Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Prkg1 (protein kinase cGMP-dependent 1) Rattus norvegicus
Symbol: Prkg1
Name: protein kinase cGMP-dependent 1
RGD ID: 1587390
Description: Exhibits identical protein binding activity and mitogen-activated protein kinase p38 binding activity. Involved in several processes, including cell growth involved in cardiac muscle cell development; regulation of cellular biosynthetic process; and regulation of ion transport. Localizes to several cellular components, including Golgi apparatus; acrosomal vesicle; and nucleoplasm. Biomarker of allergic rhinitis; hypertension; hypogonadism; impotence; and obesity. Human ortholog(s) of this gene implicated in thoracic aortic aneurysm. Orthologous to human PRKG1 (protein kinase cGMP-dependent 1); PARTICIPATES IN eicosanoid signaling pathway; long term depression; INTERACTS WITH 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one; 7-NITROINDAZOLE; 8-(4-chlorophenylthio)-cGMP.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: cGk1; cGMP dependent protein kinase type 1; cGMP dependent protein kinase type1; cGMP-dependent protein kinase 1; LOC365449; Pkgi; Prkg1_mapped; protein kinase, cGMP-dependent, type 1; protein kinase, cGMP-dependent, type 1 (mapped); Protein kinase, cGMP-dependent, type I
Homo sapiens (human) : PRKG1 (protein kinase cGMP-dependent 1)  HGNC  Alliance
Mus musculus (house mouse) : Prkg1 (protein kinase, cGMP-dependent, type I)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Prkg1 (protein kinase cGMP-dependent 1)
Pan paniscus (bonobo/pygmy chimpanzee) : PRKG1 (protein kinase cGMP-dependent 1)
Canis lupus familiaris (dog) : PRKG1 (protein kinase cGMP-dependent 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Prkg1 (protein kinase cGMP-dependent 1)
Sus scrofa (pig) : PRKG1 (protein kinase cGMP-dependent 1)
Chlorocebus sabaeus (African green monkey) : PRKG1 (protein kinase cGMP-dependent 1)
Heterocephalus glaber (naked mole-rat) : Prkg1 (protein kinase cGMP-dependent 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01248,982,039 - 250,300,952 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01256,221,067 - 257,537,289 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41234,420,597 - 235,765,375 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11235,515,049 - 235,845,833 (-)NCBI
Celera1225,545,145 - 226,760,176 (-)NCBICelera
Cytogenetic Map1q52NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Prkg1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1587390
Created: 2006-11-19
Species: Rattus norvegicus
Last Modified: 2020-11-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.