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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70500
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen activated protein kinase 1
Acc ID: CHEBI:28157
Term: pinocembrin
Definition: A dihydroxyflavanone in which the two hydroxy groups are located at positions 5 and 7. A natural product found in Piper sarmentosum and Cryptocarya chartacea.
Chemical ID: MESH:C016063
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1multiple interactionsISOMAPK1 (Homo sapiens)6480464CTDpinocembrin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK1 protein]; pinocembrin inhibits the reaction [Ethanol results in increased phosphorylation of MAPK1 protein]; pinocembrin promotes the reaction [Dasatinib inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK1 protein]]PMID:18295389 PMID:33393179
Mapk1multiple interactionsISOMapk1 (Mus musculus)6480464CTDpinocembrin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK1 protein]PMID:33393179
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