Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70500
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen activated protein kinase 1
Acc ID: CHEBI:43931
Term: methyllycaconitine
Definition: A diterpenoid that has formula C37H50N2O10.
Chemical ID: MESH:C054634
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1increases phosphorylationISOMAPK1 (Homo sapiens)6480464CTDmethyllycaconitine results in increased phosphorylation of MAPK1 proteinPMID:24012499
Mapk1multiple interactionsISOMAPK1 (Homo sapiens)6480464CTD[methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; MAPK1 mutant form inhibits the reaction [methyllycaconitine results in increased expression of SRR protein]; methyllycaconitine inhibits the reaction [Varenicline results in increased phosphorylation of MAPK1 protein]PMID:18448488 PMID:24012499 PMID:28842382
Mapk1multiple interactionsISOMapk1 (Mus musculus)6480464CTDmethyllycaconitine inhibits the reaction [Varenicline results in increased phosphorylation of MAPK1 protein]PMID:28202387
Go Back to source page   Continue to Ontology report