Frmd4b (FERM domain containing 4B) - Rat Genome Database

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Gene: Frmd4b (FERM domain containing 4B) Rattus norvegicus
Analyze
Symbol: Frmd4b
Name: FERM domain containing 4B
RGD ID: 620172
Description: Predicted to act upstream of or within establishment of epithelial cell polarity. Predicted to be located in cytoplasm and ruffle. Predicted to be active in adherens junction and bicellular tight junction. Orthologous to human FRMD4B (FERM domain containing 4B); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: FERM domain-containing protein 4B; GRP1 binding protein GRSP1; Grsp1; Nitzin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84131,452,361 - 131,778,734 (-)NCBIGRCr8
mRatBN7.24129,895,401 - 130,222,070 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4129,895,708 - 130,084,197 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.04129,658,137 - 129,984,735 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4129,658,840 - 129,846,642 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04194,157,499 - 194,480,974 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44132,012,943 - 132,207,644 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14132,278,240 - 132,323,694 (-)NCBI
Celera4118,771,260 - 119,095,704 (-)NCBICelera
Cytogenetic Map4q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
aldrin  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphotericin B  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
azoxystrobin  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
C60 fullerene  (EXP)
carbon nanotube  (ISO)
chlordecone  (ISO)
chlorpyrifos  (EXP)
chrysene  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
FR900359  (ISO)
glyphosate  (EXP)
imidacloprid  (EXP)
inulin  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
melphalan  (ISO)
methylmercury chloride  (ISO)
Muraglitazar  (EXP)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
propanal  (ISO)
quercetin  (ISO)
rimonabant  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
senecionine  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sotorasib  (ISO)
succimer  (ISO)
sunitinib  (ISO)
Tesaglitazar  (EXP)
tetraphene  (ISO)
thiabendazole  (EXP)
thioacetamide  (EXP)
trametinib  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
troglitazone  (EXP,ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Functional redundancy of acetylcholinesterase and neuroligin in mammalian neuritogenesis. Grifman M, etal., Proc Natl Acad Sci U S A 1998 Nov 10;95(23):13935-40.
3. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11445584   PMID:20080746   PMID:23580065  


Genomics

Comparative Map Data
Frmd4b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84131,452,361 - 131,778,734 (-)NCBIGRCr8
mRatBN7.24129,895,401 - 130,222,070 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4129,895,708 - 130,084,197 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.04129,658,137 - 129,984,735 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4129,658,840 - 129,846,642 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04194,157,499 - 194,480,974 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44132,012,943 - 132,207,644 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14132,278,240 - 132,323,694 (-)NCBI
Celera4118,771,260 - 119,095,704 (-)NCBICelera
Cytogenetic Map4q34NCBI
FRMD4B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38369,168,782 - 69,542,586 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl369,168,782 - 69,542,583 (-)EnsemblGRCh38hg38GRCh38
GRCh37369,217,933 - 69,435,239 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36369,301,836 - 69,518,120 (-)NCBINCBI36Build 36hg18NCBI36
Build 34369,302,666 - 69,332,399NCBI
Celera369,147,274 - 69,362,951 (-)NCBICelera
Cytogenetic Map3p14.1NCBI
HuRef369,220,047 - 69,435,240 (-)NCBIHuRef
CHM1_1369,170,368 - 69,386,663 (-)NCBICHM1_1
T2T-CHM13v2.0369,205,753 - 69,579,785 (-)NCBIT2T-CHM13v2.0
Frmd4b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39697,263,828 - 97,594,618 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl697,263,828 - 97,594,502 (-)EnsemblGRCm39 Ensembl
GRCm38697,286,867 - 97,617,657 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl697,286,867 - 97,617,541 (-)EnsemblGRCm38mm10GRCm38
MGSCv37697,236,861 - 97,567,651 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36697,252,330 - 97,583,044 (-)NCBIMGSCv36mm8
Celera699,148,219 - 99,479,337 (-)NCBICelera
Cytogenetic Map6D3NCBI
cM Map644.93NCBI
Frmd4b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542118,483,857 - 18,673,519 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542118,423,238 - 18,669,514 (+)NCBIChiLan1.0ChiLan1.0
FRMD4B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2269,124,610 - 69,497,596 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1369,130,439 - 69,502,383 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0369,105,231 - 69,478,192 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1370,471,897 - 70,842,474 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl370,471,897 - 70,686,895 (-)Ensemblpanpan1.1panPan2
FRMD4B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12022,253,619 - 22,574,917 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2022,402,128 - 22,598,594 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2022,222,606 - 22,544,043 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02022,282,339 - 22,600,372 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2022,430,099 - 22,600,861 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12021,968,263 - 22,290,330 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02022,317,068 - 22,639,260 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02022,387,643 - 22,710,010 (+)NCBIUU_Cfam_GSD_1.0
Frmd4b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049421,349,427 - 1,485,645 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366031,369,851 - 1,485,661 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366031,369,943 - 1,485,645 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FRMD4B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1350,597,414 - 50,980,016 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11350,602,910 - 50,980,236 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21355,735,642 - 56,114,900 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FRMD4B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12230,196,103 - 30,554,140 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2230,195,908 - 30,452,885 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041136,232,993 - 136,595,817 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Frmd4b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247733,763,222 - 3,961,536 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247733,763,706 - 3,961,465 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Frmd4b
2245 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:33
Count of miRNA genes:30
Interacting mature miRNAs:33
Transcripts:ENSRNOT00000010717
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)445456990146803430Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)450119848146803430Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)456647873149491524Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)470362013132642728Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)473169846132642728Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482798864152731274Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)485253748148090731Rat
12798523Anxrr56Anxiety related response QTL 562.830.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)485253748150276390Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
61476Aia3Adjuvant induced arthritis QTL 33.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)486730991131730991Rat
1578662Bss15Bone structure and strength QTL 1519.6femur width (VT:1000666)femoral neck width (CMO:0001695)487327165132327165Rat
1578670Bss14Bone structure and strength QTL 1416.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)487327165132327165Rat
1578655Bmd11Bone mineral density QTL 1111femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)490850165135850165Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
631689Scl4Serum cholesterol level QTL 41.90.008blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)495174120140174120Rat
61434Cia3Collagen induced arthritis QTL 34.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4103194656148194656Rat
2302049Pia32Pristane induced arthritis QTL 325.10.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)4105789505150789505Rat
731165Uae21Urinary albumin excretion QTL 212.40.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)4106649412151649412Rat
61406Scwia1Streptococcal cell wall induced arthritis QTL 12.3joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)4106805662151805662Rat
7207480Bss105Bone structure and strength QTL 1058.1femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)4109827074154827074Rat
1549832Bss3Bone structure and strength QTL 311femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)4109827074154827074Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4114627026159627026Rat
1300116Hrtrt5Heart rate QTL 53.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)4116179486151161268Rat
724535Cm18Cardiac mass QTL 182.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)4118856416163856416Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4119428175157578333Rat
12798527Anxrr58Anxiety related response QTL 584.110.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4119463257147278687Rat
70201Gcr1Gastric cancer resistance QTL 12.7stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)4120260281147278687Rat
2293840Kiddil9Kidney dilation QTL 92.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)4120926564148090731Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4123143783168143783Rat
631683Bp116Blood pressure QTL 1160.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4124303370169303370Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4124778595169778595Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4125590636170590636Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4126395976167139601Rat

Markers in Region
D4Rat80  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24130,142,051 - 130,142,186 (+)MAPPERmRatBN7.2
Rnor_6.04129,904,890 - 129,905,024NCBIRnor6.0
Rnor_5.04194,401,210 - 194,401,344UniSTSRnor5.0
RGSC_v3.44132,262,560 - 132,262,694UniSTSRGSC3.4
RGSC_v3.44132,262,558 - 132,262,922RGDRGSC3.4
RGSC_v3.14132,507,401 - 132,507,535RGD
Celera4119,016,792 - 119,016,926UniSTS
RH 3.4 Map4795.7RGD
RH 3.4 Map4795.7UniSTS
RH 2.0 Map4873.5RGD
SHRSP x BN Map456.66RGD
FHH x ACI Map478.46RGD
Cytogenetic Map4q34UniSTS
D4Rat88  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24130,018,906 - 130,019,145 (+)MAPPERmRatBN7.2
Rnor_6.04129,783,241 - 129,783,479NCBIRnor6.0
Rnor_5.04194,279,802 - 194,280,040UniSTSRnor5.0
RGSC_v3.44132,142,791 - 132,143,030RGDRGSC3.4
RGSC_v3.44132,142,792 - 132,143,030UniSTSRGSC3.4
RGSC_v3.14132,387,617 - 132,387,963RGD
Celera4118,893,705 - 118,893,943UniSTS
SHRSP x BN Map456.66UniSTS
SHRSP x BN Map456.66RGD
FHH x ACI Map477.9799RGD
Cytogenetic Map4q34UniSTS
D4Rat92  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24129,998,172 - 129,998,394 (+)MAPPERmRatBN7.2
Rnor_6.04129,762,437 - 129,762,658NCBIRnor6.0
Rnor_5.04194,258,998 - 194,259,219UniSTSRnor5.0
RGSC_v3.44132,121,127 - 132,121,349RGDRGSC3.4
RGSC_v3.44132,121,128 - 132,121,349UniSTSRGSC3.4
RGSC_v3.14132,365,968 - 132,366,190RGD
Celera4118,873,054 - 118,873,275UniSTS
FHH x ACI Map477.9799RGD
FHH x ACI Map477.9799UniSTS
Cytogenetic Map4q34UniSTS
D4Got96  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24129,960,443 - 129,960,637 (+)MAPPERmRatBN7.2
Rnor_6.04129,723,226 - 129,723,419NCBIRnor6.0
Rnor_5.04194,222,303 - 194,222,496UniSTSRnor5.0
RGSC_v3.44132,076,920 - 132,077,114RGDRGSC3.4
RGSC_v3.44132,076,921 - 132,077,114UniSTSRGSC3.4
RGSC_v3.14132,321,762 - 132,321,955RGD
Celera4118,835,840 - 118,836,033UniSTS
RH 3.4 Map4794.91RGD
RH 3.4 Map4794.91UniSTS
Cytogenetic Map4q34UniSTS
RH142646  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24129,911,850 - 129,912,008 (+)MAPPERmRatBN7.2
Rnor_6.04129,674,642 - 129,674,799NCBIRnor6.0
Rnor_5.04194,174,004 - 194,174,161UniSTSRnor5.0
RGSC_v3.44132,027,842 - 132,027,999UniSTSRGSC3.4
Celera4118,787,691 - 118,787,848UniSTS
RH 3.4 Map4807.91UniSTS
Cytogenetic Map4q34UniSTS
RH143872  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24129,896,509 - 129,896,750 (+)MAPPERmRatBN7.2
Rnor_6.04129,659,248 - 129,659,488NCBIRnor6.0
Rnor_5.04194,158,610 - 194,158,850UniSTSRnor5.0
RGSC_v3.44132,012,236 - 132,012,476UniSTSRGSC3.4
Celera4118,772,368 - 118,772,608UniSTS
RH 3.4 Map4794.9UniSTS
Cytogenetic Map4q34UniSTS
BF399462  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24130,113,532 - 130,113,693 (+)MAPPERmRatBN7.2
Rnor_6.04129,876,550 - 129,876,710NCBIRnor6.0
Rnor_5.04194,372,980 - 194,373,140UniSTSRnor5.0
RGSC_v3.44132,234,513 - 132,234,673UniSTSRGSC3.4
Celera4118,987,961 - 118,988,121UniSTS
RH 3.4 Map4794.3UniSTS
Cytogenetic Map4q34UniSTS
RH138356  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24129,985,162 - 129,985,383 (+)MAPPERmRatBN7.2
Rnor_6.04129,748,713 - 129,748,933NCBIRnor6.0
Rnor_5.04194,246,070 - 194,246,290UniSTSRnor5.0
RGSC_v3.44132,106,180 - 132,106,400UniSTSRGSC3.4
Celera4118,860,054 - 118,860,274UniSTS
RH 3.4 Map4794.0UniSTS
Cytogenetic Map4q34UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 18 33 25 19 25 1 1 72 35 34 11 1
Low 1 25 24 16 16 7 10 2 6 7
Below cutoff 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001427301 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_001077268 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_003749805 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_003753926 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006224996 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006236974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593022 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602839 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602840 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285579 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285580 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285582 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF087945 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000010717   ⟹   ENSRNOP00000010717
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4129,895,708 - 130,031,669 (-)Ensembl
Rnor_6.0 Ensembl4129,658,840 - 129,846,642 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000103395   ⟹   ENSRNOP00000091085
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4129,895,708 - 130,084,197 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000110229   ⟹   ENSRNOP00000079661
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4129,895,708 - 130,084,197 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000115420   ⟹   ENSRNOP00000082847
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4129,895,708 - 130,056,033 (-)Ensembl
RefSeq Acc Id: NM_001427301   ⟹   NP_001414230
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84131,452,365 - 131,640,181 (-)NCBI
RefSeq Acc Id: XM_063285579   ⟹   XP_063141649
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84131,452,361 - 131,640,612 (-)NCBI
RefSeq Acc Id: XM_063285580   ⟹   XP_063141650
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84131,452,361 - 131,589,957 (-)NCBI
RefSeq Acc Id: XM_063285582   ⟹   XP_063141652
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84131,452,361 - 131,620,171 (-)NCBI
RefSeq Acc Id: XM_063285583   ⟹   XP_063141653
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84131,452,361 - 131,778,734 (-)NCBI
RefSeq Acc Id: XM_063285584   ⟹   XP_063141654
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84131,452,361 - 131,482,190 (-)NCBI
RefSeq Acc Id: XM_063285585   ⟹   XP_063141655
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84131,452,361 - 131,477,921 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000010717   ⟸   ENSRNOT00000010717
RefSeq Acc Id: ENSRNOP00000091085   ⟸   ENSRNOT00000103395
RefSeq Acc Id: ENSRNOP00000079661   ⟸   ENSRNOT00000110229
RefSeq Acc Id: ENSRNOP00000082847   ⟸   ENSRNOT00000115420
RefSeq Acc Id: XP_063141653   ⟸   XM_063285583
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063141649   ⟸   XM_063285579
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063141652   ⟸   XM_063285582
- Peptide Label: isoform X3
- UniProtKB: A0A8I5ZUV5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063141650   ⟸   XM_063285580
- Peptide Label: isoform X2
- UniProtKB: F1LZB7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063141654   ⟸   XM_063285584
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063141655   ⟸   XM_063285585
- Peptide Label: isoform X5
RefSeq Acc Id: NP_001414230   ⟸   NM_001427301
- UniProtKB: A0A8I5ZRG3 (UniProtKB/TrEMBL)
Protein Domains
FERM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LZB7-F1-model_v2 AlphaFold F1LZB7 1-1035 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693281
Promoter ID:EPDNEW_R3795
Type:single initiation site
Name:Frmd4b_1
Description:FERM domain containing 4B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04129,846,724 - 129,846,784EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620172 AgrOrtholog
BioCyc Gene G2FUF-43599 BioCyc
Ensembl Genes ENSRNOG00000007764 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000010717.7 UniProtKB/TrEMBL
  ENSRNOT00000103395.1 UniProtKB/TrEMBL
  ENSRNOT00000110229.1 UniProtKB/TrEMBL
  ENSRNOT00000115420.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.80.10 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
InterPro Band_41_domain UniProtKB/TrEMBL
  DUF3338 UniProtKB/TrEMBL
  FERM/acyl-CoA-bd_prot_3-hlx UniProtKB/TrEMBL
  FERM_2 UniProtKB/TrEMBL
  FERM_central UniProtKB/TrEMBL
  FERM_CS UniProtKB/TrEMBL
  FERM_domain UniProtKB/TrEMBL
  FERM_N UniProtKB/TrEMBL
  FERM_PH-like_C UniProtKB/TrEMBL
  FRMD4A/B UniProtKB/TrEMBL
  FRMD4A/B_FERM_C UniProtKB/TrEMBL
  PH_type UniProtKB/TrEMBL
  Ubiquitin-rel_dom UniProtKB/TrEMBL
KEGG Report rno:252858 UniProtKB/TrEMBL
NCBI Gene 252858 ENTREZGENE
PANTHER FERM DOMAIN-CONTAINING PROTEIN 4 UniProtKB/TrEMBL
  FERM DOMAIN-CONTAINING PROTEIN 4B UniProtKB/TrEMBL
Pfam DUF3338 UniProtKB/TrEMBL
  FERM_C UniProtKB/TrEMBL
  FERM_M UniProtKB/TrEMBL
  FERM_N UniProtKB/TrEMBL
PhenoGen Frmd4b PhenoGen
PRINTS BAND41 UniProtKB/TrEMBL
PROSITE FERM_2 UniProtKB/TrEMBL
  FERM_3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007764 RatGTEx
SMART B41 UniProtKB/TrEMBL
  FERM_C UniProtKB/TrEMBL
Superfamily-SCOP FERM_3-hlx UniProtKB/TrEMBL
  PH domain-like UniProtKB/TrEMBL
  SSF54236 UniProtKB/TrEMBL
UniProt A0A8I5ZRG3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZUV5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AFH5_RAT UniProtKB/TrEMBL
  A6IBG0_RAT UniProtKB/TrEMBL
  A6IBG1_RAT UniProtKB/TrEMBL
  F1LZB7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Frmd4b  FERM domain containing 4B  Grsp1  GRP1 binding protein GRSP1  Symbol and Name updated 1299863 APPROVED
2002-08-07 Grsp1  GRP1 binding protein GRSP1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression high mRNA expression is observed in the developing nervous system 632835
gene_homology 42% homology to the band 4.1 protein superfamily 632835