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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70500
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen activated protein kinase 1
Acc ID: CHEBI:49584
Term: 4-ethylphenol
Definition: A member of the class of phenols carrying an ethyl substituent at position 4.
Chemical ID: MESH:C042291
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1increases phosphorylationEXP 6480464CTD4-ethylphenol results in increased phosphorylation of MAPK1 protein

PMID:22230296
Mapk1multiple interactionsEXP 6480464CTD4 4 ' 4'' 4'''-carbonylbisimino-5 1 3-benzenetriylbiscarbonyliminotetrakisbenzene-1 3-disulfonate inhibits the reaction [4-ethylphenol results in increased phosphorylation of MAPK1 protein] 4-ethylphenol analog affects the reaction [Estradiol affects the phosphorylation of MAPK1 protein] 4-ethylphenol analog affects the reaction [Estriol affects the phosphorylation of MAPK1 protein] 4-ethylphenol analog affects the reaction [Estrone affects the phosphorylation of MAPK1 protein] fulvestrant inhibits the reaction [4-ethylphenol results in increased phosphorylation of MAPK1 protein] NF023 inhibits the reaction [4-ethylphenol results in increased phosphorylation of MAPK1 protein] Nystatin inhibits the reaction [4-ethylphenol results in increased phosphorylation of MAPK1 protein] Pertussis Toxin inhibits the reaction [4-ethylphenol results in increased phosphorylation of MAPK1 protein]

PMID:20870566 PMID:22230296
Mapk1increases phosphorylationISORGD:7325036480464CTD4-ethylphenol results in increased phosphorylation of MAPK1 protein

PMID:20950447
Mapk1multiple interactionsISORGD:7325036480464CTD4-ethylphenol inhibits the reaction [Estradiol results in increased phosphorylation of MAPK1 protein] 4-ethylphenol inhibits the reaction [Estriol results in increased phosphorylation of MAPK1 protein] 4-ethylphenol inhibits the reaction [Estrone results in increased phosphorylation of MAPK1 protein]

PMID:20950447
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