Prkg1 (protein kinase cGMP-dependent 1) - Rat Genome Database

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Gene: Prkg1 (protein kinase cGMP-dependent 1) Rattus norvegicus
Symbol: Prkg1 (Ensembl: AABR07006724.1)
Name: protein kinase cGMP-dependent 1
RGD ID: 1587390
Description: Enables identical protein binding activity and mitogen-activated protein kinase p38 binding activity. Involved in several processes, including cell growth involved in cardiac muscle cell development; positive regulation of large conductance calcium-activated potassium channel activity; and regulation of cellular biosynthetic process. Located in acrosomal vesicle and nucleoplasm. Colocalizes with sarcolemma. Biomarker of allergic rhinitis; hypertension; hypogonadism; impotence; and obesity. Human ortholog(s) of this gene implicated in thoracic aortic aneurysm. Orthologous to human PRKG1 (protein kinase cGMP-dependent 1); PARTICIPATES IN eicosanoid signaling pathway; long term depression; INTERACTS WITH 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one; 3,4-methylenedioxymethamphetamine; 4-hydroxy-TEMPO.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cAMP-dependent protein kinase catalytic subunit PRKX-like; cGk1; cGMP dependent protein kinase type 1; cGMP dependent protein kinase type1; cGMP-dependent protein kinase 1; LOC100912084; LOC365449; Pkgi; Prkg1_mapped; protein kinase, cGMP-dependent, type 1; protein kinase, cGMP-dependent, type 1 (mapped); Protein kinase, cGMP-dependent, type I
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Candidate Gene For: Lnnr2
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21228,409,883 - 229,638,794 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1228,408,947 - 229,639,080 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1236,778,127 - 238,005,258 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01243,707,829 - 244,934,964 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01236,538,254 - 237,776,527 (-)NCBIRnor_WKY
Rnor_6.01248,982,039 - 250,300,952 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01256,221,067 - 257,537,289 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41234,420,597 - 235,765,375 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11235,515,049 - 235,845,833 (-)NCBI
Celera1225,545,145 - 226,760,176 (-)NCBICelera
Cytogenetic Map1q52NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-cotinine  (ISO)
(1->4)-beta-D-glucan  (ISO)
17alpha-ethynylestradiol  (ISO)
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxy-TEMPO  (EXP)
5-methoxypsoralen  (ISO)
8-(4-chlorophenylthio)-cGMP  (EXP,ISO)
8-bromo-3',5'-cyclic GMP  (EXP,ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucose  (EXP)
ammonia  (EXP)
apocynin  (EXP)
arsenite(3-)  (ISO)
avobenzone  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
C60 fullerene  (EXP)
calcium atom  (ISO)
calcium(0)  (ISO)
calyculin a  (ISO)
captan  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
crocidolite asbestos  (ISO)
cyclosporin A  (EXP)
D-glucose  (EXP)
dexamethasone  (ISO)
dibenziodolium  (EXP)
diethyl malate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ellagic acid  (ISO)
fluoxetine  (EXP)
folpet  (ISO)
formaldehyde  (EXP)
fulvestrant  (ISO)
geldanamycin  (ISO)
glucose  (EXP)
hydralazine  (ISO)
indometacin  (ISO)
KT 5823  (ISO)
lead diacetate  (EXP)
menadione  (EXP)
methamphetamine  (ISO)
methapyrilene  (ISO)
methylmercury chloride  (ISO)
mevinphos  (EXP)
monocrotaline  (EXP)
morphine  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
nickel atom  (ISO)
nitroglycerin  (EXP)
Nor-9-carboxy-delta9-THC  (ISO)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
picoxystrobin  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
reactive oxygen species  (EXP)
resveratrol  (EXP,ISO)
rotenone  (ISO)
S-nitroso-N-acetyl-D-penicillamine  (EXP)
SB 431542  (ISO)
sildenafil citrate  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
streptozocin  (ISO)
sucrose  (EXP)
sulindac sulfone  (ISO)
tadalafil  (ISO)
tamoxifen  (ISO)
testosterone enanthate  (EXP,ISO)
tetrachloromethane  (ISO)
thalidomide  (ISO)
thioacetamide  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triptorelin  (EXP)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vorinostat  (ISO)
Y-27632  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Atrial natriuretic peptide induces natriuretic peptide receptor-cGMP-dependent protein kinase interaction. Airhart N, etal., J Biol Chem. 2003 Oct 3;278(40):38693-8. Epub 2003 Jul 10.
2. Testosterone-induced modulation of nitric oxide-cGMP signaling pathway and androgenesis in the rat Leydig cells. Andric SA, etal., Biol Reprod. 2010 Sep;83(3):434-42. doi: 10.1095/biolreprod.110.083626. Epub 2010 May 12.
3. Dysregulation of cGMP-dependent protein kinase 1 (PKG-1) impairs erectile function in diabetic rats: influence of in vivo gene therapy of PKG1alpha. Bivalacqua TJ, etal., BJU Int. 2007 Jun;99(6):1488-94. Epub 2007 Mar 12.
4. Inhibition of cyclic GMP-dependent protein kinase-mediated effects by (Rp)-8-bromo-PET-cyclic GMPS. Butt E, etal., Br J Pharmacol. 1995 Dec;116(8):3110-6.
5. Nitric oxide modulation of agonist-evoked intracellular Ca2+ release in neurosecretory PC-12 cells: inhibition of phospholipase C activity via cyclic GMP-dependent protein kinase I. Clementi E, etal., Mol Pharmacol. 1995 Mar;47(3):517-24.
6. Guanylyl cyclase and protein kinase G mediate nitric oxide suppression of 5-lipoxygenase metabolism in rat alveolar macrophages. Coffey MJ, etal., Biochim Biophys Acta. 2008 Jun-Jul;1781(6-7):299-305. doi: 10.1016/j.bbalip.2008.04.005. Epub 2008 Apr 24.
7. cGMP-dependent protein kinase type I inhibits TAB1-p38 mitogen-activated protein kinase apoptosis signaling in cardiac myocytes. Fiedler B, etal., J Biol Chem. 2006 Oct 27;281(43):32831-40. Epub 2006 Aug 29.
8. Expression of type II cGMP-dependent protein kinase in rat kidney is regulated by dehydration and correlated with renin gene expression. Gambaryan S, etal., J Clin Invest 1996 Aug 1;98(3):662-70.
9. Alternative splicing of cGMP-dependent protein kinase I in angiotensin-hypertension: novel mechanism for nitrate tolerance in vascular smooth muscle. Gerzanich V, etal., Circ Res. 2003 Oct 31;93(9):805-12. Epub 2003 Sep 25.
10. Hyperlipidaemia induced by a high-cholesterol diet leads to the deterioration of guanosine-3',5'-cyclic monophosphate/protein kinase G-dependent cardioprotection in rats. Giricz Z, etal., Br J Pharmacol. 2009 Nov;158(6):1495-502. doi: 10.1111/j.1476-5381.2009.00424.x. Epub 2009 Oct 20.
11. Transient rise of serum testosterone level after single sildenafil treatment of adult male rats. Janjic MM, etal., J Sex Med. 2012 Oct;9(10):2534-43. doi: 10.1111/j.1743-6109.2012.02674.x. Epub 2012 Mar 16.
12. cGMP-Prkg1 signaling and Pde5 inhibition shelter cochlear hair cells and hearing function. Jaumann M, etal., Nat Med. 2012 Jan 22;18(2):252-9. doi: 10.1038/nm.2634.
13. Cyclic GMP potentiates phenylephrine but not cyclic ADP-ribose-evoked calcium release from rat lacrimal acinar cells. Jorgensen TD, etal., FEBS Lett. 1996 Aug 5;391(1-2):117-20.
14. Expression of cGMP-dependent protein kinases (I and II) and neuronal nitric oxide synthase in the developing rat cerebellum. Jurado S, etal., Brain Res Bull. 2005 Mar 15;65(2):111-5. Epub 2005 Jan 8.
15. Specific phosphorylation sites underlie the stimulation of a large conductance, Ca(2+)-activated K(+) channel by cGMP-dependent protein kinase. Kyle BD, etal., FASEB J. 2013 May;27(5):2027-38. doi: 10.1096/fj.12-223669. Epub 2013 Feb 13.
16. Vardenafil protects isolated rat hearts at reperfusion dependent on GC and PKG. Maas O, etal., Br J Pharmacol. 2008 May;154(1):25-31. doi: 10.1038/bjp.2008.71. Epub 2008 Mar 10.
17. Cyclic GMP signaling in rat urinary bladder, prostate, and epididymis: tissue-specific changes with aging and in response to Leydig cell depletion. Muller D, etal., Reproduction. 2011 Aug;142(2):333-43. doi: 10.1530/REP-10-0517. Epub 2011 Apr 21.
18. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
19. Nitrite exerts potent negative inotropy in the isolated heart via eNOS-independent nitric oxide generation and cGMP-PKG pathway activation. Pellegrino D, etal., Biochim Biophys Acta. 2009 Jul;1787(7):818-27. doi: 10.1016/j.bbabio.2009.02.007. Epub 2009 Feb 24.
20. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
21. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
22. Insulin increases glomerular filtration barrier permeability through dimerization of protein kinase G type Ialpha subunits. Piwkowska A, etal., Biochim Biophys Acta. 2013 Jun;1832(6):791-804. doi: 10.1016/j.bbadis.2013.02.011. Epub 2013 Feb 21.
23. Expression, purification, and characterization of the cGMP-dependent protein kinases I beta and II using the baculovirus system. Pohler D, etal., FEBS Lett. 1995 Nov 6;374(3):419-25.
24. GOA pipeline RGD automated data pipeline
25. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
26. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
27. Elevated guanylate cyclase and cyclic-guanosine monophosphate-dependent protein kinase levels in nasal mucosae of antigen-challenged rats. Sakai H, etal., Microvasc Res. 2013 Nov;90:150-3. doi: 10.1016/j.mvr.2013.08.009. Epub 2013 Sep 5.
28. Molecular cloning and predicted full-length amino acid sequence of the type I beta isozyme of cGMP-dependent protein kinase from human placenta. Tissue distribution and developmental changes in rat. Sandberg M, etal., FEBS Lett. 1989 Sep 25;255(2):321-9.
29. Both protein kinase G dependent and independent mechanisms are involved in the modulation of glutamate release by nitric oxide in rat hippocampal nerve terminals. Sequeira SM, etal., Neurosci Lett. 1999 Feb 12;261(1-2):29-32.
30. Stage- and cell-specific expression of soluble guanylyl cyclase alpha and beta subunits, cGMP-dependent protein kinase I alpha and beta, and cyclic nucleotide-gated channel subunit 1 in the rat testis. Shi F, etal., J Androl. 2005 Mar-Apr;26(2):258-63.
31. Advanced glycation end-products induce vascular dysfunction via resistance to nitric oxide and suppression of endothelial nitric oxide synthase. Soro-Paavonen A, etal., J Hypertens. 2010 Apr;28(4):780-8. doi: 10.1097/HJH.0b013e328335043e.
32. Proteolytic processing of cGMP-dependent protein kinase I mediates nuclear cGMP signaling in vascular smooth muscle cells. Sugiura T, etal., Circ Res. 2008 Jul 3;103(1):53-60. doi: 10.1161/CIRCRESAHA.108.176321. Epub 2008 Jun 5.
33. Dual effects of spinally delivered 8-bromo-cyclic guanosine mono-phosphate (8-bromo-cGMP) in formalin-induced nociception in rats. Tegeder I, etal., Neurosci Lett. 2002 Oct 31;332(2):146-50.
34. Reduced inflammatory hyperalgesia with preservation of acute thermal nociception in mice lacking cGMP-dependent protein kinase I. Tegeder I, etal., Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):3253-7. Epub 2004 Feb 18.
35. Circadian clock-controlled regulation of cGMP-protein kinase G in the nocturnal domain. Tischkau SA, etal., J Neurosci. 2003 Aug 20;23(20):7543-50.
36. Endogenous type II cGMP-dependent protein kinase exists as a dimer in membranes and can Be functionally distinguished from the type I isoforms. Vaandrager AB, etal., J Biol Chem. 1997 May 2;272(18):11816-23.
37. Dysregulation of the endothelial nitric oxide synthase-soluble guanylate cyclase pathway is normalized by insulin in the aorta of diabetic rat. Zanetti M, etal., Atherosclerosis. 2005 Jul;181(1):69-73. Epub 2005 Feb 12.
38. Copper-induced regression of cardiomyocyte hypertrophy is associated with enhanced vascular endothelial growth factor receptor-1 signalling pathway. Zhou Y, etal., Cardiovasc Res. 2009 Oct 1;84(1):54-63. doi: 10.1093/cvr/cvp178. Epub 2009 Jun 19.
39. Essential role of protein kinase G and decreased cytoplasmic Ca2+ levels in NO-induced inhibition of rat aortic smooth muscle cell motility. Zhuang D, etal., Am J Physiol Heart Circ Physiol. 2005 Apr;288(4):H1859-66. Epub 2004 Dec 2.
Additional References at PubMed
PMID:10671526   PMID:11799084   PMID:12177418   PMID:14608379   PMID:14609817   PMID:14960318   PMID:15184388   PMID:15465019   PMID:15483626   PMID:15564589   PMID:15905169   PMID:16055922  
PMID:16154207   PMID:16632465   PMID:16870832   PMID:16990611   PMID:17182580   PMID:17717153   PMID:17878170   PMID:18280805   PMID:18723505   PMID:19127022   PMID:19168131   PMID:19244401  
PMID:19656393   PMID:19961855   PMID:20023176   PMID:20039971   PMID:20349314   PMID:20826808   PMID:21402151   PMID:21520075   PMID:22433666   PMID:22479572   PMID:22498562   PMID:22922339  
PMID:23686857   PMID:23770744   PMID:24041960   PMID:24602613   PMID:24911927   PMID:24921837   PMID:25447536   PMID:25855081   PMID:26440524   PMID:26527422   PMID:27066748   PMID:27230807  
PMID:29196237   PMID:34830353  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21228,409,883 - 229,638,794 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1228,408,947 - 229,639,080 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1236,778,127 - 238,005,258 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01243,707,829 - 244,934,964 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01236,538,254 - 237,776,527 (-)NCBIRnor_WKY
Rnor_6.01248,982,039 - 250,300,952 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01256,221,067 - 257,537,289 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41234,420,597 - 235,765,375 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11235,515,049 - 235,845,833 (-)NCBI
Celera1225,545,145 - 226,760,176 (-)NCBICelera
Cytogenetic Map1q52NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381050,990,888 - 52,298,350 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1050,990,888 - 52,298,423 (+)EnsemblGRCh38hg38GRCh38
GRCh371052,750,648 - 54,058,110 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361052,420,951 - 53,725,280 (+)NCBINCBI36Build 36hg18NCBI36
Build 341052,504,298 - 53,725,280NCBI
Celera1046,013,603 - 47,318,321 (+)NCBICelera
Cytogenetic Map10q11.23-q21.1NCBI
HuRef1046,729,527 - 48,036,312 (+)NCBIHuRef
CHM1_11053,032,644 - 54,339,928 (+)NCBICHM1_1
T2T-CHM13v2.01051,839,480 - 53,144,930 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391930,541,887 - 31,742,675 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1930,541,889 - 31,742,433 (-)EnsemblGRCm39 Ensembl
GRCm381930,564,487 - 31,765,268 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1930,564,489 - 31,765,033 (-)EnsemblGRCm38mm10GRCm38
MGSCv371930,642,041 - 31,839,523 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361930,633,548 - 31,831,030 (-)NCBIMGSCv36mm8
Celera1931,351,778 - 32,553,439 (-)NCBICelera
Cytogenetic Map19C1NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554256,176,432 - 7,331,446 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554256,176,335 - 7,335,867 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan11063,306,357 - 64,600,543 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01047,642,312 - 48,935,188 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11049,778,821 - 51,069,314 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1049,779,211 - 51,064,882 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.12635,732,974 - 36,932,744 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2635,737,242 - 36,932,729 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2635,620,229 - 36,818,502 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02637,271,288 - 38,465,630 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2637,275,477 - 38,465,591 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12635,169,158 - 36,367,548 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02634,756,074 - 35,955,695 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02635,996,645 - 37,196,072 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440721375,309,475 - 76,469,932 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936787332,342 - 1,491,285 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936787330,390 - 1,491,994 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1497,558,533 - 98,793,010 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11497,558,531 - 98,793,080 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214106,256,149 - 107,028,245 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.214107,499,623 - 107,663,552 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1978,858,269 - 80,188,163 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604839,812,502 - 40,750,048 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462479111,338,510 - 12,654,812 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479111,334,146 - 12,656,480 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Prkg1
9246 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:96
Count of miRNA genes:83
Interacting mature miRNAs:91
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1178810256240830002Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1183970203243914901Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1183970203243914901Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1184550676229550676Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1185356336231689108Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1191019702246062233Rat
10059590Kidm44Kidney mass QTL 443.420.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1191033875236033875Rat
1358191Ept10Estrogen-induced pituitary tumorigenesis QTL 103.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)1192825253243914732Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1193113876238113876Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1195804352257091168Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1196248093241248093Rat
1358292Cm37Cardiac mass QTL 376.20.00000081heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1196248093241248093Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1197670404242670404Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1197697768238755659Rat
2302375Bw83Body weight QTL 834.870.0002body mass (VT:0001259)body weight (CMO:0000012)1197697768242697768Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1197814409242814409Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1197814409242814409Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1197814409242814409Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1199050459259647894Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1201554356246554356Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1201554356246554356Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1201554356246554356Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1201554356246554356Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1201554356246554356Rat
10059587Bw173Body weight QTL 1733.230.025body mass (VT:0001259)body weight (CMO:0000012)1202069611247069611Rat
1600363Hc6Hypercalciuria QTL 62.7urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1203995416244113296Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1206081677251081677Rat
1357399Bw45Body weight QTL 453.05body mass (VT:0001259)body mass index (BMI) (CMO:0000105)1206329708251329708Rat
1357404Bw42Body weight QTL 424.490.0001body mass (VT:0001259)body weight (CMO:0000012)1206329708251329708Rat
1300168Bp170Blood pressure QTL 1702.76arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1207702246228581766Rat
1358916Kidm22Kidney mass QTL 223.32kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1210702053240947965Rat
1358890Bp259Blood pressure QTL 2593.06arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1210702053260522016Rat
2292216Bw80Body weight QTL 803.230.0019body mass (VT:0001259)body weight (CMO:0000012)1213533809243914901Rat
724538Kidm1Kidney mass QTL 13.2kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1213707201252085212Rat
734768Niddm59Non-insulin dependent diabetes mellitus QTL 59body mass (VT:0001259)body weight (CMO:0000012)1213843987258843987Rat
61455Niddm7Non-insulin dependent diabetes mellitus QTL 75.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1214537555238757011Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1214647894259647894Rat
1549910Bw54Body weight QTL 540.05body mass (VT:0001259)body weight (CMO:0000012)1214647894259647894Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1216255568260522016Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1216255568260522016Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1218748008257976495Rat
61400Niddm1Non-insulin dependent diabetes mellitus QTL 111blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1218753689245907899Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1218753816256448513Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1221264111259647894Rat
10053715Scort24Serum corticosterone level QTL 242.130.0088blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1221414816260522016Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1222363780260522016Rat
1600392Bw123Body weight QTL 1230.001body mass (VT:0001259)body weight (CMO:0000012)1223201027260522016Rat
2293700Bmd27Bone mineral density QTL 276.60.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1224054293243747962Rat
2293701Bmd34Bone mineral density QTL 348.30.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)1224054293243747962Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1224054293260122809Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1224054293260122809Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1224569538260122809Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1225126575260522016Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1228581588259647894Rat
2316896Gluco57Glucose level QTL 577.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1228985440245907899Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21229,550,480 - 229,550,676 (+)MAPPERmRatBN7.2
Rnor_6.01250,195,095 - 250,195,290NCBIRnor6.0
Rnor_5.01257,430,524 - 257,430,719UniSTSRnor5.0
RGSC_v3.41235,677,487 - 235,677,683RGDRGSC3.4
RGSC_v3.41235,677,488 - 235,677,683UniSTSRGSC3.4
RGSC_v3.11235,841,510 - 235,841,706RGD
Celera1226,671,919 - 226,672,114UniSTS
Cytogenetic Map1q52UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21228,985,440 - 228,985,618 (+)MAPPERmRatBN7.2
Rnor_6.01249,607,907 - 249,608,084NCBIRnor6.0
Rnor_5.01256,846,704 - 256,846,881UniSTSRnor5.0
RGSC_v3.41235,098,616 - 235,098,949RGDRGSC3.4
RGSC_v3.41235,098,674 - 235,098,851UniSTSRGSC3.4
RGSC_v3.11235,262,639 - 235,262,972RGD
Celera1226,110,015 - 226,110,192UniSTS
SHRSP x BN Map1126.57UniSTS
SHRSP x BN Map1126.57RGD
FHH x ACI Map1116.87RGD
Cytogenetic Map1q52UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21228,581,588 - 228,581,766 (+)MAPPERmRatBN7.2
Rnor_6.01249,206,242 - 249,206,417NCBIRnor6.0
Rnor_5.01256,444,932 - 256,445,107UniSTSRnor5.0
Rnor_5.01262,883,614 - 262,883,789UniSTSRnor5.0
RGSC_v3.41234,595,190 - 234,595,366RGDRGSC3.4
RGSC_v3.41234,595,191 - 234,595,366UniSTSRGSC3.4
RGSC_v3.11234,759,214 - 234,759,389RGD
Celera1225,716,310 - 225,716,485UniSTS
RH 3.4 Map11618.9UniSTS
RH 3.4 Map11618.9RGD
RH 2.0 Map11185.7RGD
SHRSP x BN Map1126.57RGD
Cytogenetic Map1q52UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21228,617,884 - 228,618,176 (+)MAPPERmRatBN7.2
Rnor_6.01249,242,639 - 249,242,930NCBIRnor6.0
Rnor_5.01256,481,329 - 256,481,620UniSTSRnor5.0
RGSC_v3.41234,631,432 - 234,631,857RGDRGSC3.4
RGSC_v3.41234,631,485 - 234,631,776UniSTSRGSC3.4
RGSC_v3.11234,795,508 - 234,795,799RGD
Celera1225,752,215 - 225,752,506UniSTS
RH 3.4 Map11618.0RGD
RH 3.4 Map11618.0UniSTS
RH 2.0 Map11185.8RGD
SHRSP x BN Map1126.57RGD
Cytogenetic Map1q52UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21228,602,908 - 228,603,109 (+)MAPPERmRatBN7.2
Rnor_6.01249,227,664 - 249,227,864NCBIRnor6.0
Rnor_5.01256,466,354 - 256,466,554UniSTSRnor5.0
Rnor_5.01262,862,271 - 262,862,471UniSTSRnor5.0
RGSC_v3.41234,616,508 - 234,616,709RGDRGSC3.4
RGSC_v3.41234,616,509 - 234,616,709UniSTSRGSC3.4
RGSC_v3.11234,780,532 - 234,780,732RGD
Celera1225,737,504 - 225,737,704UniSTS
RH 3.4 Map11619.0RGD
RH 3.4 Map11619.0UniSTS
RH 2.0 Map11197.5RGD
Cytogenetic Map1q52UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21228,972,050 - 228,972,319 (+)MAPPERmRatBN7.2
Rnor_6.01249,594,421 - 249,594,689NCBIRnor6.0
Rnor_5.01256,833,218 - 256,833,486UniSTSRnor5.0
RGSC_v3.41235,079,922 - 235,080,191RGDRGSC3.4
RGSC_v3.41235,079,923 - 235,080,191UniSTSRGSC3.4
RGSC_v3.11235,243,945 - 235,244,214RGD
Celera1226,096,894 - 226,097,162UniSTS
Cytogenetic Map1q52UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21229,558,329 - 229,558,526 (+)MAPPERmRatBN7.2
Rnor_6.01250,207,927 - 250,208,123NCBIRnor6.0
Rnor_6.01250,202,943 - 250,203,139NCBIRnor6.0
Rnor_5.01257,438,372 - 257,438,568UniSTSRnor5.0
Rnor_5.01257,443,356 - 257,443,552UniSTSRnor5.0
RGSC_v3.41235,685,336 - 235,685,532UniSTSRGSC3.4
Celera1226,679,768 - 226,679,964UniSTS
Cytogenetic Map1q52UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21229,323,292 - 229,323,471 (+)MAPPERmRatBN7.2
Rnor_6.01249,954,285 - 249,954,463NCBIRnor6.0
Rnor_5.01257,190,780 - 257,190,958UniSTSRnor5.0
RGSC_v3.41235,447,302 - 235,447,480UniSTSRGSC3.4
Celera1226,444,839 - 226,445,017UniSTS
RH 3.4 Map11619.2UniSTS
Cytogenetic Map1q52UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21228,989,146 - 228,989,340 (+)MAPPERmRatBN7.2
Rnor_6.01249,611,611 - 249,611,804NCBIRnor6.0
Rnor_5.01256,850,408 - 256,850,601UniSTSRnor5.0
RGSC_v3.41235,102,378 - 235,102,571UniSTSRGSC3.4
Celera1226,113,717 - 226,113,910UniSTS
RH 3.4 Map11619.5UniSTS
Cytogenetic Map1q52UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21229,024,644 - 229,024,844 (+)MAPPERmRatBN7.2
Rnor_6.01249,647,106 - 249,647,305NCBIRnor6.0
Rnor_5.01256,885,547 - 256,885,746UniSTSRnor5.0
RGSC_v3.41237,138,936 - 237,139,135UniSTSRGSC3.4
Celera1226,148,793 - 226,148,992UniSTS
RH 3.4 Map11647.02UniSTS
Cytogenetic Map1q52UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21228,839,017 - 228,839,199 (+)MAPPERmRatBN7.2
Rnor_6.01249,461,588 - 249,461,769NCBIRnor6.0
Rnor_5.01256,700,441 - 256,700,622UniSTSRnor5.0
RGSC_v3.41234,857,973 - 234,858,154UniSTSRGSC3.4
Celera1225,969,235 - 225,969,416UniSTS
Cytogenetic Map1q52UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21229,432,243 - 229,432,391 (+)MAPPERmRatBN7.2
Rnor_6.01250,064,397 - 250,064,544NCBIRnor6.0
Rnor_5.01257,300,391 - 257,300,538UniSTSRnor5.0
RGSC_v3.41235,556,813 - 235,556,960UniSTSRGSC3.4
Celera1226,553,757 - 226,553,904UniSTS
Cytogenetic Map1q52UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21229,638,525 - 229,638,798 (+)MAPPERmRatBN7.2
Rnor_6.01250,300,684 - 250,300,956NCBIRnor6.0
Rnor_5.01257,537,021 - 257,537,293UniSTSRnor5.0
RGSC_v3.41235,765,107 - 235,765,379UniSTSRGSC3.4
Celera1226,759,908 - 226,760,180UniSTS
Cytogenetic Map1q52UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21229,174,789 - 229,174,869 (+)MAPPERmRatBN7.2
Rnor_6.01249,812,118 - 249,812,197NCBIRnor6.0
Rnor_5.01257,049,182 - 257,049,261UniSTSRnor5.0
Celera1226,297,609 - 226,297,688UniSTS
Cytogenetic Map1q52UniSTS



Reference Sequences
RefSeq Acc Id: NM_001105731   ⟹   NP_001099201
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
mRatBN7.21228,409,883 - 229,638,794 (-)NCBI
Rnor_6.01248,982,039 - 250,300,952 (-)NCBI
Rnor_5.01256,221,067 - 257,537,289 (-)NCBI
RGSC_v3.41234,420,597 - 235,765,375 (-)RGD
Celera1225,545,145 - 226,760,176 (-)RGD
Protein Sequences
Protein RefSeqs NP_001099201 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ABX38843 (Get FASTA)   NCBI Sequence Viewer  
  EDM13122 (Get FASTA)   NCBI Sequence Viewer  
  EDM13123 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001099201   ⟸   NM_001105731
- UniProtKB: A0A8I6ATM1 (UniProtKB/TrEMBL)
- Sequence:

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1587390 AgrOrtholog
BioCyc Gene G2FUF-55937 BioCyc
Ensembl Genes ENSRNOG00000053728 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000083812.1 UniProtKB/TrEMBL
  ENSRNOP00000090382.1 UniProtKB/TrEMBL
  ENSRNOP00000095894.1 UniProtKB/TrEMBL
  ENSRNOP00000096605.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000091108.2 UniProtKB/TrEMBL
  ENSRNOT00000107140.1 UniProtKB/TrEMBL
  ENSRNOT00000114405.1 UniProtKB/TrEMBL
  ENSRNOT00000119088.1 UniProtKB/TrEMBL
  Single helix bin UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro AGC-kinase_C UniProtKB/TrEMBL
  cGMP_dep_kinase UniProtKB/TrEMBL
  cNMP-bd-like UniProtKB/TrEMBL
  cNMP-bd_CS UniProtKB/TrEMBL
  cNMP-bd_dom UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  RmlC-like_jellyroll UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
KEGG Report rno:54286 UniProtKB/TrEMBL
  PTHR24353:SF68 UniProtKB/TrEMBL
Pfam cNMP_binding UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PhenoGen Prkg1 PhenoGen
PIRSF cGMP-dep_kinase UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF51206 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A8I6A017_RAT UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Prkg1  protein kinase cGMP-dependent 1  LOC100912084  cAMP-dependent protein kinase catalytic subunit PRKX-like  Data Merged 737654 PROVISIONAL
2019-04-03 Prkg1  protein kinase cGMP-dependent 1  Prkg1  protein kinase, cGMP-dependent, type 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-05 LOC100912084  cAMP-dependent protein kinase catalytic subunit PRKX-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-04-30 Prkg1  protein kinase, cGMP-dependent, type 1  Prkg1_predicted  protein kinase, cGMP-dependent, type 1  'predicted' is removed 2292626 APPROVED
2007-04-13   protein kinase, cGMP-dependent, type 1  Prkg1_predicted  protein kinase, cGMP-dependent, type 1 (predicted)  Name updated 737654 APPROVED
2007-04-12 Prkg1_predicted  protein kinase, cGMP-dependent, type 1 (predicted)  Prkg1  protein kinase, cGMP-dependent, type 1 (mapped)  Nomenclature changed to reflect predicted status 1299863 APPROVED
2007-04-12 Prkg1  protein kinase, cGMP-dependent, type 1 (mapped)  Prkg1_predicted_retired  protein kinase, cGMP-dependent, type I (RETIRED predicted)  Data Merged 737654 APPROVED
2006-11-19 Prkg1  protein kinase, cGMP-dependent, type 1 (mapped)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-11-17 Prkg1_mapped  protein kinase, cGMP-dependent, type 1 (mapped)  Prkg1  protein kinase, cGMP-dependent, type 1  Symbol and Name updated 1556543 APPROVED
2005-01-20 Prkg1  protein kinase, cGMP-dependent, type 1    cGMP dependent protein kinase type1  Name updated 1299863 APPROVED
2005-01-12 Prkg1_predicted  protein kinase, cGMP-dependent, type I (predicted)      Symbol and Name status set to approved 70820 APPROVED
2002-06-10 Prkg1  cGMP dependent protein kinase type1      Name updated 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed at high levels in cerebellar Purkinje cells and human platelets, moderately in vascular smooth muscle cells, and at a lower levels in cardiac myocytes 61502
gene_mapping maps between D1Mit6 and D1Mit7 on rat chr 1 61022
gene_process lowers intracellular Ca2+, and inhibits vascular smooth muscle contraction, platelet activation and endothelial cell permeability, thereby opposing events leading to hypertension, thrombosis, and atherosclerosis 61502