Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	70500
Species:	Rattus norvegicus
RGD Object:	Gene
Symbol:	Mapk1
Name:	mitogen activated protein kinase 1

Acc ID:	CHEBI:73390
Term:	promegestone
Definition:	A progestin consisting of 17beta-propionylestra-4,9-dien-3-one substituted at position 17 by a methyl group.
Chemical ID:	MESH:D011397

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Mapk1	increases phosphorylation	EXP		6480464	CTD	Promegestone results in increased phosphorylation of MAPK1 protein	PMID:16020483
Mapk1	multiple interactions	EXP		6480464	CTD	fulvestrant inhibits the reaction [Promegestone results in increased phosphorylation of MAPK1 protein] Mifepristone inhibits the reaction [Promegestone results in increased phosphorylation of MAPK1 protein]	PMID:16020483
Mapk1	increases phosphorylation	ISO	RGD:732502	6480464	CTD	Promegestone results in increased phosphorylation of MAPK1 protein	PMID:21258428
Mapk1	multiple interactions	ISO	RGD:732502	6480464	CTD	[Promegestone co-treated with AREG protein] results in increased phosphorylation of MAPK1 protein Gefitinib inhibits the reaction [[Promegestone co-treated with AREG protein] results in increased phosphorylation of MAPK1 protein] Gefitinib inhibits the reaction [Promegestone results in increased phosphorylation of MAPK1 protein]	PMID:21258428

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