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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70500
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen activated protein kinase 1
Acc ID: CHEBI:82436
Term: decabromodiphenyl ether
Definition: A polybromodiphenyl ether that is diphenyl ether in which all of the hydrogens have been replaced by bromines.
Chemical ID: MESH:C010902
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1decreases expressionISOMAPK1 (Homo sapiens)6480464CTDdecabromobiphenyl ether results in decreased expression of MAPK1 proteinPMID:31675489
Mapk1increases activityISOMapk1 (Mus musculus)6480464CTDdecabromobiphenyl ether results in increased activity of MAPK1 proteinPMID:23038006
Mapk1increases phosphorylationISOMAPK1 (Homo sapiens)6480464CTDdecabromobiphenyl ether results in increased phosphorylation of MAPK1 proteinPMID:33675858
Mapk1multiple interactionsISOMAPK1 (Homo sapiens)6480464CTDLuteolin inhibits the reaction [decabromobiphenyl ether results in increased phosphorylation of MAPK1 protein]PMID:33675858
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