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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70500
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen activated protein kinase 1
Acc ID: CHEBI:3374
Term: capsaicin
Definition: A capsaicinoid that has formula C18H27NO3.
Chemical ID: MESH:D002211
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1increases expressionEXP 6480464CTDCapsaicin results in increased expression of MAPK1 protein modified formPMID:17056180
Mapk1increases phosphorylationEXP 6480464CTDCapsaicin results in increased phosphorylation of MAPK1 proteinPMID:15385614 PMID:16788306 PMID:21056583
Mapk1multiple interactionsEXP 6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Capsaicin results in increased expression of MAPK1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Capsaicin results in increased phosphorylation of MAPK1 protein]; 6-Cyano-7-nitroquinoxaline-2,3-dione inhibits the reaction [Capsaicin results in increased phosphorylation of MAPK1 protein]; 7-(hydroxyimino)cyclopropan(b)chromen-1a-carbxoylic acid ethyl ester inhibits the reaction [Capsaicin results in increased phosphorylation of MAPK1 protein]; AG 1879 inhibits the reaction [Capsaicin results in increased phosphorylation of MAPK1 protein]; Capsaicin inhibits the reaction [CCK protein results in increased phosphorylation of MAPK1 protein]; Capsaicin results in increased phosphorylation of and results in increased activity of MAPK1 protein; capsazepine inhibits the reaction [Capsaicin results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Dizocilpine Maleate inhibits the reaction [Capsaicin results in increased phosphorylation of MAPK1 protein]; Genistein inhibits the reaction [Capsaicin results in increased phosphorylation of MAPK1 protein]; Lidocaine inhibits the reaction [Capsaicin results in increased phosphorylation of and results in increased activity of MAPK1 protein]; SR140333B inhibits the reaction [Capsaicin results in increased phosphorylation of MAPK1 protein]; staurosporine aglycone inhibits the reaction [Capsaicin results in increased phosphorylation of MAPK1 protein]; substance P (6-11), Tyr(6)-D-Phe(7)-D-His(9)- inhibits the reaction [Capsaicin results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Capsaicin results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Xenon inhibits the reaction [Capsaicin results in increased phosphorylation of MAPK1 protein]PMID:12196597 PMID:15385614 PMID:16788306 PMID:21056583 PMID:22508518
Mapk1decreases activityISOMAPK1 (Homo sapiens)6480464CTDCapsaicin results in decreased activity of MAPK1 proteinPMID:12478662
Mapk1increases activityISOMAPK1 (Homo sapiens)6480464CTDCapsaicin results in increased activity of MAPK1 proteinPMID:17828457 PMID:20371669
Mapk1increases localizationISOMapk1 (Mus musculus)6480464CTDCapsaicin results in increased localization of MAPK1 protein modified formPMID:12941468
Mapk1increases phosphorylationISOMAPK1 (Homo sapiens)6480464CTDCapsaicin results in increased phosphorylation of MAPK1 proteinPMID:19059400 PMID:20619260 PMID:20660715 PMID:21474332 PMID:22171160
Mapk1increases phosphorylationISOMapk1 (Mus musculus)6480464CTDCapsaicin results in increased phosphorylation of MAPK1 proteinPMID:20383154
Mapk1multiple interactionsISOMAPK1 (Homo sapiens)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Capsaicin results in increased phosphorylation of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Capsaicin results in increased phosphorylation of MAPK1 protein]; 7-oxozeanol inhibits the reaction [Capsaicin results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Capsaicin results in increased activity of MAPK1 protein]; bafilomycin A1 inhibits the reaction [Capsaicin results in increased activity of MAPK1 protein]; Capsaicin inhibits the reaction [EGF results in increased phosphorylation of MAPK1 protein]; Capsaicin results in decreased phosphorylation of and results in decreased activity of MAPK1 protein; Capsaicin results in increased phosphorylation of and results in increased activity of MAPK1 protein; capsazepine inhibits the reaction [Capsaicin results in increased phosphorylation of MAPK1 protein]; NFKB1 mutant form inhibits the reaction [Capsaicin results in increased phosphorylation of MAPK1 protein]; tricyclodecane-9-yl-xanthogenate inhibits the reaction [Capsaicin results in increased activity of MAPK1 protein]PMID:17828457 PMID:19059400 PMID:19139269 PMID:19855437 PMID:20371669 PMID:21462327 PMID:21474332 PMID:22171160
Mapk1multiple interactionsISOMapk1 (Mus musculus)6480464CTD5S,12R,18R-trihydroxy-6Z,8E,10E,14Z,16E-eicosapentaenoic acid inhibits the reaction [Capsaicin results in increased phosphorylation of MAPK1 protein]; [Tetradecanoylphorbol Acetate co-treated with Capsaicin] results in increased phosphorylation of MAPK1 protein; AG 1879 inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Capsaicin] results in increased phosphorylation of MAPK1 protein]; Capsaicin inhibits the reaction [Lipopolysaccharides results in increased activity of MAPK1 protein]; Capsaicin results in increased activity of and results in increased phosphorylation of MAPK1 protein; EGFR gene mutant form inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Capsaicin] results in increased phosphorylation of MAPK1 protein]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Capsaicin] results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Capsaicin] results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Capsaicin] results in increased phosphorylation of MAPK1 protein]PMID:12941468 PMID:14530214 PMID:20383154 PMID:20660715
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