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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70500
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen activated protein kinase 1
Acc ID: CHEBI:27504
Term: mitomycin C
Definition: A mitomycin that has formula C15H18N4O5.
Chemical ID: MESH:D016685
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1increases phosphorylationISOMAPK1 (Homo sapiens)6480464CTDMitomycin results in increased phosphorylation of MAPK1 proteinPMID:21810436 PMID:34624459
Mapk1multiple interactionsISOMAPK1 (Homo sapiens)6480464CTDCurcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK1 protein]; MAP2K1 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK1 protein]]; MAP2K2 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK1 protein]]; U 0126 promotes the reaction [Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK1 protein]]PMID:21810436
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