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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70500
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen activated protein kinase 1
Acc ID: CHEBI:92211
Term: SL-327
Definition: A nitrile that is acrylonitrile in which the hydrogen attached to the same carbon as the cyano group has been replaced by an o-(trifluoromethyl)phenyl group, while the remaining hydrogens of the ethenyl group have been replaced by amino and (4-aminophenyl)sulfanyl groups. The configuration of the double bond is not specified. It is an inhibitor of MEK1 and MEK2.
Chemical ID: MESH:C424127
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1decreases phosphorylationEXP 6480464CTDSL 327 results in decreased phosphorylation of MAPK1 proteinPMID:20081235
Mapk1multiple interactionsEXP 6480464CTDSL 327 inhibits the reaction [HU 211 results in increased phosphorylation of MAPK1 protein]; SL 327 inhibits the reaction [Isoproterenol results in increased phosphorylation of MAPK1 protein]; SL 327 results in decreased phosphorylation of and results in decreased activity of MAPK1 proteinPMID:17623046 PMID:20050970 PMID:20081235
Mapk1decreases phosphorylationISOMapk1 (Mus musculus)6480464CTDSL 327 results in decreased phosphorylation of MAPK1 proteinPMID:12871586
Mapk1multiple interactionsISOMapk1 (Mus musculus)6480464CTDSL 327 inhibits the reaction [[benserazide, levodopa drug combination co-treated with Oxidopamine] results in increased phosphorylation of MAPK1 protein]; SL 327 inhibits the reaction [[Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein] which results in increased expression of FOS protein]; SL 327 inhibits the reaction [[Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein] which results in increased expression of FOSB protein]; SL 327 inhibits the reaction [[Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein] which results in increased expression of FOSL2 protein]; SL 327 inhibits the reaction [Chenodeoxycholic Acid results in increased phosphorylation of MAPK1 protein]; SL 327 inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; SL 327 inhibits the reaction [Deoxycholic Acid results in increased phosphorylation of MAPK1 protein]; SL 327 inhibits the reaction [Dronabinol results in increased phosphorylation of and results in increased activity of MAPK1 protein]; SL 327 inhibits the reaction [Haloperidol results in increased phosphorylation of MAPK1 protein]; SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased phosphorylation of MAPK1 protein]]; SL 327 inhibits the reaction [Pilocarpine results in increased phosphorylation of MAPK1 protein]PMID:12657697 PMID:12871586 PMID:15056714 PMID:16473939 PMID:17596448 PMID:19402951 PMID:19931294 PMID:25550330
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