Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70500
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen activated protein kinase 1
Acc ID: CHEBI:46666
Term: crocidolite asbestos
Definition: null
Chemical ID: MESH:D017638
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1increases phosphorylationEXP 6480464CTD[Asbestos, Crocidolite results in increased phosphorylation of MAPK1 protein] which results in increased phosphorylation of ELK1 protein; Asbestos, Crocidolite results in increased phosphorylation of MAPK1 proteinPMID:12495932 PMID:14627993
Mapk1multiple interactionsEXP 6480464CTDarginyl-glycyl-aspartic acid inhibits the reaction [Asbestos, Crocidolite results in increased phosphorylation of MAPK1 protein]; ITGB1 protein affects the reaction [Asbestos, Crocidolite results in increased phosphorylation of MAPK1 protein]PMID:14627993
Mapk1affects localizationISOMapk1 (Mus musculus)6480464CTDAsbestos, Crocidolite affects the localization of MAPK1 protein modified formPMID:12598305
Mapk1decreases expressionISOMapk1 (Mus musculus)6480464CTDAsbestos, Crocidolite results in decreased expression of MAPK1 mRNAPMID:29279043
Mapk1decreases phosphorylationISOMAPK1 (Homo sapiens)6480464CTDAsbestos, Crocidolite results in decreased phosphorylation of MAPK1 proteinPMID:17191120 PMID:18314537
Mapk1decreases response to substanceISOMAPK1 (Homo sapiens)6480464CTDMAPK1 mRNA results in decreased susceptibility to Asbestos, CrocidolitePMID:21454801
Mapk1increases expressionISOMapk1 (Mus musculus)6480464CTDAsbestos, Crocidolite results in increased expression of MAPK1 proteinPMID:12598305
Mapk1increases phosphorylationISOMAPK1 (Homo sapiens)6480464CTDAsbestos, Crocidolite results in increased phosphorylation of MAPK1 proteinPMID:16908449 PMID:16966607 PMID:21454801 PMID:21762757 PMID:22573546
Mapk1increases phosphorylationISOMapk1 (Mus musculus)6480464CTDAsbestos, Crocidolite results in increased phosphorylation of MAPK1 proteinPMID:11306433 PMID:12598305 PMID:14737115 PMID:18192500 PMID:24130165
Mapk1multiple interactionsISOMAPK1 (Homo sapiens)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Asbestos, Crocidolite results in increased phosphorylation of MAPK1 protein]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [Asbestos, Crocidolite results in increased phosphorylation of MAPK1 protein]; CAT protein inhibits the reaction [Asbestos, Crocidolite results in increased phosphorylation of MAPK1 protein]; EGFR protein affects the reaction [Asbestos, Crocidolite results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [Asbestos, Crocidolite results in increased phosphorylation of MAPK1 protein]; SOD1 protein inhibits the reaction [Asbestos, Crocidolite results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Asbestos, Crocidolite results in increased phosphorylation of MAPK1 protein]PMID:16908449 PMID:16966607 PMID:21454801 PMID:21762757 PMID:22573546
Mapk1multiple interactionsISOMapk1 (Mus musculus)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Asbestos, Crocidolite results in increased phosphorylation of MAPK1 protein]; Antigens, Polyomavirus Transforming promotes the reaction [Asbestos, Crocidolite results in increased phosphorylation of MAPK1 protein]; Asbestos, Crocidolite results in increased phosphorylation of and affects the localization of MAPK1 protein; MAP2K1 protein affects the reaction [Asbestos, Crocidolite results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [Asbestos, Crocidolite results in increased phosphorylation of MAPK1 protein]; SRC protein affects the reaction [Asbestos, Crocidolite results in increased phosphorylation of MAPK1 protein]PMID:14737115 PMID:15374964 PMID:18192500 PMID:24130165
Go Back to source page   Continue to Ontology report