Cav2 (caveolin 2) - Rat Genome Database

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Gene: Cav2 (caveolin 2) Mus musculus
Analyze
Symbol: Cav2
Name: caveolin 2
RGD ID: 1551950
MGI Page MGI
Description: Enables several functions, including protein heterodimerization activity; protein kinase binding activity; and scaffold protein binding activity. Acts upstream of or within several processes, including negative regulation of transforming growth factor beta receptor signaling pathway; regulation of endothelial cell proliferation; and skeletal muscle fiber development. Located in acrosomal membrane and caveola. Part of caveolar macromolecular signaling complex. Colocalizes with focal adhesion. Is expressed in bronchiole epithelium; embryo; and lung. Human ortholog(s) of this gene implicated in low tension glaucoma and primary open angle glaucoma. Orthologous to human CAV2 (caveolin 2).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AI447843; caveolin-2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39617,281,184 - 17,289,129 (+)NCBIGRCm39mm39
GRCm39 Ensembl617,281,184 - 17,289,114 (+)Ensembl
GRCm38617,281,185 - 17,289,130 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl617,281,185 - 17,289,115 (+)EnsemblGRCm38mm10GRCm38
MGSCv37617,231,341 - 17,239,011 (+)NCBIGRCm37mm9NCBIm37
MGSCv36617,231,341 - 17,239,011 (+)NCBImm8
Celera617,353,818 - 17,361,488 (+)NCBICelera
Cytogenetic Map6A2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (EXP)
1,2-dichloroethane  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (ISO)
antirheumatic drug  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bisphenol F  (EXP,ISO)
bucladesine  (ISO)
butan-1-ol  (ISO)
butanal  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
chloropicrin  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
crocidolite asbestos  (EXP)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (ISO)
disodium selenite  (EXP)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethanol  (EXP)
furan  (ISO)
gentamycin  (ISO)
glafenine  (ISO)
glutathione  (ISO)
hexadecanoic acid  (ISO)
indometacin  (ISO)
isobutanol  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
manganese(II) chloride  (ISO)
medroxyprogesterone acetate  (ISO)
mercury dibromide  (ISO)
methotrexate  (ISO)
Methylazoxymethanol acetate  (ISO)
methylmercury chloride  (ISO)
monocrotaline  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
nicotine  (EXP)
oleic acid  (ISO)
oxycodone  (ISO)
p-chloromercuribenzoic acid  (ISO)
p-toluidine  (ISO)
paracetamol  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
quercetin  (EXP)
rimonabant  (EXP)
rotenone  (ISO)
SB 431542  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
simvastatin  (ISO)
sodium arsenite  (EXP)
sunitinib  (ISO)
taurocholic acid  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
triadimefon  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (EXP)
triphenyl phosphate  (ISO)
valdecoxib  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:8552590   PMID:9361015   PMID:9488658   PMID:9662443   PMID:9685399   PMID:9837809   PMID:10349636   PMID:10373486   PMID:10825283   PMID:10988290   PMID:11042159   PMID:11076861  
PMID:11208732   PMID:11316799   PMID:11884617   PMID:12054493   PMID:12069580   PMID:12091389   PMID:12138167   PMID:12388077   PMID:12388746   PMID:12477932   PMID:12633858   PMID:12743374  
PMID:12759260   PMID:12917688   PMID:14647059   PMID:15489334   PMID:15545264   PMID:15569306   PMID:15703204   PMID:15788404   PMID:16019085   PMID:16141072   PMID:16141073   PMID:16904002  
PMID:16997272   PMID:17200204   PMID:17293479   PMID:17715130   PMID:17979883   PMID:17988240   PMID:18081315   PMID:19144954   PMID:19854179   PMID:19891976   PMID:20007452   PMID:21267068  
PMID:21670588   PMID:21677750   PMID:21832243   PMID:21873635   PMID:22396494   PMID:22792322   PMID:22819829   PMID:24013648   PMID:24590285   PMID:25131634   PMID:25269481   PMID:26215374  
PMID:26367869   PMID:27317631   PMID:28130355   PMID:31831780   PMID:33416452   PMID:33964205  


Genomics

Comparative Map Data
Cav2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39617,281,184 - 17,289,129 (+)NCBIGRCm39mm39
GRCm39 Ensembl617,281,184 - 17,289,114 (+)Ensembl
GRCm38617,281,185 - 17,289,130 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl617,281,185 - 17,289,115 (+)EnsemblGRCm38mm10GRCm38
MGSCv37617,231,341 - 17,239,011 (+)NCBIGRCm37mm9NCBIm37
MGSCv36617,231,341 - 17,239,011 (+)NCBImm8
Celera617,353,818 - 17,361,488 (+)NCBICelera
Cytogenetic Map6A2NCBI
CAV2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl7116,287,380 - 116,508,541 (+)EnsemblGRCh38hg38GRCh38
GRCh387116,499,738 - 116,508,541 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh377116,139,792 - 116,148,595 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367115,926,680 - 115,935,831 (+)NCBINCBI36hg18NCBI36
Build 347115,733,394 - 115,742,545NCBI
Celera7110,946,853 - 110,956,001 (+)NCBI
Cytogenetic Map7q31.2NCBI
HuRef7110,505,654 - 110,514,581 (+)NCBIHuRef
CHM1_17116,073,006 - 116,081,933 (+)NCBICHM1_1
CRA_TCAGchr7v27115,535,087 - 115,544,028 (+)NCBI
Cav2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2445,616,766 - 45,624,144 (+)NCBImRatBN7.2
Rnor_6.0 Ensembl444,573,264 - 44,580,638 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0444,573,264 - 44,580,640 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0445,178,080 - 45,186,997 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4442,932,127 - 42,939,503 (+)NCBIRGSC3.4rn4RGSC3.4
Celera440,892,754 - 40,900,130 (+)NCBICelera
Cytogenetic Map4q21NCBI
Cav2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495543222,240,041 - 22,242,200 (+)NCBIChiLan1.0ChiLan1.0
CAV2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.17120,951,568 - 121,177,415 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7121,168,579 - 121,177,415 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v07108,254,074 - 108,480,716 (+)NCBIMhudiblu_PPA_v0panPan3
CAV2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11455,437,622 - 55,445,481 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1455,437,622 - 55,445,469 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1454,833,000 - 54,840,856 (+)NCBI
ROS_Cfam_1.01455,479,629 - 55,487,494 (+)NCBI
UMICH_Zoey_3.11455,507,542 - 55,515,378 (+)NCBI
UNSW_CanFamBas_1.01455,195,940 - 55,203,807 (+)NCBI
UU_Cfam_GSD_1.01455,567,047 - 55,574,903 (+)NCBI
Cav2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511844,128,741 - 44,135,934 (+)NCBI
SpeTri2.0NW_0049365892,553,932 - 2,561,186 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CAV2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1829,699,020 - 29,707,277 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11829,699,012 - 29,707,277 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21831,796,924 - 31,805,190 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CAV2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12185,197,452 - 85,206,521 (+)NCBI
ChlSab1.1 Ensembl2185,197,537 - 85,206,588 (+)Ensembl
Vero_WHO_p1.0NW_02366604218,527,200 - 18,536,233 (-)NCBI
Cav2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248272,897,824 - 2,905,835 (-)NCBI

Position Markers
AI447843  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38617,288,877 - 17,288,990UniSTSGRCm38
MGSCv37617,238,877 - 17,238,990UniSTSGRCm37
Celera617,361,354 - 17,361,467UniSTS
Cytogenetic Map6A2UniSTS
PMC133690P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38617,281,367 - 17,281,635UniSTSGRCm38
MGSCv37617,231,367 - 17,231,635UniSTSGRCm37
Celera617,353,844 - 17,354,112UniSTS
Cytogenetic Map6A2UniSTS
PMC133690P2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38617,281,198 - 17,281,635UniSTSGRCm38
MGSCv37617,231,198 - 17,231,635UniSTSGRCm37
Celera617,353,675 - 17,354,112UniSTS
Cytogenetic Map6A2UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
14746985Manh59_mmandible shape 59 (mouse)6120847193Mouse
1357503Nhdlq5_mnon-HDL QTL 5 (mouse)Not determined6121465015Mouse
1301178Lith10_mlithogenic gene 10 (mouse)Not determined6121465015Mouse
10043884Bhr8_mbronchial hyperresponsiveness 8 (mouse)Not determined6121465015Mouse
10044000Mobq9_mmultigenetic obesity QTL 9 (mouse)Not determined6121465015Mouse
12904934Edlmmq4_mextensor digitorum longus muscle mass QTL 4 (mouse)6125514064Mouse
12904942Tammq3_mtibialis anterior muscle mass QTL 3 (mouse)6125514064Mouse
12904955Gmmq3_mgastrocnemius muscle mass QTL 3 (mouse)6125514064Mouse
1301131Chol2_mcholesterol 2 (mouse)Not determined6132144496Mouse
5491191Mobq2_mmultigenic obesity QTL 2 (mouse)Not determined6132144496Mouse
1302024Skull7_mskull morphology 7 (mouse)Not determined6132144496Mouse
25440480Moaq2_mmodifier of alien QTL 2 (mouse)61117500000Mouse
15039372Nmrs22_mNAFLD-associated magnetic resonance shift 22 (mouse)6147633535476335Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139100000Mouse
1300731Smdq3_msegregation of mitochondrial DNA QTL 3 (mouse)Not determined6424920738249326Mouse
1300556Cia6_mcollagen induced arthritis QTL 6 (mouse)Not determined6446488487426034Mouse
11353836Bmiq1_mbody mass index QTL 1 (mouse)6450382329751334Mouse
11353840Bmiq2_mbody mass index QTL 2 (mouse)6450382345314181Mouse
1357481Aaj2_manxiety in A/J 2 (mouse)Not determined6450382348726677Mouse
1357520Axtq2_manxiety QTL 2 (mouse)Not determined6450382348726677Mouse
11353841Bmiq3_mbody mass index QTL 3 (mouse)6450382348726677Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396656149Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396656149Mouse
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396656149Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396656149Mouse
26884441Sklq3_mskull length QTL 3, 5 week (mouse)6760000080600000Mouse
1302051Sluc7_msusceptibility to lung cancer 7 (mouse)Not determined6929707543297169Mouse
10043869Cia6a_mcollagen induced arthritis QTL 6a (mouse)Not determined61211797246118070Mouse
1301998Bts2_mbladder tumor susceptibility 2 (mouse)Not determined61275122246751334Mouse
4141749Obrq2_mobesity resistance QTL 2 (mouse)Not determined1275122246751334Mouse

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir199a-1mmu-miR-199a-3pOncomiRDBexternal_infoNANA21807947
Mir29b-1mmu-miR-29b-3pMirtarbaseexternal_infoReporter assayFunctional MTI17652184
Mir29cmmu-miR-29c-3pMirtarbaseexternal_infoReporter assayFunctional MTI17652184
Mir29cmmu-miR-29c-3pTarbaseexternal_infoReporter GenePOSITIVE
Mir29ammu-miR-29a-3pMirtarbaseexternal_infoReporter assayFunctional MTI17652184
Mir29b-2mmu-miR-29b-3pMirtarbaseexternal_infoReporter assayFunctional MTI17652184

Predicted Target Of
Summary Value
Count of predictions:833
Count of miRNA genes:454
Interacting mature miRNAs:548
Transcripts:ENSMUST00000000058, ENSMUST00000115459, ENSMUST00000115462
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000000058   ⟹   ENSMUSP00000000058
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl617,281,185 - 17,289,115 (+)Ensembl
RefSeq Acc Id: ENSMUST00000115459   ⟹   ENSMUSP00000111119
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl617,281,327 - 17,282,684 (+)Ensembl
RefSeq Acc Id: ENSMUST00000115462   ⟹   ENSMUSP00000111122
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl617,281,359 - 17,287,438 (+)Ensembl
RefSeq Acc Id: NM_001277756   ⟹   NP_001264685
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39617,281,184 - 17,282,683 (+)NCBI
GRCm38617,281,185 - 17,282,684 (+)NCBI
Celera617,353,662 - 17,361,607 (+)NCBI
Sequence:
RefSeq Acc Id: NM_016900   ⟹   NP_058596
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39617,281,184 - 17,289,129 (+)NCBI
GRCm38617,281,185 - 17,289,130 (+)NCBI
MGSCv37617,231,341 - 17,239,011 (+)RGD
Celera617,353,662 - 17,361,607 (+)NCBI
cM Map6 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_058596   ⟸   NM_016900
- Peptide Label: isoform 1
- UniProtKB: Q9WVC3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001264685   ⟸   NM_001277756
- Peptide Label: isoform 2
- UniProtKB: Q924U4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000000058   ⟸   ENSMUST00000000058
RefSeq Acc Id: ENSMUSP00000111119   ⟸   ENSMUST00000115459
RefSeq Acc Id: ENSMUSP00000111122   ⟸   ENSMUST00000115462

Promoters
RGD ID:6839048
Promoter ID:MM_KWN:45216
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Lung,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000115459,   ENSMUST00000115462,   OTTMUST00000058748
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36617,231,226 - 17,231,726 (+)MPROMDB
RGD ID:6889054
Promoter ID:EPDNEW_M7978
Type:initiation region
Name:Cav2_1
Description:Mus musculus caveolin 2 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38617,281,327 - 17,281,387EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:107571 AgrOrtholog
Ensembl Genes ENSMUSG00000000058 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000000058 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000111119 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000111122 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000000058 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000115459 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000115462 UniProtKB/TrEMBL
InterPro CAV-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Caveolin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Caveolin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:12390 UniProtKB/Swiss-Prot
MGD MGI:107571 ENTREZGENE
NCBI Gene 12390 ENTREZGENE
PANTHER PTHR10844 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10844:SF3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Caveolin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cav2 PhenoGen
PROSITE CAVEOLIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt CAV2_MOUSE UniProtKB/Swiss-Prot
  D3Z147_MOUSE UniProtKB/TrEMBL
  Q924U4 ENTREZGENE, UniProtKB/TrEMBL
  Q9WVC3 ENTREZGENE
UniProt Secondary Q3TYR4 UniProtKB/Swiss-Prot