MAPK1 (mitogen-activated protein kinase 1) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: MAPK1 (mitogen-activated protein kinase 1) Sus scrofa
Analyze
Symbol: MAPK1
Name: mitogen-activated protein kinase 1
RGD ID: 14007049
Description: ENCODES a protein that exhibits ATP binding (ortholog); double-stranded DNA binding (ortholog); identical protein binding (ortholog); INVOLVED IN aging (ortholog); animal organ morphogenesis (ortholog); B cell receptor signaling pathway (ortholog); PARTICIPATES IN adenosine signaling pathway; Bone morphogenetic proteins signaling pathway; ceramide signaling pathway; ASSOCIATED WITH Aberrant Crypt Foci (ortholog); Alzheimer's disease (ortholog); Animal Disease Models (ortholog); FOUND IN axon (ortholog); cytoplasm (ortholog); cytosol (ortholog); INTERACTS WITH (S)-nicotine; 3,3',4,4',5-pentachlorobiphenyl; 3,3',4,4'-tetrachlorobiphenyl
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: ERK2; extracellular signal-regulated kinase-2; mitogen-activated protein kinase 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1450,082,896 - 50,165,523 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11450,083,079 - 50,165,528 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21453,590,429 - 53,613,224 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Aberrant Crypt Foci  (ISO)
Alzheimer's disease  (ISO)
Animal Disease Models  (ISO)
brain ischemia  (ISO)
breast cancer  (ISO)
Cardiomegaly  (ISO)
cardiomyopathy  (ISO)
childhood pilocytic astrocytoma  (ISO)
chromosome 22q11.2 deletion syndrome, distal  (ISO)
Cocaine-Related Disorders  (ISO)
colon adenocarcinoma  (ISO)
colorectal adenocarcinoma  (ISO)
Colorectal Neoplasms  (ISO)
congenital heart disease  (ISO)
coronary restenosis  (ISO)
Coronavirus infectious disease  (ISO)
demyelinating disease  (ISO)
Diabetic Cardiomyopathies  (ISO)
Diabetic Nephropathies  (ISO)
DiGeorge syndrome  (ISO)
Dwarfism  (ISO)
endometrial adenocarcinoma  (ISO)
endometrial carcinoma  (ISO)
Endometrioid Carcinomas  (ISO)
Experimental Colitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Liver Neoplasms  (ISO)
extrahepatic cholestasis  (ISO)
Female Infertility  (ISO)
gastric ulcer  (ISO)
genetic disease  (ISO)
Gliosis  (ISO)
glomerulonephritis  (ISO)
Head and Neck Neoplasms  (ISO)
head and neck squamous cell carcinoma  (ISO)
Hemorrhagic Shock  (ISO)
Hodgkin's lymphoma  (ISO)
Hyperalgesia  (ISO)
Hypertrophy  (ISO)
juvenile rheumatoid arthritis  (ISO)
kidney disease  (ISO)
Kidney Neoplasms  (ISO)
Lung Neoplasms  (ISO)
Mammary Neoplasms, Experimental  (ISO)
middle cerebral artery infarction  (ISO)
Multiple Organ Failure  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Nerve Degeneration  (ISO)
neuronal ceroid lipofuscinosis 6  (ISO)
Noonan syndrome 13  (ISO)
obesity  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic adenocarcinoma  (ISO)
Pneumococcal Pneumonia  (ISO)
prostate adenocarcinoma  (ISO)
pulmonary hypertension  (ISO)
Radiation Injuries, Experimental  (ISO)
renal cell carcinoma  (ISO)
renal fibrosis  (ISO)
Sepsis  (ISO)
severe acute respiratory syndrome  (ISO)
Sezary's disease  (ISO)
Shock  (ISO)
squamous cell carcinoma  (ISO)
Stomach Neoplasms  (ISO)
Testis Reperfusion Injury  (ISO)
thyroid gland cancer  (ISO)
transitional cell carcinoma  (ISO)
trigeminal neuralgia  (ISO)
type 2 diabetes mellitus  (ISO)
ureteral obstruction  (ISO)
urethral obstruction  (ISO)
Urinary Incontinence  (ISO)
Uterine Cervical Neoplasms  (ISO)
withdrawal disorder  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (ISO)
animal organ morphogenesis  (ISO)
B cell receptor signaling pathway  (ISO)
Bergmann glial cell differentiation  (ISO)
cardiac neural crest cell development involved in heart development  (ISO)
cell surface receptor signaling pathway  (IBA)
cellular response to amino acid starvation  (ISO)
cellular response to cadmium ion  (ISO)
cellular response to DNA damage stimulus  (ISO)
cellular response to dopamine  (ISO)
cellular response to granulocyte macrophage colony-stimulating factor stimulus  (ISO)
cellular response to organic substance  (ISO)
cellular response to reactive oxygen species  (ISO)
cellular response to tumor necrosis factor  (ISO)
cytosine metabolic process  (ISO)
decidualization  (ISO)
diadenosine tetraphosphate biosynthetic process  (ISO)
ERBB signaling pathway  (ISO)
ERK1 and ERK2 cascade  (ISO)
face development  (ISO)
heart development  (ISO)
intracellular signal transduction  (IBA,ISO)
labyrinthine layer blood vessel development  (ISO)
lipopolysaccharide-mediated signaling pathway  (ISO)
long-term synaptic potentiation  (ISO)
lung morphogenesis  (ISO)
mammary gland epithelial cell proliferation  (ISO)
MAPK cascade  (IEA,ISO)
negative regulation of cell differentiation  (ISO)
neural crest cell development  (ISO)
outer ear morphogenesis  (ISO)
peptidyl-serine phosphorylation  (ISO)
peptidyl-threonine phosphorylation  (ISO)
positive regulation of cardiac muscle cell proliferation  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of macrophage chemotaxis  (ISO)
positive regulation of macrophage proliferation  (ISO)
positive regulation of peptidyl-threonine phosphorylation  (ISO)
positive regulation of protein import into nucleus  (ISO)
positive regulation of telomerase activity  (ISO)
positive regulation of telomere capping  (ISO)
positive regulation of telomere maintenance via telomerase  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
positive regulation of translation  (ISO)
protein phosphorylation  (IEA,ISO)
regulation of cellular pH  (ISO)
regulation of ossification  (ISO)
response to epidermal growth factor  (ISO)
response to estrogen  (ISO)
response to exogenous dsRNA  (ISO)
response to lipopolysaccharide  (ISO)
response to nicotine  (ISO)
response to toxic substance  (ISO)
sensory perception of pain  (ISO)
signal transduction  (ISO)
stress-activated MAPK cascade  (ISO)
T cell receptor signaling pathway  (ISO)
thymus development  (ISO)
thyroid gland development  (ISO)
trachea formation  (ISO)

Cellular Component

References
Additional References at PubMed
PMID:12943991   PMID:14681463   PMID:16310170   PMID:18694803   PMID:19038864   PMID:19215954   PMID:19570883   PMID:19786114   PMID:19955189   PMID:20300568   PMID:21215800   PMID:21483702  
PMID:22279582   PMID:24096891   PMID:24520418   PMID:25473050   PMID:26115165   PMID:26211713   PMID:27053523   PMID:27618100  


Genomics

Comparative Map Data
MAPK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1450,082,896 - 50,165,523 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11450,083,079 - 50,165,528 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21453,590,429 - 53,613,224 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MAPK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2221,754,500 - 21,867,680 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl2221,759,657 - 21,867,680 (-)EnsemblGRCh38hg38GRCh38
GRCh382221,759,657 - 21,867,680 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372222,113,946 - 22,221,970 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362220,443,946 - 20,551,970 (-)NCBINCBI36hg18NCBI36
Build 342220,447,885 - 20,546,524NCBI
Celera225,931,476 - 6,039,519 (-)NCBI
Cytogenetic Map22q11.22NCBI
HuRef225,071,209 - 5,179,617 (-)NCBIHuRef
CHM1_12222,114,127 - 22,222,150 (-)NCBICHM1_1
Mapk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391616,801,246 - 16,865,317 (+)NCBIGRCm39mm39
GRCm39 Ensembl1616,801,246 - 16,865,317 (+)Ensembl
GRCm381616,983,382 - 17,047,453 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1616,983,382 - 17,047,453 (+)EnsemblGRCm38mm10GRCm38
MGSCv371616,983,475 - 17,047,546 (+)NCBIGRCm37mm9NCBIm37
MGSCv361616,896,945 - 16,961,016 (+)NCBImm8
Celera1617,555,561 - 17,620,101 (+)NCBICelera
Cytogenetic Map16A3NCBI
cM Map1610.53NCBI
Mapk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21183,957,813 - 84,023,629 (-)NCBI
Rnor_6.0 Ensembl1188,211,599 - 88,273,254 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01188,203,863 - 88,273,301 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01191,260,412 - 91,325,570 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41185,968,732 - 86,030,387 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11186,009,328 - 86,070,984 (-)NCBI
Celera1182,713,470 - 82,779,260 (-)NCBICelera
Cytogenetic Map11q23NCBI
Mapk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544217,284,232 - 17,380,020 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544217,284,232 - 17,380,026 (+)NCBIChiLan1.0ChiLan1.0
MAPK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12220,365,480 - 20,412,561 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2220,365,487 - 20,450,335 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0223,883,119 - 3,990,368 (-)NCBIMhudiblu_PPA_v0panPan3
MAPK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12631,013,607 - 31,132,998 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2631,013,607 - 31,132,998 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2630,970,465 - 31,089,387 (-)NCBI
ROS_Cfam_1.02632,419,917 - 32,539,219 (-)NCBI
UMICH_Zoey_3.12630,468,306 - 30,587,833 (-)NCBI
UNSW_CanFamBas_1.02630,092,195 - 30,211,589 (-)NCBI
UU_Cfam_GSD_1.02631,182,673 - 31,302,626 (-)NCBI
Mapk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118140,821,508 - 140,866,521 (-)NCBI
SpeTri2.0NW_0049366191,889,841 - 1,932,646 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAPK1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1194,246,144 - 4,352,648 (+)NCBI
ChlSab1.1 Ensembl194,246,122 - 4,353,325 (+)Ensembl
Mapk1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247471,296,062 - 1,389,674 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 10 2 3 5 23 2 3 3
Low 2 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000011042   ⟹   ENSSSCP00000010754
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1450,082,896 - 50,165,523 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000034964   ⟹   ENSSSCP00000028734
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1450,083,510 - 50,165,521 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000064696   ⟹   ENSSSCP00000033480
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1450,082,896 - 50,165,523 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000066579   ⟹   ENSSSCP00000073842
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1450,082,914 - 50,165,523 (+)Ensembl
RefSeq Acc Id: NM_001198922   ⟹   NP_001185851
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11450,083,556 - 50,162,717 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021071922   ⟹   XP_020927581
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11450,083,079 - 50,165,528 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001185851 (Get FASTA)   NCBI Sequence Viewer  
  XP_020927581 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ADP24686 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_020927581   ⟸   XM_021071922
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001185851   ⟸   NM_001198922
- UniProtKB: E3UV40 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000033480   ⟸   ENSSSCT00000064696
RefSeq Acc Id: ENSSSCP00000010754   ⟸   ENSSSCT00000011042
RefSeq Acc Id: ENSSSCP00000028734   ⟸   ENSSSCT00000034964
RefSeq Acc Id: ENSSSCP00000073842   ⟸   ENSSSCT00000066579
Protein Domains
Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000010081 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000010754 UniProtKB/TrEMBL
  ENSSSCP00000028734 UniProtKB/TrEMBL
  ENSSSCP00000033480 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000073842 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000011042 UniProtKB/TrEMBL
  ENSSSCT00000034964 UniProtKB/TrEMBL
  ENSSSCT00000064696 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000066579 ENTREZGENE, UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  MAP_kinase_CS UniProtKB/TrEMBL
  MAPK_ERK1/2 UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
KEGG Report ssc:100153927 UniProtKB/TrEMBL
NCBI Gene MAPK1 ENTREZGENE
Pfam Pkinase UniProtKB/TrEMBL
PRINTS ERK1ERK2MAPK UniProtKB/TrEMBL
PROSITE MAPK UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A286ZPF5_PIG UniProtKB/TrEMBL
  A0A5G2RG05_PIG UniProtKB/TrEMBL
  A0A5K1UVT7_PIG UniProtKB/TrEMBL
  E3UV40 ENTREZGENE, UniProtKB/TrEMBL
  F1RL02_PIG UniProtKB/TrEMBL
UniProt Secondary K7GLK3 UniProtKB/TrEMBL
VGNC ID VGNC:89996 ENTREZGENE