid Carcinomas  (ISO)
Experimental Colitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Liver Neoplasms  (ISO)
Experimental Mammary Neoplasms  (ISO)
Experimental Radiation Injuries  (ISO)
extrahepatic cholestasis  (ISO)
Female Infertility  (ISO)
gastric ulcer  (ISO)
genetic disease  (ISO)
Gliosis  (ISO)
glomerulonephritis  (ISO)
Head and Neck Neoplasms  (ISO)
head and neck squamous cell carcinoma  (ISO)
Hemorrhagic Shock  (ISO)
hepatocellular carcinoma  (ISO)
Hodgkin's lymphoma  (ISO)
Hyperalgesia  (ISO)
Hypertrophy  (ISO)
intellectual disability  (ISO)
Intimal Hyperplasia  (ISO)
juvenile rheumatoid arthritis  (ISO)
kidney disease  (ISO)
Kidney Neoplasms  (ISO)
Left Ventricular Hypertrophy  (ISO)
Lung Neoplasms  (ISO)
melanoma  (ISO)
Memory Disorders  (ISO)
middle cerebral artery infarction  (ISO)
morphine dependence  (ISO)
Multiple Organ Failure  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Nerve Degeneration  (ISO)
neuronal ceroid lipofuscinosis 6A  (ISO)
Noonan syndrome 13  (ISO)
obesity  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic adenocarcinoma  (ISO)
Parkinson's disease  (ISO)
Pneumococcal Pneumonia  (ISO)
portal hypertension  (ISO)
Postoperative Cognitive Dysfunction  (ISO)
prostate adenocarcinoma  (ISO)
pulmonary hypertension  (ISO)
renal cell carcinoma  (ISO)
renal fibrosis  (ISO)
Sepsis  (ISO)
severe acute respiratory syndrome  (ISO)
Sezary's disease  (ISO)
Shock  (ISO)
squamous cell carcinoma  (ISO)
Stomach Neoplasms  (ISO)
Testis Reperfusion Injury  (ISO)
thyroid cancer  (ISO)
Thyroid Neoplasms  (ISO)
transitional cell carcinoma  (ISO)
trigeminal neuralgia  (ISO)
type 2 diabetes mellitus  (ISO)
ureteral obstruction  (ISO)
urethral obstruction  (ISO)
Urinary Incontinence  (ISO)
Uterine Cervical Neoplasms  (ISO)
vascular dementia  (ISO)
velocardiofacial syndrome  (ISO)
Weissenbacher-Zweymuller syndrome  (ISO)
withdrawal disorder  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
androgen receptor signaling pathway  (IEA)
animal organ morphogenesis  (IEA,ISO)
apoptotic process  (IEA)
B cell receptor signaling pathway  (IEA,ISO)
Bergmann glial cell differentiation  (IEA,ISO)
cardiac neural crest cell development involved in heart development  (IEA,ISO)
caveolin-mediated endocytosis  (IEA)
cell communication  (IEA)
cellular response to amino acid starvation  (IEA)
cellular response to cAMP  (ISO)
cellular response to epidermal growth factor stimulus  (ISO)
cellular response to insulin-like growth factor stimulus  (ISO)
cellular response to methionine  (ISO)
cellular response to platelet-derived growth factor stimulus  (ISO)
cellular response to prostaglandin E stimulus  (ISO)
cellular response to toxic substance  (ISO)
cellular response to tumor necrosis factor  (IEA,ISO)
cytosine metabolic process  (IEA,ISO)
decidualization  (ISO)
diadenosine tetraphosphate biosynthetic process  (ISO)
DNA damage response  (IEA,ISO)
ERBB signaling pathway  (IEA)
ERBB2-ERBB3 signaling pathway  (IEA)
ERK1 and ERK2 cascade  (IEA,ISO)
estrous cycle  (ISO)
face development  (IEA,ISO)
heart development  (IEA,ISO)
insulin receptor signaling pathway  (IEA)
insulin-like growth factor receptor signaling pathway  (IEA)
intracellular signal transduction  (ISO)
JNK cascade  (IEA)
labyrinthine layer blood vessel development  (IEA,ISO)
lipopolysaccharide-mediated signaling pathway  (IEA,ISO)
long-term synaptic potentiation  (IEA,ISO)
lung morphogenesis  (IEA,ISO)
mammary gland epithelial cell proliferation  (IEA,ISO)
MAPK cascade  (IEA,ISO)
myelination  (IEA)
negative regulation of cell differentiation  (IEA,ISO)
neural crest cell development  (IEA,ISO)
outer ear morphogenesis  (IEA,ISO)
peptidyl-serine phosphorylation  (ISO)
peptidyl-threonine phosphorylation  (ISO)
positive regulation of cardiac muscle cell proliferation  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cholesterol biosynthetic process  (IEA)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of macrophage chemotaxis  (IEA,ISO)
positive regulation of macrophage proliferation  (IEA,ISO)
positive regulation of peptidyl-threonine phosphorylation  (ISO)
positive regulation of protein import into nucleus  (ISO)
positive regulation of telomere maintenance  (IEA,ISO)
positive regulation of translation  (ISO)
progesterone receptor signaling pathway  (IEA)
protein phosphorylation  (ISO)
regulation of cellular pH  (IEA,ISO)
regulation of cytoskeleton organization  (IEA)
regulation of early endosome to late endosome transport  (IEA)
regulation of Golgi inheritance  (IEA)
regulation of ossification  (IEA,ISO)
regulation of stress-activated MAPK cascade  (IEA)
regulation of transcription by RNA polymerase II  (IEA)
response to alcohol  (ISO)
response to cocaine  (ISO)
response to epidermal growth factor  (IEA)
response to estradiol  (ISO)
response to estrogen  (ISO)
response to exogenous dsRNA  (IEA,ISO)
response to hydrogen peroxide  (ISO)
response to lipopolysaccharide  (IEA,ISO)
response to nicotine  (IEA)
response to testosterone  (ISO)
response to toxic substance  (ISO)
Schwann cell development  (IEA)
sensory perception of pain  (ISO)
steroid hormone receptor signaling pathway  (IEA)
stress-activated MAPK cascade  (IEA)
T cell receptor signaling pathway  (IEA,ISO)
thymus development  (IEA,ISO)
thyroid gland development  (IEA,ISO)
trachea formation  (IEA,ISO)

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Mapk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118140,821,508 - 140,866,521 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366191,889,708 - 1,932,646 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366191,889,841 - 1,932,646 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAPK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382221,759,657 - 21,867,680 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2221,759,657 - 21,867,680 (-)EnsemblGRCh38hg38GRCh38
GRCh372222,113,946 - 22,221,970 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362220,443,946 - 20,551,970 (-)NCBINCBI36Build 36hg18NCBI36
Build 342220,447,885 - 20,546,524NCBI
Celera225,931,476 - 6,039,519 (-)NCBICelera
Cytogenetic Map22q11.22NCBI
HuRef225,071,209 - 5,179,617 (-)NCBIHuRef
CHM1_12222,114,127 - 22,222,150 (-)NCBICHM1_1
T2T-CHM13v2.02222,173,148 - 22,281,196 (-)NCBIT2T-CHM13v2.0
Mapk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391616,801,246 - 16,865,317 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1616,801,246 - 16,865,317 (+)EnsemblGRCm39 Ensembl
GRCm381616,983,382 - 17,047,453 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1616,983,382 - 17,047,453 (+)EnsemblGRCm38mm10GRCm38
MGSCv371616,983,475 - 17,047,546 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361616,896,945 - 16,961,016 (+)NCBIMGSCv36mm8
Celera1617,555,561 - 17,620,101 (+)NCBICelera
Cytogenetic Map16A3NCBI
cM Map1610.53NCBI
Mapk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81197,462,025 - 97,529,193 (-)NCBIGRCr8
mRatBN7.21183,957,813 - 84,023,629 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1183,957,813 - 84,023,616 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1192,681,387 - 92,746,630 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01185,342,529 - 85,407,764 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01184,396,110 - 84,461,350 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01188,203,863 - 88,273,301 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1188,211,599 - 88,273,254 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01191,260,412 - 91,325,570 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41185,968,732 - 86,030,387 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11186,009,328 - 86,070,984 (-)NCBI
Celera1182,713,470 - 82,779,260 (-)NCBICelera
Cytogenetic Map11q23NCBI
Mapk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544217,284,232 - 17,380,020 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544217,284,232 - 17,380,026 (+)NCBIChiLan1.0ChiLan1.0
MAPK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22331,305,712 - 31,412,963 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12233,856,753 - 33,961,672 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0223,883,119 - 3,990,368 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12220,365,480 - 20,412,561 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2220,365,487 - 20,450,335 (-)Ensemblpanpan1.1panPan2
MAPK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12631,013,607 - 31,132,998 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2631,013,607 - 31,132,998 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2630,970,465 - 31,089,387 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02632,419,917 - 32,539,219 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2632,418,294 - 32,539,230 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12630,468,306 - 30,587,833 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02630,092,195 - 30,211,589 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02631,182,673 - 31,302,626 (-)NCBIUU_Cfam_GSD_1.0
MAPK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1450,082,896 - 50,165,513 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11450,083,079 - 50,165,528 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21453,590,429 - 53,613,224 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MAPK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1194,246,144 - 4,352,648 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl194,246,122 - 4,353,325 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660852,649,654 - 2,756,271 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mapk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247471,296,221 - 1,389,757 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247471,296,062 - 1,389,674 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_021732652 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010000177 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSSTOT00000014796   ⟹   ENSSTOP00000013254
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049366191,889,708 - 1,932,646 (+)Ensembl
Ensembl Acc Id: ENSSTOT00000039682   ⟹   ENSSTOP00000029451
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049366191,906,649 - 1,924,053 (+)Ensembl
RefSeq Acc Id: XM_021732652   ⟹   XP_021588327
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405118140,821,508 - 140,866,521 (-)NCBI
SpeTri2.0NW_0049366191,889,841 - 1,932,646 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_021588327 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000013254.3
  ENSSTOP00000029451.1
GenBank Protein KAG3278752 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_021588327   ⟸   XM_021732652
- UniProtKB: I3MNK8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSTOP00000029451   ⟸   ENSSTOT00000039682
Ensembl Acc Id: ENSSTOP00000013254   ⟸   ENSSTOT00000014796
Protein Domains
Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000014791 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000014796.3 UniProtKB/TrEMBL
  ENSSTOT00000039682.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  MAP_kinase UniProtKB/TrEMBL
  MAP_kinase_CS UniProtKB/TrEMBL
  MAPK_ERK1/2 UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
NCBI Gene Mapk1 ENTREZGENE
PANTHER MITOGEN-ACTIVATED PROTEIN KINASE UniProtKB/TrEMBL
  MITOGEN-ACTIVATED PROTEIN KINASE 1 UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PRINTS ERK1ERK2MAPK UniProtKB/TrEMBL
PROSITE MAPK UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A287D7G2_ICTTR UniProtKB/TrEMBL
  I3MNK8 ENTREZGENE, UniProtKB/TrEMBL