Gadd45a (growth arrest and DNA-damage-inducible, alpha) - Rat Genome Database

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Gene: Gadd45a (growth arrest and DNA-damage-inducible, alpha) Rattus norvegicus
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Symbol: Gadd45a
Name: growth arrest and DNA-damage-inducible, alpha
RGD ID: 2654
Description: Predicted to enable kinase binding activity; promoter-specific chromatin binding activity; and protein dimerization activity. Involved in G2/M transition of mitotic cell cycle. Predicted to be located in nuclear speck. Predicted to be active in cytoplasm and nucleus. Orthologous to human GADD45A (growth arrest and DNA damage inducible alpha); PARTICIPATES IN p38 MAPK signaling pathway; cell cycle pathway, mitotic; mitogen activated protein kinase signaling pathway; INTERACTS WITH (+)-schisandrin B; (R,R,R)-alpha-tocopherol; (S)-colchicine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: DDIT-1; Ddit1; DNA damage-inducible transcript 1 protein; DNA-damage-inducible transcript 1; Gadd45; growth arrest and DNA damage-inducible protein GADD45 alpha; growth arrest and DNA-damage-inducible 45 alpha; Growth arrest and DNA-damage-inducible protein; growth arrest and DNA-damage-inducible protein GADD45 alpha
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8497,484,497 - 97,486,799 (-)NCBIGRCr8
mRatBN7.2496,154,789 - 96,157,091 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl496,154,789 - 96,157,115 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4101,404,229 - 101,406,531 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0497,179,202 - 97,181,504 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0495,604,320 - 95,606,622 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0497,782,512 - 97,784,814 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl497,782,512 - 97,784,842 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04162,568,472 - 162,570,774 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4496,649,941 - 96,652,243 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1496,894,423 - 96,896,724 (-)NCBI
Celera490,851,517 - 90,853,819 (-)NCBICelera
Cytogenetic Map4q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (ISO)
(+)-schisandrin B  (EXP)
(-)-alpha-phellandrene  (ISO)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(-)-quinic acid  (ISO)
(1->4)-beta-D-glucan  (ISO)
(1S)-bornane-2,3-dione  (ISO)
(R,R,R)-alpha-tocopherol  (EXP)
(S)-colchicine  (EXP)
(S)-naringenin  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-dithiothreitol  (ISO)
1-methylphenanthrene  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
1H-pyrazole  (ISO)
2'-Hydroxy-2,3,5'-trimethoxychalcone  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (ISO)
2,4-diaminotoluene  (ISO)
2,4-dinitrotoluene  (EXP,ISO)
2,5-hexanedione  (EXP)
2,6-dichloroindophenol  (ISO)
2,6-dinitrotoluene  (ISO)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
2-nitrofluorene  (EXP)
2-nitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4,8-Trimethyl-1H,2H,3H-imidazo[4,5-F]quinoxalin-2-imine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-hydroxynon-2-enal  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
4-phenylcoumarin  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-chloro-7-iodoquinolin-8-ol  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
8-Br-cAMP  (ISO)
9,11,13-octadecatrienoic acid  (ISO)
acetylsalicylic acid  (EXP,ISO)
acridines  (ISO)
acrylamide  (ISO)
actinomycin D  (ISO)
adefovir pivoxil  (ISO)
aflatoxin B1  (EXP,ISO)
alachlor  (EXP)
all-trans-retinoic acid  (ISO)
allyl isothiocyanate  (ISO)
alpha-phellandrene  (ISO)
amiodarone  (ISO)
amitriptyline  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
amphibole asbestos  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antimycin A  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (EXP)
arotinoid acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenic trichloride  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
asbestos  (ISO)
atrazine  (ISO)
auraptene  (ISO)
Aurin  (ISO)
azoxystrobin  (ISO)
bacitracin  (EXP)
Bardoxolone methyl  (ISO)
belinostat  (ISO)
benzene  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
benzyl isothiocyanate  (ISO)
beta-lapachone  (ISO)
bicalutamide  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
bortezomib  (EXP,ISO)
bromobenzene  (EXP)
bromochloroacetic acid  (EXP)
butan-1-ol  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium acetate  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
calcidiol  (EXP)
calcitriol  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
casticin  (ISO)
cefaloridine  (EXP)
CHIR 99021  (ISO)
chlordecone  (ISO)
chlornitrofen  (EXP)
chloroacetaldehyde  (ISO)
chloroethene  (ISO)
chloroform  (EXP)
chloropicrin  (ISO)
chlorotoluron  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cidofovir anhydrous  (ISO)
ciguatoxin CTX1B  (ISO)
cis-caffeic acid  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP)
cobalt dichloride  (EXP,ISO)
conjugated linoleic acid  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
corn oil  (EXP)
cortisol  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (EXP,ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (EXP,ISO)
curcumin  (EXP,ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cylindrospermopsin  (ISO)
cypermethrin  (EXP,ISO)
cyproconazole  (ISO)
cytarabine  (ISO)
D-penicillamine  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (EXP)
deguelin  (ISO)
demethoxycurcumin  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP)
Diallyl sulfide  (EXP,ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (EXP)
dibenz[a,h]anthracene  (ISO)
Dibenz[a,j]acridine  (ISO)
Dibenz[c,h]acridine  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (ISO)
dichloromethane  (ISO)
diclofenac  (EXP,ISO)
dicrotophos  (ISO)
dicyclanil  (ISO)
dieldrin  (EXP)
diethyl maleate  (ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (EXP,ISO)
Diglycolic acid  (EXP,ISO)
dihydroartemisinin  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethyl sulfoxide  (ISO)
dimethylarsinic acid  (EXP,ISO)
dioxygen  (ISO)
diquat  (ISO)
disodium selenite  (ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
emodin  (ISO)
endosulfan  (EXP,ISO)
Enterolactone  (ISO)
erythromycin estolate  (EXP)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
ethylbenzene  (ISO)
ethylparaben  (ISO)
etoposide  (ISO)
eugenol  (EXP)
fenamidone  (ISO)
fenofibrate  (EXP)
fenthion  (ISO)
ferric oxide  (EXP)
fluoranthene  (ISO)
flutamide  (EXP,ISO)
fluxapyroxad  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fotemustine  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
furazolidone  (ISO)
furosemide  (EXP)
gefitinib  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP,ISO)
gliotoxin  (EXP)
glyphosate  (ISO)
graphite  (EXP)
GSK-J4  (ISO)
hydrogen chloride  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
hydroxychloroquine  (ISO)
hydroxytyrosol  (ISO)
hydroxyurea  (ISO)
hypochlorous acid  (ISO)
idarubicin  (ISO)
indole-3-methanol  (EXP)
indometacin  (EXP)
iprodione  (ISO)
irinotecan  (EXP)
iron dichloride  (ISO)
isobutanol  (ISO)
isoniazide  (EXP)
josamycin  (ISO)
kainic acid  (EXP)
ketoconazole  (EXP)
L-1,4-dithiothreitol  (ISO)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
L-methionine  (ISO)
Lasiocarpine  (ISO)
lead diacetate  (ISO)
lead nitrate  (ISO)
leflunomide  (EXP,ISO)
leptomycin B  (ISO)
Licochalcone B  (ISO)
limonene  (EXP)
linalool  (ISO)
lipopolysaccharide  (EXP,ISO)
lupeol  (ISO)
mancozeb  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (EXP,ISO)
medroxyprogesterone acetate  (ISO)
MeIQx  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (EXP)
metacetamol  (ISO)
metformin  (EXP,ISO)
methapyrilene  (EXP)
methimazole  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylarsonic acid  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (EXP,ISO)
methylmercury(1+)  (EXP)
methylseleninic acid  (ISO)
methyltestosterone  (ISO)
microcystin-LR  (ISO)
mitomycin C  (ISO)
Mitotane  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (EXP)
monocrotaline  (ISO)
myristicin  (ISO)
Myrtucommulone A  (ISO)
N(4)-hydroxycytidine  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP,ISO)
N-nitrosomorpholine  (EXP)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
naloxone  (EXP)
nefazodone  (EXP)
nickel dichloride  (EXP,ISO)
nimesulide  (EXP)
nitenpyram  (ISO)
nitrofen  (EXP)
Nodularin  (ISO)
Nonidet P-40  (ISO)
nonivamide  (ISO)
Nutlin-3  (ISO)
o-xylene  (ISO)
ochratoxin A  (EXP,ISO)
oleanolic acid  (ISO)
oxaliplatin  (EXP,ISO)
ozone  (EXP)
p-chloromercuribenzoic acid  (ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
Paraoxon-methyl  (ISO)
paraquat  (EXP,ISO)
parathion-methyl  (ISO)
pentanal  (ISO)
Pentoxifylline  (ISO)
perfluorobutyric acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phalloidin  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
phenytoin  (ISO)
PhIP  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
picoxystrobin  (ISO)
pifithrin-alpha hydrobromide  (ISO)
pinostrobin  (ISO)
pinosylvin  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
potassium bromate  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
progesterone  (EXP,ISO)
promethazine  (EXP)
propanal  (ISO)
Ptaquiloside  (ISO)
pyrazinecarboxamide  (EXP)
pyrethrins  (ISO)
quartz  (ISO)
quercetin  (ISO)
quercitrin  (ISO)
quinomethionate  (ISO)
rac-lactic acid  (ISO)
ranitidine  (EXP)
raspberry ketone  (ISO)
Rebamipide  (EXP)
resveratrol  (EXP,ISO)
retinyl acetate  (ISO)
riddelliine  (ISO)
rifampicin  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
Salinomycin  (ISO)
sarin  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
selenium atom  (ISO)
serpentine asbestos  (ISO)
sertraline  (ISO)
sevoflurane  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sodium fluoride  (ISO)
Soman  (EXP)
succimer  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
sulindac  (ISO)
sunitinib  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
tebufenpyrad  (ISO)
temozolomide  (ISO)
terbufos  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
tetraphene  (ISO)
thapsigargin  (ISO)
theaflavin  (ISO)
thiabendazole  (EXP)
thifluzamide  (ISO)
thioacetamide  (EXP)
thiostrepton  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
tobramycin  (ISO)
toluene  (ISO)
topotecan  (EXP)
torcetrapib  (ISO)
trans-caffeic acid  (ISO)
trans-pinosylvin  (ISO)
Tributyltin oxide  (EXP,ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
troglitazone  (EXP,ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
uranium atom  (ISO)
usnic acid  (ISO)
valproic acid  (ISO)
vancomycin  (EXP)
vincaleukoblastine  (EXP)
vinclozolin  (EXP)
vincristine  (EXP,ISO)
vitamin E  (ISO)
vorinostat  (ISO)
VX nerve agent  (ISO)
XAV939  (ISO)
zearalenone  (ISO)
zerumbone  (ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (ISO)
zinc pyrithione  (ISO)
zinc sulfate  (ISO)
zinc(0)  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA,ISO)
nuclear speck  (IEA,ISO)
nucleus  (IBA,IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. GADD45a is a novel candidate gene in inflammatory lung injury via influences on Akt signaling. Meyer NJ, etal., FASEB J. 2009 May;23(5):1325-37. Epub 2009 Jan 5.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
10. DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein. Tran H, etal., Science 2002 Apr 19;296(5567):530-4.
11. Cloning of rat GADD45 gene and induction analysis following ionizing radiation in vivo. Yoshida T, etal., FEBS Lett 1996 Feb 12;380(1-2):87-92.
12. Cloning of the rat Gadd45 cDNA and its mRNA expression in the brain. Yoshida T, etal., Gene 1994 Dec 30;151(1-2):253-5.
Additional References at PubMed
PMID:9827804   PMID:10097101   PMID:12124778   PMID:12477932   PMID:15123655   PMID:15561781   PMID:17917095   PMID:19593445   PMID:19648647   PMID:19796622   PMID:20160708   PMID:20424134  
PMID:20460379   PMID:21337369   PMID:21396734   PMID:22323595   PMID:22559303   PMID:23227140   PMID:23329839   PMID:24432310   PMID:27086974   PMID:27190312   PMID:28346321   PMID:29244109  
PMID:31009659   PMID:32755658   PMID:36331027  


Genomics

Comparative Map Data
Gadd45a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8497,484,497 - 97,486,799 (-)NCBIGRCr8
mRatBN7.2496,154,789 - 96,157,091 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl496,154,789 - 96,157,115 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4101,404,229 - 101,406,531 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0497,179,202 - 97,181,504 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0495,604,320 - 95,606,622 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0497,782,512 - 97,784,814 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl497,782,512 - 97,784,842 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04162,568,472 - 162,570,774 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4496,649,941 - 96,652,243 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1496,894,423 - 96,896,724 (-)NCBI
Celera490,851,517 - 90,853,819 (-)NCBICelera
Cytogenetic Map4q31NCBI
GADD45A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38167,685,201 - 67,688,334 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl167,685,201 - 67,688,334 (+)EnsemblGRCh38hg38GRCh38
GRCh37168,150,884 - 68,154,017 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36167,923,471 - 67,926,607 (+)NCBINCBI36Build 36hg18NCBI36
Build 34167,862,903 - 67,866,040NCBI
Celera166,441,746 - 66,444,882 (+)NCBICelera
Cytogenetic Map1p31.3NCBI
HuRef166,261,120 - 66,264,281 (+)NCBIHuRef
CHM1_1168,265,339 - 68,268,500 (+)NCBICHM1_1
T2T-CHM13v2.0167,562,720 - 67,565,853 (+)NCBIT2T-CHM13v2.0
Gadd45a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39667,012,080 - 67,014,391 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl667,012,080 - 67,014,441 (-)EnsemblGRCm39 Ensembl
GRCm38667,035,096 - 67,037,407 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl667,035,096 - 67,037,457 (-)EnsemblGRCm38mm10GRCm38
MGSCv37666,985,090 - 66,987,401 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36666,964,674 - 66,966,985 (-)NCBIMGSCv36mm8
Celera669,156,594 - 69,158,906 (-)NCBICelera
Cytogenetic Map6C1NCBI
cM Map630.72NCBI
Gadd45a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542323,656,458 - 23,658,367 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542323,656,516 - 23,658,367 (-)NCBIChiLan1.0ChiLan1.0
GADD45A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21159,181,009 - 159,184,168 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11158,340,738 - 158,343,876 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0166,925,063 - 66,928,222 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1168,880,912 - 68,884,188 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl168,880,912 - 68,884,188 (+)Ensemblpanpan1.1panPan2
GADD45A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1677,393,026 - 77,396,473 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl677,393,036 - 77,396,618 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha680,002,561 - 80,006,283 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0677,992,921 - 77,996,356 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl677,992,931 - 77,996,499 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1677,573,227 - 77,576,562 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0677,441,881 - 77,445,351 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0677,928,564 - 77,931,987 (-)NCBIUU_Cfam_GSD_1.0
Gadd45a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505880,488,019 - 80,491,186 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365913,998,340 - 4,001,830 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365913,998,359 - 4,001,491 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GADD45A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6144,940,697 - 144,944,089 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16144,940,702 - 144,944,089 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
GADD45A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12065,422,668 - 65,425,845 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2065,422,451 - 65,425,840 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603352,186,272 - 52,189,568 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gadd45a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474227,727,660 - 27,730,316 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474227,727,801 - 27,730,252 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:76
Count of miRNA genes:66
Interacting mature miRNAs:74
Transcripts:ENSRNOT00000007698
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)485253748148090731Rat
631689Scl4Serum cholesterol level QTL 41.90.008blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)495174120140174120Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
1549843Bw53Body weight QTL 530.0001body mass (VT:0001259)body weight gain (CMO:0000420)461697658103194791Rat
1578655Bmd11Bone mineral density QTL 1111femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)490850165135850165Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)426775591168368347Rat
1357342Bw40Body weight QTL 400.001body mass (VT:0001259)body weight (CMO:0000012)476647384117676292Rat
631556Bp135Blood pressure QTL 1350.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)478881294117676292Rat
1358363Sradr3Stress Responsive Adrenal Weight QTL 36.19adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)457486946102486946Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)470362013132642728Rat
70167Bw22Body weight QTL 223.1body mass (VT:0001259)body weight (CMO:0000012)476647384117676292Rat
1549839Bw52Body weight QTL 520.0001body mass (VT:0001259)body weight gain (CMO:0000420)461697658115089733Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482798864152731274Rat
724522Bp146Blood pressure QTL 1462.20.0021arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)473630210118630210Rat
61476Aia3Adjuvant induced arthritis QTL 33.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)486730991131730991Rat
1641919Alc22Alcohol consumption QTL 220.0005drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)481192555126192555Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
2300179Bmd50Bone mineral density QTL 505.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)460928534105928534Rat
2317587Eae26Experimental allergic encephalomyelitis QTL 26nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)488656681103194984Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)450119848146803430Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)462933508114921294Rat
61364Iddm2Insulin dependent diabetes mellitus QTL 2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)478885890102684881Rat
1578670Bss14Bone structure and strength QTL 1416.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)487327165132327165Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)439524264116179656Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)456647873149491524Rat
1578657Bss12Bone structure and strength QTL 128.9femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)460220938105220938Rat
1578658Bss13Bone structure and strength QTL 138femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)460220938105220938Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
6478684Anxrr30Anxiety related response QTL 300.00087defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
1578662Bss15Bone structure and strength QTL 1519.6femur width (VT:1000666)femoral neck width (CMO:0001695)487327165132327165Rat
2302051Pia28Pristane induced arthritis QTL 285.30.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)473630210118630210Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)445456990146803430Rat
738015Pia9Pristane induced arthritis QTL 94.50.048joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)480694870125694870Rat
6478772Anxrr49Anxiety related response QTL 490.15488defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)473169846132642728Rat
634334Xhs3X-ray hypersensitivity QTL 310intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)484728680129854654Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)436303261103194984Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
634344Hcar7Hepatocarcinoma resistance QTL 77.8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)470808386115808386Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
631662Hcar2Hepatocarcinoma resistance QTL 23.10.0003liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)478878504123878504Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)462277855128289560Rat
631651Bp124Blood pressure QTL 1243arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)462879517107879517Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)456698790126192555Rat
2306899Bp338Blood pressure QTL 3380.071arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)481006124120102625Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
6478743Anxrr40Anxiety related response QTL 400.83076defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
12798523Anxrr56Anxiety related response QTL 562.830.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)485253748150276390Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)432583980114627242Rat

Markers in Region
RH134659  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2496,154,966 - 96,155,158 (+)MAPPERmRatBN7.2
mRatBN7.245,045,547 - 5,045,737 (-)MAPPERmRatBN7.2
Rnor_6.043,206,849 - 3,207,038NCBIRnor6.0
Rnor_6.0497,782,690 - 97,782,881NCBIRnor6.0
Rnor_5.043,256,390 - 3,256,579UniSTSRnor5.0
Rnor_5.04162,568,650 - 162,568,841UniSTSRnor5.0
RGSC_v3.4496,650,119 - 96,650,310UniSTSRGSC3.4
RGSC_v3.44244,921 - 245,110UniSTSRGSC3.4
Celera45,261,302 - 5,261,491UniSTS
Celera490,851,695 - 90,851,886UniSTS
Cytogenetic Map4q31-q33UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000007698   ⟹   ENSRNOP00000007698
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl496,154,789 - 96,157,115 (-)Ensembl
Rnor_6.0 Ensembl497,782,512 - 97,784,842 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000102107   ⟹   ENSRNOP00000084463
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl496,154,942 - 96,157,115 (-)Ensembl
RefSeq Acc Id: NM_024127   ⟹   NP_077041
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8497,484,497 - 97,486,799 (-)NCBI
mRatBN7.2496,154,789 - 96,157,091 (-)NCBI
Rnor_6.0497,782,512 - 97,784,814 (-)NCBI
Rnor_5.04162,568,472 - 162,570,774 (-)NCBI
RGSC_v3.4496,649,941 - 96,652,243 (-)RGD
Celera490,851,517 - 90,853,819 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_077041 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA96332 (Get FASTA)   NCBI Sequence Viewer  
  AAB02030 (Get FASTA)   NCBI Sequence Viewer  
  AAH81795 (Get FASTA)   NCBI Sequence Viewer  
  BAG30818 (Get FASTA)   NCBI Sequence Viewer  
  BAG30819 (Get FASTA)   NCBI Sequence Viewer  
  EDL91582 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000007698
GenBank Protein P48317 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_077041   ⟸   NM_024127
- UniProtKB: P48317 (UniProtKB/Swiss-Prot),   Q66HL6 (UniProtKB/TrEMBL),   B2DBD9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000007698   ⟸   ENSRNOT00000007698
Ensembl Acc Id: ENSRNOP00000084463   ⟸   ENSRNOT00000102107
Protein Domains
Ribosomal protein eL8/eL30/eS12/Gadd45

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P48317-F1-model_v2 AlphaFold P48317 1-165 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693102
Promoter ID:EPDNEW_R3626
Type:multiple initiation site
Name:Gadd45a_1
Description:growth arrest and DNA-damage-inducible, alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0497,784,822 - 97,784,882EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2654 AgrOrtholog
BioCyc Gene G2FUF-44579 BioCyc
Ensembl Genes ENSRNOG00000005615 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000007698 ENTREZGENE
Gene3D-CATH 3.30.1330.30 UniProtKB/Swiss-Prot
InterPro GADD45 UniProtKB/Swiss-Prot
  L30e-like UniProtKB/Swiss-Prot
  Ribosomal_L7Ae/L30e/S12e/Gad45 UniProtKB/Swiss-Prot
NCBI Gene 25112 ENTREZGENE
PANTHER GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 ALPHA UniProtKB/Swiss-Prot
  PTHR10411 UniProtKB/Swiss-Prot
Pfam Ribosomal_L7Ae UniProtKB/Swiss-Prot
PhenoGen Gadd45a PhenoGen
RatGTEx ENSRNOG00000005615 RatGTEx
Superfamily-SCOP SSF55315 UniProtKB/Swiss-Prot
TIGR TC206559
UniProt A0A8I6GBV3_RAT UniProtKB/TrEMBL
  B2DBD9 ENTREZGENE, UniProtKB/TrEMBL
  GA45A_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q66HL6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-11-14 Gadd45a  growth arrest and DNA-damage-inducible, alpha  Gadd45a  growth arrest and DNA-damage-inducible 45 alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Gadd45a  growth arrest and DNA-damage-inducible 45 alpha      Symbol and Name status set to approved 625702 APPROVED
2002-06-10 Gadd45a  growth arrest and DNA-damage-inducible 45 alpha      Name updated 70585 PROVISIONAL
2001-04-10 Ddit1  DNA-damage inducible transcript 1      Symbol withdrawn, duplicate entry of Gadd45a (RGD:2654) 61478 WITHDRAWN

RGD Curation Notes
Note Type Note Reference
gene_process stress related protein  
gene_process mediates activation of the p38/JNK pathway via MTK1/MEKK4 kinase  
gene_regulation transcription may be induced by forkhead transcription factor FOXO3a 728684