RGD Reference Report - Expression of caveolin-1 in tongue squamous cell carcinoma by quantum dots. - Rat Genome Database

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Expression of caveolin-1 in tongue squamous cell carcinoma by quantum dots.

Authors: Xue, J  Chen, H  Diao, L  Chen, X  Xia, D 
Citation: Xue J, etal., Eur J Histochem. 2010 Apr 14;54(2):e20.
RGD ID: 8661771
Pubmed: PMID:20558341   (View Abstract at PubMed)
PMCID: PMC3167300   (View Article at PubMed Central)

Quantum dots (QDs) are a new class of fluorescent probes to detect biomarker expression. The role of caveolin-1 (Cav-1) in tongue squamous cell carcinoma (TSCC) is still unknown. This study aimed to investigate the expression profile of Cav-1 in carcinogenesis and development of TSCC by QDs immunofluorescence histochemistry (QDs-IHC) and discuss the relationship between the Cav-1 expression and the clinicopathological outcomes. QDs-IHC was used to detect Cav-1 expression in tissue microarrays including normal tongue mucosa (NTM; n=10), hyperplastic tongue mucosa (HTM; n=10), tongue pre-cancer lesions (TPL; n=15) and primary tongue squamous cell carcinoma (PTSCC; n=61). Correlations between the Cav-1 expression and clinicopathologic variables were evaluated statistically. Cells positive for Cav-1 were clearly detected and bright images were obtained in a fine, granular pattern at the cell membrane and cytoplasm using QDs-IHC. The rate of Cav-1 immunoreactivity increased progressively from NTM (0%), HTM (0%), TPL (36%) to PTSCC (74%). When compared with each other, there was statistical significance among PTSCC, TPL and NTM as well as among PTSCC, TPL and HTM. Moreover, Cav-1 expression level in PTSCC was correlated positively with clinical stage and histologic grade. QDs-IHC could accurately detect protein location in tongue mucosa. An increased expression of Cav-1 in the stepwise carcinogenesis from NTM, HTM, TPL to PTSCC suggested that Cav-1 might be an oncogene in the development of tongue squamous cell carcinoma.

Disease Annotations    

Objects Annotated

Genes (Rattus norvegicus)
Cav2  (caveolin 2)

Genes (Mus musculus)
Cav2  (caveolin 2)

Genes (Homo sapiens)
CAV2  (caveolin 2)

Additional Information