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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70500
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen activated protein kinase 1
Acc ID: CHEBI:73390
Term: promegestone
Definition: A progestin consisting of 17beta-propionylestra-4,9-dien-3-one substituted at position 17 by a methyl group.
Chemical ID: MESH:D011397
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1increases phosphorylationEXP 6480464CTDPromegestone results in increased phosphorylation of MAPK1 protein

PMID:16020483
Mapk1multiple interactionsEXP 6480464CTDfulvestrant inhibits the reaction [Promegestone results in increased phosphorylation of MAPK1 protein] Mifepristone inhibits the reaction [Promegestone results in increased phosphorylation of MAPK1 protein]

PMID:16020483
Mapk1increases phosphorylationISORGD:7325026480464CTDPromegestone results in increased phosphorylation of MAPK1 protein

PMID:21258428
Mapk1multiple interactionsISORGD:7325026480464CTD[Promegestone co-treated with AREG protein] results in increased phosphorylation of MAPK1 protein Gefitinib inhibits the reaction [[Promegestone co-treated with AREG protein] results in increased phosphorylation of MAPK1 protein] Gefitinib inhibits the reaction [Promegestone results in increased phosphorylation of MAPK1 protein]

PMID:21258428
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