RGD Reference Report - Epigallocatechin-3-gallate attenuates cardiac hypertrophy partly via MAPKs signals in hypertensive rats. - Rat Genome Database

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Epigallocatechin-3-gallate attenuates cardiac hypertrophy partly via MAPKs signals in hypertensive rats.

Authors: Chen, DD  Dong, YG  Liu, D  He, JG 
Citation: Chen DD, etal., Clin Exp Pharmacol Physiol. 2009 Mar 2.
RGD ID: 5130755
Pubmed: PMID:19298531   (View Abstract at PubMed)
DOI: DOI:10.1111/j.1440-1681.2009.05173.x   (Journal Full-text)

1. It has been demonstrated that epigallocatechin-3-gallate (EGCG) inhibits cardiac hypertrophy through its anti-hypertension and anti-oxidative effects. However, the underlying molecular mechanism is not clear yet. 2. In the present study, we tested the hypothesis that EGCG attenuates transaortic abdominal aortic constriction (TAC)-induced ventricular hypertrophy via regulating mitogen-activated protein kinases (MAPK) signal pathways in hypertensive rats. 3. The results showed that the left ventricular myocyte diameter and the expression of atrial natriuretic peptide, brain natriuretic peptide, and beta-myocardial heavy chain were significantly decreased in EGCG treated (50 mg.kg(-1).day(-1), intraperitoneally) TAC group. The levels of reactive oxygen species and malondialdehyde in left ventricle were significantly reduced by EGCG in TCA group. The activities of total superoxide dismutase, catalase, and glutathione peroxidase were increased in TCA group, which were blunted by EGCG treatment. The phosphorylations of ERK2, p38, and JNK1 were significantly increased in left ventricle of EGCG treated TCA rats, accompanied with activations of NF-kappaB and AP-1. The expression of matrix metalloproteinases-9 was significantly upregulated in the left ventricle of TAC rats, which can be inhibited by EGCG treatment. The copy number of mitochondrial DNA and activities of respiratory chain complexes I, III and IV were decreased after TAC, which were reversed in EGCG treated TAC rats. 4. In conclusion, EGCG attenuates TAC-induced ventricular hypertrophy partly through suppression of antioxidant enzymes and regulations of MAPK signals in hypertensive rats.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Left Ventricular Hypertrophy  ISOCat (Rattus norvegicus)5130755; 5130755protein:decreased expression:heart left ventricleRGD 
Left Ventricular Hypertrophy  IEP 5130755protein:decreased expression:heart left ventricleRGD 
Left Ventricular Hypertrophy treatmentISOMapk1 (Rattus norvegicus)5130755; 5130755 RGD 
Left Ventricular Hypertrophy treatmentIEP 5130755 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cat  (catalase)
Mapk1  (mitogen activated protein kinase 1)

Genes (Mus musculus)
Cat  (catalase)
Mapk1  (mitogen-activated protein kinase 1)

Genes (Homo sapiens)
CAT  (catalase)
MAPK1  (mitogen-activated protein kinase 1)


Additional Information